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1. 发明授权

US5624817A Mutations in the gene encoding the alpha chain of platelet glycoprotein Ib 失效
标题翻译：编码血小板糖蛋白Ⅰα链的基因突变
公开(公告)号：US5624817A
公开(公告)日：1997-04-29
申请号：US234265
申请日：1994-04-28
申请人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch , Matthew R. Pincus
发明人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch , