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1. 发明授权

US07901885B2 Genes and markers in type 2 diabetes and obesity 有权
标题翻译： 2型糖尿病和肥胖症的基因和标志物
公开(公告)号：US07901885B2
公开(公告)日：2011-03-08
申请号：US11798002
申请日：2007-05-09
申请人： Jukka T. Salonen , Jelena Hyppönen , Jari Kaikkonen , Mia Pirskanen , Pekka Uimari , Juha-Matti Aalto
发明人： Jukka T. Salonen , Jelena Hyppönen , Jari Kaikkonen , Mia Pirskanen , Pekka Uimari , Juha-Matti Aalto
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , A61K31/00 , A61K38/1709 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N33/6893 , G01N2500/00 , G01N2800/042 , Y02A90/26
摘要： Genes, SNP markers and haplotypes of susceptibility or predisposition to T2D and subdiagnosis of T2D and related medical conditions are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for T2D, obesity and related phenotypes using polymorphisms in the risk genes are also disclosed. The genes, gene products and agents of the invention are also useful for monitoring the effectiveness of prevention and treatment of T2D and related traits. Kits are also provided for the diagnosis, selecting treatment and assessing prognosis of T2D. Novel methods for prevention and treatment of metabolic diseases such as T2D based on the disclosed T2D genes, polypeptides and related pathways are also disclosed.
摘要翻译：公开了基因，SNP标记和对T2D的易感性或易感性和T2D的亚诊断和相关医学状况的单倍型。还公开了使用多态性在风险基因中诊断，预测T2D治疗，肥胖和相关表型的临床疗效和疗效的方法。本发明的基因，基因产物和药剂也可用于监测预防和治疗T2D及相关性状的有效性。还提供了用于诊断，选择治疗和评估T2D预后的试剂盒。还公开了基于所公开的T2D基因，多肽和相关途径预防和治疗代谢疾病如T2D的新方法。

2. 发明申请

US20090155230A1 Novel genes and markers in essential arterial hypertension 审中-公开
标题翻译：基本动脉高血压中的新基因和标志物
公开(公告)号：US20090155230A1
公开(公告)日：2009-06-18
申请号：US11822412
申请日：2007-07-05
申请人： Jukka T. Salonen , Juha-Matti Aalto , Pekka Uimari , Mia Pirskanen
发明人： Jukka T. Salonen , Juha-Matti Aalto , Pekka Uimari , Mia Pirskanen
IPC分类号： A61K48/00 , G01N33/68 , C12Q1/68 , C12Q1/52 , G01N33/53 , A61K38/02 , A61K31/7088 , A61K39/395
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to previously unknown disease associations between various genes, loci and biomarkers and essential hypertension. The detection of these biomarkers provides novel in vitro methods and test kits which can be used as an aid when making risk assessment, molecular diagnosis or prognosis of HT or a HT related condition. The disclosed methods and test kits do not require interaction with the body of a subject during the biomarker detection. Instead the methods and test kits are for in vitro use (e.g. in a clinical laboratory) and typically biological samples for the biomarker analyses using a method or a test kit of this invention have been collected earlier in a different place. In addition the biomarkers provide methods and systems for identifying novel agents for preventing, treating and/or reducing risk of HT or a HT related condition. The HT associated genes can be used to develop novel therapies for prevention and/or treatment of essential hypertension.
摘要翻译：本发明涉及各种基因，基因座和生物标志物之间以前未知的疾病关联和原发性高血压。这些生物标志物的检测提供了新的体外方法和测试试剂盒，可用于在进行HT或HT相关病症的风险评估，分子诊断或预后时作为辅助。所公开的方法和测试试剂盒在生物标志物检测期间不需要与受试者的身体相互作用。相反，方法和测试试剂盒用于体外使用（例如在临床实验室中），并且通常使用本发明的方法或测试试剂盒的生物标志物分析的生物样品通常在不同的位置被收集。此外，生物标志物提供用于鉴定用于预防，治疗和/或降低HT或HT相关病症风险的新药的方法和系统。 HT相关基因可用于开发用于预防和/或治疗原发性高血压的新疗法。

