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1. 发明申请

US20110226991A1 STABLE NANOPARTICLES AND METHODS OF MAKING AND USING SUCH PARTICLES 有权
标题翻译：稳定的纳米颗粒及其制备和使用这种颗粒的方法
公开(公告)号：US20110226991A1
公开(公告)日：2011-09-22
申请号：US13125562
申请日：2009-10-23
申请人： Joseph A. Treadway , Eric Tulsky
发明人： Joseph A. Treadway , Eric Tulsky
IPC分类号： C09K11/54 , B05D7/00 , B82Y99/00
CPC分类号： B01J13/22 , A61K49/0067 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C09K11/02 , C09K11/025 , C09K11/08 , H01L29/0665 , H01L29/225
摘要： A population of nanoparticles is disclosed. The population is comprised of a plurality of core/shell nanocrystals, each including: a semiconductor core, an intermediate semiconductor shell layer disposed over the semiconductor core, an external semiconductor shell layer disposed over the intermediate semiconductor shell layer, and a hydrophilic organic layer in direct contact with the external semi-conductor shell layer. The population of nanoparticles has a αon value of less than about 1.4.
摘要翻译：公开了一群纳米颗粒。群体由多个核/壳纳米晶体组成，每个核/壳纳米晶体包括：半导体芯，设置在半导体芯上的中间半导体外壳层，设置在中间半导体外壳层上的外部半导体外壳层，以及设置在中间半导体外壳层上的亲水性有机层与外部半导体外壳层直接接触。纳米粒子的αon值小于约1.4。

2. 发明授权

US09174187B2 Water-dispersable nanoparticles 有权
标题翻译：水分散性纳米粒子
公开(公告)号：US09174187B2
公开(公告)日：2015-11-03
申请号：US13057504
申请日：2009-08-06
申请人： Eric Tulsky , Kari Haley , Imad Naasani , John Mauro , Roman Rozhkov , Joseph A. Treadway
发明人： Eric Tulsky , Kari Haley , Imad Naasani , John Mauro , Roman Rozhkov , Joseph A. Treadway
IPC分类号： C12Q1/02 , G01N21/75 , B01J13/14 , B22F1/00 , B22F1/02 , B82Y30/00
CPC分类号： G01N33/588 , B01J13/14 , B22F1/0022 , B22F1/02 , B82Y30/00 , G01N1/30 , G01N21/64 , G01N2001/302 , Y10S977/773 , Y10S977/81 , Y10S977/834 , Y10S977/902
摘要： Provided herein are methods for making water-soluble nanoparticles comprising a core/shell nanocrystal that is coated with a surface layer comprising enough hydrophilic ligands to render the nanoparticle water soluble or water dispersable. Methods for crosslinking molecules on the surface of a nanoparticle, which methods can be used on the above water-soluble nanoparticles also are provided. Nanoparticle compositions resulting from these methods are also provided.
摘要翻译：本文提供了制备包含核/壳纳米晶体的水溶性纳米颗粒的方法，其被包覆有包含足够亲水性配体的表面层以使纳米颗粒水溶性或水分散。还提供了在纳米颗粒表面上交联分子的方法，该方法可用于上述水溶性纳米颗粒。还提供了由这些方法得到的纳米颗粒组合物。

3. 发明授权

US08603792B2 Conjugates of biomolecules to nanoparticles 有权
标题翻译：生物分子与纳米颗粒的结合
公开(公告)号：US08603792B2
公开(公告)日：2013-12-10
申请号：US12748355
申请日：2010-03-26
申请人： Theo Nikiforov , Daniel Mazur , Xinzhan Peng , Tommie Lloyd Lincecum, Jr. , Yuri Belosludtsev , Howard Reese , Dmitriy Gremyachinskiy , Roman Rozhkov , John M. Mauro , Joseph Beechem , Eric Tulsky , Imad Naasani , Kari Haley , Joseph A. Treadway
发明人： Theo Nikiforov , Daniel Mazur , Xinzhan Peng , Tommie Lloyd Lincecum, Jr. , Yuri Belosludtsev , Howard Reese , Dmitriy Gremyachinskiy , Roman Rozhkov , John M. Mauro , Joseph Beechem , Eric Tulsky , Imad Naasani , Kari Haley , Joseph A. Treadway
IPC分类号： C12N9/12
CPC分类号： C12Q1/6869 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12N9/96 , C12Q1/6818 , C12Y207/07 , C12Y207/07007 , G01N21/6428 , G01N33/582 , G01N2021/6432
摘要： Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing.
摘要翻译：本文公开了包含连接到具有生物活性并可用于多种生物应用的标签的生物分子的缀合物。例如，本文提供了聚合酶 - 纳米颗粒缀合物，其包括与纳米颗粒连接的聚合酶，其中缀合物具有聚合酶活性。这样的缀合物可以表现出减少的聚集和改进的沉淀物，其中平均生物分子：纳米颗粒比接近或等于1:1。本文还公开了制备这种缀合物的改进方法，以及在生物应用中使用这种缀合物的方法和系统，例如核苷酸掺入，引物延伸和单分子测序。

