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1. 发明授权

US08512717B2 Compositions for delivery of therapeutics into the eyes and methods for making and using same 有权
公开(公告)号：US08512717B2
公开(公告)日：2013-08-20
申请号：US10911966
申请日：2004-08-05
申请人： Joseph G. Vehige , James N. Chang , Richard Graham , Robert T. Lyons , Teresa H. Kuan , Chin-Ming Chang
发明人： Joseph G. Vehige , James N. Chang , Richard Graham , Robert T. Lyons , Teresa H. Kuan , Chin-Ming Chang
IPC分类号： A61K9/00 , A61K31/40
CPC分类号： A61K31/407 , A61K9/0048 , A61K31/00 , A61K47/38
摘要： The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.

2. 发明授权

US06969706B1 Preserved pharmaceutical compositions comprising cyclodextrins 有权
标题翻译：包含环糊精的保存的药物组合物
公开(公告)号：US06969706B1
公开(公告)日：2005-11-29
申请号：US10844647
申请日：2004-05-12
申请人： Chin-Ming Chang , James Chang , Robert T. Lyons
发明人： Chin-Ming Chang , James Chang , Robert T. Lyons
IPC分类号： A61K31/573 , A61K31/724
CPC分类号： A61K31/573 , A61K9/0048 , A61K9/08 , A61K31/19 , A61K31/724 , A61K47/12 , A61K47/18 , A61K47/6951 , B82Y5/00 , Y02A50/473 , Y10S514/912 , Y10S514/914 , Y10S514/97 , A61K2300/00
摘要： A composition comprising a cyclodextrin, a guanidine-based cationic compound, and sorbic acid is disclosed herein. Preservatives and methods related thereto, and experimental results suggesting certain advantages related to these compositions, preservatives, and methods are also presented herein.
摘要翻译：本文公开了包含环糊精，基于胍的阳离子化合物和山梨酸的组合物。与此相关的防腐剂和方法以及提示与这些组合物，防腐剂和方法相关的某些优点的实验结果也在本文中给出。

3. 发明申请

US20090149435A1 PROCESS FOR MAKING A PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：制备药物组合物的方法
公开(公告)号：US20090149435A1
公开(公告)日：2009-06-11
申请号：US11952927
申请日：2007-12-07
申请人： Zhengjun Wang , Thomas M. McGrath , Toan N. Ha , Sam W. Lam , Bruce A. Firestone , Robert T. Lyons , James N. Chang , John T. Trogden
发明人： Zhengjun Wang , Thomas M. McGrath , Toan N. Ha , Sam W. Lam , Bruce A. Firestone , Robert T. Lyons , James N. Chang , John T. Trogden
IPC分类号： A61K31/573
CPC分类号： A61K9/0019
摘要： Process for making a sterile, injectable pharmaceutical composition by combining triamcinolone, a buffer and a high viscosity hyaluronate.
摘要翻译：通过组合曲安奈德，缓冲液和高粘度透明质酸来制备无菌注射药物组合物的方法。

4. 发明申请

US20090118247A1 Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods 审中-公开
公开(公告)号：US20090118247A1
公开(公告)日：2009-05-07
申请号：US12288902
申请日：2008-10-24
申请人： Patrick M. Hughes , Laurent Delahaye , Michele Boix , James N. Chang , Robert T. Lyons
发明人： Patrick M. Hughes , Laurent Delahaye , Michele Boix , James N. Chang , Robert T. Lyons
IPC分类号： A61K31/573 , A61P27/02
CPC分类号： A61K9/0048 , A61K31/573 , A61K47/36 , A61K47/40
摘要： Pharmaceutical compositions suitable for administration into the interior of an eye of a person or animal are described. The present compositions include one or more components which are effective in providing a reduced toxicity relative to existing intraocular ophthalmic compositions. The present compositions include one or more therapeutic agents in amounts effective in providing a desired therapeutic effect when placed in an eye, and one or more retinal friendly excipients that have a reduced toxicity relative to benzyl alcohol or polysorbate 80. In certain compositions, the excipient component of the compositions comprises one or more cyclodextrins or cyclodextrin derivatives. Methods of using the compositions to treat ocular conditions are also described.

