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1. 发明申请

US20130289076A1 CYCLOPROPYLAMINE INHIBITORS OF OXIDASES 有权
标题翻译：氧化锌的环丙基胺抑制剂
公开(公告)号：US20130289076A1
公开(公告)日：2013-10-31
申请号：US13877919
申请日：2011-10-07
申请人： Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe , Marc Murtinell Pedemonte , Alberto Ortega Muñoz , Núrla Valls Vidal
发明人： Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe , Marc Murtinell Pedemonte , Alberto Ortega Muñoz , Núrla Valls Vidal
IPC分类号： C07D401/12 , C07C237/30 , C07C217/92 , C07C255/58 , C07D213/74 , C07C211/52
CPC分类号： A61K31/4439 , A61K31/136 , A61K31/166 , A61K31/277 , A61K31/4418 , C07C211/52 , C07C211/53 , C07C211/55 , C07C211/56 , C07C217/92 , C07C237/30 , C07C255/58 , C07D213/74 , C07D401/12
摘要： The invention relates to cyclopropylamine compounds, in particular the compounds of Formula (I) as described and defined herein, and their use in therapy, including, e.g., the treatment or prevention of cancer.
摘要翻译：本发明涉及环丙胺化合物，特别是本文所述和定义的式（I）化合物及其在治疗中的用途，包括例如治疗或预防癌症。

2. 发明授权

US09061966B2 Cyclopropylamine inhibitors of oxidases 有权
标题翻译：氧化酶环丙胺抑制剂
公开(公告)号：US09061966B2
公开(公告)日：2015-06-23
申请号：US13877919
申请日：2011-10-07
申请人： Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Alberto Ortega Muñoz , Núrla Valls Vidal
发明人： Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Alberto Ortega Muñoz , Núrla Valls Vidal
IPC分类号： C07D401/12 , C07D213/74 , A61K31/136 , C07C211/52 , C07C211/53 , C07C211/55 , C07C211/56 , C07C217/92 , C07C237/30 , C07C255/58
CPC分类号： A61K31/4439 , A61K31/136 , A61K31/166 , A61K31/277 , A61K31/4418 , C07C211/52 , C07C211/53 , C07C211/55 , C07C211/56 , C07C217/92 , C07C237/30 , C07C255/58 , C07D213/74 , C07D401/12
摘要： The invention relates to cyclopropylamine compounds, in particular the compounds of Formula (I) as described and defined herein, and their use in therapy, including, e.g., the treatment or prevention of cancer.
摘要翻译：本发明涉及环丙胺化合物，特别是本文所述和定义的式（I）化合物及其在治疗中的用途，包括例如治疗或预防癌症。

3. 发明授权

US08946296B2 Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use 有权
标题翻译：取代的杂芳基 - 和芳基 - 环丙胺乙酰胺及其用途
公开(公告)号：US08946296B2
公开(公告)日：2015-02-03
申请号：US13500687
申请日：2010-04-19
申请人： Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
发明人： Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
IPC分类号： A61K31/165 , C07C237/20 , C07C237/06 , C07C255/54 , C07D213/36
CPC分类号： C07C237/06 , C07C255/54 , C07C2601/02 , C07D213/36
摘要： The invention relates to compounds of Formula (I): (A′)x-(A)-(B)—(Z)-(L)-C(═O)NH2 or pharmaceutically acceptable salts or solvates thereof, wherein: (A) is heteroaryl or aryl; each (A′), if present, is indepedently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A′) is substituted with 0, 1, 2 or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, sulfinyl, and carboxamide; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH—; and (L) is —(CH2)mCR1,R2—, wherein m is 0, 1, 2, 3, 4, 5, or 6, and wherein R1 and R2 are each independently hydrogen or C1-C6 alkyl; provided that, if (L) is —CH2— or —CH(CH3)—, then X is not 0. The compounds of the invention are useful in the treatment of diseases such as cancer and neurodegenerative diseases.
摘要翻译：本发明涉及式（I）化合物：（A'）x-（A） - （B） - （Z） - （L）-C（= O）NH 2或其药学上可接受的盐或溶剂合物，其中： A）是杂芳基或芳基; 每个（A'）如果存在，独立地选自芳基，芳基烷氧基，芳基烷基，杂环基，芳氧基，卤素，烷氧基，卤代烷基，环烷基，卤代烷氧基和氰基，其中每个（A'）被0,1,2 或3个独立地选自卤素，卤代烷基，芳基，芳基烷氧基，烷基，烷氧基，氰基，磺酰基，亚磺酰基和羧酰胺的取代基; X为0,1,2或3; （B）是环丙基环，其中（A）和（Z）与（B）的不同碳原子共价结合; （Z）为-NH-; 和（L）是 - （CH 2）m CR 1，R 2 - ，其中m是0,1,2,3,4,5或6，并且其中R 1和R 2各自独立地是氢或C 1 -C 6烷基; 条件是，如果（L）是-CH 2 - 或-CH（CH 3） - ，则X不为0.本发明的化合物可用于治疗疾病如癌症和神经变性疾病。

