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1. 发明授权

US06848462B2 Adhesiveless microfluidic device fabrication 有权
标题翻译：无粘性微流体装置制造
公开(公告)号：US06848462B2
公开(公告)日：2005-02-01
申请号：US10313231
申请日：2002-12-06
申请人： Joseph F. Covington , Steven E. Hobbs , Jeffrey A. Koehler , Paren P. Patel , Marci Pezzuto , Mark S. Scheib
发明人： Joseph F. Covington , Steven E. Hobbs , Jeffrey A. Koehler , Paren P. Patel , Marci Pezzuto , Mark S. Scheib
IPC分类号： B01L3/00 , B29C65/00 , B29C65/18 , B32B37/08 , B81C1/00 , G01N27/447 , F15C1/06
CPC分类号： B01L3/502707 , B01J2219/00783 , B01J2219/00833 , B01J2219/00835 , B01J2219/00891 , B01J2219/00952 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0681 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B29C65/18 , B29C66/02 , B29C66/026 , B29C66/1122 , B29C66/45 , B29C66/71 , B29C66/727 , B29C66/73112 , B29C66/8322 , B29C66/91212 , B29C66/91213 , B29C66/91216 , B29C66/91221 , B29C66/91231 , B29C66/91411 , B29C66/91445 , B29C66/91645 , B29C66/92445 , B29C66/929 , B29C66/961 , B29K2023/00 , B29K2023/12 , B29L2031/756 , B32B37/0023 , B32B37/08 , B32B37/10 , B32B38/004 , B32B41/00 , B32B2037/0092 , B32B2038/166 , B32B2309/02 , B32B2309/022 , B32B2309/12 , B32B2310/024 , B81B2201/058 , B81C1/00119 , B81C3/008 , B81C2201/019 , G01N27/44791 , G01N30/6095 , Y10T29/49002 , Y10T137/0402 , Y10T137/2224 , Y10T137/598 , B29C2035/0827 , B29K2067/00
摘要： A method for fabricating a microfluidic device where first and second substantially flat platens are provided. Multiple substantially planar, substantially metal-free, adhesiveless polymer device layers, the device layers including a first cover layer, second cover layer, and at least one stencil layer defining a microfluidic channel penetrating through the entire thickness of the stencil layer also are provided. Each stencil layer is disposed between other device layers such that the channel is bounded laterally by a stencil layer, and bounded from above and below by surrounding device layers to define an upper channel surface and a lower channel surface. The device layers are stacked between the first platen and the second platen. The stacked device layers are controllably heated according to a heating profile adapted to form a substantially sealed adhesiveless microfluidic device wherein each upper channel surface remains distinct from its corresponding lower channel surface. The resulting microfluidic device has high inter-layer bond strength while preserving the integrity of the channel(s) defined in the stencil layer(s).
摘要翻译：一种制造微流体装置的方法，其中设置有第一和第二基本平坦的压板。还提供了多个基本平坦的，基本上无金属的无粘合剂聚合物器件层，所述器件层包括第一覆盖层，第二覆盖层和限定穿透模板层的整个厚度的微流体通道的至少一个模板层。每个模版层设置在其它装置层之间，使得通道被模板层横向限定，并且由周围装置层从上方和下方界定，以限定上通道表面和下通道表面。装置层堆叠在第一压板和第二压板之间。根据适于形成基本上密封的无粘合微流体装置的加热轮廓可控制地加热堆叠的装置层，其中每个上部通道表面保持与其相应的下部通道表面不同。所得到的微流体装置具有高的层间结合强度，同时保持在模版层中定义的通道的完整性。

