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1. 发明授权

US08642067B2 Methods and compositions for intraocular administration to treat ocular conditions 有权
标题翻译：用于眼内给药以治疗眼部病症的方法和组合物
公开(公告)号：US08642067B2
公开(公告)日：2014-02-04
申请号：US11695527
申请日：2007-04-02
申请人： John T. Trogden , Robert T. Lyons , James N. Chang , Scott M. Whitcup
发明人： John T. Trogden , Robert T. Lyons , James N. Chang , Scott M. Whitcup
IPC分类号： A61F2/00
CPC分类号： A61K31/404 , A61K9/0048 , A61K31/33 , A61K31/728 , A61K47/14 , A61K47/36 , A61K2300/00
摘要： Anti-angiogenesis compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes are provided. Such compositions can include TKI component solutions or particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities at about 25° C. of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity at 25° C. is in the range of from about 80,000 cps to about 300,000 cps.
摘要翻译：提供了抗血管生成组合物，以及使用这些组合物的方法，其可用于注射到人眼玻璃体中。这样的组合物可以包括TKI组分溶液或以治疗有效量存在的颗粒，粘度诱导组分和水性载体组分。组合物在约25℃下的粘度为0.1 /秒的剪切速率为至少约10cps或约100cps。在优选的实施方案中，25℃下的粘度在约80,000cps至约300,000cps的范围内。

2. 发明申请

US20080269181A1 METHODS FOR TREATING A POSTERIOR SEGMENT OF AN EYE 有权
标题翻译：治疗眼睛前期部分的方法
公开(公告)号：US20080269181A1
公开(公告)日：2008-10-30
申请号：US12172194
申请日：2008-07-11
申请人： Robert T. LYONS , James N. Chang , John T. Trogden , Scott M. Whitcup
发明人： Robert T. LYONS , James N. Chang , John T. Trogden , Scott M. Whitcup
IPC分类号： A61K31/56 , A61P27/02
CPC分类号： A61K31/58 , A61K9/0048 , A61K31/573 , A61K47/36
摘要： Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include corticosteroid component-containing particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 300,000 cps. The compositions advantageously suspend the particles for prolonged periods of time.
摘要翻译：提供了组合物和使用这种组合物的方法，其可用于注射到人或动物眼睛的后段中。这样的组合物包括以治疗有效量存在的含皮质类固醇成分的颗粒，粘度诱导组分和水性载体组分。组合物在0.1 /秒的剪切速率下具有至少约10cps或约100cps的粘度。在优选的实施方案中，粘度在约140,000cps至约300,000cps的范围内。组合物有利地将颗粒悬浮长时间。

3. 发明授权

US08569272B2 Methods for treating a posterior segment of an eye 有权
标题翻译：治疗眼后段的方法
公开(公告)号：US08569272B2
公开(公告)日：2013-10-29
申请号：US12172194
申请日：2008-07-11
申请人： Robert T. Lyons , James N. Chang , John T. Trogden , Scott M. Whitcup
发明人： Robert T. Lyons , James N. Chang , John T. Trogden , Scott M. Whitcup
IPC分类号： A01N45/00 , A61F2/00 , A61K9/14 , A61K33/32
CPC分类号： A61K31/58 , A61K9/0048 , A61K31/573 , A61K47/36
摘要： Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include corticosteroid component-containing particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 300,000 cps. The compositions advantageously suspend the particles for prolonged periods of time.
摘要翻译：提供了组合物和使用这种组合物的方法，其可用于注射到人或动物眼睛的后段中。这样的组合物包括以治疗有效量存在的含皮质类固醇成分的颗粒，粘度诱导组分和水性载体组分。组合物在0.1 /秒的剪切速率下具有至少约10cps或约100cps的粘度。在优选的实施方案中，粘度在约140,000cps至约300,000cps的范围内。组合物有利地将颗粒悬浮长时间。