4. 发明申请

US20120264823A1 SUBSTITUTED HETEROARYL- AND ARYL-CYCLOPROPYLAMINE ACETAMIDES AND THEIR USE 有权
标题翻译：取代的杂芳基和芳基环丙基氨基甲酸酯及其用途
公开(公告)号：US20120264823A1
公开(公告)日：2012-10-18
申请号：US13500687
申请日：2010-04-19
申请人： Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
发明人： Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
IPC分类号： A61K31/165 , A61K31/277 , C07C237/20 , A61P25/28 , A61P25/16 , C07C255/60 , A61P35/00
CPC分类号： C07C237/06 , C07C255/54 , C07C2601/02 , C07D213/36
摘要： The invention relates to compounds of Formula (I): (A′)x-(A)-(B)—(Z)-(L)-C(═O)NH2 or pharmaceutically acceptable salts or solvates thereof, wherein: (A) is heteroaryl or aryl; each (A′), if present, is indepedently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A′) is substituted with 0, 1, 2 or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, sulfinyl, and carboxamide; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH—; and (L) is —(CH2)mCR1,R2—, wherein m is 0, 1, 2, 3, 4, 5, or 6, and wherein R1 and R2 are each independently hydrogen or C1-C6 alkyl; provided that, if (L) is —CH2— or —CH(CH3)—, then X is not 0. The compounds of the invention are useful in the treatment of diseases such as cancer and neurodegenerative diseases.
摘要翻译：本发明涉及式（I）化合物：（A'）x-（A） - （B） - （Z） - （L）-C（= O）NH 2或其药学上可接受的盐或溶剂合物，其中： A）是杂芳基或芳基; 每个（A'）如果存在，独立地选自芳基，芳基烷氧基，芳烷基，杂环基，芳氧基，卤素，烷氧基，卤代烷基，环烷基，卤代烷氧基和氰基，其中每个（A'）被0,1,2 或3个独立地选自卤素，卤代烷基，芳基，芳基烷氧基，烷基，烷氧基，氰基，磺酰基，亚磺酰基和羧酰胺的取代基; X为0,1,2或3; （B）是环丙基环，其中（A）和（Z）与（B）的不同碳原子共价结合; （Z）为-NH-; 和（L）是 - （CH 2）m CR 1，R 2 - ，其中m是0,1,2,3,4,5或6，并且其中R 1和R 2各自独立地是氢或C 1 -C 6烷基; 条件是，如果（L）是-CH 2 - 或-CH（CH 3） - ，则X不为0.本发明的化合物可用于治疗疾病如癌症和神经变性疾病。