5. 发明授权

US09039761B2 Ocular implant delivery assemblies with distal caps 有权
标题翻译：具有远端帽的眼部植入物输送组件
公开(公告)号：US09039761B2
公开(公告)日：2015-05-26
申请号：US11552630
申请日：2006-10-25
申请人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson , Werhner C. Orilla
发明人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson , Werhner C. Orilla
IPC分类号： A61F2/16 , A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Ocular implant delivery assemblies are provided which include a cannula having a lumen extending therethrough, a proximal end, a proximal end opening, a distal end, a distal end opening, and a lumen extending through the cannula. A cap is provided having a closed distal end, being in contact with the outer wall of the cannula, and covering the distal end and the distal end opening of the cannula, the cap being structured to allow the distal end and the distal end opening of the cannula to pass through the cap as the cannula is passed into an eye. An ocular implant is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.
摘要翻译：提供了眼部植入物递送组件，其包括具有延伸穿过其中的内腔的套管，近端，近端开口，远端，远端开口和延伸穿过套管的内腔。提供具有封闭的远端的盖，其与套管的外壁接触并且覆盖套管的远端和远端开口，帽被构造成允许远端和远端开口当套管穿过眼睛时，套管穿过帽子。眼内植入物位于内腔中。植入物可以密封在套管中而不加入液体载体，或者其可以包含在插管中的液体载体介质中。植入物可以由具有不同组成或不同形式的许多微粒组成。组件还包括位于套管的近端上的套筒，并且适于将组件耦合到包含推动凝胶的注射器。

6. 发明授权

US08569272B2 Methods for treating a posterior segment of an eye 有权
标题翻译：治疗眼后段的方法
公开(公告)号：US08569272B2
公开(公告)日：2013-10-29
申请号：US12172194
申请日：2008-07-11
申请人： Robert T. Lyons , James N. Chang , John T. Trogden , Scott M. Whitcup
发明人： Robert T. Lyons , James N. Chang , John T. Trogden , Scott M. Whitcup
IPC分类号： A01N45/00 , A61F2/00 , A61K9/14 , A61K33/32
CPC分类号： A61K31/58 , A61K9/0048 , A61K31/573 , A61K47/36
摘要： Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include corticosteroid component-containing particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 300,000 cps. The compositions advantageously suspend the particles for prolonged periods of time.
摘要翻译：提供了组合物和使用这种组合物的方法，其可用于注射到人或动物眼睛的后段中。这样的组合物包括以治疗有效量存在的含皮质类固醇成分的颗粒，粘度诱导组分和水性载体组分。组合物在0.1 /秒的剪切速率下具有至少约10cps或约100cps的粘度。在优选的实施方案中，粘度在约140,000cps至约300,000cps的范围内。组合物有利地将颗粒悬浮长时间。

7. 发明申请

US20090197847A1 Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods 审中-公开
公开(公告)号：US20090197847A1
公开(公告)日：2009-08-06
申请号：US12288886
申请日：2008-10-24
申请人： Patrick M. Hughes , Laurent Delahaye , Michele Boix , James N. Chang , Robert T. Lyons
发明人： Patrick M. Hughes , Laurent Delahaye , Michele Boix , James N. Chang , Robert T. Lyons
IPC分类号： A61K31/58
CPC分类号： A61K9/0048 , A61K31/573 , A61K47/36 , A61K47/40
摘要： Pharmaceutical compositions suitable for administration into the interior of an eye of a person or animal are described. The present compositions include one or more components which are effective in providing a reduced toxicity relative to existing intraocular ophthalmic compositions. The present compositions include one or more therapeutic agents in amounts effective in providing a desired therapeutic effect when placed in an eye, and one or more retinal friendly excipients that have a reduced toxicity relative to benzyl alcohol or polysorbate 80. In certain compositions, the excipient component of the compositions comprises one or more cyclodextrins or cyclodextrin derivatives. Methods of using the compositions to treat ocular conditions are also described.

