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1. 发明申请

US20060193788A1 Acute treatment of headache with phenothiazine antipsychotics 审中-公开
标题翻译：用吩噻嗪抗精神病药物急性治疗头痛
公开(公告)号：US20060193788A1
公开(公告)日：2006-08-31
申请号：US11346548
申请日：2006-02-02
申请人： Ron Hale , Peter Lloyd , Amy Lu , Patrik Munzar , Joshua Rabinowitz , Roman Skowronski
发明人： Ron Hale , Peter Lloyd , Amy Lu , Patrik Munzar , Joshua Rabinowitz , Roman Skowronski
IPC分类号： A61K9/14 , A61L9/04
CPC分类号： A61K31/553 , A61K9/007 , A61K9/0073 , A61K31/382 , A61K31/4439 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , A61M15/00 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.
摘要翻译：提供了使用抗精神病药治疗头痛的方法。还提供了用于治疗头痛的试剂盒，其包含抗精神病药和用于快速递送抗精神病药的装置。

2. 发明申请

US20050131739A1 Methods for monitoring severity of panic attacks and other rapidly evolving medical events in real time 审中-公开
标题翻译：监测恐慌发作严重程度及其他快速发展的医疗事件的方法
公开(公告)号：US20050131739A1
公开(公告)日：2005-06-16
申请号：US10996114
申请日：2004-11-23
申请人： Joshua Rabinowitz , Roman Skowronski
发明人： Joshua Rabinowitz , Roman Skowronski
IPC分类号： A61B5/16 , G06F19/00 , G06Q10/00 , G06F17/60 , A61B5/00
CPC分类号： G06Q10/109 , A61B5/16 , A61B5/165 , A61B5/411 , G06Q50/22
摘要： The present invention provides novel methods of recording a medical event in real-time. One aspect of the invention comprises providing a subject an electronic diary for recording one or more aspects of a medical event, wherein the diary electronically records a time at which entries to the diary are made without requiring the subject to input the time of each entry and wherein the diary further prompts the subject to make an entry in the diary at various time intervals. Other aspects of the invention include methods of determining whether a medical treatment produces a therapeutic effect in a subject using real-time data; methods of measuring response of a subject experiencing panic attack symptoms to a treatment in real-time; and methods of assessing the relative effectiveness in real-time of a first medical treatment and a second medical treatment.
摘要翻译：本发明提供了实时记录医疗事件的新颖方法。本发明的一个方面包括向受试者提供用于记录医疗事件的一个或多个方面的电子日记，其中日记以电子方式记录在日志的条目下进行的时间，而不要求受试者输入每个记录的时间，其中日记进一步提示受试者以不同的时间间隔在日记中进入。本发明的其它方面包括使用实时数据确定医疗治疗是否在受试者中产生治疗效果的方法; 测量遭受恐慌症状的受试者对实时治疗的反应的方法; 以及评估第一次医疗和第二次医疗的实时相对有效性的方法。

3. 发明申请

US20080038363A1 AEROSOL DELIVERY SYSTEM AND USES THEREOF 审中-公开
标题翻译：航空运输系统及其用途
公开(公告)号：US20080038363A1
公开(公告)日：2008-02-14
申请号：US11687466
申请日：2007-03-16
申请人： Alejandro Zaffaroni , Joshua Rabinowitz
发明人： Alejandro Zaffaroni , Joshua Rabinowitz
IPC分类号： A61K9/14 , A61K31/5513 , A61P25/00 , A61K31/5517
CPC分类号： A61M11/041 , A61M11/001 , A61M11/005 , A61M11/042 , A61M11/048 , A61M15/002
摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300 oC, and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
摘要翻译：公开了一种用于生产冷凝气雾剂的装置，方法和系统。该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。装置中的热源可操作以向基板供应热量以产生大于300℃的基板温度，并且在2秒或更短的时间段内基本上使药物组合物膜从基板挥发。该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。

