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1. 发明申请

US20140142031A1 CYCLIC PEPTIDE FROM NONOMURAEA SP., PROCESS FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF MYCOBACTERIA RELATED DISEASE COMPRISING THE SAME 有权
标题翻译：非生产菌株的循环肽，其生产方法和用于预防或治疗包含其的MYCOBACTERIA相关疾病的药物组合物
公开(公告)号：US20140142031A1
公开(公告)日：2014-05-22
申请号：US14112720
申请日：2012-04-18
申请人： Jong Woo Kim , Sang Wook Lee , Sang jin Park , Joo Won Suh , In Ae Lee , Tae Mi Yoon , Jong Keun Choi , Ji Ean Lee , Jin Yong Kim , Ying Yu Jin , Scott Franzblau , Sanghyum Cho , Wei Gao , Guido Pauli , James McAlpine , Jose Napolitano , Birgit Jaki , Brent Friesen , Maria Florencia Rodriguez Brasco , David Lankin
发明人： Jong Woo Kim , Sang Wook Lee , Sang jin Park , Joo Won Suh , In Ae Lee , Tae Mi Yoon , Jong Keun Choi , Ji Ean Lee , Jin Yong Kim , Ying Yu Jin , Scott Franzblau , Sanghyum Cho , Wei Gao , Guido Pauli , James McAlpine , Jose Napolitano , Birgit Jaki , Brent Friesen , Maria Florencia Rodriguez Brasco , David Lankin
IPC分类号： C07K7/54
CPC分类号： C07K7/54 , A61K38/00 , C07K7/08
摘要： The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.
摘要翻译：本发明涉及来自Nonomuraea sp。的新型抗TB环肽。 MJM5123是生产抗结核肽的方法和用于预防和治疗包含其的分枝杆菌感染的药物组合物。本发明的组合物对复制/非复制性结核分枝杆菌（包括MDR和XDR菌株）具有高度活性，因此可有效地用作结核病的治疗剂。

2. 发明授权

US09090667B2 Cyclic peptide from Nonomuraea sp., process for the production thereof, and pharmaceutical composition for the prevention or treatment of mycobacteria related disease comprising the same 有权
标题翻译：来自Nonomuraea sp。的环肽，其制备方法，以及用于预防或治疗包含其的分枝杆菌相关疾病的药物组合物
公开(公告)号：US09090667B2
公开(公告)日：2015-07-28
申请号：US14112720
申请日：2012-04-18
申请人： Jong Woo Kim , Sang Wook Lee , Sang Jin Park , Joo Won Suh , In Ae Lee , Tae Mi Yoon , Jong Keun Choi , Ji Ean Lee , Jin Yong Kim , Ying Yu Jin , Scott Franzblau , Sanghyun Cho , Wei Gao , Guido Pauli , James McAlpine , Jose Napolitano , Birgit Jaki , Brent Friesen , Maria Florencia Rodriguez Brasco , David Lankin
发明人： Jong Woo Kim , Sang Wook Lee , Sang Jin Park , Joo Won Suh , In Ae Lee , Tae Mi Yoon , Jong Keun Choi , Ji Ean Lee , Jin Yong Kim , Ying Yu Jin , Scott Franzblau , Sanghyun Cho , Wei Gao , Guido Pauli , James McAlpine , Jose Napolitano , Birgit Jaki , Brent Friesen , Maria Florencia Rodriguez Brasco , David Lankin
IPC分类号： C07K7/54 , C07K7/08 , A61K38/00
CPC分类号： C07K7/54 , A61K38/00 , C07K7/08
摘要： The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.
摘要翻译：本发明涉及来自Nonomuraea sp。的新型抗TB环肽。 MJM5123是生产抗结核肽的方法和用于预防和治疗包含其的分枝杆菌感染的药物组合物。本发明的组合物对复制/非复制性结核分枝杆菌（包括MDR和XDR菌株）具有高度活性，因此可有效地用作结核病的治疗剂。

3. 发明授权

US07698245B2 Applying rules to validating data for a machine arrangement 有权
标题翻译：应用规则验证机器安排的数据
公开(公告)号：US07698245B2
公开(公告)日：2010-04-13
申请号：US11685859
申请日：2007-03-14
申请人： Eric Newman , Joseph Walacavage , Earl Dishaw , James McAlpine
发明人： Eric Newman , Joseph Walacavage , Earl Dishaw , James McAlpine
IPC分类号： G06F17/00 , G06N5/02
CPC分类号： G05B19/4183 , G05B2219/31318 , G05B2219/31395 , G05B2219/31402 , Y02P90/10
摘要： A system and method for validating data for a machine arrangement includes a controller, such as a programmable logic controller, connected to a processor, which is configured to execute an algorithm using the data collected by the controller. The algorithm includes one or more rules that are applicable to the collected data. Each rule is applied to the data to determine if any of the data entries violate one or more of the rules. An output is generated indicating whether the data violates any of the rules, thereby providing information regarding the validity of the data being captured.
摘要翻译：用于验证机器布置的数据的系统和方法包括连接到处理器的诸如可编程逻辑控制器的控制器，其被配置为使用由控制器收集的数据来执行算法。该算法包括适用于收集的数据的一个或多个规则。每个规则都应用于数据，以确定任何数据条目是否违反一个或多个规则。生成指示数据是否违反任何规则的输出，从而提供关于正在捕获的数据的有效性的信息。