2. 发明授权

US08545495B2 Catheter having circular ablation assembly 有权
标题翻译：导管具有圆形消融组件
公开(公告)号：US08545495B2
公开(公告)日：2013-10-01
申请号：US12120086
申请日：2008-05-13
申请人： Mark S. Scheib
发明人： Mark S. Scheib
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00821 , A61B2018/1405 , A61B2018/1435
摘要： A catheter comprises a catheter body with an ablation assembly at its distal end. The ablation assembly has a preformed generally circular curve generally transverse to the axis of the catheter body, and comprises a flexible tubing that carries a tip electrode at its distal end. In use, the generally circular curve contacts the inner circumference of a tubular region of a patient's heart so that the tip electrode contacts tissue along the inner circumference. After ablating the tissue at this first position, the ablation assembly can be rotated so that the tip electrode contacts tissue at a second position along the inner circumference. After ablating the tissue at the second position, the procedure can be repeated to form a lesion of the desired length.
摘要翻译：导管包括其远端处具有消融组件的导管主体。消融组件具有大致横向于导管主体的轴线的预制的大致圆形曲线，并且包括在其远端处承载尖端电极的柔性管。在使用中，通常圆形的曲线接触患者心脏的管状区域的内圆周，使得尖端电极沿着内圆周接触组织。在该第一位置消融组织之后，消融组件可以旋转，使得尖端电极沿着内圆周在第二位置接触组织。在第二位置消融组织后，可以重复该过程以形成所需长度的损伤。

3. 发明授权

US08152829B2 Retractable dilator needle 有权
标题翻译：伸缩扩张针
公开(公告)号：US08152829B2
公开(公告)日：2012-04-10
申请号：US12579318
申请日：2009-10-14
申请人： Mark S. Scheib
发明人： Mark S. Scheib
IPC分类号： A61M29/00
CPC分类号： A61M25/0606 , A61B17/3417 , A61B17/3478 , A61B2017/00243 , A61B2090/062 , A61M29/00
摘要： A dilator having a retractable needle is disclosed. The dilator includes an elongated dilator body having a proximal end, a distal end and at least one lumen longitudinally extending therethrough. A handle is mounted at the proximal end of the dilator body, and a control button is moveably connected to the outside of the handle. The needle extends through the lumen and has a distal end comprising a needle tip section. An arm attached the control button to the needle. Distal movement of the control button causes the needle to move from a retracted position, wherein the needle tip is disposed within the lumen of the dilator body, to a protruding position, wherein the needle tip protrudes beyond the distal end of the dilator body. In use, the distal end of the dilator is inserted into the right atrium of a patient, a position on the atrial septum to be punctured is located with the distal end of the dilator body, the needle tip is advanced beyond the distal end of the dilator body, and the atrial septum is punctured with the needle tip.
摘要翻译：公开了一种具有伸缩针的扩张器。扩张器包括细长的扩张器主体，其具有近端，远端以及纵向延伸穿过其中的至少一个内腔。手柄安装在扩张器本体的近端处，并且控制按钮可移动地连接到手柄的外部。针延伸穿过内腔并且具有包括针尖部分的远端。手臂将控制按钮连接到针上。控制按钮的远端运动使得针从缩回位置移动，其中针尖设置在扩张器主体的内腔内到达突出位置，其中针尖突出超出扩张器主体的远端。在使用中，扩张器的远端插入患者的右心房，待穿刺的房间隔中的位置与扩张器主体的远端相对，针尖前进超过扩张器体，并用针尖刺穿房间隔。

4. 发明申请

US20100036409A1 RETRACTABLE DILATOR NEEDLE 有权
标题翻译：可收缩的皮带针
公开(公告)号：US20100036409A1
公开(公告)日：2010-02-11
申请号：US12579318
申请日：2009-10-14
申请人： Mark S. Scheib
发明人： Mark S. Scheib
IPC分类号： A61M29/00
CPC分类号： A61M25/0606 , A61B17/3417 , A61B17/3478 , A61B2017/00243 , A61B2090/062 , A61M29/00
摘要： A dilator having a retractable needle is disclosed. The dilator includes an elongated dilator body having a proximal end, a distal end and at least one lumen longitudinally extending therethrough. A handle is mounted at the proximal end of the dilator body, and a control button is moveably connected to the outside of the handle. The needle extends through the lumen and has a distal end comprising a needle tip section. An arm attached the control button to the needle. Distal movement of the control button causes the needle to move from a retracted position, wherein the needle tip is disposed within the lumen of the dilator body, to a protruding position, wherein the needle tip protrudes beyond the distal end of the dilator body. In use, the distal end of the dilator is inserted into the right atrium of a patient, a position on the atrial septum to be punctured is located with the distal end of the dilator body, the needle tip is advanced beyond the distal end of the dilator body, and the atrial septum is punctured with the needle tip.
摘要翻译：公开了一种具有伸缩针的扩张器。扩张器包括细长的扩张器主体，其具有近端，远端以及纵向延伸穿过其中的至少一个内腔。手柄安装在扩张器本体的近端处，并且控制按钮可移动地连接到手柄的外部。针延伸穿过内腔并且具有包括针尖部分的远端。手臂将控制按钮连接到针上。控制按钮的远端运动使得针从缩回位置移动，其中针尖设置在扩张器主体的内腔内到达突出位置，其中针尖突出超出扩张器主体的远端。在使用中，扩张器的远端插入患者的右心房，待穿刺的房间隔中的位置与扩张器主体的远端相对，针尖前进超过扩张器体，并用针尖刺穿房间隔。

