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1. 发明申请

US20070248959A1 Genetic markers for obesity 审中-公开
标题翻译：遗传标记肥胖
公开(公告)号：US20070248959A1
公开(公告)日：2007-10-25
申请号：US11384619
申请日：2006-03-20
申请人： Jose Ordovas , Lu Qi , Andrew Greenberg , Dolores Corella
发明人： Jose Ordovas , Lu Qi , Andrew Greenberg , Dolores Corella
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , C12Q1/6883 , C12Q2600/156
摘要： The present invention is directed to new genetic variants or polymorphisms at the perilipin locus (PLIN) including PLIN1: 6209T (allele 1)>C (allele 2); PLIN3 10171 (allele 1) A>T (allele 2); PLIN4: 11482G (allele 1)>A (allele 2); PLIN5: 13041A (allele 1)>G (allele 2) and PLIN6: 14995A (allele 1)>T (allele 2), and their use in diagnostic and prognostic applications for obesity and obesity-related diseases, such as metabolic syndrome and cardiovascular disease.
摘要翻译：本发明涉及包含PLIN1：6209T（等位基因1）> C（等位基因2）的perilipin基因座（PLIN）的新基因变异或多态性; PLIN3 10171（等位基因1）A> T（等位基因2）; PLIN4：11482G（等位基因1）> A（等位基因2）; T（等位基因1）> G（等位基因2）和PLIN6：14995A（等位基因1）> T（等位基因2），以及它们在诊断和预后应用中用于肥胖和肥胖相关疾病如代谢综合征和心血管疾病。

2. 发明申请

US20100184081A1 GENETIC MARKERS FOR OBESITY 审中-公开
标题翻译：遗传标记为肥胖
公开(公告)号：US20100184081A1
公开(公告)日：2010-07-22
申请号：US12749899
申请日：2010-03-30
申请人： Jose M. Ordovas , Lu Qi , Andrew Greenberg , Dolores Corella
发明人： Jose M. Ordovas , Lu Qi , Andrew Greenberg , Dolores Corella
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , C12Q1/6883 , C12Q2600/156
摘要： The present invention is directed to new genetic variants or polymorphisms at the perilipin locus (PLIN) including PLIN1: 6209T (allele 1)>C (allele 2); PLIN3 10171 (allele 1) A >T (allele 2); PLIN4: 11482G (allele 1)>A (allele 2); PLIN5: 13041A (allele 1)>G (allele 2) and PLIN6: 14995A (allele 1)>T (allele 2), and their use in diagnostic and prognostic applications for obesity and obesity-related diseases, such as metabolic syndrome and cardiovascular disease.
摘要翻译：本发明涉及包含PLIN1：6209T（等位基因1）> C（等位基因2）的perilipin基因座（PLIN）的新基因变异或多态性; PLIN3 10171（等位基因1）A> T（等位基因2）; PLIN4：11482G（等位基因1）> A（等位基因2）; T（等位基因1）> G（等位基因2）和PLIN6：14995A（等位基因1）> T（等位基因2），以及它们在诊断和预后应用中用于肥胖和肥胖相关疾病如代谢综合征和心血管疾病。

3. 发明申请

US20060252050A1 Genetic marker for weight regulation 审中-公开
标题翻译：用于体重调节的遗传标记
公开(公告)号：US20060252050A1
公开(公告)日：2006-11-09
申请号：US11123845
申请日：2005-05-06
申请人： Jose Ordovas , Dolores Corella
发明人： Jose Ordovas , Dolores Corella
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention is directed to methods capable of predicting likely response to weight loss and weight management based on genetic polymorphisms in the perilipin (PLIN) locus. The invention also provides kits to determine whether an individual is resistant to weight gain or weight loss based on analysis of genetic polymorphisms at the perilipin locus. This information can be used to screen individuals, such as obese and overweight individuals and classify them based on their genetic tendency to either lose weight or resistance to lose weight. Similarly, the polymorphisms can be used to identify individuals who are underweight, such as anorectic individuals, who could be genetically resistant to weight-gain using dietary intervention alone. Screening of normal weight individuals could help to identify people who are resistant to gaining or losing weight, or alternatively individuals, who are more susceptible for weight changes either to extreme high or low. Appropriate measures can then be implemented in life-style, diet, medicinal and possible surgical interventions. Such a genetic approach will help professionals in the field of weight-management to improve targeting patients with appropriate advise regarding their weight management.
摘要翻译：本发明涉及能够基于perilipin（PLIN）基因座中的遗传多态性来预测对体重减轻和体重管理的可能反应的方法。本发明还提供用于基于对perilipin基因座的遗传多态性的分析来确定个体是否抗体重增加或减肥的试剂盒。该信息可用于筛选个体，例如肥胖和超重个体，并根据其遗传倾向进行分类，以减肥或抵抗减肥。类似地，多态性可以用于鉴别体重不足的个体，例如厌食症个体，其可以单独使用饮食干预而在遗传上抵抗体重增加。筛查正常体重的个体可以帮助识别抵抗或减轻体重的人，或者可能是更容易受到体重变化影响的极端高低者。然后可以在生活方式，饮食，药物和可能的外科手术中实施适当的措施。这种遗传方法将帮助体重管理领域的专业人员改善针对患者的适当建议，以体重管理。

