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1. 发明授权

US08986769B2 Methods for preserving endogenous TGF-β 有权
标题翻译：保存内源性TGF-和bgr的方法
公开(公告)号：US08986769B2
公开(公告)日：2015-03-24
申请号：US12370374
申请日：2009-02-12
申请人： Juan M. Gonzalez , Dattatreya Banavara , John D. Alvey
发明人： Juan M. Gonzalez , Dattatreya Banavara , John D. Alvey
IPC分类号： A23C9/16 , A23L1/305 , A23L1/29
CPC分类号： A23L1/3056 , A23L33/19 , A23L33/40 , A23V2002/00 , A23V2300/46
摘要： The present invention is directed to a processing method and a selection of ingredients that will retain TGF-β levels, bioactivity, and/or bioavailability in a liquid nutritional product. The method involves selecting one or more protein ingredients that have been subjected to a heat load comprising medium-heat or less; combining the protein ingredients with other components of the liquid nutritional product to form a slurry; subjecting the slurry to a pressure of from about 2500 psi to about 3500 psi at a temperature of from about 55° C. to about 65° C. for about 5 to 20 seconds; subjecting the slurry to a temperature of about 135 to 150° C. for about 1.5 to 15 seconds; and cooling the slurry to a temperature of less than about 8° C. over about 30 minutes or less.
摘要翻译：本发明涉及一种将保留TGF-β的成分的加工方法和选择; 液体营养产品中的水平，生物活性和/或生物利用度。该方法包括选择一种或多种已经经受包含中等或更低的热负荷的蛋白质成分; 将蛋白质成分与液体营养产品的其它成分混合以形成浆料; 在约55℃至约65℃的温度下使浆料经受约2500psi至约3500psi的压力约5至20秒; 将浆料经受约135至150℃的温度约1.5至15秒; 并在约30分钟或更短时间内将浆料冷却至小于约8℃的温度。

2. 发明申请

US20120171328A1 COMPOSITION COMPRISING HEAT LABILE MILK PROTEINS AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：包含热可食乳蛋白的组合物及其制备方法
公开(公告)号：US20120171328A1
公开(公告)日：2012-07-05
申请号：US12984660
申请日：2011-01-05
申请人： Dattatreya Banavara , John D. Alvey , Juan M. Gonzalez
发明人： Dattatreya Banavara , John D. Alvey , Juan M. Gonzalez
IPC分类号： A23D9/00
CPC分类号： A23C11/04 , A23L33/135 , A23L33/19 , A23L33/40 , A23V2002/00 , A23V2200/3202 , A23V2200/3204 , A23V2250/1862 , A23V2250/1868 , A23V2250/54248
摘要： A method for preparing compositions comprising heat labile milk proteins is disclosed herein. In certain embodiments, the method involves subjecting a first composition comprising a fat or lipid source and a protein source to a temperature of at least about 130° C. and combining the first composition with a second composition comprising a heat labile milk protein. In another embodiment, the method includes combining a first composition comprising a fat or lipid source and a protein source that has been subjected to a temperature of at least about 130° C. with a composition comprising a heat labile milk protein to form a third composition including a fat or lipid source, a protein source and a heat labile milk protein and packaging the third composition aseptically.
摘要翻译：本文公开了一种制备包含热不稳定乳蛋白质的组合物的方法。在某些实施方案中，该方法包括将包含脂肪或脂质源和蛋白质源的第一组合物经受至少约130℃的温度，并将第一组合物与包含热不稳定性乳蛋白质的第二组合物组合。在另一个实施方案中，该方法包括将包含脂肪或脂质源的第一组合物和已经经受至少约130℃的温度的蛋白质源与包含热不稳定乳蛋白质的组合物组合以形成第三组合物包括脂肪或脂质来源，蛋白质来源和热不稳定的乳蛋白质，并且无菌地包装第三组合物。

3. 发明授权

US08652096B2 Compressible multi-chamber feeding tube delivery device and methods 有权
标题翻译：可压缩多室给料管输送装置及方法
公开(公告)号：US08652096B2
公开(公告)日：2014-02-18
申请号：US13031297
申请日：2011-02-21
申请人： John D. Alvey , Marc S. Velmer
发明人： John D. Alvey , Marc S. Velmer
IPC分类号： A61M5/14
CPC分类号： A61J1/2093 , A61J1/2027 , A61J9/005 , A61J15/00
摘要： An ingestible material delivery device for sequentially delivering first and second ingestible materials to a user through a feeding tube provides a tube body having first and second chambers separated by a seal. A puncture tool is disposed in the second chamber extending toward the seal. The puncture tool engages and disrupts the seal when the second chamber is compressed. In some embodiments, the second chamber includes a plurality of interconnected bellows operable for axial compression of the second chamber. Another embodiment of a delivery device provides a tube body having first and second chambers with exit nozzles extending in opposite flow directions. A method of sequentially delivering first and second ingestible materials to a user through a feeding tube is also provided.
摘要翻译：一种用于通过进料管将第一和第二可摄取材料顺序递送给使用者的可摄入材料输送装置提供了具有由密封件分隔开的第一和第二腔室的管体。穿刺工具设置在朝向密封件延伸的第二腔室中。当第二腔被压缩时，穿刺工具接合并破坏密封。在一些实施例中，第二腔室包括可操作用于第二腔室的轴向压缩的多个互连的波纹管。输送装置的另一实施例提供一种具有第一和第二腔室的管体，其中出口喷嘴在相反的流动方向上延伸。还提供了通过进料管将第一和第二可摄取材料依次递送给使用者的方法。

