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1. 发明授权

US08569367B2 Ophthalmic compositions and methods for treating eyes 有权
标题翻译：眼用组合物和治疗眼睛的方法
公开(公告)号：US08569367B2
公开(公告)日：2013-10-29
申请号：US10990811
申请日：2004-11-16
申请人： Joseph G. Vehige , Peter A. Simmons , Joan-En Chang-Lin
发明人： Joseph G. Vehige , Peter A. Simmons , Joan-En Chang-Lin
IPC分类号： A01N37/30 , A61K31/205
CPC分类号： A61K31/205 , A61K9/0048 , A61K9/08 , A61K31/047 , A61K31/14 , A61K31/70 , A61K31/717 , A61K31/728 , A61K38/1732 , A61K47/02 , A61K47/26 , A61K47/38
摘要： Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.
摘要翻译：包括相容的溶质组分和/或聚阴离子组分的眼科组合物可用于治疗眼睛，例如缓解干眼综合征，保护眼睛免受高渗侮辱和/或阳离子物质对眼睛表面的不良影响和/ 或为了便于眼科手术恢复。

2. 发明授权

US6063745A Mutli-purpose contact lens care compositions 失效
标题翻译：多用途隐形眼镜护理组合物
公开(公告)号：US6063745A
公开(公告)日：2000-05-16
申请号：US980033
申请日：1997-11-26
申请人： Richard Graham , Joseph G. Vehige
发明人： Richard Graham , Joseph G. Vehige
IPC分类号： G02C13/00 , A61L2/18 , A61L12/14 , A61K31/155 , A01N55/00 , C11D3/06
CPC分类号： A61L12/141 , A61L12/142
摘要： Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.
摘要翻译：用于隐形眼镜护理的多功能解决方案提供了大量的镜片佩戴者/使用者的舒适性和/或可接受性。这种溶液包括水性液体介质; 抗微生物组分，优选以小于约5ppm的量存在的双胍聚合物; 表面活性剂组分，优选聚（氧乙烯） - 聚（氧丙烯）嵌段共聚物表面活性剂; 有效量的磷酸盐缓冲剂组分; 粘度诱导组分，优选选自纤维素衍生物;有效量; 和有效量的张力成分。这样的解决方案具有显着的性能，舒适性和可接受性的优点，这最终导致眼睛健康的优点和避免由隐形眼镜磨损引起的问题。

3. 发明授权

US08512717B2 Compositions for delivery of therapeutics into the eyes and methods for making and using same 有权
公开(公告)号：US08512717B2
公开(公告)日：2013-08-20
申请号：US10911966
申请日：2004-08-05
申请人： Joseph G. Vehige , James N. Chang , Richard Graham , Robert T. Lyons , Teresa H. Kuan , Chin-Ming Chang
发明人： Joseph G. Vehige , James N. Chang , Richard Graham , Robert T. Lyons , Teresa H. Kuan , Chin-Ming Chang
IPC分类号： A61K9/00 , A61K31/40
CPC分类号： A61K31/407 , A61K9/0048 , A61K31/00 , A61K47/38
摘要： The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.

4. 发明授权

US5858346A Compositions and methods for enhancing contact lens wearability 失效
标题翻译：增强隐形眼镜耐磨性的组合物和方法
公开(公告)号：US5858346A
公开(公告)日：1999-01-12
申请号：US854221
申请日：1997-05-09
申请人： Joseph G. Vehige , James P. Currie
发明人： Joseph G. Vehige , James P. Currie
IPC分类号： G02C13/00 , A01N25/34 , A61L2/18 , A61L12/08 , A61K31/74
CPC分类号： A61L12/08 , Y10S514/84
摘要： Compositions and methods for treating a contact lens very effectively and conveniently provide enhanced contact lens wearability by reducing the actual or perceived ocular sensitivity which results from exposing a contact lens to non-oxidative antimicrobial components. The present system takes advantage of inactivating or deactivating a non-oxidative antimicrobial component located on or in a contact lens to reduce the ocular sensitivity caused by placing the lens in the eye.
摘要翻译：通过减少由将隐形眼镜暴露于非氧化性抗微生物组分而导致的实际或感觉到的眼睛敏感性，非常有效地和方便地提供增强的隐形眼镜佩戴性的组合物和方法。本系统利用使位于隐形眼镜上或隐形眼镜中的非氧化性抗微生物成分失活或去活化，以减少将眼镜放置在眼睛中引起的眼睛敏感度。

