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1. 发明申请

US20140083174A1 SAMPLE NEBULIZATION 审中-公开
标题翻译：样本网络化
公开(公告)号：US20140083174A1
公开(公告)日：2014-03-27
申请号：US14117822
申请日：2012-05-18
申请人： Julien Reboud , Robert Wilson , Jonathan Cooper
发明人： Julien Reboud , Robert Wilson , Jonathan Cooper
IPC分类号： G01N1/28 , B05B17/06
CPC分类号： G01N1/28 , B05B17/0607 , B05B17/0653 , G01N1/2813 , G01N30/724 , H01J49/165
摘要： A device for generating a nebulized sample for detection of an analyte. The device includes a surface acoustic wave (SAW) transducer and a superstrate. The superstrate has a first surface for coupling with the SAW transducer and a second surface for receiving a fluid sample incorporating the analyte. The fluid sample is nebulized from the second surface. The superstrate is provided with an electrical connection extending from the second surface of the superstrate to provide a conducting path from a charge source to the second surface of the superstrate. The charge source may be the surface of the transducer or an external voltage source.
摘要翻译：用于产生用于检测分析物的雾化样品的装置。该装置包括表面声波（SAW）传感器和覆盖层。上覆层具有用于与SAW换能器耦合的第一表面和用于接收包含分析物的流体样品的第二表面。流体样品从第二表面喷雾。所述顶板设置有从所述覆板的第二表面延伸的电连接，以提供从电荷源到所述覆盖层的第二表面的导电路径。电荷源可以是换能器的表面或外部电压源。

2. 发明授权

US07785890B2 Method and device for the analysis of living reaction media 失效
标题翻译：生活反应介质分析方法和装置
公开(公告)号：US07785890B2
公开(公告)日：2010-08-31
申请号：US10563817
申请日：2004-07-09
申请人： Julien Reboud , Béatrice Schaack , François Chatelain
发明人： Julien Reboud , Béatrice Schaack , François Chatelain
IPC分类号： G01N33/48 , G01N24/00 , C12Q1/02
CPC分类号： G01N33/5023 , G01N33/5008 , G01N33/54386 , G01N33/6848 , G01N33/6851 , Y10T436/112499 , Y10T436/24 , Y10T436/25
摘要： A method and device for analysis of reaction media containing one or more cells. This method and device can be used to perform an automated high-throughput analysis.
摘要翻译：用于分析含有一个或多个细胞的反应介质的方法和装置。该方法和装置可用于执行自动化高通量分析。

3. 发明授权

US09410873B2 Fluidics apparatus for surface acoustic wave manipulation of fluid samples, use of fluidics apparatus and process for the manufacture of fluidics apparatus 有权
标题翻译：用于流体样品的表面声波处理的流体装置，流体装置的使用和用于制造流体装置的方法
公开(公告)号：US09410873B2
公开(公告)日：2016-08-09
申请号：US14000958
申请日：2012-02-24
申请人： Rab Wilson , Jonathan M. Cooper , Julien Reboud
发明人： Rab Wilson , Jonathan M. Cooper , Julien Reboud
IPC分类号： G01N1/00 , G01N1/28 , G01N29/22 , B06B1/00 , B01L3/00
CPC分类号： G01N1/286 , B01L3/502707 , B01L3/50273 , B01L3/502792 , B01L2200/10 , B01L2300/0816 , B01L2400/0436 , B01L2400/0439 , B01L2400/0496 , G01N29/222 , G01N2291/0423
摘要： A fluidics apparatus for manipulation of at least one fluid sample is disclosed. A manipulation surface locates the fluid sample. A surface acoustic wave (SAW) generation material layer is provided. This is a polycrystalline material, textured polycrystalline material, biaxially textured polycrystalline material, microcrystalline material, nanocrystalline material, amorphous material or composite material. A transducer electrode structure arranged at the SAW generation material layer provides SAWs at the manipulation surface for interaction with the fluid sample. The manipulation surface has a phononic structure, for affecting the transmission, distribution and/or behavior of SAWs at the manipulation surface. The apparatus is typically manufactured by reel-to-reel processes, to reduce the unit cost to a level at which the apparatus can be considered to be disposable after a single use.
摘要翻译：公开了一种用于操纵至少一种流体样品的流体装置。操纵表面定位流体样品。提供表面声波（SAW）生成材料层。这是多晶材料，纹理多晶材料，双轴纹理多晶材料，微晶材料，纳米晶体材料，无定形材料或复合材料。布置在SAW生成材料层处的换能器电极结构在操作表面处提供SAW以与流体样品相互作用。操纵表面具有声子结构，用于影响SAW在操纵表面上的传输，分布和/或行为。该设备通常通过卷对卷工艺制造，以将单位成本降低到在单次使用之后该装置可以被认为是一次性的水平。

