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1. 发明申请

US20130141098A1 Alignment Phantom for MR/PET System 有权
标题翻译： MR / PET系统对准体模
公开(公告)号：US20130141098A1
公开(公告)日：2013-06-06
申请号：US13753894
申请日：2013-01-30
申请人： Jun Bao , David Faul , Ralf Ladebeck , John Thomas Pawlak , Elmar Rummert , Charles C. Watson
发明人： Jun Bao , David Faul , Ralf Ladebeck , John Thomas Pawlak , Elmar Rummert , Charles C. Watson
IPC分类号： G01R33/48
CPC分类号： G01R33/58 , G01R33/48 , G01R33/481 , G01R33/4812 , G01T1/1603 , G01T7/005
摘要： A phantom for co-registering a magnetic resonance image and a nuclear medical image is disclosed. The phantom includes a longitudinal member having a first end cap and a second end cap and a chamber contained within the longitudinal member. The chamber contains a fluid for producing a first image using a first imaging modality. The phantom further includes a first rod disposed within the chamber of the longitudinal member. The first rod contains a radioactive substance for producing a second image using a second imaging modality.
摘要翻译：公开了用于共同配准磁共振图像和核医学图像的体模。该体模包括具有第一端盖和第二端盖以及容纳在纵向构件内的室的纵向构件。该腔室包含用于使用第一成像模态产生第一图像的流体。体模还包括设置在纵向构件的腔室内的第一杆。第一杆包含用于使用第二成像模态产生第二图像的放射性物质。

2. 发明授权

US09459333B2 Alignment phantom for MR/PET system 有权
标题翻译： MR / PET系统对准体模
公开(公告)号：US09459333B2
公开(公告)日：2016-10-04
申请号：US13753894
申请日：2013-01-30
申请人： Jun Bao , David Faul , Ralf Ladebeck , John Thomas Pawlak , Elmar Rummert , Charles C. Watson
发明人： Jun Bao , David Faul , Ralf Ladebeck , John Thomas Pawlak , Elmar Rummert , Charles C. Watson
IPC分类号： G01R33/58 , G01T1/16 , G01R33/48
CPC分类号： G01R33/58 , G01R33/48 , G01R33/481 , G01R33/4812 , G01T1/1603 , G01T7/005
摘要： A phantom for co-registering a magnetic resonance image and a nuclear medical image is disclosed. The phantom includes a longitudinal member having a first end cap and a second end cap and a chamber contained within the longitudinal member. The chamber contains a fluid for producing a first image using a first imaging modality. The phantom further includes a first rod disposed within the chamber of the longitudinal member. The first rod contains a radioactive substance for producing a second image using a second imaging modality.
摘要翻译：公开了用于共同配准磁共振图像和核医学图像的体模。该体模包括具有第一端盖和第二端盖以及容纳在纵向构件内的室的纵向构件。该腔室包含用于使用第一成像模态产生第一图像的流体。体模还包括设置在纵向构件的腔室内的第一杆。第一杆包含用于使用第二成像模态产生第二图像的放射性物质。

3. 发明授权

US08817245B2 High-powered optical module safety systems and methods 有权
标题翻译：大功率光模块安全系统及方法
公开(公告)号：US08817245B2
公开(公告)日：2014-08-26
申请号：US13593212
申请日：2012-08-23
申请人： Jean-Luc Archambault , Jun Bao
发明人： Jean-Luc Archambault , Jun Bao
IPC分类号： G01N21/00 , G01M11/00
CPC分类号： G01M11/3145 , G01M11/335 , H01S3/0014 , H01S3/06754 , H01S3/094003 , H01S3/10007 , H01S3/1608 , H01S3/302
摘要： A method, optical module, and optical amplifier are configured to detect fiber discontinuities at or near a port from which high powered optical signals are input into a fiber span. These fiber discontinuities can include fiber pinches, and are detected by monitoring for slight changes in a backscatter signal. Detection is quick and efficient based on the backscatter signal being attenuated by the fiber discontinuities twice, namely once as the high powered optical signals and again as the associated backscatter signal of the high powered optical signals returning to the port. Various remedial actions can be taken upon detecting fiber pinches at or near the port.
摘要翻译：一种方法，光学模块和光学放大器被配置为检测光纤不连续性，其中高功率光信号从该端口输入到光纤跨度。这些光纤不连续性可以包括光纤夹紧，并通过监视反向散射信号的轻微变化来检测。基于后向散射信号被光纤不连续性衰减两次，即一次作为高功率光信号，再次作为返回到端口的大功率光信号的相关后向散射信号，检测是快速和有效的。在端口处或附近检测光纤夹点时可以采取各种补救措施。

