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    • 3. 发明授权
    • Method for controlling microbial biofilm in aqueous systems
    • 在水系统中控制微生物生物膜的方法
    • US08784659B2
    • 2014-07-22
    • US12892490
    • 2010-09-28
    • Wilson Kurt WhitekettleGloria Jean TafelQing ZhaoLinna WangDorothy ReynoldsPaul FrailJuan JiangDavid M. Polizzotti
    • Wilson Kurt WhitekettleGloria Jean TafelQing ZhaoLinna WangDorothy ReynoldsPaul FrailJuan JiangDavid M. Polizzotti
    • C02F1/50
    • C02F1/50A01N47/44A01N47/48C02F2303/04C02F2303/20C02F2305/04C02F2305/14A01N25/04A01N2300/00
    • A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
    • 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法,从而消除工业含水系统中的生物污垢,包括管道,热交换器,冷凝器,过滤系统和流体储存罐 。 根据本发明的一个实施方案,将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带,就可以进行脂质体的分解或程序分解。 此后,释放杀生物的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时,多糖/蛋白质基质分解,从而导致含水系统的结垢减少,导致增加的热传递,增加的通量,较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜,从而降低膜清洗的频率和持续时间并最终更换。
    • 5. 发明授权
    • Method for controlling microbial biofilm in aqueous systems
    • 在水系统中控制微生物生物膜的方法
    • US07824557B2
    • 2010-11-02
    • US11835722
    • 2007-08-08
    • Wilson Kurt WhitekettleGloria Jean TafelQing Zhao
    • Wilson Kurt WhitekettleGloria Jean TafelQing Zhao
    • C02F1/50
    • C02F1/50A01N47/44A01N47/48C02F2303/20C02F2305/14Y10S210/916A01N25/04A01N2300/00
    • A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
    • 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法,从而消除工业含水系统中的生物污垢,包括管道,热交换器,冷凝器,过滤系统和流体储存罐 。 根据本发明的一个实施方案,将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带,就可以进行脂质体的分解或程序分解。 此后,释放杀生物活性的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时,多糖/蛋白质基质分解,从而导致含水系统的结垢减少,导致增加的热传递,增加的通量,较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜,从而降低膜清洗的频率和持续时间并最终更换。
    • 6. 发明申请
    • BIODELIVERY SYSTEMS
    • 生物系统
    • US20120114728A1
    • 2012-05-10
    • US13257211
    • 2010-02-12
    • Wilson Kurt WhitekettleGloria Jean TafelKimberly MurphyQing Zhao
    • Wilson Kurt WhitekettleGloria Jean TafelKimberly MurphyQing Zhao
    • A01N25/26A01N37/34A01N33/20A01N57/20A01P1/00A01N43/80A01N33/12B82Y99/00
    • A61K31/425A01N25/28A01N43/80
    • A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
    • 已经发现了一种生物输送系统,其通过使用脂质体载体提高了将抗微生物化合物引入复杂生物膜基质的效率和有效性,从而消除了工业含水系统中的生物污垢,包括管道,热交换,冷凝器,过滤系统和流体储存 坦克 根据本发明的一个实施方案,将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦含有脂质体的抗微生物化合物变得与生物膜基质夹带,则脂质体的分解或分解进行。 此后,释放出杀生物核心,直接与生物膜包裹的微生物反应。 在生物体死亡时,基质分解,从而导致含水系统的结垢减少,导致增加的热传递,增加的通量,在微滤膜的表面上胶体和颗粒固体以及溶解的有机物的沉积少 降低膜清洗的频率和持续时间并最终更换。
    • 7. 发明申请
    • METHOD FOR CONTROLLING MICROBIAL BIOFLIM IN AQUEOUS SYSTEMS
    • 用于控制水质系统微生物生物量的方法
    • US20090039035A1
    • 2009-02-12
    • US11835722
    • 2007-08-08
    • Wilson Kurt WhitekettleGloria Jean TafelQing Zhao
    • Wilson Kurt WhitekettleGloria Jean TafelQing Zhao
    • C02F1/50
    • C02F1/50A01N47/44A01N47/48C02F2303/20C02F2305/14Y10S210/916A01N25/04A01N2300/00
    • A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
    • 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法,从而消除工业含水系统中的生物污垢,包括管道,热交换器,冷凝器,过滤系统和流体储存罐 。 根据本发明的一个实施方案,将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带,就可以进行脂质体的分解或程序分解。 此后,释放杀生物活性的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时,多糖/蛋白质基质分解,从而导致含水系统的结垢减少,导致增加的热传递,增加的通量,较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜,从而降低膜清洗的频率和持续时间并最终更换。
    • 8. 发明申请
    • PROPANEDIOL DELIVERY SYSTEMS
    • 丙烷输送系统
    • US20100239626A1
    • 2010-09-23
    • US12408048
    • 2009-03-20
    • Wilson Kurt WHITEKETTLEKimberly MurphyQing Zhao
    • Wilson Kurt WHITEKETTLEKimberly MurphyQing Zhao
    • A01N25/34A01N31/02A01P1/00
    • A01N25/28A01N25/34C02F1/444C02F1/50C02F2303/20A01N31/02A01N35/08
    • A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
    • 已经发现了一种生物输送系统,其通过使用脂质体载体提高了将抗微生物化合物引入复杂生物膜基质的效率和有效性,从而消除了工业含水系统中的生物污垢,包括管道,热交换,冷凝器,过滤系统和流体储存 坦克 根据本发明的一个实施方案,将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦含有脂质体的抗微生物化合物变得与生物膜基质夹带,则脂质体的分解或分解进行。 此后,释放出杀生物核心,直接与生物膜包裹的微生物反应。 在生物体死亡时,基质分解,从而导致含水系统的结垢减少,导致增加的热传递,增加的通量,在微滤膜的表面上胶体和颗粒固体以及溶解的有机物的沉积少 降低膜清洗的频率和持续时间并最终更换。