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1. 发明授权

US4916711A Lasing compositions and methods for using the same 失效
标题翻译：激光组合物及其使用方法
公开(公告)号：US4916711A
公开(公告)日：1990-04-10
申请号：US251188
申请日：1988-09-29
申请人： Joseph H. Boyer , Lee R. Morgan
发明人： Joseph H. Boyer , Lee R. Morgan
IPC分类号： A61K31/00 , A61K31/13 , A61K31/33 , A61K31/35 , A61K31/40 , A61K31/415 , A61K31/495 , A61K31/505 , A61K31/555 , A61K31/69 , A61K33/06 , A61K33/22 , A61P35/00 , C07D241/38 , C07D311/82 , C07D487/04 , C07D487/14 , C07F1/08 , C07F3/02 , C07F3/06 , C07F5/02 , C09B11/28 , C09B57/00 , C09K11/06 , H01S3/213
CPC分类号： C07D241/38 , C07D311/82 , C07D487/04 , C07D487/14 , C07F1/08 , C07F3/02 , C07F3/06 , C07F5/022 , C09B57/00 , C09K11/06 , H01S3/213
摘要： A new group of fluorescent organic materials having a variety of uses are described. They are especially useful as dye compounds in dye laser systems, and as photochemical agents in the treatment of diseased tissues using photodynamic therapy techniques. The materials involve a tri-cyclic compound having the following structure: ##STR1## In this structure, R.sub.1 -R.sub.21 represent a variety of organic and inorganic groups.

2. 发明授权

US5446157A Boron difluoride compounds useful in photodynamic therapy and production of laser light 失效
标题翻译：可用于光动力疗法和激光生产的二氟化硼化合物
公开(公告)号：US5446157A
公开(公告)日：1995-08-29
申请号：US20293
申请日：1993-02-19
申请人： Lee R. Morgan , Joseph H. Boyer
发明人： Lee R. Morgan , Joseph H. Boyer
IPC分类号： A61K31/69 , A61K41/00 , C07F5/02 , C09B57/00 , C09K11/06
CPC分类号： C09B57/00 , A61K31/69 , A61K41/0057 , C07F5/022 , C09K11/06
摘要： A new group of fluorescent organic compounds having a variety of uses are described. They are especially useful as dye compounds in dye laser systems, and as photochemical agents in the treatment of diseased tissues using photodynamic therapy techniques. The compounds include a tri-cyclic compound having the following structure: ##STR1## Preferably R.sub.1 -R.sub.5 .dbd.R.sub.9 -R.sub.12 .dbd.C; R.sub.7 .dbd.B; R.sub.6 and R.sub.8 .dbd.N; R.sub.14 .dbd.lower n-alkyl or an electron withdrawing group such as CN.sup.- ; R.sub.16 and R.sub.19 are independently selected from the group consisting of lower n-alkyl, a sulfate or an acid or salt thereof, or hydrogen; and R.sub.20 .dbd.R.sub.21 .dbd.F. Other compounds include compounds of the formula ##STR2##
摘要翻译：描述了一组具有多种用途的荧光有机化合物。它们在染料激光系统中作为染料化合物特别有用，并且作为使用光动力学治疗技术治疗患病组织的光化学试剂。化合物包括具有以下结构的三环化合物：优选地，R1-R5 = R9-R12 = C; R7 = B; R6和R8 = N; R14 =低级正烷基或吸电子基团，例如CN-; R 16和R 19独立地选自低级正烷基，硫酸根或其酸或其盐或氢; R20 = R21 = F。（a）其中的化合物包括下式的化合物：（a）（b）（c）（d）（e）