4. 发明申请

US20080010025A1 System, knowledge repository and computer-readable medium for identifying a secondary metabolite from a microorganism 审中-公开
标题翻译：用于从微生物鉴定次级代谢物的系统，知识库和计算机可读介质
公开(公告)号：US20080010025A1
公开(公告)日：2008-01-10
申请号：US11551137
申请日：2006-10-19
申请人： Chris Farnet , James McAlpine , Brian Bachmann , Alfredo Staffa , Emmanuel Zazopoulos
发明人： Chris Farnet , James McAlpine , Brian Bachmann , Alfredo Staffa , Emmanuel Zazopoulos
IPC分类号： G01N33/50
CPC分类号： C12Q1/025
摘要： The invention relates to a method and system for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.
摘要翻译：本发明涉及鉴定由微生物内的靶基因簇合成的次级代谢物的方法和系统。推定或确认的功能归因于基因簇内的基因，并且获得了怀疑含有由基因簇合成的次级代谢物的微生物提取物。然后评估提取物的化学，物理或生物学性质，并鉴定和任选分离代谢物。此外，本发明提供了知识库，其中基因簇信息与次级代谢产生数据相关联。本发明还涉及用于访问知识库的图形用户界面和用于存储数据的存储器，其具有存储在存储器中的数据结构。

5. 发明申请

US20070143076A1 Identifying and visualizing faults in PLC-based manufacturing systems 有权
标题翻译：识别和可视化基于PLC的制造系统中的故障
公开(公告)号：US20070143076A1
公开(公告)日：2007-06-21
申请号：US11295027
申请日：2005-12-05
申请人： Joe Walacavage , Eric Newman , James McAlpine
发明人： Joe Walacavage , Eric Newman , James McAlpine
IPC分类号： G06F15/00
CPC分类号： G05B19/058 , G05B23/0272
摘要： Textual fault messages in PLC-based manufacturing systems are supplemented by automatically displayed sets of information that allow an operator to quickly identify, recognize and visualize components responsible for producing faults. Visual display of stored computer generated images showing system components and tooling allow the operator to visually pinpoint the exact component responsible for the fault, and its location within the manufacturing system. Stored information associated with the component producing the fault, such as installation date, vendor sources, replacement part inventory, programming logic and editing software, is also automatically recalled and displayed along with the fault message to aid fault diagnosis and correction.
摘要翻译：基于PLC的制造系统中的文本故障消息由自动显示的信息组合补充，允许操作员快速识别，识别和可视化负责生成故障的组件。显示系统组件和工具的存储计算机生成的图像的可视化显示允许操作者在视觉上精确定位负责故障的确切组件及其在制造系统内的位置。与产生故障的部件相关联的存储信息，如安装日期，供应商来源，更换部件库存，编程逻辑和编辑软件，也会自动调出并显示与故障信息一起，以帮助故障诊断和更正。

6. 发明申请

US20060079509A1 Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals 失效
公开(公告)号：US20060079509A1
公开(公告)日：2006-04-13
申请号：US11235398
申请日：2005-09-27
申请人： James McAlpine , Arjun Banskota , Mustapha Aouidate
发明人： James McAlpine , Arjun Banskota , Mustapha Aouidate
IPC分类号： A61K31/551 , C07D243/10
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.

7. 发明申请

US20060079508A1 Compositions and methods comprising farnesyl dibenzodiazepinones for treating neoplastic cells and conditions 失效
标题翻译：包含法呢基二苯并二氮杂酮用于治疗肿瘤细胞和病症的组合物和方法
公开(公告)号：US20060079508A1
公开(公告)日：2006-04-13
申请号：US11130295
申请日：2005-05-16
申请人： Pierre Falardeau , Francois Berger , Henriette Gourdeau , James McAlpine , Chris Farnet , Violetta Dimitriadou
发明人： Pierre Falardeau , Francois Berger , Henriette Gourdeau , James McAlpine , Chris Farnet , Violetta Dimitriadou
IPC分类号： A61K31/551 , C07D243/10
CPC分类号： C07D243/38 , A61K31/551
摘要： This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms using the farnesylated dibenzodiazepinone compound of Formula I. The invention includes pharmaceutical compositions comprising the compound of Formula I:
摘要翻译：本发明涉及抑制肿瘤细胞生长和/或增殖的方法，以及使用式I的法呢基化二苯并二氮杂酮化合物治疗肿瘤的方法。本发明包括药物组合物，其包含式I化合物：

