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1. 发明授权

US4909320A Detonation assembly for explosive wellhead severing system 失效
标题翻译：爆炸井口切断系统爆轰装置
公开(公告)号：US4909320A
公开(公告)日：1990-03-20
申请号：US258228
申请日：1988-10-14
申请人： Joseph V. Hebert , Robert J. Schwartz
发明人： Joseph V. Hebert , Robert J. Schwartz
IPC分类号： E21B31/16 , E21B29/02 , E21B29/12
CPC分类号： E21B29/12 , E21B29/02
摘要： A detonation assembly for an explosive wellhead severing system which employs a battery pack lowerable through a drill string to engage and power the detonation assembly positioned within the well bore. The lowerable unit includes a biased shutter which seals the contacts from discharge of the battery pack by the surrounding fluids. The shuttered unit is lowered into contact with the receiving unit to arm the detonation assembly. Until the power unit is lowered into engagement, the severing system is not armed. In case of malfunction or misfire, the power unit can be retrieved to disarm the detonator assembly. The entire assembly is housed within the drill string to isolate the critical elements from the surrounding environment.
摘要翻译：一种用于爆炸性井口切断系统的爆炸组件，其采用可通过钻柱可降低的电池组，以接合和驱动位于井眼内的爆震组件。可降低的单元包括偏置的快门，其将接触件密封，以防止周围流体对电池组的排出。快门单元下降到与接收单元接触以支撑爆震组件。在动力单元下降到接合之前，切断系统未装备。在发生故障或失火的情况下，可以检索动力单元以撤离雷管组件。整个组件安装在钻柱内，以将关键元件与周围环境隔离开来。

2. 发明授权

US07960536B2 Synthetic cell-or tissue-specific transcriptional regulatory regions 有权
标题翻译：合成细胞或组织特异性转录调控区
公开(公告)号：US07960536B2
公开(公告)日：2011-06-14
申请号：US11080827
申请日：2005-03-14
申请人： Robert J. Schwartz , Eric M. Eastman , Xuyang Li , Jeff Nordstrom
发明人： Robert J. Schwartz , Eric M. Eastman , Xuyang Li , Jeff Nordstrom
IPC分类号： C12N15/63
CPC分类号： C12N15/1051 , C12N15/1034 , C12Q1/6811 , C12Q1/6876 , C12Q1/6897 , C12Q2600/158
摘要： The invention concerns making and evaluating synthetic regulatory regions for controlling gene expression. The invention features a method for identifying transcription factor binding sites and a method for evaluating the regulatory functions of synthetic regulatory regions.
摘要翻译：本发明涉及制备和评估用于控制基因表达的合成调节区。本发明特征在于鉴定转录因子结合位点的方法和评估合成调节区的调节功能的方法。

3. 发明授权

US07895109B2 System and method for providing a financial instrument utilizing a liability ratio 有权
标题翻译：使用负债比率提供金融工具的制度和方法
公开(公告)号：US07895109B2
公开(公告)日：2011-02-22
申请号：US11671625
申请日：2007-02-06
申请人： Jacob M. Herschler , Daniel O. Kane , N. David Kuperstock , Robert Francis O'Donnell , Steven Lee Putterman , Dain Eric Runestad , Robert J. Schwartz , Nicholas Berardis, Jr. , John L. Grucza , Michael Albert Guido , J. Scott Dunn
发明人： Jacob M. Herschler , Daniel O. Kane , N. David Kuperstock , Robert Francis O'Donnell , Steven Lee Putterman , Dain Eric Runestad , Robert J. Schwartz , Nicholas Berardis, Jr. , John L. Grucza , Michael Albert Guido , J. Scott Dunn
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q40/00 , G06Q40/06 , G06Q40/08 , G06Q99/00
摘要： One embodiment of the invention is a method for providing a financial instrument including determining a current account balance for a financial account, calculating a liability ratio for the financial account, and determining whether to transfer at least a portion of the account balance from a variable sub-account to a low-risk sub-account based on the liability ratio.
摘要翻译：本发明的一个实施例是一种用于提供金融工具的方法，包括确定金融账户的经常账户余额，计算金融账户的负债率，以及确定是否从可变子流程中转移账户余额的至少一部分 - 根据负债比率计算低风险子科目。

