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    • 4. 发明申请
    • Compositions and Methods for Treating Type II Diabetes and Related Disorders
    • 治疗II型糖尿病及相关疾病的组合物和方法
    • US20120095059A1
    • 2012-04-19
    • US13086213
    • 2011-04-13
    • Jorge Luis RosadoMiguel Angel Duarte-Vázquez
    • Jorge Luis RosadoMiguel Angel Duarte-Vázquez
    • A61K31/4439A61P3/10
    • A61K31/155A61K31/44A61K45/06A61K2300/00
    • The present invention relates to methods and compositions for treating type II diabetes. This invention discloses an orally administrable pharmaceutical formulation, as convenient therapy to reduce glucose levels in blood, preventing the development of diabetes and an earlier exhausting of the pancreas. In certain embodiments, the invention provides orally administerable combination pharmaceutical formulations, comprising at least one insulin sensitizer (e.g., a glitazone such as pioglitazone or rosiglitazone), at least one sulfonylurea (e.g., glimepiride), and at least one biguanide (e.g., metformin or a pharmaceutically acceptable salt or ester thereof, such as metformin HCl). The present invention also provides methods of treating type II diabetes and related disorders in a mammal, suitably a human, by administering to a mammal in need thereof one or more of the compositions of the present invention.
    • 本发明涉及用于治疗II型糖尿病的方法和组合物。 本发明公开了一种可口服给药的药物制剂,作为减少血液中葡萄糖水平的方便疗法,预防糖尿病的发展和胰腺早期排尿。 在某些实施方案中,本发明提供口服给药的组合药物制剂,其包含至少一种胰岛素敏化剂(例如,格列酮如吡格列酮或罗格列酮),至少一种磺酰脲(例如格列美脲)和至少一种双胍(例如二甲双胍 或其药学上可接受的盐或酯,例如二甲双胍HCl)。 本发明还提供了通过向有需要的哺乳动物施用本发明的一种或多种组合物来治疗哺乳动物,适合人类II型糖尿病和相关疾病的方法。