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1. 发明授权

US06623980B1 Exo1 and Exo2, exocytotic proteins 有权
标题翻译： Exo1和Exo2，胞吐蛋白
公开(公告)号：US06623980B1
公开(公告)日：2003-09-23
申请号：US09255920
申请日：1999-02-23
申请人： Joseph Fisher , James Lorens , David Anderson , Ying Luo , Chao Bai (Betty) Huang , Mary Shen
发明人： Joseph Fisher , James Lorens , David Anderson , Ying Luo , Chao Bai (Betty) Huang , Mary Shen
IPC分类号： G01N33566
CPC分类号： C07K14/4703
摘要： The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which mediate exocytotic polypeptide bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及新颖的胞吐多肽，例如Exo1和Exo2多肽及相关分子，其对胞吐作用具有抑制作用，以及编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定介导胞吐多肽生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

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