4. 发明申请

US20080241252A1 METHODS AND COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION TO TREAT OCULAR CONDITIONS 有权
标题翻译：用于治疗眼睛条件的室间管理的方法和组合
公开(公告)号：US20080241252A1
公开(公告)日：2008-10-02
申请号：US11695527
申请日：2007-04-02
申请人： Robert T. Lyons , James N. Chang , John T. Trogden , Scott M. Whitcup
发明人： Robert T. Lyons , James N. Chang , John T. Trogden , Scott M. Whitcup
IPC分类号： A61K9/14 , A61K31/33
CPC分类号： A61K31/404 , A61K9/0048 , A61K31/33 , A61K31/728 , A61K47/14 , A61K47/36 , A61K2300/00
摘要： Anti-angiogenesis compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes are provided. Such compositions can include TKI component solutions or particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities at about 25° C. of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity at 25° C. is in the range of from about 80,000 cps to about 300,000 cps.
摘要翻译：提供了抗血管生成组合物，以及使用这些组合物的方法，其可用于注射到人眼玻璃体中。这样的组合物可以包括TKI组分溶液或以治疗有效量存在的颗粒，粘度诱导组分和水性载体组分。组合物在约25℃下的粘度为0.1 /秒的剪切速率为至少约10cps或约100cps。在优选的实施方案中，25℃下的粘度在约80,000cps至约300,000cps的范围内。

5. 发明授权

US08846094B2 Peripherally administered viscous formulations 有权
标题翻译：外周施用的粘稠制剂
公开(公告)号：US08846094B2
公开(公告)日：2014-09-30
申请号：US11828561
申请日：2007-07-26
申请人： Robert T. Lyons , Michael R. Robinson , John T. Trogden , Scott M. Whitcup
发明人： Robert T. Lyons , Michael R. Robinson , John T. Trogden , Scott M. Whitcup
IPC分类号： A61K9/14 , A61K31/56 , A61K47/02 , A61K47/36 , A61K47/40 , A61K31/715 , A61K47/34 , A61K31/573 , A61K9/00
CPC分类号： A61K9/0019 , A61K9/0048 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/715 , A61K47/02 , A61K47/34 , A61K47/36 , A61K47/40
摘要： Viscous formulations and methods of using such compositions, useful for intramuscular and intra-articular injection are provided to treat peripheral conditions. Such compositions can include triamcinolone particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 80,000 cps to about 300,000 cps. In a most preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 280,000 cps at a shear rate of 0.1/second at 25° C. The compositions advantageously suspend the triamcinolone particles for prolonged periods of time.
摘要翻译：提供使用这种组合物的粘性制剂和方法，其可用于肌肉内和关节内注射以治疗外周病症。这样的组合物可以包括以治疗有效量存在的曲安奈德颗粒，粘度诱导组分和水性载体组分。组合物在0.1 /秒的剪切速率下具有至少约10cps或约100cps的粘度。在优选的实施方案中，粘度在约80,000cps至约300,000cps的范围内。在最优选的实施方案中，粘度在25℃下以0.1 /秒的剪切速率在约140,000cps至约280,000cps的范围内。组合物有利地将曲安奈德颗粒悬浮较长时间。

6. 发明授权

US11078262B2 High viscosity macromolecular compositions for treating ocular conditions 有权
公开(公告)号：US11078262B2
公开(公告)日：2021-08-03
申请号：US11742350
申请日：2007-04-30
申请人： Patrick M. Hughes , Gerald W. DeVries , Robert T. Lyons , John T. Trogden , Scott M. Whitcup
发明人： Patrick M. Hughes , Gerald W. DeVries , Robert T. Lyons , John T. Trogden , Scott M. Whitcup
IPC分类号： C07K16/22 , A61K47/34 , A61K38/39 , A61K9/00 , C12N15/113 , A61K9/08 , A61K39/00
摘要： Anti-angiogenesis compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes are provided. Such compositions include MAAC solutions or particles present in a therapeutically effective amount, a viscosity-inducing component, and an aqueous carrier component. The compositions have viscosities at about 25° C. of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity at 25° C. is in the range of from about 80,000 cps to about 300,000 cps.