4. 发明授权

US5925564A Expression vector systems and method of use 失效
标题翻译：表达载体系统和使用方法
公开(公告)号：US5925564A
公开(公告)日：1999-07-20
申请号：US472809
申请日：1995-06-07
申请人： Robert J. Schwartz , Franco J. DeMayo , Bert W. O'Malley
发明人： Robert J. Schwartz , Franco J. DeMayo , Bert W. O'Malley
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C12N15/85 , C12N5/16 , C12N15/63
CPC分类号： A61K48/00 , C07K14/4708 , C12N15/85 , A61K38/00 , A61K39/00 , C12N2830/008 , C12N2830/90
摘要： This invention relates to gene therapy by using vectors which encode stable MRNA and methods of using such vectors. In particular, this invention relates to vectors which establish controlled expression of recombinant genes within tissues at certain levels. The vector includes a 5' flanking region which includes necessary sequences for expression of a nucleic acid cassette, a 3' flanking region including a 3' UTR and/or 3' NCR which stabilizes mRNA expressed from the nucleic acid cassette, and a linker which connects the 5' flanking region to a nucleic acid sequence. The linker has a position for inserting a nucleic acid cassette. The linker does not contain the coding sequence of a gene that the linker is naturally associated with. The 3' flanking region is 3' to the position for inserting the nucleic acid cassette. The expression vectors of the present invention can also be regulated by a regulatory system and/or constructed with a coating.
摘要翻译：本发明涉及通过使用编码稳定MRNA的载体和使用这些载体的方法进行基因治疗。特别地，本发明涉及在某些水平的组织内建立重组基因的受控表达的载体。载体包括5'侧翼区，其包含用于表达核酸盒的必需序列，包含稳定从核酸盒表达的mRNA的3'UTR和/或3'NCR的3'侧翼区和连接体将5'侧翼区连接到核酸序列。接头具有用于插入核酸盒的位置。接头不包含接头天然相关基因的编码序列。 3'侧翼区域为插入核酸盒的位置3'。本发明的表达载体也可以通过调节系统调节和/或用涂层构建。

5. 发明授权

US08178504B2 Gene therapy expression of GHRH for increasing RBC count in subjects 有权
标题翻译：基因治疗GHRH表达增加受试者的RBC计数
公开(公告)号：US08178504B2
公开(公告)日：2012-05-15
申请号：US11726291
申请日：2007-03-21
申请人： Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern , Robert J. Schwartz , Glen King , Kevin Hahn , Malcolm K. Brenner
发明人： Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern , Robert J. Schwartz , Glen King , Kevin Hahn , Malcolm K. Brenner
IPC分类号： A61K48/00 , A01N63/00 , A01N65/00
CPC分类号： A61K38/25 , A61K48/00
摘要： The present invention pertains to compositions and methods useful for treating anemia and other effects that are commonly associated in cancer bearing animals. The invention is accomplished by delivering an effective amount of a nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of an animal and allowing expression of the encoded gene in the animal.
摘要翻译：本发明涉及可用于治疗贫血的组合物和方法以及通常与携带癌症的动物相关的其它作用。本发明通过将有效量的编码GHRH或其功能生物等价物的核酸表达构建体递送到动物的组织中并允许编码的基因在动物中表达来实现。