5. 发明授权

US06733499B2 Catheter having circular ablation assembly 有权
标题翻译：导管具有圆形消融组件
公开(公告)号：US06733499B2
公开(公告)日：2004-05-11
申请号：US10118680
申请日：2002-04-09
申请人： Mark S. Scheib
发明人： Mark S. Scheib
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2018/00821 , A61B2018/1405 , A61B2018/1435
摘要： A catheter particularly useful for ablation lesions within a tubular region of or near the heart is provided. The catheter comprises an elongated flexible tubular catheter body having an axis and proximal and distal ends. An ablation assembly is mounted at the distal end of the tubular body. The ablation assembly has a preformed generally circular curve having an outer surface and being generally transverse to the axis of the catheter body. The ablation assembly comprises a flexible tubing having proximal and distal ends that carries a tip electrode at its distal end. An electrode lead wire extends through the catheter body and into the ablation assembly and has a distal end connected to the tip electrode. In use the distal end of the catheter is interested into the heart of a patient. At least a portion of the outer circumference of the generally circular curve is contacted with the inner circumference of the tubular region so that the tip electrode is in a first position in contact with tissue along the inner circumference. The tip electrode is used to ablate tissue at the first position. The ablation assembly can then be rotated so that the tip electrode is in a second position in contact with tissue along the inner circumference different from the first position, and the tip electrode is used to ablate tissue at the second position. This procedure can be repeated to form a lesion of the desired length along the inner circumference.
摘要翻译：提供了一种特别适用于心脏内或心脏附近的消融病变的导管。导管包括具有轴线和近端和远端的细长柔性管状导管主体。消融组件安装在管体的远端。消融组件具有预制的大致圆形曲线，其具有外表面并且大致横向于导管主体的轴线。消融组件包括柔性管，其具有在其远端处承载尖端电极的近端和远端。电极引线延伸穿过导管主体并进入消融组件，并具有连接到尖端电极的远端。在使用中，导管的远端对患者的心脏感兴趣。大致圆形曲线的外周的至少一部分与管状区域的内周接触，使得尖端电极处于与内周的组织接触的第一位置。尖端电极用于在第一位置烧蚀组织。然后可以旋转消融组件，使得尖端电极处于与不同于第一位置的内圆周与组织接触的第二位置，并且尖端电极用于在第二位置烧蚀组织。可以重复该过程以沿着内周形成期望长度的损伤。