8. 发明申请

US20080241252A1 METHODS AND COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION TO TREAT OCULAR CONDITIONS 有权
标题翻译：用于治疗眼睛条件的室间管理的方法和组合
公开(公告)号：US20080241252A1
公开(公告)日：2008-10-02
申请号：US11695527
申请日：2007-04-02
申请人： Robert T. Lyons , James N. Chang , John T. Trogden , Scott M. Whitcup
发明人： Robert T. Lyons , James N. Chang , John T. Trogden , Scott M. Whitcup
IPC分类号： A61K9/14 , A61K31/33
CPC分类号： A61K31/404 , A61K9/0048 , A61K31/33 , A61K31/728 , A61K47/14 , A61K47/36 , A61K2300/00
摘要： Anti-angiogenesis compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes are provided. Such compositions can include TKI component solutions or particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities at about 25° C. of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity at 25° C. is in the range of from about 80,000 cps to about 300,000 cps.
摘要翻译：提供了抗血管生成组合物，以及使用这些组合物的方法，其可用于注射到人眼玻璃体中。这样的组合物可以包括TKI组分溶液或以治疗有效量存在的颗粒，粘度诱导组分和水性载体组分。组合物在约25℃下的粘度为0.1 /秒的剪切速率为至少约10cps或约100cps。在优选的实施方案中，25℃下的粘度在约80,000cps至约300,000cps的范围内。

9. 发明申请

US20080033351A1 OCULAR IMPLANT DELIVERY ASSEMBLIES WITH DISTAL CAPS 有权
标题翻译： OCULAR IMPLANT交付组件与远端CAPS
公开(公告)号：US20080033351A1
公开(公告)日：2008-02-07
申请号：US11552630
申请日：2006-10-25
申请人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson , Werhner C. Orilla
发明人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson , Werhner C. Orilla
IPC分类号： A61M31/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Ocular implant delivery assemblies are provided which include a cannula having a lumen extending therethrough, a proximal end, a proximal end opening, a distal end, a distal end opening, and a lumen extending through the cannula. A cap is provided having a closed distal end, being in contact with the outer wall of the cannula, and covering the distal end and the distal end opening of the cannula, the cap being structured to allow the distal end and the distal end opening of the cannula to pass through the cap as the cannula is passed into an eye. An ocular implant is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.
摘要翻译：提供了眼部植入物递送组件，其包括具有延伸穿过其中的内腔的套管，近端，近端开口，远端，远端开口和延伸穿过套管的内腔。提供具有封闭的远端的盖，其与套管的外壁接触并且覆盖套管的远端和远端开口，帽被构造成允许远端和远端开口当套管穿过眼睛时，套管穿过帽子。眼内植入物位于内腔中。植入物可以密封在套管中而不加入液体载体，或者其可以包含在插管中的液体载体介质中。植入物可以由具有不同组成或不同形式的许多微粒组成。组件还包括位于套管的近端上的套筒，并且适于将组件耦合到包含推动凝胶的注射器。

10. 发明申请

US20120283232A9 PROCESS FOR MAKING A PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：制备药物组合物的方法
公开(公告)号：US20120283232A9
公开(公告)日：2012-11-08
申请号：US11952927
申请日：2007-12-07
申请人： Zhengjun Wang , Thomas M. McGrath , Toan N. Ha , Sam W. Lam , Bruce A. Firestone , Robert T. Lyons , James N. Chang , John T. Trogden
发明人： Zhengjun Wang , Thomas M. McGrath , Toan N. Ha , Sam W. Lam , Bruce A. Firestone , Robert T. Lyons , James N. Chang , John T. Trogden
IPC分类号： A61K31/573
CPC分类号： A61K9/0019
摘要： Process for making a sterile, injectable pharmaceutical composition by combining triamcinolone, a buffer and a high viscosity hyaluronate.
摘要翻译：通过组合曲安奈德，缓冲液和高粘度透明质酸来制备无菌注射药物组合物的方法。

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