4. 发明申请

US20110306079A1 WATER-DISPERSABLE NANOPARTICLES 有权
标题翻译：水分散纳米颗粒
公开(公告)号：US20110306079A1
公开(公告)日：2011-12-15
申请号：US13057504
申请日：2009-08-06
申请人： Eric Tulsky , Kari Haley , Imad Naasani , John Mauro , Roman Rozhkow , Joseph A. Treadway
发明人： Eric Tulsky , Kari Haley , Imad Naasani , John Mauro , Roman Rozhkow , Joseph A. Treadway
IPC分类号： C12Q1/02 , G01N21/75 , B82B1/00 , B82B3/00 , B82Y15/00
CPC分类号： G01N33/588 , B01J13/14 , B22F1/0022 , B22F1/02 , B82Y30/00 , G01N1/30 , G01N21/64 , G01N2001/302 , Y10S977/773 , Y10S977/81 , Y10S977/834 , Y10S977/902
摘要： Provided herein are methods for making water-soluble nanoparticles comprising a core/shell nanocrystal that is coated with a surface layer comprising enough hydrophilic ligands to render the nanoparticle water soluble or water dispersable. Methods for crosslinking molecules on the surface of a nanoparticle, which methods can be used on the above water-soluble nanoparticles also are provided. Nanoparticle compositions resulting from these methods are also provided.
摘要翻译：本文提供了制备包含核/壳纳米晶体的水溶性纳米颗粒的方法，其被包覆有包含足够亲水性配体的表面层以使纳米颗粒水溶性或水分散。还提供了在纳米颗粒表面上交联分子的方法，该方法可用于上述水溶性纳米颗粒。还提供了由这些方法得到的纳米颗粒组合物。

5. 发明申请

US20110003343A1 CONJUGATES OF BIOMOLECULES TO NANOPARTICLES 有权
标题翻译：生物分子与纳米颗粒的结合
公开(公告)号：US20110003343A1
公开(公告)日：2011-01-06
申请号：US12748355
申请日：2010-03-26
申请人： Theo Nikiforov , Daniel Mazur , Xinzhan Peng , Tommie Lloyd Lincecum, JR. , Yuri Belosludtsev , Howard Reese , Dmitriy Gremyachinskiy , Roman Rozhkov , John M. Mauro , Joseph Beechem , Eric Tulsky , Imad Naasani , Kari Haley , Joseph A. Treadway
发明人： Theo Nikiforov , Daniel Mazur , Xinzhan Peng , Tommie Lloyd Lincecum, JR. , Yuri Belosludtsev , Howard Reese , Dmitriy Gremyachinskiy , Roman Rozhkov , John M. Mauro , Joseph Beechem , Eric Tulsky , Imad Naasani , Kari Haley , Joseph A. Treadway
IPC分类号： C12P19/34 , C12N9/10
CPC分类号： C12Q1/6869 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12N9/96 , C12Q1/6818 , C12Y207/07 , C12Y207/07007 , G01N21/6428 , G01N33/582 , G01N2021/6432
摘要： Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing.
摘要翻译：本文公开了包含连接到具有生物活性并可用于多种生物应用的标签的生物分子的缀合物。例如，本文提供了聚合酶 - 纳米颗粒缀合物，其包括与纳米颗粒连接的聚合酶，其中缀合物具有聚合酶活性。这样的缀合物可以表现出减少的聚集和改进的沉淀物，其中平均生物分子：纳米颗粒比接近或等于1:1。本文还公开了制备这种缀合物的改进方法，以及在生物应用中使用这种缀合物的方法和系统，例如核苷酸掺入，引物延伸和单分子测序。