6. 发明授权

US07618430B2 Retractable dilator needle 有权
标题翻译：伸缩扩张针
公开(公告)号：US07618430B2
公开(公告)日：2009-11-17
申请号：US10118679
申请日：2002-04-09
申请人： Mark S. Scheib
发明人： Mark S. Scheib
IPC分类号： A61M29/00
CPC分类号： A61M25/0606 , A61B17/3417 , A61B17/3478 , A61B2017/00243 , A61B2090/062 , A61M29/00
摘要： A dilator having a retractable needle is disclosed. The dilator includes an elongated dilator body having a proximal end, a distal end and at least one lumen longitudinally extending therethrough. A handle is mounted at the proximal end of the dilator body, and a control button is moveably connected to the outside of the handle. The needle extends through the lumen and has a distal end comprising a needle tip section. An arm attached the control button to the needle. Distal movement of the control button causes the needle to move from a retracted position, wherein the needle tip is disposed within the lumen of the dilator body, to a protruding position, wherein the needle tip protrudes beyond the distal end of the dilator body. In use, the distal end of the dilator is inserted into the right atrium of a patient, a position on the atrial septum to be punctured is located with the distal end of the dilator body, the needle tip is advanced beyond the distal end of the dilator body, and the atrial septum is punctured with the needle tip.
摘要翻译：公开了一种具有伸缩针的扩张器。扩张器包括细长的扩张器主体，其具有近端，远端以及纵向延伸穿过其中的至少一个内腔。手柄安装在扩张器本体的近端处，并且控制按钮可移动地连接到手柄的外部。针延伸穿过内腔并且具有包括针尖部分的远端。手臂将控制按钮连接到针上。控制按钮的远端运动使得针从缩回位置移动，其中针尖设置在扩张器主体的内腔内到达突出位置，其中针尖突出超出扩张器主体的远端。在使用中，扩张器的远端插入患者的右心房，待穿刺的房间隔中的位置与扩张器主体的远端相对，针尖前进超过扩张器体，并用针尖刺穿房间隔。

7. 发明授权

US07575566B2 Catheter having circular ablation assembly 有权
标题翻译：导管具有圆形消融组件
公开(公告)号：US07575566B2
公开(公告)日：2009-08-18
申请号：US10750501
申请日：2003-12-31
申请人： Mark S. Scheib
发明人： Mark S. Scheib
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00821 , A61B2018/1405 , A61B2018/1435
摘要： A catheter particularly useful for ablation lesions within a tubular region of or near the heart is provided. The catheter comprises an elongated flexible tubular catheter body having an axis and proximal and distal ends. An ablation assembly is mounted at the distal end of the tubular body. The ablation assembly has a preformed generally circular curve having an outer surface and being generally transverse to the axis of the catheter body. The ablation assembly comprises a flexible tubing having proximal and distal ends that carries a tip electrode at its distal end. An electrode lead wire extends through the catheter body and into the ablation assembly and has a distal end connected to the tip electrode. In use, the distal end of the catheter is inserted into the heart of a patient. At least a portion of the outer circumference of the generally circular curve is contacted with the inner circumference of the tubular region so that the tip electrode is in a first position in contact with tissue along the inner circumference. The tip electrode is used to ablate tissue at the first position. The ablation assembly can then be rotated so that the tip electrode is in a second position in contact with tissue along the inner circumference different from the first position, and the tip electrode is used to ablate tissue at the second position. This procedure can be repeated to form a lesion of the desired length along the inner circumference.
摘要翻译：提供了一种特别适用于心脏内或心脏附近的消融病变的导管。导管包括具有轴线和近端和远端的细长柔性管状导管主体。消融组件安装在管体的远端。消融组件具有预制的大致圆形曲线，其具有外表面并且大致横向于导管主体的轴线。消融组件包括柔性管，其具有在其远端处承载尖端电极的近端和远端。电极引线延伸穿过导管主体并进入消融组件，并具有连接到尖端电极的远端。在使用中，导管的远端插入患者的心脏。大致圆形曲线的外周的至少一部分与管状区域的内周接触，使得尖端电极处于与内周的组织接触的第一位置。尖端电极用于在第一位置烧蚀组织。然后可以旋转消融组件，使得尖端电极处于与不同于第一位置的内圆周与组织接触的第二位置，并且尖端电极用于在第二位置烧蚀组织。可以重复该过程以沿着内周形成期望长度的损伤。