3. 发明授权

US07029849B2 Method for detecting a risk of hypertension and uses thereof 有权
标题翻译：检测高血压风险的方法及其用途
公开(公告)号：US07029849B2
公开(公告)日：2006-04-18
申请号：US10077870
申请日：2002-02-20
申请人： Jukka T. Salonen
发明人： Jukka T. Salonen
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6883 , C07K14/70571 , C12Q2600/106 , C12Q2600/156
摘要： This invention relates to a method for detecting a risk of hypertension and for targeting antihypertensive treatment in a subject, the method comprising isolating genomic DNA from said subject, determining the DNA sequence comprising a nucleotide sequence encoding a variant α2B-adrenoceptor protein.
摘要翻译：本发明涉及一种用于检测受试者的高血压风险和靶向抗高血压治疗的方法，所述方法包括从所述受试者中分离基因组DNA，确定包含编码变体α2B2的核苷酸序列的DNA序列 - 肾上腺素受体蛋白。

4. 发明申请

US20110111404A1 Novel genes and markers in type 2 diabetes and obesity 审中-公开
标题翻译： 2型糖尿病和肥胖中的新型基因和标志物
公开(公告)号：US20110111404A1
公开(公告)日：2011-05-12
申请号：US12923065
申请日：2010-08-31
申请人： Jukka T. Salonen , Jelena Hyppönen , Jari Kaikkonen , Mia Pirskanen , Pekka Uimari , Juha-Matti Aaalto
发明人： Jukka T. Salonen , Jelena Hyppönen , Jari Kaikkonen , Mia Pirskanen , Pekka Uimari , Juha-Matti Aaalto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/00 , A61K38/1709 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N33/6893 , G01N2500/00 , G01N2800/042 , Y02A90/26
摘要： Genes, SNP markers and haplotypes of susceptibility or predisposition to T2D and subdiagnosis of T2D and related medical conditions are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for T2D, obesity and related phenotypes using polymorphisms in the risk genes are also disclosed. The genes, gene products and agents of the invention are also useful for monitoring the effectiveness of prevention and treatment of T2D and related traits. Kits are also provided for the diagnosis, selecting treatment and assessing prognosis of T2D. Novel methods for prevention and treatment of metabolic diseases such as T2D based on the disclosed T2D genes, polypeptides and related pathways are also disclosed.
摘要翻译：公开了基因，SNP标记和对T2D的易感性或易感性和T2D的亚诊断和相关医学状况的单倍型。还公开了使用多态性在风险基因中诊断，预测T2D治疗，肥胖和相关表型的临床疗效和疗效的方法。本发明的基因，基因产物和药剂也可用于监测预防和治疗T2D及相关性状的有效性。还提供了用于诊断，选择治疗和评估T2D预后的试剂盒。还公开了基于所公开的T2D基因，多肽和相关途径预防和治疗代谢疾病如T2D的新方法。

5. 发明授权

US06740746B2 DNA molecule encoding a variant paraoxonase and uses thereof 有权
标题翻译：编码变体对氧磷酶的DNA分子及其用途
公开(公告)号：US06740746B2
公开(公告)日：2004-05-25
申请号：US09811673
申请日：2001-03-20
申请人： Jukka T. Salonen , Marja Marchesani , Tomi-Pekka Tuomainen , Jari Kaikkonen
发明人： Jukka T. Salonen , Marja Marchesani , Tomi-Pekka Tuomainen , Jari Kaikkonen
IPC分类号： C07H2104
CPC分类号： C12N9/18 , A01K2217/05 , C12Q1/6886 , C12Q2600/156 , C12Y301/01002
摘要： This invention is directed to a DNA sequence comprising a nucleotide sequence encoding a variant paraoxonase protein and to said variant paraoxonase protein as well as a method and a kit for detecting a risk of cancer, coronary or cerebrovascular disease, hypertension, type 2 diabetes, dementia, joint arthrosis, cataract, or sensitivity to organophosphorus compounds in a subject, the method comprising isolating genomic DNA from said subject, determining the allelic pattern for the codon 102 of the paraoxonase encoding PON1 gene in the genomic DNA, identification of Ile101Val mutation indicating said risk being increased and for targeting paraoxonase activity modulating therapies. Further this invention relates to transgenic animals comprising a human DNA molecule encoding said variant paraoxonase and to a method of phenotype-targeted gene sequencing.
摘要翻译：本发明涉及包含编码变体对氧磷酶蛋白质核苷酸序列和所述变体对氧磷酶蛋白质的DNA序列，以及用于检测癌症，冠状动脉或脑血管疾病，高血压，2型糖尿病，痴呆风险的方法和试剂盒，联合关节病，白内障或对受试者中有机磷化合物的敏感性，所述方法包括从所述受试者中分离基因组DNA，确定编码基因组DNA中的PON1基因的对氧磷酶的密码子102的等位基因图谱，鉴定表示所述受体的Ile101Val突变风险增加，靶向对氧磷酶活性调节疗法。此外，本发明涉及包含编码所述变体对氧磷酶的人DNA分子和表型靶向基因测序方法的转基因动物。