4. 发明申请

US20080171335A1 METHOD FOR PERSONALIZED DIET DESIGN 审中-公开
标题翻译：个性化饮食设计方法
公开(公告)号：US20080171335A1
公开(公告)日：2008-07-17
申请号：US11948099
申请日：2007-11-30
申请人： Jose M. Ordovas , Dolores Corella , Chao-Qiang Lai
发明人： Jose M. Ordovas , Dolores Corella , Chao-Qiang Lai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides methods and kits for designing a diet with a desired fat content for an individual in need thereof to allow the individual to, for example, maintain or reduce healthy weight, manage diabetes, for example by managing weight or accommodate a food allergy. The method comprises determining whether the individual carries APOA5 −1131T and/or C allele or both or any allele in chromosome 11 that is in a tight linkage disequilibrium with said-alleles, wherein if the individual is a homozygote for APOA5 −1131T allele or an allele in tight linkage disequilibrium with APOA5 −1131T allele, the designing of a diet comprises reducing a total fat content of the diet below 30% of total calorie intake and/or reducing the amount of monounsaturated fatty acids in the diet under about 11% of total calorie intake. We surprisingly found that these methods and kits apply to both females and males and to a variety of ethnic backgrounds.
摘要翻译：本发明提供了用于为有需要的个体设计具有所需脂肪含量的饮食的方法和试剂盒，以允许个体例如维持或减少健康体重，例如通过控制体重或适应食物过敏来控制糖尿病。该方法包括确定个体是否携带与所述等位基因处于紧密连锁不平衡中的APOA5 -1131T和/或C等位基因或两者或任何等位基因，其中如果个体是APOA5 -1131T等位基因的纯合子或等位基因与APOA5 -1131T等位基因紧密连锁不平衡，饮食的设计包括将膳食中总脂肪含量降低至总卡路里摄入量的30％以下，和/或减少饮食中单不饱和脂肪酸的量约11％总卡路里摄入量我们惊奇地发现，这些方法和试剂盒适用于女性和男性以及各种种族背景。

5. 发明申请

US20090222282A1 Method for Personalized Diet Design 审中-公开
标题翻译：个性化饮食设计方法
公开(公告)号：US20090222282A1
公开(公告)日：2009-09-03
申请号：US12066902
申请日：2006-09-15
申请人： Jose M. Ordovas , Dolores Corella
发明人： Jose M. Ordovas , Dolores Corella
IPC分类号： G06Q50/00 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , G06Q50/22
摘要： The present invention is directed to methods of developing dietary guidelines, particularly associated with dietary consumption of fatty acids. We discovered an association of a polymorphic marker with regulation of plasma lipid levels in response to dietary intake of polyunsaturated fatty acids. Accordingly, the present invention provides methods for providing individualized guidance in design of dietary interventions to alter plasma lipid profiles by genotyping APOA5 locus, wherein the presence of APOA5−1131C, APOA5−3G, APOA5 IVS3+476A, and APOA5 1259C alleles or alleles that are found to be in tight linkage disequilibrium with APOA5−1131C, APOA5−3G, APOA5 IVS3+476A, and APOA5 1259C alleles, is indicative of the individual being susceptible to altered plasma lipid levels in response to intake of n-6 polyunsaturated fatty acids.
摘要翻译：本发明涉及制定饮食指南的方法，特别是与脂肪酸的饮食消耗相关。我们发现多态性标记物与多种不饱和脂肪酸饮食摄入的血浆脂质水平调节有关。因此，本发明提供了通过基因分型APOA5基因座在膳食干预设计中提供个体化指导以提供血浆脂质谱的方法，其中APOA5-1131C，APOA5-3G，APOA5 IVS3 + 476A和APOA5 1259C等位基因或等位基因的存在被发现与APOA5-1131C，APOA5-3G，APOA5 IVS3 + 476A和APOA5 1259C等位基因处于紧密连锁不平衡状态，这表明个体对n-6多不饱和脂肪酸摄入的响应易于血浆脂质水平改变。

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