4. 发明授权

US08372657B2 Microfluidic system for detecting a biological entity in a sample 失效
标题翻译：用于检测样品中生物实体的微流体系统
公开(公告)号：US08372657B2
公开(公告)日：2013-02-12
申请号：US12908561
申请日：2010-10-20
申请人： Julien Reboud , Linus Tzu-Hsiang Kao , Andre Yao-Kuang Chung , Shin Yun Ng , Yu Chen , Yan Ping Wang , Janice Hao Yuan Liaw , Kum Cheong Tang
发明人： Julien Reboud , Linus Tzu-Hsiang Kao , Andre Yao-Kuang Chung , Shin Yun Ng , Yu Chen , Yan Ping Wang , Janice Hao Yuan Liaw , Kum Cheong Tang
IPC分类号： G01N1/18 , G01N33/48 , C12M1/34
CPC分类号： G01N33/54366 , B01L3/502753 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B01L2300/0681 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： According to various embodiments, a microfluidic system for detecting a biological entity in a sample volume is provided. The microfluidic system may include: a chamber configured to receive the sample volume, wherein the chamber includes a detection region for detecting the biological entity; a first port in fluid communication with the chamber; and a second port including a filter in fluid communication with the chamber; and wherein a fluid provided to the first port or the second port flows between the first port and the second port through the chamber.
摘要翻译：根据各种实施方案，提供了用于检测样品体积中的生物实体的微流体系统。微流体系统可以包括：被配置为接收样品体积的腔室，其中腔室包括用于检测生物体的检测区域; 与腔室流体连通的第一端口; 以及包括与所述室流体连通的过滤器的第二端口; 并且其中设置到所述第一端口或所述第二端口的流体通过所述室在所述第一端口和所述第二端口之间流动。

5. 发明授权

US08323572B2 Measuring device 有权
标题翻译：测量工具
公开(公告)号：US08323572B2
公开(公告)日：2012-12-04
申请号：US13445186
申请日：2012-04-12
申请人： Masaya Nakatani , Levent Yobas , Julien Reboud
发明人： Masaya Nakatani , Levent Yobas , Julien Reboud
IPC分类号： G01N27/00
CPC分类号： G01N27/44756 , B01L3/5027 , B01L2200/0694 , B01L2300/0816 , B01L2300/0867 , B01L2400/0472
摘要： A measuring device includes a first substrate; and a second substrate bonded on the first substrate. The second substrate has at least two inflow ports, at least two outflow ports, and an injection port. The two inflow ports, the two outflow ports, and the injection port penetrate the second substrate. The first substrate includes partition wall portions opposing to each other, and forming a first cavity between the partition wall portions, and forming at least two second cavities close against one of the partition wall portions. Each second cavity is provided adjacent to the first cavity. Through holes are provided in the respective partition wall portions to connect the first cavity and the second cavity to each other, and the through holes are adapted to capture an object to-be-tested introduced in the first cavity.
摘要翻译：测量装置包括第一基板; 以及接合在第一基板上的第二基板。第二基板具有至少两个流入端口，至少两个流出端口和注入端口。两个流入口，两个流出口和注入口穿透第二基底。第一基板包括彼此相对的分隔壁部分，并且在分隔壁部分之间形成第一空腔，并且形成至少两个紧邻其中一个分隔壁部分的第二腔。每个第二腔被设置成与第一腔相邻。通孔设置在相应的隔壁部分中，以将第一腔和第二腔彼此连接，并且通孔适于捕获引入到第一腔中的被测物体。