4. 发明授权

US08306425B2 High-degree reconfigurable optical add-drop multiplexing systems using bi-directional wavelength selective switches 有权
标题翻译：使用双向波长选择开关的高度可重构光分插复用系统
公开(公告)号：US08306425B2
公开(公告)日：2012-11-06
申请号：US12356593
申请日：2009-01-21
申请人： Xiaohui Yang , Zhonghua Zhu , Jun Bao
发明人： Xiaohui Yang , Zhonghua Zhu , Jun Bao
IPC分类号： H04J14/02 , H04J14/00
CPC分类号： H04Q11/0005 , H04J14/0205 , H04J14/0206 , H04J14/0212 , H04J14/0213 , H04J14/0217 , H04J14/0219 , H04J14/0284 , H04Q2011/0035 , H04Q2011/0052
摘要： The present disclosure provides high-degree reconfigurable optical add-drop multiplexing (ROADM) systems using bi-directional wavelength selective switches (WSSs) and optical circulators. A single WSS is utilized on each degree of a node in a bi-directional manner, i.e. both ingress and egress share the same WSS. Advantageously, the present invention eliminates conventional splitters/combiners thereby capping intra-node insertion loss to a certain value regardless of the number of degrees. More importantly, the present invention reduces noise penalty associated with high-degree nodes while minimizing cost.
摘要翻译：本公开提供使用双向波长选择开关（WSS）和光学循环器的高度可重构的光分插复用（ROADM）系统。以双向方式在每个节点上使用单个WSS，即入口和出口共享相同的WSS。有利地，本发明消除了常规的分离器/组合器，从而将节点内插入损耗限制到一定值，而不管度数。更重要的是，本发明降低了与高度节点相关联的噪声，同时最小化了成本。

5. 发明授权

US08233215B2 Optical module manufacturing and testing systems and methods 有权
标题翻译：光模块制造和测试系统及方法
公开(公告)号：US08233215B2
公开(公告)日：2012-07-31
申请号：US12542899
申请日：2009-08-18
申请人： Jun Bao
发明人： Jun Bao
IPC分类号： H04B10/08 , H04B10/17 , G02B6/46
CPC分类号： H01S3/06704
摘要： The present disclosure relates to streamlining optical module and/or subassembly development, manufacturing, and testing through introducing a memory component within a module and/or subassembly that is utilized with a host module for system calibration and/or configuration. In an exemplary embodiment, the present invention can streamline optical amplifier (EDFA) module and/or subassembly development, manufacturing, and testing. The present invention includes an optical module/sub-assembly without control circuitry, i.e. a “dumb module”, but with a memory that is used to load relevant data from a supplier. This data is utilized to calibrate, test, and configure the optical module/sub-assembly in a host module. The host module includes control circuitry to access this memory in the optical module/sub-assembly and to calibrate, test, configure, and control the optical module/sub-assembly. Advantageously, this additional memory reduces manufacturing time without the disadvantage of adding complexity in the optical module/sub-assembly.
摘要翻译：本公开涉及通过在与主机模块一起用于系统校准和/或配置的模块和/或子组件中引入存储器组件来简化光学模块和/或子组件开发，制造和测试。在示例性实施例中，本发明可以简化光放大器（EDFA）模块和/或子组件开发，制造和测试。本发明包括没有控制电路的光学模块/子组件，即“哑模块”，但是具有用于从供应商加载相关数据的存储器。该数据用于校准，测试和配置主机模块中的光模块/子组件。主机模块包括用于访问光学模块/子组件中的该存储器并且校准，测试，配置和控制光学模块/子组件的控制电路。有利地，该附加存储器减少了制造时间，而没有增加光学模块/子组件的复杂性的缺点。

