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1. 发明授权

US08361012B2 Dry to wet injector 有权
标题翻译：干湿式注射器
公开(公告)号：US08361012B2
公开(公告)日：2013-01-29
申请号：US12502713
申请日：2009-07-14
申请人： Joseph T. Persyn , Joseph A McDonough , James D Oxley
发明人： Joseph T. Persyn , Joseph A McDonough , James D Oxley
IPC分类号： A61M37/00
CPC分类号： A61M5/284 , A61K9/0019 , A61K9/5031 , A61M5/286 , A61M5/3145 , A61M25/00 , C09B67/0097
摘要： The present disclosure relates to an apparatus and method for combining a solid particulate with a solvent prior to an injection protocol within an injector device. The solid particulate may be a pharmaceutical compound and the microcapsules contain a solvent for such particulate. Upon application of pressure, the microcapsules may be configured to burst and release the solvent, thereby dispersing and/or partially dissolving the particulate. The injector therefore allows for the use of relatively unstable pharmaceutically active compounds in a device that requires relatively long storage times and the use of pharmaceutical compounds that are relatively stable in the dry state.
摘要翻译：本公开涉及一种用于在注射器装置内的注射方案之前将固体颗粒与溶剂组合的装置和方法。固体颗粒可以是药物化合物，微胶囊含有这种颗粒的溶剂。施加压力时，微胶囊可构造成使溶剂爆裂和释放，从而分散和/或部分溶解颗粒。因此，注射器允许在需要相对长的储存时间的装置中使用相对不稳定的药物活性化合物，以及使用在干燥状态下相对稳定的药物化合物。

2. 发明授权

US08557382B2 Layer by layer modification of microcapsules with inorganic materials 有权
标题翻译：用无机材料逐层改性微胶囊
公开(公告)号：US08557382B2
公开(公告)日：2013-10-15
申请号：US12468571
申请日：2009-05-19
申请人： James D Oxley , Jenny J. Finkbiner , Darren E. Barlow
发明人： James D Oxley , Jenny J. Finkbiner , Darren E. Barlow
IPC分类号： C25D9/00 , A61K9/00
CPC分类号： B01J13/22 , Y10T428/2984 , Y10T428/2989 , Y10T428/2991
摘要： The present disclosure relates to a microcapsule and a method of forming a microcapsule which may be used for oxygen sensitive materials. The microcapsule may comprise a shell encapsulating a core material having a surface, wherein the shell comprises a first organic or inorganic polyelectrolyte providing a plurality of cationic or anionic charges. This may then be followed by forming a first layer comprising an inorganic or organic polyelectrolyte on the microcapsule surface, where the polyelectrolyte of the first layer provides a plurality of cationic or anionic charges, opposite to the charge of the shell polyelectrolyte. This may then be followed by forming a second layer comprising a second organic or inorganic polyelectrolyte providing a plurality of cationic or anionic charges, opposite to the charge of the first layer polyelectrolyte.
摘要翻译：本发明涉及微胶囊和形成可用于氧敏感材料的微胶囊的方法。微胶囊可以包括包封具有表面的芯材的壳，其中壳包含提供多个阳离子或阴离子电荷的第一有机或无机聚电解质。然后可以在微胶囊表面上形成包含无机或有机聚电解质的第一层，其中第一层的聚电解质提供与壳聚电解质电荷相反的多个阳离子或阴离子电荷。然后可以随后形成包含第二有机或无机聚电解质的第二层，其提供与第一层聚电解质的电荷相反的多个阳离子或阴离子电荷。

3. 发明授权

US08581209B2 Fluorescent monitoring of microcapsule oxidation 有权
标题翻译：微胶囊氧化荧光监测
公开(公告)号：US08581209B2
公开(公告)日：2013-11-12
申请号：US12362323
申请日：2009-01-29
申请人： James D Oxley , Jenny J. Finkbiner , Nitin Nitin
发明人： James D Oxley , Jenny J. Finkbiner , Nitin Nitin
IPC分类号： G01N21/64 , B05D3/00
CPC分类号： B01J13/10 , B01J13/14 , C09B67/0097 , C09K11/025 , C09K11/06 , G01N21/278 , G01N21/6408 , G01N2021/7786
摘要： The present disclosure relates to microcapsules that include a shell material and a core material. The core material of the microcapsules contains an environmentally sensitive luminescent colorant which exhibits characteristics of an emitted wavelength bandwidth, a peak intensity for emission and a time for luminescence decay, one or more of the characteristics capable of changing upon exposure to a given environment, and a luminescent standard which exhibits characteristics of an emitted wavelength bandwidth, a peak intensity for emission and a time for luminescence decay, one or more of the characteristics do not change upon exposure to said given environment.
摘要翻译：本公开涉及包括壳材料和芯材料的微胶囊。微胶囊的核心材料含有环境敏感的发光着色剂，其具有发射波长带宽，发光峰值强度和发光衰减时间的特性，能够在暴露于给定环境时改变的特性中的一种或多种，以及具有发射波长带宽特性，发光峰值强度和发光衰减时间的发光标准，一个或多个特性在暴露于所述给定环境时不改变。

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