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1. 发明申请

US20120095059A1 Compositions and Methods for Treating Type II Diabetes and Related Disorders 审中-公开
标题翻译：治疗II型糖尿病及相关疾病的组合物和方法
公开(公告)号：US20120095059A1
公开(公告)日：2012-04-19
申请号：US13086213
申请日：2011-04-13
申请人： Jorge Luis Rosado , Miguel Angel Duarte-Vázquez
发明人： Jorge Luis Rosado , Miguel Angel Duarte-Vázquez
IPC分类号： A61K31/4439 , A61P3/10
CPC分类号： A61K31/155 , A61K31/44 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods and compositions for treating type II diabetes. This invention discloses an orally administrable pharmaceutical formulation, as convenient therapy to reduce glucose levels in blood, preventing the development of diabetes and an earlier exhausting of the pancreas. In certain embodiments, the invention provides orally administerable combination pharmaceutical formulations, comprising at least one insulin sensitizer (e.g., a glitazone such as pioglitazone or rosiglitazone), at least one sulfonylurea (e.g., glimepiride), and at least one biguanide (e.g., metformin or a pharmaceutically acceptable salt or ester thereof, such as metformin HCl). The present invention also provides methods of treating type II diabetes and related disorders in a mammal, suitably a human, by administering to a mammal in need thereof one or more of the compositions of the present invention.
摘要翻译：本发明涉及用于治疗II型糖尿病的方法和组合物。本发明公开了一种可口服给药的药物制剂，作为减少血液中葡萄糖水平的方便疗法，预防糖尿病的发展和胰腺早期排尿。在某些实施方案中，本发明提供口服给药的组合药物制剂，其包含至少一种胰岛素敏化剂（例如，格列酮如吡格列酮或罗格列酮），至少一种磺酰脲（例如格列美脲）和至少一种双胍（例如二甲双胍或其药学上可接受的盐或酯，例如二甲双胍HCl）。本发明还提供了通过向有需要的哺乳动物施用本发明的一种或多种组合物来治疗哺乳动物，适合人类II型糖尿病和相关疾病的方法。

2. 发明申请

US20120021049A1 Single Daily Dosage Form for Prevention and Treatment of Metabolic Syndrome 有权
标题翻译：单次日剂量代谢综合征预防和治疗方法
公开(公告)号：US20120021049A1
公开(公告)日：2012-01-26
申请号：US13188265
申请日：2011-07-21
申请人： Miguel Angel Duarte-Vázquez , Sandra Garcia Padilla , Jorge Luis Rosado
发明人： Miguel Angel Duarte-Vázquez , Sandra Garcia Padilla , Jorge Luis Rosado
IPC分类号： A61K9/48 , A61K31/403 , A61P3/00 , A61K31/60 , A61K31/155 , A61K31/40 , A61K31/41
CPC分类号： A61K45/06 , A61K9/4808 , A61K31/155 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/60 , A61K2300/00
摘要： The present invention is in the fields of medicine, pharmaceuticals, nutraceuticals, endocrinology and cardiology. The invention provides compositions comprising a statin, an inhibitor of the angiotensin converting enzyme, an antiplatelet compound and an anti-hyperglycemic compound for use in the treatment and/or prevention of cardiometabolic risk factors of Metabolic Syndrome and treatment and/or prevention of Metabolic Syndrome. The present invention provides for the use of such compositions in the manufacture of products for treatment and/or prevention of Metabolic Syndrome. The biguanide metformin of the composition could be present in extended release form allowing its use together with the other drugs in a single dosage form at low dose. This combination of drugs in a single daily dosage greatly improves compliance and adherence to treatment which is a critical factor for treating patients with Metabolic Syndrome.
摘要翻译：本发明涉及药物，药物，保健品，内分泌学和心脏病学领域。本发明提供了包含他汀类药物，血管紧张素转换酶抑制剂，抗血小板药物和抗高血糖化合物的组合物，其用于治疗和/或预防代谢综合征的心脏代谢危险因素，并且治疗和/或预防代谢综合征。本发明提供了这种组合物在制备用于治疗和/或预防代谢综合征的产品中的用途。组合物的双胍二甲双胍可以以延长释放形式存在，允许其与低剂量的单一剂型与其它药物一起使用。这种单一日剂量的药物组合大大提高了依从性和对治疗的依从性，这是治疗代谢综合征患者的关键因素。

3. 发明授权

US09056134B2 Single daily dosage form for prevention and treatment of metabolic syndrome 有权
标题翻译：单次日剂量预防和治疗代谢综合征
公开(公告)号：US09056134B2
公开(公告)日：2015-06-16
申请号：US13188265
申请日：2011-07-21
申请人： Miguel Angel Duarte-Vazquez , Sandra Garcia Padilla , Jorge Luis Rosado
发明人： Miguel Angel Duarte-Vazquez , Sandra Garcia Padilla , Jorge Luis Rosado
IPC分类号： A61K9/48 , A61K45/06 , A61K31/155 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/60
CPC分类号： A61K45/06 , A61K9/4808 , A61K31/155 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/60 , A61K2300/00
摘要： The present invention is in the fields of medicine, pharmaceuticals, nutraceuticals, endocrinology and cardiology. The invention provides compositions comprising a statin, an inhibitor of the angiotensin converting enzyme, an antiplatelet compound and an anti-hyperglycemic compound for use in the treatment and/or prevention of cardiometabolic risk factors of Metabolic Syndrome and treatment and/or prevention of Metabolic Syndrome. The present invention provides for the use of such compositions in the manufacture of products for treatment and/or prevention of Metabolic Syndrome. The biguanide metformin of the composition could be present in extended release form allowing its use together with the other drugs in a single dosage form at low dose. This combination of drugs in a single daily dosage greatly improves compliance and adherence to treatment which is a critical factor for treating patients with Metabolic Syndrome.
摘要翻译：本发明涉及药物，药物，保健品，内分泌学和心脏病学领域。本发明提供了包含他汀类药物，血管紧张素转换酶抑制剂，抗血小板药化合物和抗高血糖化合物的组合物，其用于治疗和/或预防代谢综合征的心脏代谢危险因素，以及治疗和/或预防代谢综合征。本发明提供了这种组合物在制备用于治疗和/或预防代谢综合征的产品中的用途。组合物的双胍二甲双胍可以以延长释放形式存在，允许其与低剂量的单一剂型与其它药物一起使用。这种单一日剂量的药物组合大大提高了依从性和对治疗的依从性，这是治疗代谢综合征患者的关键因素。

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