5. 发明授权

US09006449B2 Cyclopropylamine derivatives useful as LSD1 inhibitors 有权
标题翻译：可用作LSD1抑制剂的环丙胺衍生物
公开(公告)号：US09006449B2
公开(公告)日：2015-04-14
申请号：US13812386
申请日：2011-07-27
申请人： Matthew Colin Thor Fyfe , Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Marc Martinell Pedemonte , Maria de los Ángeles Estiarte-Martinez , Nuria Valls Vidal
发明人： Matthew Colin Thor Fyfe , Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Marc Martinell Pedemonte , Maria de los Ángeles Estiarte-Martinez , Nuria Valls Vidal
IPC分类号： C07D401/00 , C07D277/28 , A61K31/44 , C07C211/40 , C07C215/64 , C07C217/74 , C07C255/53 , C07C255/54 , C07C311/08 , C07C311/09 , C07C311/21 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/56 , C07D213/57 , C07D239/26 , C07D333/20 , C07D401/04 , C07D405/04 , C07D409/04 , C07C255/59 , C07D213/64 , C07D401/10 , C07D405/10 , C07D409/10
CPC分类号： C07C211/40 , C07B2200/07 , C07C215/64 , C07C217/74 , C07C255/53 , C07C255/54 , C07C255/59 , C07C311/08 , C07C311/09 , C07C311/21 , C07C2601/02 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/56 , C07D213/57 , C07D213/64 , C07D239/26 , C07D277/28 , C07D333/20 , C07D401/04 , C07D401/10 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10
摘要： The invention relates to cyclopropylamine compounds, in particular the compounds of Formula (I), and their use in therapy, including e.g. in the treatment or prevention of cancer, a neurological disease or condition, or viral infection.
摘要翻译：本发明涉及环丙胺化合物，特别是式（I）的化合物及其在治疗中的应用，包括例如。治疗或预防癌症，神经系统疾病或病症或病毒感染。

6. 发明授权

US08859555B2 Lysine Specific Demethylase-1 inhibitors and their use 有权
公开(公告)号：US08859555B2
公开(公告)日：2014-10-14
申请号：US13497994
申请日：2010-04-19
申请人： Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
发明人： Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
IPC分类号： A61K31/495 , C07D295/13 , A61K31/075 , C07C211/40 , C07D211/14 , C07D241/04 , A61K45/06 , C07C323/25 , C07C217/74 , C07D207/14 , A61K31/40 , C07C217/08 , A61K31/095
CPC分类号： C07D241/04 , A61K31/075 , A61K31/095 , A61K31/40 , A61K31/495 , A61K45/06 , C07C211/40 , C07C217/08 , C07C217/74 , C07C323/25 , C07C2601/02 , C07D207/14 , C07D211/14 , A61K2300/00
摘要： The invention relates to a compound of Formula (I): (A′)x-(A)-(B)-(Z)-(L)-(D), wherein: (A) is heteroaryl or aryl; each (A′), if present, is independently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A′) is substituted with 0, 1, 2, or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, amido, and sulfinyl; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH—; (L) is chosen from —CH2CH2—, —CH2CH2CH2—, and —CH2CH2CH2CH2—; and (D) is chosen from —N(—R1)-R2, —O—R3, and —S—R3, wherein: R1 and R2 are mutually linked to form a heterocyclic ring together with the nitrogen atom that R1 and R2 are attached to, wherein said heterocyclic ring has 0, 1, 2, or 3 substituents independently chosen from —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), alkyl, halo, cyano, alkoxy, haloalkyl, and haloalkoxy, or R1 and R2 are independently chosen from —H, alkyl, cycloalkyl, haloalkyl, and heterocyclyl, wherein the sum of substituents on R1 and R2 together is 0, 1, 2, or 3, and the substituents are independently chosen from —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), and fluoro; and R3 is chosen from —H, alkyl, cycloalkyl, haloalkyl, and heterocyclyl, wherein R3 has 0, 1, 2, or 3 substituents independently chosen from —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), and fluoro; or an enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt or solvate thereof. The compounds of the invention show inhibitory LSD1 activity, which makes them useful in the treatment or prevention of diseases such as cancer.