6. 发明申请

US20100108530A1 METHOD OF SEMICONDUCTOR NANOCRYSTAL SYNTHESIS 有权
标题翻译：半导体纳米晶合成方法
公开(公告)号：US20100108530A1
公开(公告)日：2010-05-06
申请号：US12646799
申请日：2009-12-23
申请人： Donald A. ZEHNDER , Joseph A. Treadway
发明人： Donald A. ZEHNDER , Joseph A. Treadway
IPC分类号： C01B19/04 , B05D5/12 , B05D7/00 , C25D5/34
CPC分类号： C01B19/007 , B82Y30/00 , C01P2004/64 , C30B7/00 , C30B7/14 , C30B29/48 , C30B29/60
摘要： A method is described for the manufacture of semiconductor nanoparticles. Improved yields are obtained by use of a reducing agent or oxygen reaction promoter.
摘要翻译：描述了制造半导体纳米颗粒的方法。通过使用还原剂或氧反应促进剂获得提高的产率。

7. 发明授权

US06734420B2 Differentiable spectral bar code methods and systems 有权
标题翻译：可分辨光谱条形码方法和系统
公开(公告)号：US06734420B2
公开(公告)日：2004-05-11
申请号：US09827013
申请日：2001-04-05
申请人： Stephen A. Empedocles , Joseph A. Treadway , Andrew R. Watson
发明人： Stephen A. Empedocles , Joseph A. Treadway , Andrew R. Watson
IPC分类号： G01N2129
CPC分类号： G01N21/272 , B01J2219/00317 , B01J2219/00432 , B01J2219/005 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L3/545 , B01L2200/0668 , B01L2300/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/0454 , B01L2400/0457 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/25 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/6489 , G01N33/54373 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00742 , G01N2035/00752 , G01N2201/04 , G01N2201/06113 , G01N2201/12
摘要： Devices, systems, methods, and compositions of matter can track and/or identify a library of elements, particularly for use with fluids, particulates, cells, and the like. Signals from one or more semiconductor nanocrystals may be combined to define spectral codes. Separation of signal wavelengths within dedicated wavelength ranges or windows facilitates differentiation of spectral codes, while calibration signals within the spectral codes can avoid ambiguity. Modeling based on prior testing can help derive libraries of acceptable codes.
摘要翻译：物质的装置，系统，方法和组合物可以跟踪和/或识别元件库，特别是用于流体，微粒，细胞等。来自一个或多个半导体纳米晶体的信号可以被组合以限定光谱代码。信号波长在专用波长范围或窗口内的分离有助于光谱代码的分化，而光谱码内的校准信号可以避免歧义。基于先前测试的建模可以帮助导出可接受代码的库。

8. 发明授权

US07695642B2 Preparation of stable, bright luminescent nanoparticles having compositionally engineered properties 有权
标题翻译：具有组成工程化特性的稳定的，明亮的发光纳米颗粒的制备
公开(公告)号：US07695642B2
公开(公告)日：2010-04-13
申请号：US11011827
申请日：2004-12-13
申请人： Marc D. Schrier , Donald A. Zehnder , Joseph A. Treadway , Joseph A. Bartel
发明人： Marc D. Schrier , Donald A. Zehnder , Joseph A. Treadway , Joseph A. Bartel
IPC分类号： C09K11/88
CPC分类号： H01L33/28 , B82Y30/00 , C01P2004/04 , C01P2004/64 , C09C1/10 , C09K11/02 , C09K11/565 , C09K11/883 , Y10S977/824 , Y10S977/834 , Y10T428/2991
摘要： A method is provided for preparing luminescent semiconductor nanoparticles composed of a first component X, a second component A, and a third component B, wherein X, A, and B are different, by combining B with X and A in an amount such that the molar ratio B:(A+B) is in the range of approximately 0.001 to 0.20 and the molar ratio X:(A+B) is in the range of approximately 0.5:1.0 to 2:1. The characteristics of the thus-prepared nanoparticles can be substantially similar to those of nanoparticles containing only X and B while maintaining many useful properties characteristic of nanoparticles containing only X and A. The nanoparticles so prepared can additionally exhibit emergent properties such as a peak emission energy less than that characteristic of a particle composed of XA or XB alone; this method is particularly applicable to the preparation of stable, bright nanoparticles that emit in the red to infrared regions of the electromagnetic spectrum. Luminescent semiconductor nanoparticles having exemplary properties are also provided.
摘要翻译：提供一种制备由第一组分X，第二组分A和第三组分B组成的发光半导体纳米颗粒的方法，其中X，A和B不同，通过将B与X和A组合使得其量使得摩尔比B：（A + B）在约0.001至0.20的范围内，摩尔比X：（A + B）在约0.5:1.0至2:1的范围内。如此制备的纳米颗粒的特征可以与仅含有X和B的纳米颗粒的特征基本相似，同时保持了仅含有X和A的纳米颗粒的许多有用特性。如此制备的纳米颗粒可另外显示出出现的特性，例如峰值发射能小于单独由XA或XB组成的颗粒的特征; 该方法特别适用于在电磁光谱的红色至红外区域中发射的稳定的明亮纳米粒子的制备。还提供了具有示例性质的发光半导体纳米颗粒。

