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1. 发明授权

US07960098B2 Methods and compositions for the preservation of cells and tissues 有权
标题翻译：用于保存细胞和组织的方法和组合物
公开(公告)号：US07960098B2
公开(公告)日：2011-06-14
申请号：US11777093
申请日：2007-07-12
申请人： Josee Roy , Susan J. Drapeau , Daniel A. Shimko
发明人： Josee Roy , Susan J. Drapeau , Daniel A. Shimko
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/021
摘要： Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic, or near-freezing, and then transported and implanted into a site within the body of a selected recipient animal, all without significant loss of cellular viability, tissue integrity, and/or biochemical function of the stored biological sample.
摘要翻译：公开了用于保存和储存活的生物组织，器官和分离细胞群体的方法。还公开了允许从合适的供体动物收获生物样品（包括例如细胞，细胞培养物，组织和器官）的组合物和方法，在冷藏，低温或近冷冻下长时间储存，然后运输和植入选定受体动物体内的部位，所有这些都不会显着损失存储的生物样品的细胞活力，组织完整性和/或生物化学功能。

2. 发明授权

US07892724B2 Method for enhancing the viability of mammalian cells, tissues and organs using a solution comprising two low molecular weight PEGs 有权
标题翻译：使用包含两种低分子量PEG的溶液增强哺乳动物细胞，组织和器官的存活力的方法
公开(公告)号：US07892724B2
公开(公告)日：2011-02-22
申请号：US11777167
申请日：2007-07-12
申请人： Daniel A. Shimko , Scott Noel , Susan J. Drapeau , Josee Roy
发明人： Daniel A. Shimko , Scott Noel , Susan J. Drapeau , Josee Roy
IPC分类号： A01N1/00
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/021 , C12N5/0018 , C12N2500/30 , C12N2500/46 , C12N2500/60
摘要： Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity.
摘要翻译：公开了用于保存，储存和运输生物体组织，器官和分离细胞群体的组合物和方法。特别地，所公开的组合物和方法允许哺乳动物细胞，组织和器官从合适的供体动物中收获，长时间储存并转运到受体植入部位，所有细胞，组织和器官都不会显着损失细胞活力，生物活性和 /或组织完整性。

3. 发明授权

US09789161B2 Methods for treating back or neck pain caused by NGF using a therapeutic agent consisting of ReN-1820, ALE-0540 and capsaicin 有权
公开(公告)号：US09789161B2
公开(公告)日：2017-10-17
申请号：US11414689
申请日：2006-04-28
申请人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx
发明人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx
IPC分类号： A61K38/00 , A61K39/00 , A61K38/16 , A61K38/18 , A61K38/20 , A61K38/21
CPC分类号： A61K38/1825 , A61K38/185 , A61K38/1858 , A61K38/2093 , A61K38/212
摘要： The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.

4. 发明申请

US20070287991A1 Devices and methods for detection of markers of axial pain with or without radiculopathy 审中-公开
标题翻译：用于检测具有或不具有神经根病变的轴向疼痛标记物的装置和方法
公开(公告)号：US20070287991A1
公开(公告)日：2007-12-13
申请号：US11449530
申请日：2006-06-08
申请人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
IPC分类号： A61K9/22
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/032 , A61B5/14539 , A61B5/4514 , A61B5/4561 , A61B5/4824 , A61B5/4896 , A61B5/6848 , G01N33/54366 , G01N33/6896 , G01N2800/2842
摘要： The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的装置和相关方法和组合，以及用于筛选潜在地可用于治疗或不发生神经根病变的轴向疼痛的测试化合物的方法。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。退行性椎间盘的疼痛标志物和标志物包括神经元，血管，免疫和基质元件的标记物。

5. 发明申请

US20090035250A1 Compositions and methods for treating cavity conditions 有权
标题翻译：用于治疗腔状况的组合物和方法
公开(公告)号：US20090035250A1
公开(公告)日：2009-02-05
申请号：US11890154
申请日：2007-08-03
申请人： Susan J. Drapeau , Josee Roy , Daniel Andrew Shimko
发明人： Susan J. Drapeau , Josee Roy , Daniel Andrew Shimko
IPC分类号： A61K31/74 , A61K33/06 , A61P43/00
CPC分类号： A61K31/74 , A61K31/77 , A61K33/06 , A61K45/06 , A61K2300/00
摘要： Compositions, methods and kits to be used as a lubricant and for treatment of a cavity pathology including joint pathology are provided. The composition comprises therapeutically effective amounts of at least one bioactive agent, such as magnesium compound, at least one lubricating agent, such as hyaluronic acid, and at least one cell membrane repairing agent, such as polyethylene glycol. The components of these compositions may be administered by a direct application, an application through a cannula, an intra-articular injection, as a flush fluid during an arthroscopy of the affected area, as a post-arthroscopy injection, or as part of a lavage of the area affected by the intra-articular pathology. In addition, the composition of the present invention may be administered to the patient from a pump or a depot.
摘要翻译：提供了用作润滑剂的组合物，方法和试剂盒以及用于治疗包括关节病理学在内的腔病理学。组合物包含治疗有效量的至少一种生物活性剂，例如镁化合物，至少一种润滑剂，例如透明质酸，和至少一种细胞膜修复剂，例如聚乙二醇。这些组合物的组分可以通过直接应用，通过插管施用，关节内注射，作为受影响区域的关节镜检查期间的冲洗液，作为关节内窥镜注射后或作为灌洗液的一部分施用的受关节内病变影响的区域。此外，本发明的组合物可以从泵或贮库给予患者。