7. 发明申请

US20120283266A1 LYSINE SPECIFIC DEMETHYLASE-1 INHIBITORS AND THEIR USE 有权
公开(公告)号：US20120283266A1
公开(公告)日：2012-11-08
申请号：US13497994
申请日：2010-04-19
申请人： Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
发明人： Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
IPC分类号： A61K31/135 , A61K31/495 , C07C211/36 , A61P35/00 , A61K31/40 , C07D211/26 , A61K31/445 , C07C323/29 , C07D241/04 , C07D207/14
CPC分类号： C07D241/04 , A61K31/075 , A61K31/095 , A61K31/40 , A61K31/495 , A61K45/06 , C07C211/40 , C07C217/08 , C07C217/74 , C07C323/25 , C07C2601/02 , C07D207/14 , C07D211/14 , A61K2300/00
摘要： The invention relates to a compound of Formula (I): (A′)x-(A)-(B)-(Z)-(L)-(D), wherein: (A) is heteroaryl or aryl; each (A′), if present, is independently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A′) is substituted with 0, 1, 2, or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, amido, and sulfinyl; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH—; (L) is chosen from —CH2CH2—, —CH2CH2CH2—, and —CH2CH2CH2CH2—; and (D) is chosen from —N(—R1)—R2, —O—R3, and —S—R3, wherein: R1 and R2 are mutually linked to form a heterocyclic ring together with the nitrogen atom that R1 and R2 are attached to, wherein said heterocyclic ring has 0, 1, 2, or 3 substituents independently chosen from —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), alkyl, halo, cyano, alkoxy, haloalkyl, and haloalkoxy, or R1 and R2 are independently chosen from —H, alkyl, cycloalkyl, haloalkyl, and heterocyclyl, wherein the sum of substituents on R1 and R2 together is 0, 1, 2, or 3, and the substituents are independently chosen from —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), and fluoro; and R3 is chosen from —H, alkyl, cycloalkyl, haloalkyl, and heterocyclyl, wherein R3 has 0, 1, 2, or 3 substituents independently chosen from —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), and fluoro; or an enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt or solvate thereof. The compounds of the invention show inhibitory LSD1 activity, which makes them useful in the treatment or prevention of diseases such as cancer.

8. 发明授权

US08722743B2 Lysine specific demethylase-1 inhibitors and their use 有权
标题翻译：赖氨酸特异性脱甲基酶-1抑制剂及其用途
公开(公告)号：US08722743B2
公开(公告)日：2014-05-13
申请号：US13641916
申请日：2011-04-19
申请人： Alberto Ortega Munoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
发明人： Alberto Ortega Munoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
IPC分类号： A61K31/165 , C07C211/00
CPC分类号： C07C217/74 , A61K31/135 , A61K31/165 , A61K45/06 , A61N5/10 , C07C211/35 , C07C211/40 , C07C211/42 , C07C217/52 , C07C237/24 , C07C2101/02 , C07C2101/14 , C07C2101/18 , C07C2102/08 , C07C2102/10 , C07C2601/02 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10
摘要： The present invention relates to a compound of Formula 1, wherein: (A) is heteroaryl or aryl; each (A′), if present, is independently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A′) is substituted with 0, 1, 2, or 3 substituents independently chosen from halo, haloalkyl, haloalkoxy, aryl, arylalkoxy, alkyl, alkoxy, amido, —CH2C(=0)NH2, heteroaryl, cyano, sulfonyl, and sulfinyl; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH—; (L) is chosen from a single bond, —CH2—, —CH2CH2—, —CH2CH2CH2—, and —CH2CH2CH2CH2—; and (D) is an aliphatic carbocyclic group or benzocycloalkyl, wherein said aliphatic carbocyclic group or said benzocycloalkyl has 0, 1, 2, or 3 substituents independently chosen from —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), alkyl, halo, amido, cyano, alkoxy, haloalkyl, and haloalkoxy. (A′)X-(A)-(B)—(Z)-(L)-(D) formula (I) The compounds of the invention show activity for inhibiting LSD1, which makes them useful in the treatment or prevention of diseases such as cancer.
摘要翻译：本发明涉及式1的化合物，其中：（A）是杂芳基或芳基; 每个（A'）如果存在，独立地选自芳基，芳基烷氧基，芳基烷基，杂环基，芳氧基，卤素，烷氧基，卤代烷基，环烷基，卤代烷氧基和氰基，其中每个（A'）被0,1,2 ，或3个独立地选自卤素，卤代烷基，卤代烷氧基，芳基，芳基烷氧基，烷基，烷氧基，酰氨基，-CH 2 C（= O）NH 2，杂芳基，氰基，磺酰基和亚磺酰基的取代基。 X为0,1,2或3; （B）是环丙基环，其中（A）和（Z）与（B）的不同碳原子共价结合; （Z）为-NH-; （L）选自单键-CH 2 - ， - CH 2 CH 2 - ， - CH 2 CH 2 CH 2 - 和-CH 2 CH 2 CH 2 CH 2 - ; - 和（D）是脂族碳环基或苯并环烷基，其中所述脂族碳环基或所述苯并环烷基具有0,1,2或3个独立地选自-NH 2，-NH（C 1 -C 6烷基）， - N（C1- C6烷基）（C1-C6烷基），烷基，卤素，酰胺基，氰基，烷氧基，卤代烷基和卤代烷氧基。（A'）X-（A） - （B） - （Z） - （L） - （D）式（I）本发明化合物显示出抑制LSD1的活性，使其可用于治疗或预防疾病如癌症。