4. 发明授权

US09375028B2 Compositions and methods for nutrient delivery 有权
标题翻译：营养物质的组成和方法
公开(公告)号：US09375028B2
公开(公告)日：2016-06-28
申请号：US12963762
申请日：2010-12-09
申请人： John D. Alvey , Carol Lynn Berseth , Deborah Schade , Kristin Morris
发明人： John D. Alvey , Carol Lynn Berseth , Deborah Schade , Kristin Morris
IPC分类号： A61K31/20 , A23L1/29 , A23L1/30
CPC分类号： A23L1/296 , A23L33/115 , A23L33/40 , A23V2002/00 , A23V2250/1862 , A23V2250/1868 , A23V2200/322
摘要： The present disclosure provides compositions and methods for delivering nutrients to subjects requiring small-volume nutritional support, such as preterm infants. The compositions may comprise an emulsion of docosahexaenoic acid (DHA) and arachidonic acid (ARA). The nutritional compositions are useful, for example, in correcting nutritional deficiencies by increasing a subject's intake of nutrients, such as ω-3 or ω-6 long-chain polyunsaturated acids. The nutritional compositions are suitable for enteral delivery as a nutritional supplement or for oral delivery as a human milk or infant formula fortifier.
摘要翻译：本公开提供了用于将营养物质递送至需要小量营养支持的受试者（例如早产儿）的组合物和方法。组合物可以包含二十二碳六烯酸（DHA）和花生四烯酸（ARA）的乳液。营养组合物可用于例如通过增加受试者的营养物质的摄取来纠正营养缺乏症，例如ω-3或ω-6长链多不饱和酸。营养组合物适合作为营养补充剂或作为人乳或婴儿配方强化剂的口服递送的肠内输送。

5. 发明申请

US20120149774A1 COMPOSITIONS AND METHODS FOR NUTRIENT DELIVERY 有权
标题翻译：营养成分的组合物和方法
公开(公告)号：US20120149774A1
公开(公告)日：2012-06-14
申请号：US12963762
申请日：2010-12-09
申请人： John D. Alvey , Carol Lynn Berseth , Deborah Schade , Kristin Morris
发明人： John D. Alvey , Carol Lynn Berseth , Deborah Schade , Kristin Morris
IPC分类号： A61K31/20 , A61P3/00 , A23L1/302 , A61P3/02 , A23L1/30 , A23L1/305
CPC分类号： A23L1/296 , A23L33/115 , A23L33/40 , A23V2002/00 , A23V2250/1862 , A23V2250/1868 , A23V2200/322
摘要： The present disclosure provides compositions and methods for delivering nutrients to subjects requiring small-volume nutritional support, such as preterm infants. The compositions may comprise an emulsion of docosahexaenoic acid (DHA) and arachidonic acid (ARA). The nutritional compositions are useful, for example, in correcting nutritional deficiencies by increasing a subject's intake of nutrients, such as ω-3 or ω-6 long-chain polyunsaturated acids. The nutritional compositions are suitable for enteral delivery as a nutritional supplement or for oral delivery as a human milk or infant formula fortifier.
摘要翻译：本公开提供了用于将营养物质递送至需要小量营养支持的受试者（例如早产儿）的组合物和方法。组合物可以包含二十二碳六烯酸（DHA）和花生四烯酸（ARA）的乳液。营养组合物可用于例如通过增加受试者的营养物质的摄取来纠正营养缺乏症，例如ω-3或ω-6长链多不饱和酸。营养组合物适合于作为营养补充剂的肠内输送或作为人乳或婴儿配方强化剂的口服递送。

