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1. 发明授权

US07069073B2 Electrokinetic delivery of medicaments 失效
公开(公告)号：US07069073B2
公开(公告)日：2006-06-27
申请号：US10807295
申请日：2004-03-24
申请人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , Christopher H. Porter , V. Lorenzo Porcelli
发明人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , Christopher H. Porter , V. Lorenzo Porcelli
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site. In another form, the applicator is self-contained, having a power supply, a first electrode overlying a pad and a ground electrode from the opposite side from the pad whereby the individual presses the pad against the treatment site to complete the electrical circuit and electrokinetically drive the medicament into the treatment site.

2. 发明申请

US20110208111A1 Electrokinetic Delivery System for Self-Administration of Medicaments and Methods Therefor 审中-公开
标题翻译：药物自我管理电动输送系统及其方法
公开(公告)号：US20110208111A1
公开(公告)日：2011-08-25
申请号：US13097982
申请日：2011-04-29
申请人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , James Derouin
发明人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , James Derouin
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： The invention relates to systems and methods for treating a fungal infection of the nail of an individual. In various embodiments, the methods include applying a device to at least one nail of the individual that is infected by a fungus. In various embodiments, the devices include at least one active electrode and at least one counter electrode, with the at least one counter electrode in contact with the individual.
摘要翻译：本发明涉及用于治疗个体的指甲真菌感染的系统和方法。在各种实施方案中，所述方法包括将装置应用于由真菌感染的个体的至少一个指甲。在各种实施例中，装置包括至少一个有效电极和至少一个对电极，其中至少一个对电极与个体接触。

3. 发明申请

US20110213295A1 Methods and Systems for Electrokinetic Delivery of a Substance 失效
标题翻译：物质电动输送的方法和系统
公开(公告)号：US20110213295A1
公开(公告)日：2011-09-01
申请号：US13105630
申请日：2011-05-11
申请人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , James Derouin
发明人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , James Derouin
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： A method for delivering a substance to an infected nail of an individual is described. The method includes the step of applying a device to at least one infected nail of an individual, where the device includes at least one active electrode and at least one counter electrode, where the at least one counter electrode is in contact with the individual, and where the device is connected to at least one power source. The method also includes the steps of disposing a medicament between the at least one active electrode and the at least one infected nail, applying a salt solution to the at least one infected nail, and providing an electrical current from the power source to the at least one active electrode to facilitate delivery of the medicament into the region of the at least one infected nail.
摘要翻译：描述了将物质递送到个体的感染指甲的方法。该方法包括将装置应用于个体的至少一个受感染的钉，其中该装置包括至少一个有效电极和至少一个对电极，其中至少一个对电极与个体接触，以及其中设备连接到至少一个电源。该方法还包括以下步骤：在至少一个活性电极与至少一个受感染的指甲之间设置药物，将盐溶液施加到至少一个受感染的指甲，并且将电流从电源提供给至少一个有源电极，以促进药物输送到至少一个感染的指甲的区域中。

4. 发明授权

US06735470B2 Electrokinetic delivery of medicaments 有权
标题翻译：药物电动输送
公开(公告)号：US06735470B2
公开(公告)日：2004-05-11
申请号：US10245337
申请日：2002-09-18
申请人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , Christopher H. Porter , V. Lorenzo Porcelli
发明人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , Christopher H. Porter , V. Lorenzo Porcelli
IPC分类号： A61N130
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site. In another form, the applicator is self-contained, having a power supply, a first electrode overlying a pad and a ground electrode from the opposite side from the pad whereby the individual presses the pad against the treatment site to complete the electrical circuit and electrokinetically drive the medicament into the treatment site.
摘要翻译：提供了一种用于个人使用的电动输送或诊断装置以及药物自动施用于治疗部位。该装置包括容纳电源，第一有源电极和接地触觉电极的壳体。涂抹器包括用于容纳用于覆盖装置的第一电极的药物的垫。使用者可以将药物施用到包含在垫内的垫或包含在垫内的可破裂胶囊中，以及如果需要赋予导电性的水凝胶，由此当将施用器施加到治疗部位时，药物是电动运输到治疗部位。在另一种形式中，施用器是独立的，具有电源，与衬垫相重叠的第一电极和接地电极，其中个体将衬垫压在治疗部位上以完成电路和电动驱使药物进入治疗部位。

5. 发明授权

US08352024B2 Electrokinetic delivery system for self-administration of medicaments and methods therefor 有权
标题翻译：用于药物自我管理的电动输送系统及其方法
公开(公告)号：US08352024B2
公开(公告)日：2013-01-08
申请号：US11373301
申请日：2006-03-13
申请人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , James Derouin
发明人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , James Derouin
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.
摘要翻译：个人使用的用于药物自身给药到个体治疗部位的电动输送系统包括成形为符合个体手指的一部分从其尖端到经过第一手指关节的位置的形状的装置。该装置携带独立的电源，并且第一电极由邻近其远端部分和个体手指的尖端的装置承载。第一电极与电源电接触。第二电极由装置承载以与个体的手指接触。第二电极与电源电接触。当将第一电极施加在处理位置上时，药物设置在第一电极和处理部位之间，并通过个体的身体和所述电极完成电路，该装置施加用于电动驱动药物的电流到治疗部位。