3. 发明授权

US5189029A Indacene compounds and methods for using the same 失效
标题翻译：新泽西化合物及其使用方法
公开(公告)号：US5189029A
公开(公告)日：1993-02-23
申请号：US513059
申请日：1990-04-23
申请人： Joseph H. Boyer , Lee R. Morgan
发明人： Joseph H. Boyer , Lee R. Morgan
IPC分类号： A61K31/69 , A61K41/00 , C07F5/02 , C09B57/00 , C09K11/06
CPC分类号： C09K11/06 , A61K31/69 , A61K41/0057 , C07F5/022 , C09B57/00
摘要： A new group of fluorescent organic materials having a variety of uses are described. They are especially useful as dye compounds in dye laser systems, and as photochemical agents in the treatment of sensitive diseased tissues using photodynamic therapy techniques. The materials involve a tri-cyclic compound such as 4,4'-difluoro-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene, the disodium salt of 4,4- difluoro-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene-2,6-disulfonic acid monohydrate, and 4,4-difluoro-1,3,5,7-tetramethyl-8-ethyl-4-bora-3a,4a-diaza-s-indacene, having the following structures: ##STR1##
摘要翻译：描述了一组具有多种用途的荧光有机材料。它们特别用作染料激光系统中的染料化合物，并且作为使用光动力学治疗技术治疗敏感性病变组织的光化学试剂。这些材料涉及三环化合物，例如4,4'-二氟-1,3,5,7,8-五甲基-4-硼酸-3a，4a-二氮杂-s-引达省，4,4'-二 - 二氟-1,3,5,7,8-五甲基-4-硼酸-3aa，4a-二氮杂 - 引嗪并-2,6-二磺酸一水合物和4,4-二氟-1,3,5 ，7-四甲基-8-乙基-4-硼烷-3a，4a-diaza-s-indacene，具有以下结构：

4. 发明授权

US5183455A Apparatus for in situ radiotherapy 失效
标题翻译：器械用于原位放射治疗
公开(公告)号：US5183455A
公开(公告)日：1993-02-02
申请号：US609437
申请日：1990-11-05
申请人： Michael H. Hayman , Lee R. Morgan , Samuel F. Liprie
发明人： Michael H. Hayman , Lee R. Morgan , Samuel F. Liprie
IPC分类号： A61M36/04 , A61N5/10
CPC分类号： A61N5/1027 , A61N2005/1012
摘要： Apparatus for in situ radiotherapy has a flexible catheter having a proximal end for receiving a radioisotope and a distal end for positioning the flexible catheter within a patient to be treated. An anchor, which is permanently connectable to tissues deep inside the patient, has a sealing collar connected to it which seals the distal end of the catheter. The catheter also includes a plug near the distal end which seals the distal end in addititon to the seal provided by the sealing collar. The anchor has a penetration point connected to it to assist a surgeon in implanting the catheter within a tumor. A threaded fastener on the anchor is screwed into the catheter. The flexible catheter can be released remotely from the anchor by unscrewing it. A suture eye is connected to the anchor. The suture eye may be sutured to healthy tissue within the patient when the apparatus is implanted to secure the anchor to the patient. When the radioisotope is not being received, the proximal end of the catheter is sealed by a cylindrical plug connected to a manipulation handle.
摘要翻译：用于原位放射治疗的装置具有柔性导管，其具有用于接收放射性同位素的近端和用于将柔性导管定位在待治疗患者内的远端。永久连接到患者深处的组织的锚固件具有连接到其上的密封套，其密封导管的远端。导管还包括靠近远端的塞子，该密封件除了由密封套环提供的密封件之外密封远端。锚固件具有连接到其的穿透点，以帮助外科医生将导管植入肿瘤内。锚固件上的螺纹紧固件被拧入导管中。柔性导管可以通过旋转将其远离锚点释放。缝线眼连接到锚。当植入装置以将锚固定到病人身上时，缝线眼可被缝合到患者体内的健康组织。当放射性同位素未被接收时，导管的近端通过连接到操纵手柄的圆柱塞密封。

5. 发明授权

US4724239A Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine 失效
标题翻译：用N，N'-二乙酰胱氨酸，N-乙酰基高半胱氨酸和N-乙酰半胱氨酸处理化学溃疡的方法
公开(公告)号：US4724239A
公开(公告)日：1988-02-09
申请号：US776579
申请日：1985-09-16
申请人： Lee R. Morgan
发明人： Lee R. Morgan
IPC分类号： A61K31/195
CPC分类号： A61K31/195
摘要： A method of treating chemical ulcers caused by leukotriene production, the method comprising the step of applying to the ulcer a compound that interferes with leukotriene production, the compound being selected from the group consisting of N,N'-diacetylcystine, N-acetylhomocysteine and N-acetylcysteine.
摘要翻译：一种治疗由白细胞三烯生成引起的化学溃疡的方法，所述方法包括向所述溃疡施用干扰白细胞三烯生成的化合物的步骤，所述化合物选自N，N'-二乙酰胱氨酸，N-乙酰高半胱氨酸和N 乙酰半胱氨酸。

