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1. 发明申请

US20070248959A1 Genetic markers for obesity 审中-公开
标题翻译：遗传标记肥胖
公开(公告)号：US20070248959A1
公开(公告)日：2007-10-25
申请号：US11384619
申请日：2006-03-20
申请人： Jose Ordovas , Lu Qi , Andrew Greenberg , Dolores Corella
发明人： Jose Ordovas , Lu Qi , Andrew Greenberg , Dolores Corella
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , C12Q1/6883 , C12Q2600/156
摘要： The present invention is directed to new genetic variants or polymorphisms at the perilipin locus (PLIN) including PLIN1: 6209T (allele 1)>C (allele 2); PLIN3 10171 (allele 1) A>T (allele 2); PLIN4: 11482G (allele 1)>A (allele 2); PLIN5: 13041A (allele 1)>G (allele 2) and PLIN6: 14995A (allele 1)>T (allele 2), and their use in diagnostic and prognostic applications for obesity and obesity-related diseases, such as metabolic syndrome and cardiovascular disease.
摘要翻译：本发明涉及包含PLIN1：6209T（等位基因1）> C（等位基因2）的perilipin基因座（PLIN）的新基因变异或多态性; PLIN3 10171（等位基因1）A> T（等位基因2）; PLIN4：11482G（等位基因1）> A（等位基因2）; T（等位基因1）> G（等位基因2）和PLIN6：14995A（等位基因1）> T（等位基因2），以及它们在诊断和预后应用中用于肥胖和肥胖相关疾病如代谢综合征和心血管疾病。

2. 发明申请

US20060252050A1 Genetic marker for weight regulation 审中-公开
标题翻译：用于体重调节的遗传标记
公开(公告)号：US20060252050A1
公开(公告)日：2006-11-09
申请号：US11123845
申请日：2005-05-06
申请人： Jose Ordovas , Dolores Corella
发明人： Jose Ordovas , Dolores Corella
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention is directed to methods capable of predicting likely response to weight loss and weight management based on genetic polymorphisms in the perilipin (PLIN) locus. The invention also provides kits to determine whether an individual is resistant to weight gain or weight loss based on analysis of genetic polymorphisms at the perilipin locus. This information can be used to screen individuals, such as obese and overweight individuals and classify them based on their genetic tendency to either lose weight or resistance to lose weight. Similarly, the polymorphisms can be used to identify individuals who are underweight, such as anorectic individuals, who could be genetically resistant to weight-gain using dietary intervention alone. Screening of normal weight individuals could help to identify people who are resistant to gaining or losing weight, or alternatively individuals, who are more susceptible for weight changes either to extreme high or low. Appropriate measures can then be implemented in life-style, diet, medicinal and possible surgical interventions. Such a genetic approach will help professionals in the field of weight-management to improve targeting patients with appropriate advise regarding their weight management.
摘要翻译：本发明涉及能够基于perilipin（PLIN）基因座中的遗传多态性来预测对体重减轻和体重管理的可能反应的方法。本发明还提供用于基于对perilipin基因座的遗传多态性的分析来确定个体是否抗体重增加或减肥的试剂盒。该信息可用于筛选个体，例如肥胖和超重个体，并根据其遗传倾向进行分类，以减肥或抵抗减肥。类似地，多态性可以用于鉴别体重不足的个体，例如厌食症个体，其可以单独使用饮食干预而在遗传上抵抗体重增加。筛查正常体重的个体可以帮助识别抵抗或减轻体重的人，或者可能是更容易受到体重变化影响的极端高低者。然后可以在生活方式，饮食，药物和可能的外科手术中实施适当的措施。这种遗传方法将帮助体重管理领域的专业人员改善针对患者的适当建议，以体重管理。

3. 发明申请

US20130011841A1 Genetic Association of Polymorphisms in Perilipin (PLIN) Gene With Resistance to Weight Loss 审中-公开
标题翻译：具有抗体重减肥作用的Perilipin（PLIN）基因多态性遗传学研究
公开(公告)号：US20130011841A1
公开(公告)日：2013-01-10
申请号：US13615204
申请日：2012-09-13
申请人： Nazneen Aziz , Prakash Prabhakar , Venkateswarlu Kondragunta , Jose Ordovas , Susan B. Roberts , Sai Krupa Das
发明人： Nazneen Aziz , Prakash Prabhakar , Venkateswarlu Kondragunta , Jose Ordovas , Susan B. Roberts , Sai Krupa Das
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , Y10T436/143333
摘要： Diagnostics and therapeutics for resistance to weight-loss, which are based upon the identification of a subject's PLIN polymorphisms, haplotype and genotype pattern, are described in this invention.
摘要翻译：在本发明中描述了基于对象的PLIN多态性，单体型和基因型模式的鉴定的抗体重减轻的诊断和治疗。

4. 发明申请

US20110008906A1 Genetic Association of Polymorphisms in Perilipin (PLIN) Gene With Resistance to Weight Loss 审中-公开
标题翻译：具有抗体重减肥作用的Perilipin（PLIN）基因多态性遗传学研究
公开(公告)号：US20110008906A1
公开(公告)日：2011-01-13
申请号：US12833467
申请日：2010-07-09
申请人： Nazneen Aziz , Prakash Prabhakar , Venkateswarlu Kondragunta , Jose Ordovas , Susan B. Roberts , Sai Krupa Das
发明人： Nazneen Aziz , Prakash Prabhakar , Venkateswarlu Kondragunta , Jose Ordovas , Susan B. Roberts , Sai Krupa Das
IPC分类号： G01N33/48
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , Y10T436/143333
摘要： Diagnostics and therapeutics for resistance to weight-loss, which are based upon the identification of a subject's PLIN polymorphisms, haplotype and genotype pattern, are described in this invention.
摘要翻译：在本发明中描述了基于对象的PLIN多态性，单体型和基因型模式的鉴定的抗体重减轻的诊断和治疗。

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