8. 发明申请

US20050004185A1 Polyene polyketides, processes for their production and their use as pharmaceuticals 审中-公开
标题翻译：聚烯烃聚合物，其生产工艺及其作为药物的使用
公开(公告)号：US20050004185A1
公开(公告)日：2005-01-06
申请号：US10844701
申请日：2004-05-13
申请人： Brian Bachmann , James McAlpine , Emmanuel Zazopoulos , Chris Farnet
发明人： Brian Bachmann , James McAlpine , Emmanuel Zazopoulos , Chris Farnet
IPC分类号： A61P31/00 , C07C215/24 , C07C279/14 , C07C279/22 , C07C305/14 , C12P7/42 , C12P11/00 , C12P13/00 , C12P19/44 , C07D213/42 , C07D207/10
CPC分类号： C07C59/42 , C07C59/90 , C07C215/24 , C07C279/14 , C07C279/22 , C07C305/14 , C07C2601/14 , C07D207/16 , C07D213/53 , C07D213/82 , C07D303/36 , C07D317/30 , C12P7/42 , C12P11/00 , C12P13/001 , C12P13/02 , C12P19/44 , C12R1/465
摘要： This invention relates to a novel class of linear polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for their production. The compounds may be obtained by cultivation of Streptomyces melanosporafaciens species and isolation of the polyene polyketide, followed by optional chemical production of the isolated polyene polyketide. The compounds may also be produced by other known bacteria. The invention further includes the use of these compounds as inhibitors of fungal cell growth and inhibitors of cancer cell growth. Finally, the invention encompasses pharmaceutical compositions comprising these novel polyketide compounds, or their pharmaceutically acceptable salts or derivatives thereof.
摘要翻译：本发明涉及新型线型多烯聚酮化合物，其药学上可接受的盐和衍生物及其生产方法。可以通过培养黑色链霉菌属物种并分离多烯聚酮来获得化合物，然后任选化学制备分离的多烯聚酮化合物。化合物也可以由其他已知细菌产生。本发明还包括这些化合物作为真菌细胞生长抑制剂和癌细胞生长抑制剂的用途。最后，本发明包括包含这些新型聚酮化合物或其药学上可接受的盐或衍生物的药物组合物。

9. 发明授权

US07433801B2 Identifying and visualizing faults in PLC-based manufacturing systems 有权
标题翻译：识别和可视化基于PLC的制造系统中的故障
公开(公告)号：US07433801B2
公开(公告)日：2008-10-07
申请号：US11295027
申请日：2005-12-05
申请人： Joe Walacavage , Eric Newman , James McAlpine
发明人： Joe Walacavage , Eric Newman , James McAlpine
IPC分类号： G06F15/00
CPC分类号： G05B19/058 , G05B23/0272
摘要： Textual fault messages in PLC-based manufacturing systems are supplemented by automatically displayed sets of information that allow an operator to quickly identify, recognize and visualize components responsible for producing faults. Visual display of stored computer generated images showing system components and tooling allow the operator to visually pinpoint the exact component responsible for the fault, and its location within the manufacturing system. Stored information associated with the component producing the fault, such as installation date, vendor sources, replacement part inventory, programming logic and editing software, is also automatically recalled and displayed along with the fault message to aid fault diagnosis and correction.
摘要翻译：基于PLC的制造系统中的文本故障消息由自动显示的信息组合补充，允许操作员快速识别，识别和可视化负责生成故障的组件。显示系统组件和工具的存储计算机生成的图像的可视化显示允许操作者在视觉上精确定位负责故障的确切组件及其在制造系统内的位置。与产生故障的部件相关联的存储信息，如安装日期，供应商来源，更换部件库存，编程逻辑和编辑软件，也会自动调出并显示与故障信息一起，以帮助故障诊断和更正。

10. 发明申请

US20080133031A1 SYSTEM AND METHOD FOR VALIDATING DATA FOR A MACHINE 有权
标题翻译：用于机器数据验证的系统和方法
公开(公告)号：US20080133031A1
公开(公告)日：2008-06-05
申请号：US11685859
申请日：2007-03-14
申请人： Eric Newman , Joseph Walacavage , Earl Dishaw , James McAlpine
发明人： Eric Newman , Joseph Walacavage , Earl Dishaw , James McAlpine
IPC分类号： G05B21/02 , G05B15/00 , G06F7/42 , G05B19/42
CPC分类号： G05B19/4183 , G05B2219/31318 , G05B2219/31395 , G05B2219/31402 , Y02P90/10
摘要： A system and method for validating data for a machine arrangement includes a controller, such as a programmable logic controller, connected to a processor, which is configured to execute an algorithm using the data collected by the controller. The algorithm includes one or more rules that are applicable to the collected data. Each rule is applied to the data to determine if any of the data entries violate one or more of the rules. An output is generated indicating whether the data violates any of the rules, thereby providing information regarding the validity of the data being captured.
摘要翻译：用于验证机器布置的数据的系统和方法包括连接到处理器的诸如可编程逻辑控制器的控制器，其被配置为使用由控制器收集的数据来执行算法。该算法包括适用于收集的数据的一个或多个规则。每个规则都应用于数据，以确定任何数据条目是否违反一个或多个规则。生成指示数据是否违反任何规则的输出，从而提供关于正在捕获的数据的有效性的信息。

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