6. 发明申请

US20110243944A1 Fusion Protein Inhibiting Osteoclast Formation, Preparation Method and Medicine Compositions Thereof 有权
标题翻译：融合蛋白抑制破骨细胞形成，制备方法和药物组合物
公开(公告)号：US20110243944A1
公开(公告)日：2011-10-06
申请号：US13123235
申请日：2009-09-29
申请人： Jun Bao , Haiming Chen , Daocheng Zhu
发明人： Jun Bao , Haiming Chen , Daocheng Zhu
IPC分类号： A61K39/395 , C07H21/04 , C07K19/00 , C12P21/02 , A61P19/08 , A61P19/10
CPC分类号： C07K14/70575 , A61K38/00 , C07K2319/30
摘要： The present invention provides a coding gene having the nucleic acid sequence shown as SEQ ID NO:1 and the fusion protein RIG (SEQ ID NO:2) that inhibits osteoclast formation. The present invention also provides the preparation method for the fusion protein RIG as well as synthetic oligo-nucleotide primers, plasmids and host cells used in the method and a medicine having the above fusion protein RIG as active ingredient. The fusion protein RIG in present invention is derived from humanized immunoglobulin and RANKL with a flexible hinge region. RIG can cross link the cell surface receptor RANK and Fcγ 1 to induce a cytosolic inhibitory signal leading to the inhibition of osteoclast formation. The fusion protein RIG in present invention can play an essential role in treating osteoporosis and bone resorption diseases caused by tumor metastasis.
摘要翻译：本发明提供具有SEQ ID NO：1所示的核酸序列和抑制破骨细胞形成的融合蛋白RIG（SEQ ID NO：2）的编码基因。本发明还提供了融合蛋白RIG的制备方法以及该方法中使用的合成寡核苷酸引物，质粒和宿主细胞以及具有上述融合蛋白RIG作为活性成分的药物。本发明的融合蛋白RIG衍生自具有柔性铰链区的人源化免疫球蛋白和RANKL。 RIG可以将细胞表面受体RANK和Fcγ1交联以诱导抑制破骨细胞形成的细胞溶质抑制信号。本发明的融合蛋白RIG可以在治疗由肿瘤转移引起的骨质疏松症和骨吸收疾病中发挥重要作用。

7. 发明授权

US07569829B2 Apparatus for automatic calibration of PET/CT systems 有权
标题翻译： PET / CT系统自动校准装置
公开(公告)号：US07569829B2
公开(公告)日：2009-08-04
申请号：US12034095
申请日：2008-02-20
申请人： Mu Chen , Michael E. Casey , Jun Bao
发明人： Mu Chen , Michael E. Casey , Jun Bao
IPC分类号： G01T1/161 , G01T1/164 , G12B13/00
CPC分类号： G01T7/005
摘要： A calibration system for a combined Positron Emission Tomography (PET)/Computed Tomography scanner system, may have a support structure carrying a rotation motor driving a phantom, wherein the phantom has at least two phantom rods and the rods are positioned such that they are neither parallel nor connected to each other.
摘要翻译：用于组合正电子发射断层扫描（PET）/计算机断层摄影扫描仪系统的校准系统可以具有承载驱动模体的旋转马达的支撑结构，其中，模体具有至少两个幻影棒，并且杆被定位成使得它们不是平行或相互连接。

