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1. 发明申请

US20070054002A1 Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents 有权
公开(公告)号：US20070054002A1
公开(公告)日：2007-03-08
申请号：US11221337
申请日：2005-09-07
申请人： Joseph Persyn , Joseph McDonough , Neal Vail , Darren Barlow , Albert Zwiener , Eliot Slovin
发明人： Joseph Persyn , Joseph McDonough , Neal Vail , Darren Barlow , Albert Zwiener , Eliot Slovin
IPC分类号： B29C67/02
CPC分类号： A61K9/5089 , A61K9/0048 , A61K9/1694 , A61K9/5015 , A61K9/5031 , A61K9/5073 , B01J2/10
摘要： This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

2. 发明申请

US20070053990A1 Pharmaceutical formulations exhibiting improved release rates 有权
标题翻译：具有改善释放速率的药物制剂
公开(公告)号：US20070053990A1
公开(公告)日：2007-03-08
申请号：US11220807
申请日：2005-09-07
申请人： Joseph Persyn , Joseph McDonough , Neal Vail , Darren Barlow , Albert Zwiener , Eliot Slovin
发明人： Joseph Persyn , Joseph McDonough , Neal Vail , Darren Barlow , Albert Zwiener , Eliot Slovin
IPC分类号： A61K9/50 , A61K9/16
CPC分类号： A61K9/5089 , A61K9/0048 , A61K9/1694
摘要： This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.
摘要翻译：本发明涉及一种用于生产包含药理活性剂和可生物降解聚合物的微粒的装置和方法。该装置包括在其中心包含储存器的旋转盘和平坦的倾斜表面。该装置可选地包括锯齿和/或平行于盘的旋转轴线的盘周边下方的平坦表面。本发明还涉及使用旋转圆盘装置的含有药理活性剂的微粒的制造方法。提供含有眼科活性剂的制剂。还描述了显示零级释放速率的制剂。

3. 发明申请

US20070053989A1 Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents 有权
标题翻译：制备含有药物活性剂的可生物降解的微粒制剂的方法
公开(公告)号：US20070053989A1
公开(公告)日：2007-03-08
申请号：US11220430
申请日：2005-09-07
申请人： Joseph Persyn , Joseph McDonough , Neal Vail , Darren Barlow , Albert Zwiener , Eliot Slovin
发明人： Joseph Persyn , Joseph McDonough , Neal Vail , Darren Barlow , Albert Zwiener , Eliot Slovin
IPC分类号： A61K9/14 , A61K9/50 , B01J13/04 , B29B9/00
CPC分类号： B01J13/04 , A61K9/1682 , A61K9/5089
摘要： This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.
摘要翻译：本发明涉及一种用于生产包含药理活性剂和可生物降解聚合物的微粒的装置和方法。该装置包括在其中心包含储存器的旋转盘和平坦的倾斜表面。该装置可选地包括锯齿和/或平行于盘的旋转轴线的盘周边下方的平坦表面。本发明还涉及使用旋转圆盘装置的含有药理活性剂的微粒的制造方法。提供含有眼科活性剂的制剂。还描述了显示零级释放速率的制剂。

4. 发明授权

US07428922B2 Valve and position control using magnetorheological fluids 失效
标题翻译：阀门和位置控制使用磁流变流体
公开(公告)号：US07428922B2
公开(公告)日：2008-09-30
申请号：US10090054
申请日：2002-03-01
申请人： Michael Fripp , Darren Barlow , Brandon Soileau
发明人： Michael Fripp , Darren Barlow , Brandon Soileau
IPC分类号： E21B43/1185
CPC分类号： E21B21/10 , E21B34/06 , E21B43/1185 , F15B20/002 , F15B21/065
摘要： Magnetorheological fluids, which solidify in response to a magnetic field, offer the ability to simplify many of the valves and control systems used downhole in the search for and production of oil and gas. They lessen the need for moving parts, provide solid-state valves, and can provide a differential movement of fluid through the valves by varying the strength of the magnetic field. Combinations of permanent and electro-magnets can improve safety by providing valves that fail, when power is lost, in either an open or closed position, depending on design. A number of examples are given.
摘要翻译：响应于磁场而固化的磁流变流体提供了简化在井下使用的许多阀门和控制系统，以寻找和生产油气。它们减少了移动部件的需要，提供固态阀，并且可以通过改变磁场的强度来提供流体通过阀的差动运动。根据设计，永磁和电磁铁的组合可以提供安全性，通过在断电或关闭位置提供失电的阀门。给出了一些例子。

5. 发明申请

US20050249952A1 Microencapsulation of oxygen or water sensitive materials 有权
标题翻译：氧气或水敏感材料的微胶囊化
公开(公告)号：US20050249952A1
公开(公告)日：2005-11-10
申请号：US10654422
申请日：2003-09-04
申请人： Niraj Vasishtha , Herman Schlameus , Darren Barlow
发明人： Niraj Vasishtha , Herman Schlameus , Darren Barlow
IPC分类号： A23L1/00 , B01J13/02 , B01J13/04 , B01J13/08 , B01J13/10 , B32B5/16
CPC分类号： B01J13/08 , A23P10/30 , A23P20/20 , B01J13/02 , B01J13/04 , B01J13/10 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991
摘要： A barrier coating composition includes a polymer material and a structuring agent dispersed in said polymer material, wherein the structuring agent decreases oxygen or water permeability through the polymer material. The barrier coating composition can be used to coat a core component, which can be oxygen or water sensitive, to form a microencapsulated material. The microencapsulated material can be formed by microencapsulation methods, which include atomization or coacervation methods, including forming an oil emulsion of an oil phase and an aqueous phase, the oil phase including the core component and the aqueous phase including the polymer material, adding the structuring agent to one of the oil phase and the aqueous phase, mixing the oil emulsion to form desired particle sizes of the core component, forming the shell component around the core component to form the microencapsulated material, and extracting the formed microencapsulated material from the oil emulsion.
摘要翻译：阻隔涂层组合物包括分散在所述聚合物材料中的聚合物材料和结构化剂，其中所述结构剂通过所述聚合物材料降低氧气或水的渗透性。阻挡涂层组合物可用于涂覆可以是氧或水敏感的核心组分以形成微胶囊化材料。微胶囊化材料可以通过包括雾化或凝聚方法在内的微囊化方法形成，包括形成油相和水相的油乳液，所述油相包括核心组分和包含聚合物材料的水相，添加结构化将其与油相和水相之一混合，将油乳液混合以形成所需粒径的核心组分，在芯组分周围形成壳组分以形成微囊化材料，并从油乳液中提取形成的微胶囊化材料。

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