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1. 发明授权

US4859599A Antibiotic A26201-1 and antibiotic A26201-2 produced by a novel strain of actinoplanes 失效
标题翻译：抗生素A26201-1和抗生素A26201-2由新型动力学体系产生
公开(公告)号：US4859599A
公开(公告)日：1989-08-22
申请号：US877581
申请日：1986-08-08
申请人： Joseph W. Whalen , Gregory L. Swartz , Lisa J. Rheaume , Karen M. McCoy
发明人： Joseph W. Whalen , Gregory L. Swartz , Lisa J. Rheaume , Karen M. McCoy
IPC分类号： A23K20/195 , C12P1/06
CPC分类号： C12R1/045 , A23K20/195 , C12P1/06 , Y10S435/827
摘要： Antibiotic A26201-1 and antibiotic A26201-2 are produced by the novel microorganism, Actinoplanes species A26201 (ATCC 39573), under aqueous aerobic fermentation conditions. The antibiotics are useful for inhibiting bacteria, particularly gram positive bacteria, and are also useful for promoting the growth of monogastric and ruminant animals.
摘要翻译：抗生素A26201-1和抗生素A26201-2由新型微生物Actinoplanes物种A26201（ATCC 39573）在水性好氧发酵条件下生产。抗生素可用于抑制细菌，特别是革兰氏阳性细菌，也可用于促进单胃和反刍动物的生长。

2. 发明授权

US4613503A Antibiotic A26201-1 and antibiotic A26201-2 produced by a novel strain of actinoplanes 失效
标题翻译：抗生素A26201-1和抗生素A26201-2由新型动力学体系产生
公开(公告)号：US4613503A
公开(公告)日：1986-09-23
申请号：US659912
申请日：1984-10-11
申请人： Joseph W. Whalen , Gregory L. Swartz , Lisa J. Rheaume , Karen M. McCoy
发明人： Joseph W. Whalen , Gregory L. Swartz , Lisa J. Rheaume , Karen M. McCoy
IPC分类号： C12N1/20 , A23K20/195 , A61K35/74 , A61K38/00 , A61P31/04 , C07G11/00 , C12P1/06 , C12R1/01
CPC分类号： C12R1/045 , A23K20/195 , C12P1/06
摘要： Antibiotic A26201-1 and antibiotic A26201-2 are produced by the novel microorganism, Actinoplanes species A26201 (ATCC 39573), under aqueous aerobic fermentation conditions. The antibiotics are useful for inhibiting bacteria, particularly gram positive bacteria, and are also useful for promoting the growth of monogastric and ruminant animals.
摘要翻译：抗生素A26201-1和抗生素A26201-2由新型微生物Actinoplanes物种A26201（ATCC 39573）在水性好氧发酵条件下生产。抗生素可用于抑制细菌，特别是革兰氏阳性细菌，也可用于促进单胃和反刍动物的生长。

3. 发明授权

US4950596A Stabilization of intracellular enzymes 失效
标题翻译：稳定细胞内酶
公开(公告)号：US4950596A
公开(公告)日：1990-08-21
申请号：US20407
申请日：1987-03-02
申请人： Roberta C. Cheng , Norman G. Moll , Robert A. Houtchens , Karen M. McCoy
发明人： Roberta C. Cheng , Norman G. Moll , Robert A. Houtchens , Karen M. McCoy
IPC分类号： C12N1/04 , C12N9/96 , C12N11/02 , C12N11/04 , C12P19/24
CPC分类号： C12P19/24 , C12N1/04 , C12N11/02 , C12N11/04 , C12N9/96
摘要： The subject invention concerns a process for stabilizing intact or ruptured microbial cells having glucose isomerase associated therewith. Specifically exemplified is a process for stabilizing glucose isomerase producing cells of a microorganism belonging to the genus Ampullariella. In the invention process the whole or ruptured microbial cells are contacted with a partially carboxyalkylated- or partially phosphonoalkylated-cationic polyelectrolyte, for example, a partially carboxymethylated polyethyleneimine to flocculate and stabilize the cells. The flocculated cells are further stabilized by encapsulation with a partially carboxyalkylated- or partially phosphonoalkylated-cationic polyelectrolyte. The encapsulation can be done prior to or after the flocculated cells are crosslinked. The net effect is manifested by a dramatic increase in the half-life of the glucose isomerase.
摘要翻译：本发明涉及用于稳定具有与其相关的葡萄糖异构酶的完整或破裂的微生物细胞的方法。具体举例说明了稳定葡萄糖异构酶产生细胞的方法，该细胞属于安瓿属（Ampullariella）属。在本发明方法中，将全部或破裂的微生物细胞与部分羧烷基化或部分膦酰烷基化阳离子聚电解质（例如部分羧甲基化的聚乙烯亚胺）接触以使细胞絮凝和稳定。通过用部分羧烷基化或部分膦酰烷基化阳离子聚电解质包封进一步稳定絮凝的细胞。可以在絮凝的细胞交联之前或之后进行封装。净效应表现在葡萄糖异构酶的半衰期急剧增加。

4. 发明授权

US4735939A Insecticidal activity of staurosporine 失效
标题翻译：星形孢菌素的杀虫活性
公开(公告)号：US4735939A
公开(公告)日：1988-04-05
申请号：US19909
申请日：1987-02-27
申请人： Karen M. McCoy , Christopher J. Hatton
发明人： Karen M. McCoy , Christopher J. Hatton
IPC分类号： A01N43/90 , A01N43/00
CPC分类号： A01N43/90
摘要： A method for inhibiting insects by contacting insects or habitat thereof with an effective amount of staurosporine.
摘要翻译：通过使昆虫或其栖息地与有效量的星形孢菌素接触来抑制昆虫的方法。

5. 发明授权

US4675292A Stabilization of glucose isomerase 失效
标题翻译：葡萄糖异构酶稳定
公开(公告)号：US4675292A
公开(公告)日：1987-06-23
申请号：US707774
申请日：1985-03-04
申请人： Robert A. Houtchens , Roberta C. Cheng , Karen M. McCoy , Carol C. Epstein , Norman G. Moll
发明人： Robert A. Houtchens , Roberta C. Cheng , Karen M. McCoy , Carol C. Epstein , Norman G. Moll
IPC分类号： C12N11/00 , C12N9/96 , C12N11/04 , C12N11/08 , C12P19/24
CPC分类号： C12N11/08 , C12N11/04 , C12N9/96 , C12P19/24
摘要： Extracellular enzymes are stabilized with a carboxyalkylated or phosphonoalkylated polymer having a molecular weight of at least 500 Daltons. Exemplified is the stabilization of the enzyme glucose isomerase used in a process to convert D-glucose to D-fructose. In a preferred embodiment of the invention the feedstream containing the substrate is contacted initially with the stabilizer and then with the enzyme. In this system the stabilizer and enzyme are maintained in separate reactors. This separation, advantageously, results in a higher half-life for the enzyme.
摘要翻译：用分子量至少为500道尔顿的羧基烷基化或膦酰基烷基化聚合物稳定细胞外酶。示例是用于将D-葡萄糖转化为D-果糖的方法中使用的酶葡萄糖异构酶的稳定化。在本发明的优选实施方案中，含有底物的进料流最初与稳定剂接触，然后与酶接触。在该系统中，稳定剂和酶保持在单独的反应器中。这种分离有利地导致酶的较长的半衰期。

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