9. 发明申请

US20130197013A1 CYCLOPROPYLAMINE DERIVATIVES USEFUL AS LSD1 INHIBITORS 有权
标题翻译：环丙基胺衍生物作为LSD1抑制剂有用
公开(公告)号：US20130197013A1
公开(公告)日：2013-08-01
申请号：US13812386
申请日：2011-07-27
申请人： Mathew Colin Thor Fyfe , Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Marc Martinell Pedemonte , Maria de los Ángeles Estiarte-Martínez , Nuria Valls Vidal
发明人： Mathew Colin Thor Fyfe , Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Marc Martinell Pedemonte , Maria de los Ángeles Estiarte-Martínez , Nuria Valls Vidal
IPC分类号： C07C211/40 , C07D213/38 , C07D213/57 , C07D213/56 , C07D409/04 , C07D277/28 , C07D409/10 , C07D213/42 , C07C255/59 , C07D405/10 , C07D213/64 , C07D333/20 , C07C215/64 , C07D401/10
CPC分类号： C07C211/40 , C07B2200/07 , C07C215/64 , C07C217/74 , C07C255/53 , C07C255/54 , C07C255/59 , C07C311/08 , C07C311/09 , C07C311/21 , C07C2601/02 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/56 , C07D213/57 , C07D213/64 , C07D239/26 , C07D277/28 , C07D333/20 , C07D401/04 , C07D401/10 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10
摘要： The invention relates to cyclopropylamine compounds, in particular the compounds of Formula (I), and their use in therapy, including e.g. in the treatment or prevention of cancer, a neurological disease or condition, or viral infection.
摘要翻译：本发明涉及环丙胺化合物，特别是式（I）的化合物及其在治疗中的应用，包括例如。治疗或预防癌症，神经系统疾病或病症或病毒感染。

10. 发明申请

US20110263604A1 Oxidase inhibitors and their use 有权
标题翻译：氧化酶抑制剂及其用途
公开(公告)号：US20110263604A1
公开(公告)日：2011-10-27
申请号：US13066616
申请日：2011-04-18
申请人： Nathalie Guibourt , Alberto Ortega Munoz , Julio Castro-Palomino Laria
发明人： Nathalie Guibourt , Alberto Ortega Munoz , Julio Castro-Palomino Laria
IPC分类号： A61K31/165 , C07D265/30 , C07C229/46 , C07D211/34 , C07D207/14 , C07D295/14 , C07D401/12 , A61K31/5375 , A61K31/4465 , A61K31/197 , A61K31/40 , A61K31/495 , A61K31/496 , A61P35/00 , A61P25/28 , C07C237/20
CPC分类号： C07C237/04 , C07C229/14 , C07C237/06 , C07C237/10 , C07C2601/02 , C07D207/14 , C07D211/26 , C07D295/185 , C07D401/12
摘要： The invention relates to phenylcyclopropylamine acetamide derivatives and their use in treating diseases.
摘要翻译：本发明涉及苯基环丙胺乙酰胺衍生物及其在治疗疾病中的应用。

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