6. 发明申请

US20090292107A1 COMPOSITION AND METHOD TO ALTER LEAN BODY MASS AND BONE PROPERTIES IN A SUBJECT 审中-公开
标题翻译：组合物和方法，以提高身体质量和骨质量在一个主题
公开(公告)号：US20090292107A1
公开(公告)日：2009-11-26
申请号：US12018582
申请日：2008-01-23
申请人： Ruxandra Draghia-Akli , Robert J. Schwartz
发明人： Ruxandra Draghia-Akli , Robert J. Schwartz
IPC分类号： C07K14/00
CPC分类号： C07K14/60 , A61K38/25 , A61K48/00 , A61K48/0041 , A61K48/005 , A61K48/0083
摘要： The present invention pertains to a method for decreasing the body fat proportion, increasing lean body mass (“LBM”), increasing bone density, or improving the rate of bone healing, or all, of a subject. Overall, the embodiments of the invention can be accomplished by delivering a heterologous nucleic acid sequence encoding GHRH or functional biological equivalent thereof into the cells of the subject and allowing expression of the encoded gene to occur while the modified cells are within the subject. For instance, when such a nucleic acid sequence is delivered into the specific cells of the subject tissue specific constitutive expression is achieved. Furthermore, external regulation of the GHRH or functional biological equivalent thereof gene can be accomplished by utilizing inducible promoters that are regulated by molecular switch molecules, which are given to the subject. The preferred method to deliver the constitutive or inducible nucleic acid encoding sequences of GHRH or the functional biological equivalents thereof is directly into the cells of the subject by the process of in vivo electroporation. A decrease the body fat proportion and an increase in lean body mass (“LBM”), or both of a subject is achieved by the delivery of GHRH or functional biological equivalent thereof as described herein by into the subject as recombinant proteins. In addition, an increase in bone density and improvement in the rate of bone healing is also achieved.
摘要翻译：本发明涉及一种降低身体脂肪比例，增加瘦体重（“LBM”），增加骨密度或改善受试者的骨愈合速率或全身的方法。总的来说，本发明的实施方案可以通过将编码GHRH的异源核酸序列或其功能生物学等同物递送到受试者的细胞中并且允许在修饰的细胞在受试者内发生编码基因的表达来实现。例如，当这样的核酸序列被递送到对象组织的特定细胞中时，实现了特异性组成型表达。此外，GHRH或其功能生物等效基因的外部调节可以通过利用被给予受试者的由分子开关分子调节的诱导型启动子来实现。递送GHRH的组成型或诱导型核酸编码序列或其功能生物学等价物的优选方法通过体内电穿孔的方法直接进入受试者的细胞。通过将本文所述的GHRH或其功能生物学等同物作为重组蛋白递送到受试者中，可以降低身体脂肪比例和瘦体重增加（“LBM”）或两者。此外，还可以实现骨密度的增加和骨愈合速度的提高。

7. 发明申请

US20080189220A1 SYSTEM AND METHOD FOR PROVIDING A FINANCIAL INSTRUMENT WITH A PERIODIC STEP-UP FEATURE 有权
标题翻译：提供具有周期性特征的金融仪器的系统和方法
公开(公告)号：US20080189220A1
公开(公告)日：2008-08-07
申请号：US11671679
申请日：2007-02-06
申请人： Jacob M. Herschler , Daniel O. Kane , N. David Kuperstock , Robert Francis O'Donnell , Steven Lee Putterman , Dain Eric Runestad , Robert J. Schwartz , Nicholas Berardis , John L. Grucza , Michael Albert Guido , J. Scott Dunn
发明人： Jacob M. Herschler , Daniel O. Kane , N. David Kuperstock , Robert Francis O'Donnell , Steven Lee Putterman , Dain Eric Runestad , Robert J. Schwartz , Nicholas Berardis , John L. Grucza , Michael Albert Guido , J. Scott Dunn
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q40/06
摘要： One embodiment of the invention is a method for providing a financial instrument including determining a current account balance for a financial account and on a first periodic basis: determining a specified percentage of the value of the financial account, determine the greater of a particular limit and the highest value of the financial account multiplied by the specified percentage on a second periodic basis, and in response to a determination that the highest value of the financial account multiplied by the specified percentage on the second periodic basis is greater than the particular limit, stepping-up the particular limit to equal the highest value of the financial account multiplied by the specified percentage on the second periodic basis.
摘要翻译：本发明的一个实施例是一种用于提供金融工具的方法，包括确定金融账户的经常账户余额并且在第一周期性基础上：确定金融账户的价值的指定百分比，确定特定限额中的较大者; 财务账户的最高价值在第二次定期基础上乘以指定百分比，并且响应于确定财务帐户的最高价值乘以第二周期性基准的指定百分比大于特定限额的步骤 - 在第二次定期基础上将财务帐户的最高价值乘以指定百分比的特殊限制。