4. 发明申请

US20070286816A1 Drug and excipient aerosol compositions 审中-公开
标题翻译：药物和赋形剂气溶胶组合物
公开(公告)号：US20070286816A1
公开(公告)日：2007-12-13
申请号：US11744799
申请日：2007-05-04
申请人： Ron Hale , Joshua Rabinowitz , Daniel Myers , Amy Lu , Alejandro Zaffaroni
发明人： Ron Hale , Joshua Rabinowitz , Daniel Myers , Amy Lu , Alejandro Zaffaroni
IPC分类号： A61K9/12
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件以形成气溶胶。还公开了使用这些气溶胶和试剂盒的方法。

5. 发明申请

US20070161078A1 Methods and compositions for diagnosis and treatment of influenza 有权
标题翻译：用于流感诊断和治疗的方法和组成
公开(公告)号：US20070161078A1
公开(公告)日：2007-07-12
申请号：US11481411
申请日：2006-07-03
申请人： Peter Lu , Joshua Rabinowitz , Michael Belmares
发明人： Peter Lu , Joshua Rabinowitz , Michael Belmares
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： A61K38/07 , A61K38/08 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K7/06 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2500/02
摘要： The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells.
摘要翻译：本发明提供用于确定样品中流感病毒的存在和量的方法和组合物，其包括流感A的高风险菌株。还提供了确定受试者是否感染流感病毒的方法以及类型和流感病毒株。所述方法包括使来自受试者的样品与PDZ多肽（PDZ）和/或PDZ配体（PL）接触并确定在PDZ和PL之间是否发生结合相互作用。还提供了用于鉴定抗病毒剂的测定法，以及使用该组合物改变流感病毒感染细胞中PDZ与PL结合的方法。

6. 发明申请

US20060269486A1 Delivery of diazepam through an inhalation route 失效
标题翻译：通过吸入路线递送地西泮
公开(公告)号：US20060269486A1
公开(公告)日：2006-11-30
申请号：US11500736
申请日：2006-08-07
申请人： Joshua Rabinowitz , Alejandro Zaffaroni
发明人： Joshua Rabinowitz , Alejandro Zaffaroni
IPC分类号： A61K9/14 , A61L9/04
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/5513 , Y10S514/958
摘要： The present invention relates to the delivery of compounds for the treatment of anxiety disorders and symptoms of such disorders through an inhalation route. Specifically, it relates to aerosols containing diazepam that are used in inhalation therapy. In a method aspect of the present invention, diazepam is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of diazepam on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering diazepam through an inhalation route is provided which comprises: a) a thin coating of a diazepam composition; and, b) a device for dispending said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送用于治疗焦虑症和这种病症症状的化合物。具体来说，它涉及用于吸入治疗的含有地西泮的气溶胶。在本发明的方法方面，通过吸入途径向患者施用地西泮。该方法包括：a）在固体支持物上加热薄层的地西泮以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了用于通过吸入途径递送地西泮的试剂盒，其包括：a）地西泮组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。

7. 发明申请

US20060257329A1 Delivery of drug esters through an inhalation route 审中-公开
公开(公告)号：US20060257329A1
公开(公告)日：2006-11-16
申请号：US11488943
申请日：2006-07-18
申请人： Joshua Rabinowitz , Alejandro Zaffaroni
发明人： Joshua Rabinowitz , Alejandro Zaffaroni
IPC分类号： A61K9/14 , A61L9/04
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of drug esters through an inhalation route. Specifically, it relates to aerosols containing drug esters that are used in inhalation therapy. In a method aspect of the present invention, a drug ester is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises a drug ester, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% drug ester degradation product. In a kit aspect of the present invention, a kit for delivering a drug ester through an inhalation route is provided which comprises: a) a thin coating of a drug ester composition and b) a device for dispensing said thin coating as a condensation aerosol.