6. 发明授权

US08622974B2 Plunger-driven feeding tube delivery device and methods 有权
标题翻译：柱塞式输送管输送装置及方法
公开(公告)号：US08622974B2
公开(公告)日：2014-01-07
申请号：US13031298
申请日：2011-02-21
申请人： John D. Alvey , Marc S. Velmer
发明人： John D. Alvey , Marc S. Velmer
IPC分类号： A61M5/00 , A61M37/00 , A61M5/315
CPC分类号： A61J1/2093 , A61J1/2048 , A61J15/0003 , A61J15/0069 , A61J15/0076 , A61M5/19 , A61M5/31505 , A61M31/00 , A61M2005/1787
摘要： A plunger-driven delivery device for use with a feeding tube for delivering an ingestible material to a user is provided. The delivery device includes a device body having a first chamber, a second chamber and an exit orifice through which the ingestible material is delivered to the feeding tube. A first plunger is disposed in the first chamber, and a second plunger is disposed in the second chamber. The delivery device can be provided with the ingestible material disposed in the first chamber and a flushing liquid disposed in the second chamber. The delivery device is operable to provide sequential delivery first of the ingestible material and then the flushing liquid into the feeding tube. In some embodiments, a mechanical interlock is disposed between the first and second plungers to prevent use of the second plunger until the first plunger has been depressed. In additional embodiments, a first passage is defined between the first chamber and the exit orifice and a second passage is defined between the second chamber and the exit orifice. The second passage has a longer passage length than the first passage, allowing delivery of the ingestible material into the feeding tube before the flushing liquid is ejected from the delivery device. A method of delivering an ingestible material to a user through a feeding tube is also provided.
摘要翻译：提供了一种用于与供给管一起用于将可摄取材料输送给使用者的柱塞驱动输送装置。输送装置包括具有第一腔室，第二腔室和出口孔的装置体，所述可摄取材料通过所述出口孔输送到所述进料管。第一柱塞设置在第一室中，第二柱塞设置在第二室中。输送装置可以设置有设置在第一室中的可摄取材料和设置在第二室中的冲洗液。输送装置可操作以首先提供可摄取材料的顺序输送，然后将冲洗液体提供到进料管中。在一些实施例中，机械互锁装置设置在第一和第二柱塞之间，以防止使用第二柱塞，直到第一柱塞被压下。在另外的实施例中，第一通道限定在第一室和出口孔之间，并且第二通道限定在第二室和出口孔之间。第二通道具有比第一通道更长的通道长度，允许在从输送装置喷射冲洗液体之前将可摄入材料输送到进料管中。还提供了通过进料管将可摄取材料递送给使用者的方法。

7. 发明申请

US20120215205A1 PLUNGER-DRIVEN FEEDING TUBE DELIVERY DEVICE AND METHODS 有权
标题翻译：串联输送管输送装置及方法
公开(公告)号：US20120215205A1
公开(公告)日：2012-08-23
申请号：US13031298
申请日：2011-02-21
申请人： John D. Alvey , Mare S. Velmer
发明人： John D. Alvey , Mare S. Velmer
IPC分类号： A61M31/00
CPC分类号： A61J1/2093 , A61J1/2048 , A61J15/0003 , A61J15/0069 , A61J15/0076 , A61M5/19 , A61M5/31505 , A61M31/00 , A61M2005/1787
摘要： A plunger-driven delivery device for use with a feeding tube for delivering an ingestible material to a user is provided. The delivery device includes a device body having a first chamber, a second chamber and an exit orifice through which the ingestible material is delivered to the feeding tube. A first plunger is disposed in the first chamber, and a second plunger is disposed in the second chamber. The delivery device can be provided with an ingestible material disposed in the first chamber and a flushing liquid disposed in the second chamber. The delivery device is operable to provide sequential delivery first of ingestible material and then flushing liquid into a feeding tube. In some embodiments, a mechanical interlock is disposed between the first and second plungers to prevent use of the second plunger until the first plunger has been depressed. In additional embodiments, a first passage is defined between the first chamber and the exit orifice and a second passage is defined between the second chamber and the exit orifice. The second passage has a longer passage length than the first passage, allowing delivery of the ingestible material into the feeding tube before flushing liquid is ejected from the delivery device. A method of delivering ingestible material to a user through a feeding tube is also provided.
摘要翻译：提供了一种用于与供给管一起用于将可摄取材料输送给使用者的柱塞驱动输送装置。输送装置包括具有第一腔室，第二腔室和出口孔的装置体，所述可摄取材料通过所述出口孔输送到所述进料管。第一柱塞设置在第一室中，第二柱塞设置在第二室中。输送装置可以设置有设置在第一室中的可摄取材料和设置在第二室中的冲洗液。输送装置可操作以首先提供可摄取材料的顺序输送，然后将液体冲洗到进料管中。在一些实施例中，机械互锁装置设置在第一和第二柱塞之间，以防止使用第二柱塞，直到第一柱塞被压下。在另外的实施例中，第一通道限定在第一室和出口孔之间，并且第二通道限定在第二室和出口孔之间。第二通道具有比第一通道更长的通道长度，允许将可摄入材料输送到进料管中，同时冲洗液体从输送装置喷出。还提供了通过进料管将可摄取材料递送给使用者的方法。

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