6. 发明授权

US09375690B2 Fluidics apparatus and fluidics substrate 有权
标题翻译：流体设备和流体底物
公开(公告)号：US09375690B2
公开(公告)日：2016-06-28
申请号：US13391762
申请日：2010-08-24
申请人： Rab Wilson , Jonathan M. Cooper , Julien Reboud
发明人： Rab Wilson , Jonathan M. Cooper , Julien Reboud
IPC分类号： G01N1/00 , B06B1/00 , B01F13/00 , B01F11/02 , B01J19/00 , B01L3/00
CPC分类号： B01F13/0071 , B01F11/0266 , B01F2215/0073 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00828 , B01J2219/00837 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00905 , B01J2219/00932 , B01J2219/00952 , B01L3/502792 , B01L2200/10 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2400/0436 , B01L2400/0439 , B01L2400/0496 , C12N13/00 , G01N33/48 , Y10T436/25125
摘要： A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location of the fluid sample. A transducer arrangement such as an interdigitated electrode structure on a piezoelectric body provides surface acoustic waves at the substrate surface for manipulation of the fluid sample. The substrate surface has an arrangement of surface acoustic wave scattering elements forming a phononic crystal structure for affecting the transmission, distribution and/or behavior of surface acoustic waves at the substrate surface. Also disclosed is a method for lysing a cell. In this method, the cell is comprised in a fluid sample contacting a substrate surface, the method comprising providing surface acoustic waves at the substrate surface, such that the cell lyses.
摘要翻译：公开了用于操纵至少一种流体样品的流体装置，通常为液滴的形式。该设备具有一个具有用于定位流体样品的样品操作区的基底表面。诸如压电体之间的交错电极结构的换能器装置在衬底表面上提供表面声波，用于操纵流体样品。衬底表面具有形成声子晶体结构的表面声波散射元件的布置，用于影响衬底表面处表面声波的透射，分布和/或行为。还公开了一种裂解细胞的方法。在该方法中，电池被包含在与衬底表面接触的流体样品中，该方法包括在衬底表面提供表面声波，使得细胞裂解。

7. 发明申请

US20110129931A1 MICROFLUIDIC SYSTEM FOR DETECTING A BIOLOGICAL ENTITY IN A SAMPLE 失效
标题翻译：用于检测样品中生物体的微流感系统
公开(公告)号：US20110129931A1
公开(公告)日：2011-06-02
申请号：US12908561
申请日：2010-10-20
申请人： Julien Reboud , Linus Tzu-Hsiang Kao , Andre Yao-Kuang Chung , Shi Yun Ng , Yu Chen , Yan Ping Wang , Janice Hao Yuan Liaw
发明人： Julien Reboud , Linus Tzu-Hsiang Kao , Andre Yao-Kuang Chung , Shi Yun Ng , Yu Chen , Yan Ping Wang , Janice Hao Yuan Liaw
IPC分类号： G01N33/48 , C40B60/12 , C12M1/34 , G01N1/18
CPC分类号： G01N33/54366 , B01L3/502753 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B01L2300/0681 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： According to various embodiments, a microfluidic system for detecting a biological entity in a sample volume is provided. The microfluidic system may include: a chamber configured to receive the sample volume, wherein the chamber includes a detection region for detecting the biological entity; a first port in fluid communication with the chamber; and a second port including a filter in fluid communication with the chamber; and wherein a fluid provided to the first port or the second port flows between the first port and the second port through the chamber.
摘要翻译：根据各种实施方案，提供了用于检测样品体积中的生物实体的微流体系统。微流体系统可以包括：被配置为接收样品体积的腔室，其中腔室包括用于检测生物体的检测区域; 与腔室流体连通的第一端口; 以及包括与所述室流体连通的过滤器的第二端口; 并且其中设置到所述第一端口或所述第二端口的流体通过所述室在所述第一端口和所述第二端口之间流动。

8. 发明申请

US20130330247A1 Fluidics Apparatus for Surface Acoustic Wave Manipulation of Fluid Samples, Use of Fluidics Apparatus and Process for the Manufacture of Fluidics Apparatus 有权
标题翻译：用于流体样品的表面声波操作的流体设备，流体设备的使用和用于制造流体设备的方法
公开(公告)号：US20130330247A1
公开(公告)日：2013-12-12
申请号：US14000958
申请日：2012-02-24
申请人： Rab Wilson , Jonathan M. Cooper , Julien Reboud
发明人： Rab Wilson , Jonathan M. Cooper , Julien Reboud
IPC分类号： G01N1/28
CPC分类号： G01N1/286 , B01L3/502707 , B01L3/50273 , B01L3/502792 , B01L2200/10 , B01L2300/0816 , B01L2400/0436 , B01L2400/0439 , B01L2400/0496 , G01N29/222 , G01N2291/0423
摘要： A fluidics apparatus for manipulation of at least one fluid sample is disclosed. A manipulation surface locates the fluid sample. A surface acoustic wave (SAW) generation material layer is provided. This is a polycrystalline material, textured polycrystalline material, biaxially textured polycrystalline material, microcrystalline material, nanocrystalline material, amorphous material or composite material. A transducer electrode structure arranged at the SAW generation material layer provides SAWs at the manipulation surface for interaction with the fluid sample. The manipulation surface has a phononic structure, for affecting the transmission, distribution and/or behaviour of SAWs at the manipulation surface. The apparatus is typically manufactured by reel-to-reel processes, to reduce the unit cost to a level at which the apparatus can be considered to be disposable after a single use.
摘要翻译：公开了一种用于操纵至少一种流体样品的流体装置。操纵表面定位流体样品。提供表面声波（SAW）生成材料层。这是多晶材料，纹理多晶材料，双轴纹理多晶材料，微晶材料，纳米晶体材料，无定形材料或复合材料。布置在SAW生成材料层处的换能器电极结构在操作表面处提供SAW以与流体样品相互作用。操纵表面具有声子结构，用于影响SAW在操纵表面上的传输，分布和/或行为。该设备通常通过卷对卷工艺制造，以将单位成本降低到在单次使用之后该装置可以被认为是一次性的水平。

