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1. 发明申请

US20110200705A1 RUMINANT DIETARY SUPPLEMENT COMPOSITIONS AND METHODS OF MANUFACTURING AND USING THE SAME 审中-公开
标题翻译：发酵食物补充剂组合物及其制造方法和使用方法
公开(公告)号：US20110200705A1
公开(公告)日：2011-08-18
申请号：US13028176
申请日：2011-02-15
申请人： Juan M. Tricarico , Karl A. Dawson , James D. Johnston
发明人： Juan M. Tricarico , Karl A. Dawson , James D. Johnston
IPC分类号： A23K1/22 , A23K1/18
CPC分类号： A23K50/10 , A23K10/16 , A23K20/147
摘要： This invention relates to dietary supplement compositions, foodstuffs (e.g., animal feed) comprising the same and methods of utilizing the same. In particular, the invention provides ruminant dietary supplement compositions (e.g., comprising a protein extract (e.g., a crude protein extract (e.g., a bacterial or yeast extract))) having a specific nitrogen and/or amino acid profile and a small particle size, methods of manufacturing the same, and compositions containing and methods of using the same (e.g., as a liquid or dry dietary supplement composition or as a component of a foodstuff (e.g., animal feed) to increase ruminant protein and amino acid absorption).
摘要翻译：本发明涉及膳食补充剂组合物，包含其的食品（例如动物饲料）及其利用方法。特别地，本发明提供了反刍动物膳食补充剂组合物（例如，包含蛋白质提取物（例如，粗蛋白质提取物（例如，细菌或酵母提取物））），其具有特定的氮和/或氨基酸分布和小的粒度，其制备方法和含有其的组合物和使用其的方法（例如，作为液体或干燥膳食补充剂组合物或作为食物（例如动物饲料）的组分以增加反刍动物蛋白质和氨基酸吸收）。

2. 发明申请

US20090263416A1 REDUCTION OF ANTIBIOTIC RESISTANCE IN BACTERIA 审中-公开
标题翻译：减少细菌中的抗生素耐药性
公开(公告)号：US20090263416A1
公开(公告)日：2009-10-22
申请号：US12305156
申请日：2007-06-18
申请人： Karl A. Dawson , Melissa C. Newman
发明人： Karl A. Dawson , Melissa C. Newman
IPC分类号： A61K36/06 , C12N1/20
CPC分类号： A01N63/04 , A61K36/062 , A61K36/064
摘要： In one aspect of the present invention, a method is provided for reducing or eliminating antibiotic resistance in bacteria, comprising exposing the bacteria to a composition comprising a yeast cell wall preparation in an amount effective for reducing or eliminating resistance of the bacteria to at least one antibiotic. In one embodiment, the method comprises exposing the bacteria to the yeast cell wall preparation in an amount effective for eliminating a plasmid conferring resistance to the antibiotic, or for preventing transfer of the plasmid between bacteria. In another aspect, a method is provided for reducing prevalence of antibiotic-resistant bacteria in an animal, comprising administering to the animal a composition comprising a yeast cell wall preparation in an amount effective for reducing or eliminating the presence of an antibiotic-resistant bacterial population in the animal.
摘要翻译：在本发明的一个方面，提供了减少或消除细菌抗生素抗性的方法，包括将细菌暴露于包含酵母细胞壁制剂的组合物中，所述组合物有效地将细菌的抗性降至或消除至少一种抗生素。在一个实施方案中，该方法包括以有效消除赋予抗生素抗性的质粒或防止质粒在细菌之间转移的量将细菌暴露于酵母细胞壁制剂。在另一方面，提供了一种用于降低动物中抗生素抗性细菌流行率的方法，包括向动物施用包含酵母细胞壁制剂的组合物，其量可有效减少或消除抗生素抗性细菌群体的存在在动物中

3. 发明授权

US06750051B2 Compositions and methods for enhancing fiber digestion 有权
标题翻译：用于增强纤维消化的组合物和方法
公开(公告)号：US06750051B2
公开(公告)日：2004-06-15
申请号：US10121476
申请日：2002-04-10
申请人： Juan M. Tricárico , Karl A. Dawson
发明人： Juan M. Tricárico , Karl A. Dawson
IPC分类号： C12N900
CPC分类号： C12N1/16 , A23K20/189
摘要： Methods and enzyme supplements for enhancing fiber digestion in mammals and birds are described. The supplement comprises an effective amount of acetyl esterase, formulated for feeding to animals consuming significant percentages of forages in the diet. The compositions of this invention improve dry matter and neutral detergent fiber disappearance rates, and are useful dietary supplements for improving fiber digestion. The compositions of this invention may be utilized alone or in combination with known exogenous fibrolytic enzyme supplement to improve fiber digestion in mammals and birds. The acetyl esterase advantageously used in the compositions and methods of the present invention is produced by a ruminal isolate of Orpinomyces.
摘要翻译：描述了用于增强哺乳动物和鸟类中的纤维消化的方法和酶补充剂。补充剂包含有效量的乙酰酯酶，其被配制用于饲喂在饮食中消耗大量饲料的动物。本发明的组合物改善干物质和中性洗涤剂纤维消失速率，并且是用于改善纤维消化的有用的膳食补充剂。本发明的组合物可以单独使用或与已知的外源性纤维蛋白酶补充剂组合使用，以改善哺乳动物和鸟类中的纤维消化。在本发明的组合物和方法中有利地使用的乙酰酯酶由Orpinomyces的瘤胃分离物产生。