7. 发明申请

US20080268051A1 HIGH VISCOSITY MACROMOLECULAR COMPOSITIONS FOR TREATING OCULAR CONDITIONS 审中-公开
标题翻译：用于治疗眼睛病症的高粘度大分子组合物
公开(公告)号：US20080268051A1
公开(公告)日：2008-10-30
申请号：US11742350
申请日：2007-04-30
申请人： Patrick M. Hughes , Gerald W. DeVries , Robert T. Lyons , John T. Trogden , Scott M. Whitcup
发明人： Patrick M. Hughes , Gerald W. DeVries , Robert T. Lyons , John T. Trogden , Scott M. Whitcup
IPC分类号： A61K9/00 , A61P27/02 , A61K38/00 , A61K31/711 , A61K39/395
CPC分类号： C07K16/22 , A61K9/0048 , A61K9/08 , A61K38/39 , A61K47/34 , A61K2039/505 , C07K2317/24 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/332 , C12N2320/32
摘要： Anti-angiogenesis compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes are provided. Such compositions include MAAC solutions or particles present in a therapeutically effective amount, a viscosity-inducing component, and an aqueous carrier component. The compositions have viscosities at about 25° C. of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity at 25° C. is in the range of from about 80,000 cps to about 300,000 cps.
摘要翻译：提供了抗血管生成组合物，以及使用这些组合物的方法，其可用于注射到人眼玻璃体中。这样的组合物包括以治疗有效量存在的MAAC溶液或颗粒，粘度诱导组分和水性载体组分。组合物在约25℃下的粘度为0.1 /秒的剪切速率为至少约10cps或约100cps。在优选的实施方案中，25℃下的粘度在约80,000cps至约300,000cps的范围内。

8. 发明申请

US20080097335A1 OCULAR IMPLANT DELIVERY ASSEMBLIES 审中-公开
标题翻译： OCULAR IMPLANT交付组件
公开(公告)号：US20080097335A1
公开(公告)日：2008-04-24
申请号：US11552835
申请日：2006-10-25
申请人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson
发明人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson
IPC分类号： A61M5/178
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Ocular implant delivery assemblies are provided which include a cannula having a lumen extending therethrough, a proximal end, a proximal end opening, a distal end, a distal end opening, and a lumen extending through the cannula. A removable distal closure element is provided for closing the distal end opening, and a removable proximal closure element is provided for closing the proximal end opening. An ocular implant is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.
摘要翻译：提供了眼部植入物递送组件，其包括具有延伸穿过其中的内腔的套管，近端，近端开口，远端，远端开口和延伸穿过套管的内腔。提供可移除的远端闭合元件用于封闭远端开口，并且提供可移除的近端闭合元件用于封闭近端开口。眼内植入物位于内腔中。植入物可以密封在套管中而不加入液体载体，或者其可以包含在插管中的液体载体介质中。植入物可以由具有不同组成或不同形式的许多微粒组成。组件还包括位于套管的近端上的套筒，并且适于将组件耦合到包含推动凝胶的注射器。

9. 发明申请

US20120283232A9 PROCESS FOR MAKING A PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：制备药物组合物的方法
公开(公告)号：US20120283232A9
公开(公告)日：2012-11-08
申请号：US11952927
申请日：2007-12-07
申请人： Zhengjun Wang , Thomas M. McGrath , Toan N. Ha , Sam W. Lam , Bruce A. Firestone , Robert T. Lyons , James N. Chang , John T. Trogden
发明人： Zhengjun Wang , Thomas M. McGrath , Toan N. Ha , Sam W. Lam , Bruce A. Firestone , Robert T. Lyons , James N. Chang , John T. Trogden
IPC分类号： A61K31/573
CPC分类号： A61K9/0019
摘要： Process for making a sterile, injectable pharmaceutical composition by combining triamcinolone, a buffer and a high viscosity hyaluronate.
摘要翻译：通过组合曲安奈德，缓冲液和高粘度透明质酸来制备无菌注射药物组合物的方法。

10. 发明申请

US20090149435A1 PROCESS FOR MAKING A PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：制备药物组合物的方法
公开(公告)号：US20090149435A1
公开(公告)日：2009-06-11
申请号：US11952927
申请日：2007-12-07
申请人： Zhengjun Wang , Thomas M. McGrath , Toan N. Ha , Sam W. Lam , Bruce A. Firestone , Robert T. Lyons , James N. Chang , John T. Trogden
发明人： Zhengjun Wang , Thomas M. McGrath , Toan N. Ha , Sam W. Lam , Bruce A. Firestone , Robert T. Lyons , James N. Chang , John T. Trogden
IPC分类号： A61K31/573
CPC分类号： A61K9/0019
摘要： Process for making a sterile, injectable pharmaceutical composition by combining triamcinolone, a buffer and a high viscosity hyaluronate.
摘要翻译：通过组合曲安奈德，缓冲液和高粘度透明质酸来制备无菌注射药物组合物的方法。

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