5. 发明授权

US06482781B2 Multi-purpose contact lens care compositions 有权
标题翻译：多用途隐形眼镜护理组合物
公开(公告)号：US06482781B2
公开(公告)日：2002-11-19
申请号：US09968253
申请日：2001-10-01
申请人： Richard Graham , Joseph G. Vehige
发明人： Richard Graham , Joseph G. Vehige
IPC分类号： C11D1722
CPC分类号： A61L12/141 , A61L12/142
摘要： Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and-acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.
摘要翻译：用于隐形眼镜护理的多功能解决方案提供了大量的镜片佩戴者/使用者的舒适性和/或可接受性这种溶液包括水性液体介质; 抗微生物组分，优选以小于约5ppm的量存在的双胍聚合物; 表面活性剂组分，优选聚（氧乙烯） - 聚（氧丙烯）嵌段共聚物表面活性剂; 有效量的磷酸盐缓冲剂组分; 粘度诱导组分，优选选自纤维素衍生物;有效量; 和有效量的张力成分。这样的解决方案具有显着的性能，舒适性和可接受性的优点，其最终导致眼睛健康优点并避免由隐形眼镜磨损引起的问题。

6. 发明授权

US06586377B2 Contact lens cleaning compositions 有权
标题翻译：隐形眼镜清洁剂
公开(公告)号：US06586377B2
公开(公告)日：2003-07-01
申请号：US10005638
申请日：2001-12-03
申请人： Richard Graham , Joseph G. Vehige
发明人： Richard Graham , Joseph G. Vehige
IPC分类号： C11D1722
CPC分类号： C11D3/0078 , C11D1/008 , C11D1/29 , C11D1/667 , C11D1/72 , C11D1/722 , C11D3/225
摘要： Solutions useful to clean contact lenses include a surfactant component in an effective amount; and a viscosity inducing component, preferably selected from cellulosic derivatives and more preferably hydroxypropylmethyl cellulose, in an effective amount. Such solutions, which may include one or more additional components, have substantial contact lens cleaning benefits which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.
摘要翻译：用于清洁隐形眼镜的溶液包括有效量的表面活性剂组分; 和优选选自纤维素衍生物，更优选羟丙基甲基纤维素的粘度诱导组分。可以包括一个或多个另外的组件的这种解决方案具有显着的隐形眼镜清洁益处，其最终导致眼睛健康优点和避免由隐形眼镜磨损引起的问题。

7. 发明授权

US5451237A Compositions and methods for inhibiting and reducing lysozyme deposition on hydrophilic contact lenses using biocompatible colored compounds 失效
标题翻译：使用生物相容性有色化合物抑制和减少亲水隐形眼镜上溶菌酶沉积的组合物和方法
公开(公告)号：US5451237A
公开(公告)日：1995-09-19
申请号：US149860
申请日：1993-11-10
申请人： Joseph G. Vehige
发明人： Joseph G. Vehige
IPC分类号： G02B1/04 , D06P3/00
CPC分类号： G02B1/043 , Y10S134/901
摘要： Disclosed are compositions and methods for inhibiting the uptake of proteins and reducing the formation of lysozyme deposits on the outer surface and inner bulk matrix of hydrophilic contact lenses. The method comprises contacting a contact lens with a positively charged chemical which imparts a tint to the lens.
摘要翻译：公开了抑制蛋白质摄取并减少亲水性隐形眼镜的外表面和内体积基质上溶菌酶沉积物形成的组合物和方法。该方法包括使隐形眼镜与赋予透镜色调的带正电的化学品接触。

8. 发明授权

US06319883B1 Multi-purpose contact lens care compositions 有权
标题翻译：多用途隐形眼镜护理组合物
公开(公告)号：US06319883B1
公开(公告)日：2001-11-20
申请号：US09417526
申请日：1999-10-13
申请人： Richard Graham , Joseph G. Vehige
发明人： Richard Graham , Joseph G. Vehige
IPC分类号： C11D1722
CPC分类号： A61L12/141 , A61L12/142
摘要： Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.
摘要翻译：用于隐形眼镜护理的多功能解决方案提供了大量的镜片佩戴者/使用者的舒适性和/或可接受性。这种溶液包括水性液体介质; 抗微生物组分，优选以小于约5ppm的量存在的双胍聚合物; 表面活性剂组分，优选聚（氧乙烯） - 聚（氧丙烯）嵌段共聚物表面活性剂; 有效量的磷酸盐缓冲剂组分; 粘度诱导组分，优选选自纤维素衍生物;有效量; 和有效量的张力成分。这样的解决方案具有显着的性能，舒适性和可接受性的优点，这最终导致眼睛健康的优点和避免由隐形眼镜磨损引起的问题。

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