6. 发明申请

US20120225047A1 NUTRIGENETIC BIOMARKERS FOR OBESITY AND TYPE 2 DIABETES 审中-公开
标题翻译：营养和2型糖尿病的营养生物标志物
公开(公告)号：US20120225047A1
公开(公告)日：2012-09-06
申请号：US13509903
申请日：2010-11-16
申请人： Jukka T. Salonen
发明人： Jukka T. Salonen
IPC分类号： A61K38/45 , C40B40/10 , C07K14/47 , C40B20/00 , A61K38/17 , A61P3/10 , A61P3/04 , C40B40/06 , C12N9/12
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention discloses genes, SNP markers and haplotypes of susceptibility or predisposition to obesity, type 2 diabetes (T2D) and subdiagnosis of obesity and T2D and related medical conditions. Particularly, the present invention provides T2D and obesity associated markers from gene SUCLA2. Methods for diagnosis, prediction of clinical course and efficacy of treatments for T2D, obesity and related phenotypes using polymorphisms in the risk genes and other related biomarkers are also disclosed. Kits are also provided for the diagnosis, selecting treatment and assessing prognosis of obesity and T2D.
摘要翻译：本发明公开了对肥胖，2型糖尿病（T2D）和肥胖和T2D的亚诊断及相关医学状况的易感性或倾向性的基因，SNP标记和单倍型。特别地，本发明提供了来自基因SUCLA2的T2D和肥胖相关标志物。还披露了使用风险基因和其他相关生物标志物中多态性进行诊断，预测T2D治疗，肥胖和相关表型的临床疗效和疗效的方法。还提供了用于诊断，选择治疗和评估肥胖和T2D预后的试剂盒。

7. 发明申请

US20110111405A1 Novel genes and markers in type 2 diabetes and obesity 审中-公开
公开(公告)号：US20110111405A1
公开(公告)日：2011-05-12
申请号：US12923066
申请日：2010-08-31
申请人： Jukka T. Salonen , Jelena Hyppönen , Jari Kaikkonen , Mia Pirskannen , Pekka Uimari , Juha-Matti Aalto
发明人： Jukka T. Salonen , Jelena Hyppönen , Jari Kaikkonen , Mia Pirskannen , Pekka Uimari , Juha-Matti Aalto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/00 , A61K38/1709 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N33/6893 , G01N2500/00 , G01N2800/042 , Y02A90/26
摘要： Genes, SNP markers and haplotypes of susceptibility or predisposition to T2D and subdiagnosis of T2D and related medical conditions are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for T2D, obesity and related phenotypes using polymorphisms in the risk genes are also disclosed. The genes, gene products and agents of the invention are also useful for monitoring the effectiveness of prevention and treatment of T2D and related traits. Kits are also provided for the diagnosis, selecting treatment and assessing prognosis of T2D. Novel methods for prevention and treatment of metabolic diseases such as T2D based on the disclosed T2D genes, polypeptides and related pathways are also disclosed.