6. 发明授权

US07016724B2 Electrokinetic delivery system for self-administration of medicaments and methods therefor 失效
公开(公告)号：US07016724B2
公开(公告)日：2006-03-21
申请号：US10724160
申请日：2003-12-01
申请人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg
发明人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

7. 发明授权

US06477410B1 Electrokinetic delivery of medicaments 失效
标题翻译：药物电动输送
公开(公告)号：US06477410B1
公开(公告)日：2002-11-05
申请号：US09584138
申请日：2000-05-31
申请人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , Christopher H. Porter , V. Lorenzo Porcelli
发明人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , Christopher H. Porter , V. Lorenzo Porcelli
IPC分类号： A61N130
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site. In another form, the applicator is self-contained, having a power supply, a first electrode overlying a pad and a ground electrode from the opposite side from the pad whereby the individual presses the pad against the treatment site to complete the electrical circuit and electrokinetically drive the medicament into the treatment site.
摘要翻译：提供了一种用于个人使用的电动输送或诊断装置以及药物自动施用于治疗部位。该装置包括容纳电源，第一有源电极和接地触觉电极的壳体。涂抹器包括用于容纳用于覆盖装置的第一电极的药物的垫。使用者可以将药物施用到包含在垫内的垫或包含在垫内的可破裂胶囊中，以及如果需要赋予导电性的水凝胶，由此当将施用器施加到治疗部位时，药物是电动运输到治疗部位。在另一种形式中，施用器是独立的，具有电源，与衬垫相重叠的第一电极和接地电极，其中个体将衬垫压在治疗部位上以完成电路和电动驱使药物进入治疗部位。

8. 发明授权

US08328788B2 Methods and systems for electrokinetic delivery of a substance 失效
标题翻译：物质电动输送的方法和系统
公开(公告)号：US08328788B2
公开(公告)日：2012-12-11
申请号：US13105630
申请日：2011-05-11
申请人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , James Derouin
发明人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , James Derouin
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： A method for delivering a substance to an infected nail of an individual is described. The method includes the step of applying a device to at least one infected nail of an individual, where the device includes at least one active electrode and at least one counter electrode, where the at least one counter electrode is in contact with the individual, and where the device is connected to at least one power source. The method also includes the steps of disposing a medicament between the at least one active electrode and the at least one infected nail, applying a salt solution to the at least one infected nail, and providing an electrical current from the power source to the at least one active electrode to facilitate delivery of the medicament into the region of the at least one infected nail.
摘要翻译：描述了将物质递送到个体的感染指甲的方法。该方法包括将装置应用于个体的至少一个受感染的钉，其中该装置包括至少一个有效电极和至少一个对电极，其中至少一个对电极与个体接触，以及其中设备连接到至少一个电源。该方法还包括以下步骤：在至少一个活性电极与至少一个受感染的指甲之间设置药物，将盐溶液施加到至少一个受感染的指甲，并且将电流从电源提供给至少一个有源电极，以促进药物输送到至少一个感染的指甲的区域中。

9. 发明授权

US07127285B2 Systems and methods for electrokinetic delivery of a substance 失效
标题翻译：物质电动输送的系统和方法
公开(公告)号：US07127285B2
公开(公告)日：2006-10-24
申请号：US10359559
申请日：2003-02-07
申请人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , James Derouin
发明人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg , James Derouin
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/30 , A61N1/325
摘要： A system for delivering a substance into a body at a treatment site that includes an alternating current source and a plurality of electrodes. Circuitry is connected between the alternating current source and the electrodes for supplying current to the electrodes when the electrodes are in electrical contact with said body so that a uni-directional current flow for delivering the substance into the body is maintained at the treatment site and a bi-directional current flow is maintained throughout the body. At least one of the electrodes is divided into sub-electrodes to, for example, reduce hazards associated with current concentration. These and other systems and methods are adaptable for large treatment areas and/or use a convenient and low-cost arrangement of electronics.
摘要翻译：一种用于在包括交流电源和多个电极的治疗部位将物质递送到体内的系统。电路连接在交流电源和电极之间，用于当电极与所述主体电接触时向电极提供电流，从而将物质输送到体内的单向电流保持在治疗部位，并且在整个身体中保持双向电流。电极中的至少一个被分成子电极，以例如减少与电流集中相关的危险。这些和其他系统和方法适用于大型治疗区域和/或使用方便且低成本的电子设备。

10. 发明授权

US06792306B2 Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor 有权
标题翻译：手指电动输送系统，用于药物的自我管理及其方法
公开(公告)号：US06792306B2
公开(公告)日：2004-09-14
申请号：US10117346
申请日：2002-04-08
申请人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg
发明人： Julian L. Henley , Kuo Wei Chang , Joseph Potter , Dennis I. Goldberg
IPC分类号： A61N130
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.
摘要翻译：个人使用的用于药物自身给药到个体治疗部位的电动输送系统包括成形为符合个体手指的一部分从其尖端到经过第一手指关节的位置的形状的装置。该装置携带独立的电源，并且第一电极由邻近其远端部分和个体手指的尖端的装置承载。第一电极与电源电接触。第二电极由装置承载以与个体的手指接触。第二电极与电源电接触。当将第一电极施加在处理位置上时，药物设置在第一电极和处理部位之间，并通过个体的身体和所述电极完成电路，该装置施加用于电动驱动药物的电流到治疗部位。

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