8. 发明申请

US20080281320A1 CATHETER HAVING CIRCULAR ABLATION ASSEMBLY 有权
标题翻译：具有圆形排水装置的导管
公开(公告)号：US20080281320A1
公开(公告)日：2008-11-13
申请号：US12120086
申请日：2008-05-13
申请人： Mark S. Scheib
发明人： Mark S. Scheib
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00821 , A61B2018/1405 , A61B2018/1435
摘要： A catheter particularly useful for ablation lesions within a tubular region of or near the heart is provided. The catheter comprises an elongated flexible tubular catheter body having an axis and proximal and distal ends. An ablation assembly is mounted at the distal end of the tubular body. The ablation assembly has a preformed generally circular curve having an outer surface and being generally transverse to the axis of the catheter body. The ablation assembly comprises a flexible tubing having proximal and distal ends that carries a tip electrode at its distal end. An electrode lead wire extends through the catheter body and into the ablation assembly and has a distal end connected to the tip electrode. In use the distal end of the catheter is interested into the heart of a patient. At least a portion of the outer circumference of the generally circular curve is contacted with the inner circumference of the tubular region so that the tip electrode is in a first position in contact with tissue along the inner circumference. The tip electrode is used to ablate tissue at the first position. The ablation assembly can then be rotated so that the tip electrode is in a second position in contact with tissue along the inner circumference different from the first position, and the tip electrode is used to ablate tissue at the second position. This procedure can be repeated to form a lesion of the desired length along the inner circumference.
摘要翻译：提供了一种特别适用于心脏内或心脏附近的消融病变的导管。导管包括具有轴线和近端和远端的细长柔性管状导管主体。消融组件安装在管体的远端。消融组件具有预制的大致圆形曲线，其具有外表面并且大致横向于导管主体的轴线。消融组件包括柔性管，其具有在其远端处承载尖端电极的近端和远端。电极引线延伸穿过导管主体并进入消融组件，并具有连接到尖端电极的远端。在使用中，导管的远端对患者的心脏感兴趣。大致圆形曲线的外周的至少一部分与管状区域的内周接触，使得尖端电极处于与内周的组织接触的第一位置。尖端电极用于在第一位置烧蚀组织。然后可以旋转消融组件，使得尖端电极处于与不同于第一位置的内圆周与组织接触的第二位置，并且尖端电极用于在第二位置烧蚀组织。可以重复该过程以沿着内周形成期望长度的损伤。

9. 发明授权

US07371232B2 Catheter having circular ablation assembly 有权
标题翻译：导管具有圆形消融组件
公开(公告)号：US07371232B2
公开(公告)日：2008-05-13
申请号：US10428023
申请日：2003-05-01
申请人： Mark S. Scheib
发明人： Mark S. Scheib
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00821 , A61B2018/1405 , A61B2018/1435
摘要： A catheter particularly useful for ablation lesions within a tubular region of or near the heart is provided. The catheter comprises an elongated flexible tubular catheter body having an axis and proximal and distal ends. An ablation assembly is mounted at the distal end of the tubular body. The ablation assembly has a preformed generally circular curve having an outer surface and being generally transverse to the axis of the catheter body. The ablation assembly comprises a flexible tubing having proximal and distal ends that carries a tip electrode at its distal end. An electrode lead wire extends through the catheter body and into the ablation assembly and has a distal end connected to the tip electrode. In use the distal end of the catheter is interested into the heart of a patient. At least a portion of the outer circumference of the generally circular curve is contacted with the inner circumference of the tubular region so that the tip electrode is in a first position in contact with tissue along the inner circumference. The tip electrode is used to ablate tissue at the first position. The ablation assembly can then be rotated so that the tip electrode is in a second position in contact with tissue along the inner circumference different from the first position, and the tip electrode is used to ablate tissue at the second position. This procedure can be repeated to form a lesion of the desired length along the inner circumference.
摘要翻译：提供了一种特别适用于心脏内或心脏附近的消融病变的导管。导管包括具有轴线和近端和远端的细长柔性管状导管主体。消融组件安装在管体的远端。消融组件具有预制的大致圆形曲线，其具有外表面并且大致横向于导管主体的轴线。消融组件包括柔性管，其具有在其远端处承载尖端电极的近端和远端。电极引线延伸穿过导管主体并进入消融组件，并具有连接到尖端电极的远端。在使用中，导管的远端插入患者的心脏。大致圆形曲线的外周的至少一部分与管状区域的内周接触，使得尖端电极处于与内周的组织接触的第一位置。尖端电极用于在第一位置烧蚀组织。然后可以旋转消融组件，使得尖端电极处于与不同于第一位置的内圆周与组织接触的第二位置，并且尖端电极用于在第二位置烧蚀组织。可以重复该过程以沿着内周形成期望长度的损伤。

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