4. 发明授权

US4999283A Method for x and y spermatozoa separation 失效
标题翻译： x和y精子分离方法
公开(公告)号：US4999283A
公开(公告)日：1991-03-12
申请号：US396738
申请日：1989-08-18
申请人： Panayiotis M. Zavos , Karl A. Dawson
发明人： Panayiotis M. Zavos , Karl A. Dawson
IPC分类号： A01N1/02 , A61K35/52 , C12N5/08
CPC分类号： A61K35/52 , A01N1/021 , A01N1/0231 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/906
摘要： A method for separating male and female determining spermatozoa includes the initial step of exposing freshly ejaculated spermatozoa in a substantially protein free diluent to an excess concentration of a monoclonal antibody directed against H-Y antigen that binds substantially exclusively with male determining spermatozoa. The method continues with the suspending of the exposed spermatozoa together with a conjugate of (1) an immunoglobulin G antibody that binds substantially exclusively to the monoclonal antibody and (2) an immunoabsorbant substrate in a substantially protein free diluent. This forms a conjugate/spermatozoa preparation. The method concludes with the recovering of the separated male and female determining spermatozoa.
摘要翻译：用于分离男性和女性确定精子的方法包括将基本上无蛋白质的稀释剂中的新鲜喷射的精子暴露于过量浓度的靶向H-Y抗原的单克隆抗体的初始步骤，其基本上仅与男性确定的精子结合。该方法继续将暴露的精子悬浮在一起，与（1）基本上仅与单克隆抗体结合的免疫球蛋白G抗体和（2）基本上不含蛋白质的稀释剂中的免疫吸收底物的缀合物。这形成了一种共轭/精子制剂。该方法的结论是分离的男性和女性确定精子的恢复。

5. 发明申请

US20110034400A1 COMPOSITIONS AND METHODS FOR ANALYZING BACTERIAL ADHERENCE AND ANTI-ADHERENCE TO MUCUS, EPITHELIAL CELLS AND OTHER CELLS 审中-公开
标题翻译：用于分析细菌粘附和抗MUCUS，上皮细胞和其他细胞的组合物和方法
公开(公告)号：US20110034400A1
公开(公告)日：2011-02-10
申请号：US12832746
申请日：2010-07-08
申请人： Karl A. Dawson , Colm Moran , Juha Apajalahti , Marko Lauraeus
发明人： Karl A. Dawson , Colm Moran , Juha Apajalahti , Marko Lauraeus
IPC分类号： A61K38/14 , G01N33/53 , C07K14/00 , A61P43/00
CPC分类号： C12Q1/10 , G01N33/56916 , G01N2333/245
摘要： The present invention generally relates to methods for detecting, identifying, and measuring bacterial adherence to mucus and epithelial cells. In particular, the present invention provides assays for detecting and identifying the presence or absence of bacterial adherence to mucus (epithelial cells (e.g., present in the intestines), or other portion of an animal where bacteria may be present, and methods for identifying and characterizing (e.g., the efficacy of) modulators of bacterial adherence to mucus and epithelial cells, or other portion of the animal where bacteria may be present.
摘要翻译：本发明一般涉及用于检测，鉴定和测量细菌粘附于粘液和上皮细胞的方法。特别地，本发明提供了用于检测和鉴定存在或不存在细菌粘附于粘液（上皮细胞（例如存在于肠中）或其中可能存在细菌的动物的其它部分）的方法，以及用于鉴定和表征细菌粘附于粘液和上皮细胞或可能存在细菌的动物的其他部分的调节剂的功能（例如，功效）。

6. 发明授权

US07048937B2 Methods and compositions for control of coccidiosis 有权
公开(公告)号：US07048937B2
公开(公告)日：2006-05-23
申请号：US10206132
申请日：2002-07-26
申请人： Karl A. Dawson , Arnold E. Sefton
发明人： Karl A. Dawson , Arnold E. Sefton
IPC分类号： A01N25/32
CPC分类号： A61K36/064 , A61K36/062
摘要： Feeding yeast cell wall-containing compositions, including those compositions comprising mannanoligosaccharide(s), to animals exposed to or infected with coccidia, especially poultry exposed to pathogenic species of Eimeria, results in improved livestock performance and physical condition as compared with those animals who were not fed such compositions.

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