8. 发明授权

US07211387B2 DNA molecule encoding a variant paraoxonase and uses thereof 有权
标题翻译：编码变体对氧磷酶的DNA分子及其用途
公开(公告)号：US07211387B2
公开(公告)日：2007-05-01
申请号：US10691562
申请日：2003-10-24
申请人： Jukka T. Salonen , Marja Marchesani , Tomi-Pekka Tuomainen , Jari Kaikkonen
发明人： Jukka T. Salonen , Marja Marchesani , Tomi-Pekka Tuomainen , Jari Kaikkonen
IPC分类号： C12Q1/68 , C12Q1/34 , C12Q1/44 , C12N9/16 , C12N9/18 , C07H21/04
CPC分类号： C12N9/18 , A01K2217/05 , C12Q1/6886 , C12Q2600/156 , C12Y301/01002
摘要： This invention is directed to a DNA sequence comprising a nucleotide sequence encoding a variant paraoxonase protein and to said variant paraoxonase protein as well as a method and a kit for detecting a risk of cancer, coronary or cerebrovascular disease, hypertension, type 2 diabetes, dementia, joint arthrosis, cataract, or sensitivity to organophosphorus compounds in a subject, the method comprising isolating genomic DNA from said subject, determining the allelic pattern for the codon 102 of the paraoxonase encoding PON1 gene in the genomic DNA, identification of Ile101Val mutation indicating said risk being increased and for targeting paraoxonase activity modulating therapies. Further this invention relates to transgenic animals comprising a human DNA molecule encoding said variant paraoxonase and to a method of phenotype-targeted gene sequencing.
摘要翻译：本发明涉及包含编码变体对氧磷酶蛋白质核苷酸序列和所述变体对氧磷酶蛋白质的DNA序列，以及用于检测癌症，冠状动脉或脑血管疾病，高血压，2型糖尿病，痴呆风险的方法和试剂盒，联合关节病，白内障或对受试者中有机磷化合物的敏感性，所述方法包括从所述受试者中分离基因组DNA，确定编码基因组DNA中的PON1基因的对氧磷酶的密码子102的等位基因图谱，鉴定表示所述受体的Ile101Val突变风险增加，靶向对氧磷酶活性调节疗法。此外，本发明涉及包含编码所述变体对氧磷酶的人DNA分子和表型靶向基因测序方法的转基因动物。

9. 发明授权

US06696556B2 DNA molecule encoding a variant &agr;2B-adrenoceptor protein, and uses thereof 失效
标题翻译：编码变体α2B肾上腺素受体蛋白的DNA分子及其用途
公开(公告)号：US06696556B2
公开(公告)日：2004-02-24
申请号：US09825923
申请日：2001-04-05
申请人： Amir Snapir , Paula Heinonen , Pia Alhopuro , Matti Karvonen , Markku Koulu , Ullamari Pesonen , Mika Scheinin , Jukka T. Salonen , Tomi-Pekka Tuomainen , Timo A. Lakka , Kristiina Nyyssönen , Riitta Salonen , Jussi Kauhanen , Veli-Pekka Valkonen
发明人： Amir Snapir , Paula Heinonen , Pia Alhopuro , Matti Karvonen , Markku Koulu , Ullamari Pesonen , Mika Scheinin , Jukka T. Salonen , Tomi-Pekka Tuomainen , Timo A. Lakka , Kristiina Nyyssönen , Riitta Salonen , Jussi Kauhanen , Veli-Pekka Valkonen
IPC分类号： C12N1511
CPC分类号： C07K14/70571 , A01K2217/05 , A61K38/00
摘要： This invention relates to a DNA sequence comprising a nucleotide sequence encoding a variant &agr;2B-adrenoceptor protein and to the variant &agr;2B-adrenoceptor protein as well as a method for screening a subject to determine if the subject is a carrier of a variant gene that encodes the variant &agr;2B-adrenoceptor protein. Further this invention relates to a method for treating a mammal suffering from vascular contraction of coronary arteries, the method comprising the step of administering a selective &agr;2B-adrenoceptor antagonist to the mammal and to transgenic animals comprising a human DNA molecule encoding human &agr;2B-adrenoceptor protein or the variant &agr;2B-adrenoceptor protein.
摘要翻译：本发明涉及包含编码变体α2B肾上腺素受体蛋白的核苷酸序列和变体α2B肾上腺素受体蛋白的DNA序列，以及用于筛选受试者以确定受试者是否是编码变体α2B肾上腺素受体蛋白。本发明还涉及治疗患有冠状动脉血管收缩的哺乳动物的方法，所述方法包括向哺乳动物施用选择性α2B-肾上腺素受体拮抗剂和包含编码人α2B肾上腺素受体蛋白质的人类DNA分子的转基因动物或变体α2B肾上腺素受体蛋白。

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