6. 发明授权

US08795659B2 Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents 有权
标题翻译：异磷酰胺芥酸盐及其类似物作为抗肿瘤剂
公开(公告)号：US08795659B2
公开(公告)日：2014-08-05
申请号：US13541522
申请日：2012-07-03
申请人： Lee R. Morgan
发明人： Lee R. Morgan
IPC分类号： A61K39/395 , A61K38/43 , A61K38/46 , A61K38/14 , A61K31/70 , A61K31/685 , C07F9/22
CPC分类号： C07F9/222 , A61K31/664 , A61K45/06 , C07C229/26
摘要： The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula I: (I) wherein A+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.
摘要翻译：本公开涉及异磷酰胺芥酸和异磷酰胺芥菜类似物的盐和组合物。在一个实施方案中，盐可以由式I表示：（I）其中A +表示选自质子化（共轭酸）或季形式的脂族胺和芳族胺的铵类，包括碱性氨基酸，杂环胺，取代和未取代的吡啶，胍和脒; X和Y独立地表示离去基团。本文还公开了制备这些化合物和配制其药物组合物的方法。公开了给予受试者，特别是治疗过度增殖性疾病的方法。

7. 发明授权

US4976680A Apparatus for in situ radiotherapy 失效
标题翻译：器械用于原位放射治疗
公开(公告)号：US4976680A
公开(公告)日：1990-12-11
申请号：US255045
申请日：1988-10-07
申请人： Michael H. Hayman , Lee R. Morgan , Samuel F. Liprie
发明人： Michael H. Hayman , Lee R. Morgan , Samuel F. Liprie
IPC分类号： A61M36/04 , A61N5/10
CPC分类号： A61N5/1027 , A61N2005/1012
摘要： Apparatus for in situ radiotherapy has a flexible catheter having a proximal end for receiving a radiosotope and a distal end for positioning the flexible catheter within a patient to be treated. An anchor, which is permanently connectable to tissues deep inside the patient, has a sealing collar connected to it which seals the distal end of the catheter. The anchor has a penetration point connected to it to assist a surgeon in implanting the catheter within a tumor. A threaded fastener is connected to the anchor and screwed into the catheter. The flexible catheter can be released remotely from the anchor by unscrewing it. A suture eye is connected to the anchor. The suture eye may be sutured to healthy tissue within the patient when the apparatus is implanted to secure the anchor to the patient.
摘要翻译：用于原位放射治疗的装置具有柔性导管，其具有用于接收放射性物质的近端和用于将柔性导管定位在待治疗患者内的远端。永久连接到患者深处的组织的锚固件具有连接到其上的密封套，其密封导管的远端。锚固件具有连接到其的穿透点，以帮助外科医生将导管植入肿瘤内。螺纹紧固件连接到锚固件并拧入导管中。柔性导管可以通过旋转将其远离锚点释放。缝线眼连接到锚。当植入装置以将锚固定到病人身上时，缝线眼可被缝合到患者体内的健康组织。

8. 发明授权

US4732904A Antiestrogenic hydrazones 失效
标题翻译：抗雌激素腙
公开(公告)号：US4732904A
公开(公告)日：1988-03-22
申请号：US776424
申请日：1985-09-16
申请人： Lee R. Morgan
发明人： Lee R. Morgan
IPC分类号： A61K31/15 , C07D213/53 , A61K31/44 , C07C109/14 , C07D213/65
CPC分类号： C07D213/53 , C07C247/00 , C07C251/72 , Y10S514/874
摘要： Azido-, 4-nitro and 2,4-dinitrophenylhydrazones as well as 4,4'-dihydroxybenzophenone-hydrazone and other hydrazones are disclosed which have antiestrogenic activity useful in treating estrogen-requiring tumor cells. The described hydrazones bind to estrogen receptors in the cytoplasm of tumor cells. The azido-, 4-nitro- and 2,4-dinitro-phenyl branches of the molecules appear to bind to the receptors and prevent translocation of estrogenic information into the nucleus, thereby blocking the synthesis of necessary macromolecules such as proteins. Absence of geometric isomerization from antiestrogenic to estrogenic forms of the drug minimizes estrogenic side-effects.
摘要翻译：公开了叠氮基 - ，4-硝基和2,4-二硝基苯腙以及4,4'-二羟基二苯甲酮 - 腙等腙，其具有抗雌激素活性，可用于治疗需要雌激素的肿瘤细胞。描述的腙与肿瘤细胞的细胞质中的雌激素受体结合。分子的叠氮基，4-硝基 - 和2,4-二硝基 - 苯基分支似乎与受体结合，并防止雌激素信息转运到细胞核中，从而阻断合成必需的大分子如蛋白质。没有几何异构化从抗雌激素药物到雌激素形式的药物使雌激素副作用最小化。