6. 发明授权

US08354221B2 Methods and compositions for the preservation of cells and tissues 有权
标题翻译：用于保存细胞和组织的方法和组合物
公开(公告)号：US08354221B2
公开(公告)日：2013-01-15
申请号：US13033908
申请日：2011-02-24
申请人： Josee Roy , Susan J. Drapeau , Daniel Andrew Shimko
发明人： Josee Roy , Susan J. Drapeau , Daniel Andrew Shimko
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/021
摘要： Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic, or near-freezing, and then transported and implanted into a site within the body of a selected recipient animal, all without significant loss of cellular viability, tissue integrity, and/or biochemical function of the stored biological sample.
摘要翻译：公开了用于保存和储存活的生物组织，器官和分离细胞群体的方法。还公开了允许从合适的供体动物收获生物样品（包括例如细胞，细胞培养物，组织和器官）的组合物和方法，在冷藏，低温或近冷冻下长时间储存，然后运输和植入选定受体动物体内的部位，所有这些都不会显着损失存储的生物样品的细胞活力，组织完整性和/或生物化学功能。

7. 发明申请

US20110065083A1 Compositions and Methods for Enhancing the Viability of Animal Cells, Tissues, and Organ Explants 审中-公开
标题翻译：用于增强动物细胞，组织和器官外植体活力的组合物和方法
公开(公告)号：US20110065083A1
公开(公告)日：2011-03-17
申请号：US12950368
申请日：2010-11-19
申请人： Daniel Shimko , Scott Noel , Susan J. Drapeau , Josee Roy
发明人： Daniel Shimko , Scott Noel , Susan J. Drapeau , Josee Roy
IPC分类号： A01N1/02 , C12N5/07
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/021 , C12N5/0018 , C12N2500/30 , C12N2500/46 , C12N2500/60
摘要： Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity.
摘要翻译：公开了用于保存，储存和运输生物体组织，器官和分离细胞群体的组合物和方法。特别地，所公开的组合物和方法允许哺乳动物细胞，组织和器官从合适的供体动物中收获，长时间储存并转运到受体植入部位，所有细胞，组织和器官都不会显着损失细胞活力，生物活性和 /或组织完整性。

8. 发明申请

US20090017439A1 COMPOSITIONS AND METHODS FOR ENHANCING THE VIABILITY OF ANIMAL CELLS, TISSUES, AND ORGAN EXPLANTS 有权
标题翻译：用于增强动物细胞，组织和器官的可能性的组合物和方法
公开(公告)号：US20090017439A1
公开(公告)日：2009-01-15
申请号：US11777167
申请日：2007-07-12
申请人： Daniel Shimko , Scott Noel , Susan J. Drapeau , Josee Roy
发明人： Daniel Shimko , Scott Noel , Susan J. Drapeau , Josee Roy
IPC分类号： A01N1/02 , C12N5/02 , C12N5/06
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/021 , C12N5/0018 , C12N2500/30 , C12N2500/46 , C12N2500/60
摘要： Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity.
摘要翻译：公开了用于保存，储存和运输生物体组织，器官和分离细胞群体的组合物和方法。特别地，所公开的组合物和方法允许哺乳动物细胞，组织和器官从合适的供体动物中收获，长时间储存并转运到受体植入部位，所有细胞，组织和器官都不会显着损失细胞活力，生物活性和 /或组织完整性。

9. 发明申请

US20090017438A1 METHODS AND COMPOSITIONS FOR THE PRESERVATION OF CELLS AND TISSUES 有权
标题翻译：用于保存细胞和组织的方法和组合物
公开(公告)号：US20090017438A1
公开(公告)日：2009-01-15
申请号：US11777093
申请日：2007-07-12
申请人： Josee Roy , Susan J. Drapeau , Daniel Shimko
发明人： Josee Roy , Susan J. Drapeau , Daniel Shimko
IPC分类号： A01N1/00 , C12N5/06
CPC分类号： A01N1/02 , A01N1/021
摘要： Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic, or near-freezing, and then transported and implanted into a site within the body of a selected recipient animal, all without significant loss of cellular viability, tissue integrity, and/or biochemical function of the stored biological sample.
摘要翻译：公开了用于保存和储存活的生物组织，器官和分离细胞群体的方法。还公开了允许从合适的供体动物收获生物样品（包括例如细胞，细胞培养物，组织和器官）的组合物和方法，在冷藏，低温或近冷冻下长时间储存，然后运输和植入选定受体动物体内的部位，所有这些都不会显着损失存储的生物样品的细胞活力，组织完整性和/或生物化学功能。

10. 发明申请

US20080008988A1 Compositions and methods for diagnosis of axial pain with or without radiculopathy 有权
标题翻译：用于诊断具有或不具有神经根病变的轴向疼痛的组合物和方法
公开(公告)号：US20080008988A1
公开(公告)日：2008-01-10
申请号：US11449309
申请日：2006-06-08
申请人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
IPC分类号： C12Q1/00
CPC分类号： A61K49/0004 , A61K49/00
摘要： The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了与成像技术一起使用并且可用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的方法和组合以及用于筛选潜在地可用于治疗具有或没有神经根病变的轴向疼痛的治疗化合物的方法和组合物。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。疼痛标记和变性标记包括神经元，血管，免疫和基质元件的标记。

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