9. 发明申请

US20120213671A1 MEASURING DEVICE 有权
标题翻译：测量工具
公开(公告)号：US20120213671A1
公开(公告)日：2012-08-23
申请号：US13445186
申请日：2012-04-12
申请人： Masaya NAKATANI , Levent Yobas , Julien Reboud
发明人： Masaya NAKATANI , Levent Yobas , Julien Reboud
IPC分类号： G01N27/22 , G01N35/08
CPC分类号： G01N27/44756 , B01L3/5027 , B01L2200/0694 , B01L2300/0816 , B01L2300/0867 , B01L2400/0472
摘要： A measuring device includes a first substrate; and a second substrate bonded on the first substrate. The second substrate has at least two inflow ports, at least two outflow ports, and an injection port. The two inflow ports, the two outflow ports, and the injection port penetrate the second substrate. The first substrate includes partition wall portions opposing to each other, and forming a first cavity between the partition wall portions, and forming at least two second cavities close against one of the partition wall portions. Each second cavity is provided adjacent to the first cavity. Through holes are provided in the respective partition wall portions to connect the first cavity and the second cavity to each other, and the through holes are adapted to capture an object to-be-tested introduced in the first cavity.
摘要翻译：测量装置包括第一基板; 以及接合在第一基板上的第二基板。第二基板具有至少两个流入端口，至少两个流出端口和注入端口。两个流入口，两个流出口和注入口穿透第二基底。第一基板包括彼此相对的分隔壁部分，并且在分隔壁部分之间形成第一空腔，并且形成至少两个紧邻其中一个分隔壁部分的第二腔。每个第二腔被设置成与第一腔相邻。通孔设置在相应的隔壁部分中，以将第一腔和第二腔彼此连接，并且通孔适于捕获引入到第一腔中的被测物体。

10. 发明申请

US20120149126A1 Fluidics Apparatus and Fluidics Substrate 有权
标题翻译：流体设备和流体基板
公开(公告)号：US20120149126A1
公开(公告)日：2012-06-14
申请号：US13391762
申请日：2010-08-24
申请人： Rab Wilson , Jonathan M. Cooper , Julien Reboud
发明人： Rab Wilson , Jonathan M. Cooper , Julien Reboud
IPC分类号： G01N1/00 , B06B1/00
CPC分类号： B01F13/0071 , B01F11/0266 , B01F2215/0073 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00828 , B01J2219/00837 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00905 , B01J2219/00932 , B01J2219/00952 , B01L3/502792 , B01L2200/10 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2400/0436 , B01L2400/0439 , B01L2400/0496 , C12N13/00 , G01N33/48 , Y10T436/25125
摘要： A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location of the fluid sample. A transducer arrangement such as an interdigitated electrode structure on a piezoelectric body provides surface acoustic waves at the substrate surface for manipulation of the fluid sample. The substrate surface has an arrangement of surface acoustic wave scattering elements forming a phononic crystal structure for affecting the transmission, distribution and/or behaviour of surface acoustic waves at the substrate surface. Also disclosed is a method for lysing a cell. In this method, the cell is comprised in a fluid sample contacting a substrate surface, the method comprising providing surface acoustic waves at the substrate surface, such that the cell lyses.
摘要翻译：公开了用于操纵至少一种流体样品的流体装置，通常为液滴的形式。该设备具有一个具有用于定位流体样品的样品操作区的基底表面。诸如压电体之间的交错电极结构的换能器装置在衬底表面上提供表面声波，用于操纵流体样品。衬底表面具有形成声子晶体结构的表面声波散射元件的布置，用于影响衬底表面处的表面声波的透射，分布和/或行为。还公开了一种裂解细胞的方法。在该方法中，电池被包含在与衬底表面接触的流体样品中，该方法包括在衬底表面提供表面声波，使得细胞裂解。

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