9. 发明授权

US4708965A Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives 失效
标题翻译：用N，N'-二乙酰胱氨酸及其衍生物治疗疱疹病毒感染的方法
公开(公告)号：US4708965A
公开(公告)日：1987-11-24
申请号：US776580
申请日：1985-09-16
申请人： Lee R. Morgan
发明人： Lee R. Morgan
IPC分类号： A61K31/195
CPC分类号： A61K31/195
摘要： A method of treating herpes, comprising the step of applying to the herpes lesions a compound that interferes with leukotriene production, the compound being selected from the group consisting of N,N'-diacetylcystine, N-acetylhomocysteine and N-acetylcysteine.

10. 发明授权

US5270172A Method to predict tumor response to therapy 失效
标题翻译：预测肿瘤对治疗反应的方法
公开(公告)号：US5270172A
公开(公告)日：1993-12-14
申请号：US692240
申请日：1991-04-26
申请人： Lee R. Morgan
发明人： Lee R. Morgan
IPC分类号： C12Q1/02 , C07C251/86 , C12Q1/18 , G01N33/50 , A01N1/02 , C12N5/00
CPC分类号： G01N33/5011 , C07C251/86 , G01N2800/52
摘要： A method is disclosed for predicting response of a tumor patient to therapy, and selecting appropriate therapy for malignant neoplasms such as breast, ovarian and gastrointestinal cancer. A sample of tumor cells is cultured in the presence of 10 .mu.g/ml estradiol, and inhibition of cell growth in the culture paradoxically indicates an estrogen dependent tumor that will respond to antiestrogenic therapy. Another sample of tumor cells is cultured in the presence of a chemotherapeutic agent which predicts response of the tumor to in vivo administration of a cytotoxic agent. The chemotherapeutic agent is preferably a cytotoxic drug, or a drug having both cytotoxic and antiestrogenic mechanisms of action. A particularly suitable substance having both mechanisms of action is: ##STR1## wherein R.sup.1 H, OH, OOC(CH.sub.2).sub.2 CO.sub.2 H or CH.sub.3 COO; R.sup.2 is C.sub.6 H.sub.4 OH, C.sub.6 H.sub.4 OCOCH.sub.3, C.sub.6 H.sub.4 OOC(CH.sub.2)CO.sub.2 H, or C.sub.6 H.sub.5 ; and X is C.sub.6 H.sub.3 -2,4(NO.sub.2).sub.2, C.sub.6 H.sub.5, C.sub.6 H.sub.4 -4(NO.sub.2), C.sub.6 H.sub.4 -3(NO.sub.2), or C.sub.6 H.sub.3 -2,4(NO.sub.2).sub.2 ;Predictive power of the assay is increased by combining information from the estradiol and chemotherapeutic assays. These assays are preferably performed in culture flasks having removable bases that function as conventional microscope slides.
摘要翻译：公开了一种用于预测肿瘤患者对治疗的反应并选择适合于恶性肿瘤如乳腺癌，卵巢癌和胃肠癌的治疗的方法。肿瘤细胞样本在10μg/ ml雌二醇的存在下培养，并且培养物中细胞生长的抑制反而表示雌激素依赖性肿瘤，其将对抗雌激素疗法作出反应。在化学治疗剂存在下培养另一个肿瘤细胞样品，该化学治疗剂预测肿瘤对体内施用细胞毒性剂的反应。化学治疗剂优选是细胞毒性药物，或具有细胞毒性和抗雌激素作用机制的药物。具有两种作用机理的特别合适的物质是：其中R 1 H，OH，OOC（CH 2）2 CO 2 H或CH 3 COO; R2是C6H4OH，C6H4OCOCH3，C6H4OOC（CH2）CO2H或C6H5; X为C6H3-2.4（NO2）2，C6H5，C6H4-4（NO2），C6H4-3（NO2）或C6H3-2.4（NO2）2; 通过组合来自雌二醇和化学治疗测定的信息来增加测定的预测能力。这些测定优选在具有作为常规显微镜幻灯片起作用的可移除碱基的培养瓶中进行。

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