8. 发明授权

US07166461B2 Polynucleotides encoding a super-active porcine growth hormone releasing hormone analog 有权
标题翻译：编码超活性猪生长激素释放激素类似物的多核苷酸
公开(公告)号：US07166461B2
公开(公告)日：2007-01-23
申请号：US10262141
申请日：2002-10-01
申请人： Robert J. Schwartz , Ruxandra Draghia-Alki
发明人： Robert J. Schwartz , Ruxandra Draghia-Alki
IPC分类号： C12N15/63 , C12N15/18
CPC分类号： C07K14/60 , A61K38/00 , A61K48/00
摘要： Inadequate growth due to deficiencies in growth hormone (GR), growth hormone releasing hormone (GHRH), or genetic diseases can be ameliorated utilizing recombinant protein therapy with a novel GHRH analog having a sequence (SEQ ID NO:1). Also included is (1) a method of treating growth hormone-related deficiencies associated with the growth hormone pathway; (2) a method for treating growth hormone-related deficiencies associated with genetic disease; (3) a method to improve growth performance in an animal; (4) a method of treating an animal having a growth deficiency disease; (5) a method of increasing the efficiency of an animal used for food; and (6) a method to enhance growth in an animal.
摘要翻译：可以利用具有序列（SEQ ID NO：1）的新型GHRH类似物利用重组蛋白质治疗来改善由于生长激素（GR），生长激素释放激素（GHRH）或遗传性疾病的缺陷导致的生长不足。还包括（1）治疗与生长激素途径相关的生长激素相关缺陷的方法; （2）治疗与遗传性疾病相关的生长激素相关缺陷的方法; （3）改善动物生长性能的方法; （4）治疗具有生长缺陷病的动物的方法; （5）提高用于食物的动物的效率的方法; 和（6）增强动物生长的方法。

9. 发明授权

US5374544A Mutated skeletal actin promoter 失效
标题翻译：突变骨骼肌动蛋白启动子
公开(公告)号：US5374544A
公开(公告)日：1994-12-20
申请号：US823024
申请日：1992-01-15
申请人： Robert J. Schwartz , King L. Chow
发明人： Robert J. Schwartz , King L. Chow
IPC分类号： C12N15/85 , C12N15/00 , C07H17/00 , C12N5/00
CPC分类号： C12N15/85 , C12N2830/008 , C12N2830/90
摘要： A mutated skeletal actin promoter which differs from the naturally occurring DNA sequence by nucleotide substitution has been found to increase gene expression. The mutation sites are specific to the cis-acting regions of the gene. Double mutations created a strong promoter. Transformed myogenic cells had ten times the transcriptional activity over the wild type. The mutated skeletal actin promoter can be used to overly express polypeptides, particularly in myogenic cells.
摘要翻译：已经发现通过核苷酸取代与天然存在的DNA序列不同的突变骨架肌动蛋白启动子增加基因表达。突变位点对基因的顺式作用区域是特异性的。双重突变产生强烈的启动子。转化的肌原细胞比野生型具有十倍的转录活性。突变的骨骼肌动蛋白启动子可用于过度表达多肽，特别是在肌原细胞中。

10. 发明授权

US4100319A Stabilized nonwoven web 失效
标题翻译：稳定的非织造纤维网
公开(公告)号：US4100319A
公开(公告)日：1978-07-11
申请号：US791832
申请日：1977-04-28
申请人： Robert J. Schwartz
发明人： Robert J. Schwartz
IPC分类号： D04H3/16 , D04H1/58
CPC分类号： D04H3/16 , Y10T428/24603 , Y10T428/24802 , Y10T442/69
摘要： A process is described for the intermittent autogenous bonding of a continuous filament web wherein the filaments have a low degree of crystallinity. In one embodiment, the process involves passing the web directly through a nip formed by a smooth hard surfaced roll and a roll containing raised points on its surface with both rolls being maintained at a temperature near the softening point of the filaments. The speed of the web through the nip, the roll size and the configuration of the raised points are coordinated such that the surface temperature of the web is not substantially increased before maximum pressure has been developed in the nip, but then is rapidly raised to a point where surface fusion is effected before a significant increase in filament crystallinity occurs. Webs prepared as illustrated possess a desirable combination of surface abrasion resistance and strength.
摘要翻译：描述了用于连续长丝纤维网的间歇自粘接的方法，其中长丝具有低结晶度。在一个实施方案中，该方法包括将幅材直接通过由光滑的硬表面辊和包含在其表面上的凸起点的辊形成的辊隙，两个辊保持在接近于长丝的软化点的温度。纤维网通过辊隙的速度，辊的尺寸和凸起的构造被协调，使得在辊隙中已经形成最大压力之前，幅材的表面温度基本上不增加，然后迅速升高到在发生长丝结晶度的显着增加之前进行表面熔融的点。如图所示制备的网具有表面耐磨性和强度的理想组合。

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