9. 发明授权

US09012204B2 Activation and monitoring of cellular transmembrane potentials 有权
标题翻译：激活和监测细胞跨膜电位
公开(公告)号：US09012204B2
公开(公告)日：2015-04-21
申请号：US13187297
申请日：2011-07-20
申请人： Michael J. Ignatius , Elena Molokanova , Alexei Savtchenko , Joseph A. Bartel , Weiwen Zhao , Joseph A. Treadway
发明人： Michael J. Ignatius , Elena Molokanova , Alexei Savtchenko , Joseph A. Bartel , Weiwen Zhao , Joseph A. Treadway
IPC分类号： C12M1/34 , G01N33/68 , B82Y5/00 , B82Y15/00 , G01N33/58
CPC分类号： G01N33/6872 , B82Y5/00 , B82Y15/00 , G01N33/588 , G01N2500/10
摘要： The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed.
摘要翻译：公开了使用纳米结构来监测或调节细胞膜电位的变化。

10. 发明申请

US20130037762A1 Preparation of Stable, Bright Luminescent Nanoparticles Having Compositionally Engineered Properties 有权
标题翻译：具有组成性能的稳定，明亮的发光纳米颗粒的制备
公开(公告)号：US20130037762A1
公开(公告)日：2013-02-14
申请号：US13608296
申请日：2012-09-10
申请人： Marc D. Schrier , Donald A. Zehnder , Joseph A. Treadway , Joseph A. Bartel
发明人： Marc D. Schrier , Donald A. Zehnder , Joseph A. Treadway , Joseph A. Bartel
IPC分类号： H01B1/06 , B82Y30/00
CPC分类号： H01L33/28 , B82Y30/00 , C01P2004/04 , C01P2004/64 , C09C1/10 , C09K11/02 , C09K11/565 , C09K11/883 , Y10S977/824 , Y10S977/834 , Y10T428/2991
摘要： A method is provided for preparing luminescent semiconductor nanoparticles composed of a first component X, a second component A, and a third component B, wherein X, A, and B are different, by combining B with X and A in an amount such that the molar ratio B:(A+B) is in the range of approximately 0.001 to 0.20 and the molar ratio X:(A+B) is in the range of approximately 0.5:1.0 to 2:1. The characteristics of these nanoparticles can be substantially similar to those of nanoparticles containing only X and B while maintaining many useful properties characteristic of nanoparticles containing only X and A; and can additionally exhibit emergent properties such as a peak emission energy less than that characteristic of a particle composed of XA or XB alone. This method is particularly applicable to the preparation of stable, bright nanoparticles that emit in the red to infrared regions of the electromagnetic spectrum.
摘要翻译：提供一种制备由第一组分X，第二组分A和第三组分B组成的发光半导体纳米颗粒的方法，其中X，A和B不同，通过将B与X和A组合使得其量使得摩尔比B：（A + B）在约0.001至0.20的范围内，摩尔比X：（A + B）在约0.5:1.0至2:1的范围内。这些纳米颗粒的特征可以与仅含有X和B的纳米颗粒的特征基本相似，同时保持仅含有X和A的纳米颗粒的许多有用特性; 并且可以另外表现出突出性质，例如小于单独由XA或XB组成的颗粒的特征的峰值发射能量。该方法特别适用于制备在电磁光谱的红色至红外区域发射的稳定的明亮纳米粒子。

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