8. 发明申请

US20060251588A1 Delivery of erectile dysfunction drugs through an inhalation route 失效
标题翻译：通过吸入路线输送勃起功能障碍药物
公开(公告)号：US20060251588A1
公开(公告)日：2006-11-09
申请号：US11481279
申请日：2006-07-05
申请人： Joshua Rabinowitz , Alejandro Zaffaroni
发明人： Joshua Rabinowitz , Alejandro Zaffaroni
IPC分类号： A61K9/14 , A61L9/04 , A61K31/519
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of erectile dysfunction drugs through an inhalation route. Specifically, it relates to aerosols containing erectile dysfunction drugs that are used in inhalation therapy. In a method aspect of the present invention, an erectile dysfunction drug is delivered to a patient through an inhalation route. The method comprises: a) heating a thin film of an erectile dysfunction drug, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% erectile dysfunction drug degradation products. In a kit aspect of the present invention, a kit for delivering an erectile dysfunction drug through an inhalation route is provided which comprises: a) a thin film of an erectile dysfunction drug composition and b) a device for dispensing said thin film as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送勃起功能障碍药物。具体来说，它涉及含有用于吸入治疗的勃起功能障碍药物的气溶胶。在本发明的方法方面，勃起功能障碍药物通过吸入途径输送给患者。该方法包括：a）在固体支持物上加热勃起功能障碍药物的薄膜以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％勃起功能障碍药物降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了一种用于通过吸入途径递送勃起功能障碍药物的试剂盒，其包括：a）勃起功能障碍药物组合物的薄膜和b）用于分配所述薄膜作为冷凝物的装置气雾剂。

9. 发明授权

US08158677B2 Treatment of viral infections by modulation of host cell metabolic pathways 有权
标题翻译：通过调节宿主细胞代谢途径治疗病毒感染
公开(公告)号：US08158677B2
公开(公告)日：2012-04-17
申请号：US12156517
申请日：2008-06-02
申请人： Josh Munger , Bryson Bennett , Thomas Shenk , Joshua Rabinowitz
发明人： Josh Munger , Bryson Bennett , Thomas Shenk , Joshua Rabinowitz
IPC分类号： A61K31/34 , A61K31/38 , A61K31/35
CPC分类号： A61K31/7076 , A61K31/122 , A61K31/15 , A61K31/194 , A61K31/22 , A61K31/221 , A61K31/336 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/365 , A61K31/381 , A61K31/403 , A61K31/405 , A61K31/44 , A61K31/4545 , A61K31/52 , A61K31/522 , A61K31/53 , A61K31/5377 , A61K31/675 , A61K31/706 , Y02A50/463 , A61K2300/00
摘要： Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.
摘要翻译：描述了响应于病毒感染发生的某些代谢物浓度和通量的变化。所选代谢途径中的宿主细胞酶被选为干预的目标; 即恢复代谢通量以不利于病毒复制，或进一步破坏导致病毒感染细胞（但不是未感染细胞）“自杀”的代谢通量，以限制病毒传播。虽然可以选择相关代谢途径中的任何酶，但在这些代谢途径的关键控制点的关键酶优选作为候选抗病毒药物靶标。这些酶的抑制剂用于逆转或重定向病毒感染的作用。使用体外和宿主细胞的筛选测定以及动物模型测试候选药物的抗病毒活性。然后使用动物模型来测试候选化合物在预防和治疗病毒感染中的功效。证明酶抑制剂的抗病毒活性。

10. 发明申请

US20070178052A1 DELIVERY OF OPIOIDS THROUGH AN INHALATION ROUTE 有权
标题翻译：通过吸入路线输送OPIOIDS
公开(公告)号：US20070178052A1
公开(公告)日：2007-08-02
申请号：US11621397
申请日：2007-01-09
申请人： Joshua Rabinowitz , Alejandro Zaffaroni
发明人： Joshua Rabinowitz , Alejandro Zaffaroni
IPC分类号： A61K31/485 , A61K9/14
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a method aspect of the present invention, an opioid is delivered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an opioid, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% opioid degradation products. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route is provided which comprises: a) a thin layer of an opioid and b) a device for dispensing said thin layer as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送阿片样物质。具体地说，它涉及用于吸入治疗的含有阿片样物质的气溶胶。在本发明的方法方面，通过吸入途径将阿片样物质递送至患者。该方法包括：a）在固体支持物上加热阿片样物质的薄层以形成蒸气; 并且b）使空气通过加热的蒸气以产生具有小于5％阿片样降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了一种用于通过吸入途径递送阿片样物质的试剂盒，其包括：a）阿片样物质的薄层，以及b）用于将所述薄层分配为冷凝气溶胶的装置。

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