8. 发明申请

US20070212682A1 Methods And Apparatus For Detection Of Viral Infection 有权
标题翻译：用于检测病毒感染的方法和装置
公开(公告)号：US20070212682A1
公开(公告)日：2007-09-13
申请号：US11578372
申请日：2005-04-12
申请人： Yongyi Yu , Lina Li , Zhuangwu Li , Jun Bao
发明人： Yongyi Yu , Lina Li , Zhuangwu Li , Jun Bao
IPC分类号： C12Q1/70 , C12M3/00
CPC分类号： G01N33/543 , B01J2219/00315 , B01J2219/00367 , B01J2219/00378 , B01J2219/00387 , B01J2219/00432 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00527 , B01J2219/00545 , B01J2219/00547 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00641 , B01J2219/00662 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , G01N33/56983 , G01N2469/20
摘要： This invention generally relates to apparatus and methods for high-throughput, reproducible and inexpensive detection of virus infection using multiplexing technologies such as slide-based, microtiter plate-based and membrane-based microarrays and beads technologies. The apparatus and methods allow simultaneous detection of multiple viral infections in a plurality of test samples.
摘要翻译：本发明一般涉及使用诸如基于幻灯片，微量滴定板和基于膜的微阵列和珠粒技术的复用技术来高度通过，可再现和便宜地检测病毒感染的装置和方法。该装置和方法允许在多个测试样品中同时检测多个病毒感染。

9. 发明授权

US09392958B2 Method of attenuation correction of positron emission tomography data and combined positron emission tomography and magnetic resonance tomography system 有权
标题翻译：正电子发射断层扫描数据和组合正电子发射断层扫描和磁共振断层扫描系统的衰减校正方法
公开(公告)号：US09392958B2
公开(公告)日：2016-07-19
申请号：US13483454
申请日：2012-05-30
申请人： Matthias Fenchel , Kirstin Jattke , Jun Bao , Alto Stemmer , William Curtis Howe
发明人： Matthias Fenchel , Kirstin Jattke , Jun Bao , Alto Stemmer , William Curtis Howe
IPC分类号： A61B5/055 , A61B5/00 , A61B6/03 , A61B6/00 , G01R33/48
CPC分类号： A61B5/055 , A61B5/0035 , A61B5/7285 , A61B6/037 , A61B6/4417 , A61B6/5205 , A61B6/5247 , A61B6/5258 , A61B6/5264 , A61B6/527 , A61B6/5288 , A61B6/548 , G01R33/481
摘要： Various embodiments relate to a method of attenuation correction of Positron Emission Tomography (PET) data based on Magnetic Resonance Tomography (MRT) data. A method of at least one embodiment further includes determining further data being indicative of an iterative cycle of a physiological observable of a patient and matching the PET data with the MRT data based on the further data.
摘要翻译：各种实施方案涉及基于磁共振层析成像（MRT）数据的正电子发射断层扫描（PET）数据的衰减校正方法。至少一个实施例的方法还包括确定指示患者的生理可观察的迭代循环的另外的数据，并且基于进一步的数据将PET数据与MRT数据进行匹配。

10. 发明授权

US09345765B2 Diagnostic and therapeutic uses of moesin fragments 有权
标题翻译： moesin片段的诊断和治疗用途
公开(公告)号：US09345765B2
公开(公告)日：2016-05-24
申请号：US13878239
申请日：2011-10-08
申请人： Yue Zhang , Jun Bao
发明人： Yue Zhang , Jun Bao
IPC分类号： A61K38/00 , A61K39/395 , A61K38/17 , C07K16/18 , G01N33/564 , G01N33/68
CPC分类号： A61K39/3955 , A61K38/1703 , A61K38/1709 , C07K16/18 , C07K2317/76 , G01N33/564 , G01N33/6854 , G01N2800/10 , G01N2800/52
摘要： The present application provides compositions and methods for modulating the activity and quantity of platelets and preventing and treating disorders or diseases associated with abnormal activity and quantity of platelets.
摘要翻译：本申请提供调节血小板的活性和量的组合物和方法，并预防和治疗与血小板的异常活性和数量相关的疾病或疾病。

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