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1. 发明授权

US07113825B2 Method and apparatus for detecting acoustic oscillations in cardiac rhythm 有权
公开(公告)号：US07113825B2
公开(公告)日：2006-09-26
申请号：US10138046
申请日：2002-05-03
申请人： Joseph M. Pastore , William C. Lincoln , Gerrard M. Carlson , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , William C. Lincoln , Gerrard M. Carlson , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/39 , A61B5/02
CPC分类号： A61N1/3925 , A61N1/3622 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by measuring the amplitudes of heart sounds during successive heart beats. Upon detection of acoustic alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

2. 发明授权

US07930019B2 Method and apparatus for phonocardiographic image acquisition and presentation 有权
标题翻译：用于心律图像获取和呈现的方法和装置
公开(公告)号：US07930019B2
公开(公告)日：2011-04-19
申请号：US11780405
申请日：2007-07-19
申请人： Krzysztof Z. Siejko , Gerrard M. Carlson , William C. Lincoln , Qingsheng Zhu
发明人： Krzysztof Z. Siejko , Gerrard M. Carlson , William C. Lincoln , Qingsheng Zhu
IPC分类号： A61B5/04
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/36514 , A61N1/36542 , A61N1/36578 , A61N1/3682 , A61N1/3702
摘要： A cardiac rhythm management system provides a phonocardiographic image indicative of a heart's mechanical events related to hemodynamic performance. The phonocardiographic image includes a stack of acoustic sensor signal segments representing multiple cardiac cycles. Each acoustic sensor signal segment includes heart sounds indicative of the heart's mechanical events and representations of the heart's electrical events. The stack of acoustic sensor signal segments are aligned by a selected type of the heart's mechanical or electrical events and are grouped by a cardiac timing parameter for presentation.
摘要翻译：心律管理系统提供指示与血液动力学性能相关的心脏的机械事件的心音图像。心音图像包括表示多个心动周期的一组声传感器信号段。每个声学传感器信号段包括指示心脏的机械事件和心脏电气事件的表示的心脏声音。声学传感器信号段的堆叠通过所选择的心脏的机械或电气事件的类型对准，并且通过心脏定时参数分组以进行呈现。

3. 发明授权

US07260429B2 Method and apparatus for phonocardiographic image acquisition and presentation 有权
标题翻译：用于心律图像获取和呈现的方法和装置
公开(公告)号：US07260429B2
公开(公告)日：2007-08-21
申请号：US10307900
申请日：2002-12-02
申请人： Krzysztof Z. Siejko , Gerrard M. Carlson , William C. Lincoln , Qingsheng Zhu
发明人： Krzysztof Z. Siejko , Gerrard M. Carlson , William C. Lincoln , Qingsheng Zhu
IPC分类号： A61B5/04
CPC分类号： A61B7/04 , A61N1/3627 , A61N1/36514 , A61N1/3682 , A61N1/3684
摘要： A cardiac rhythm management system provides a phonocardiographic image indicative of a heart's mechanical events related to hemodynamic performance. The phonocardiographic image includes a stack of acoustic sensor signal segments representing multiple cardiac cycles. Each acoustic sensor signal segment includes heart sounds indicative of the heart's mechanical events and representations of the heart's electrical events. The stack of acoustic sensor signal segments are aligned by a selected type of the heart's mechanical or electrical events and are grouped by a cardiac timing parameter for presentation.
摘要翻译：心律管理系统提供指示与血液动力学性能相关的心脏的机械事件的心音图像。心音图像包括表示多个心动周期的一组声传感器信号段。每个声学传感器信号段包括指示心脏的机械事件的心脏声音和心脏电气事件的表示。声学传感器信号段的堆叠通过所选择的心脏的机械或电气事件的类型对准，并且通过心脏定时参数分组以进行呈现。

4. 发明授权

US07257443B2 Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals 失效
标题翻译：用电针信号检测心律的振荡的方法和装置
公开(公告)号：US07257443B2
公开(公告)日：2007-08-14
申请号：US11184325
申请日：2005-07-19
申请人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.
摘要翻译：心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

5. 发明授权

US07881789B2 Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals 失效
标题翻译：用电针信号检测心律的振荡的方法和装置
公开(公告)号：US07881789B2
公开(公告)日：2011-02-01
申请号：US11832552
申请日：2007-08-01
申请人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.
摘要翻译：心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

6. 发明授权

US06957105B2 Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals 失效
公开(公告)号：US06957105B2
公开(公告)日：2005-10-18
申请号：US10106836
申请日：2002-03-26
申请人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

7. 发明授权

US07039462B2 Method and apparatus for detecting oscillations in cardiac rhythm 有权
公开(公告)号：US07039462B2
公开(公告)日：2006-05-02
申请号：US10172825
申请日：2002-06-14
申请人： Joseph M. Pastore , Rodney W. Salo , Quan Ni , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Rodney W. Salo , Quan Ni , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/39 , A61B5/05
CPC分类号： A61N1/3925 , A61N1/3627 , A61N1/365 , A61N1/36514 , A61N1/36521 , A61N1/36542
摘要： A cardiac rhythm management device is configured to detect mechanical oscillations in cardiac rhythm. Upon detection of such oscillations, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

8. 发明授权

US08636669B2 Method and apparatus for monitoring of diastolic hemodynamics 有权
标题翻译：用于监测舒张血流动力学的方法和装置
公开(公告)号：US08636669B2
公开(公告)日：2014-01-28
申请号：US12985055
申请日：2011-01-05
申请人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
发明人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译：心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应心脏恶化

9. 发明授权

US07972275B2 Method and apparatus for monitoring of diastolic hemodynamics 有权
标题翻译：用于监测舒张血流动力学的方法和装置
公开(公告)号：US07972275B2
公开(公告)日：2011-07-05
申请号：US10334694
申请日：2002-12-30
申请人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
发明人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译：心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应心脏恶化

10. 发明授权

US07953486B2 Maximum pacing rate limiter implemented using the evoked response—T-wave interval 失效
标题翻译：使用诱发响应T波间隔实现最大起搏速率限制器
公开(公告)号：US07953486B2
公开(公告)日：2011-05-31
申请号：US11225712
申请日：2005-09-13
申请人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio Spinelli
发明人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

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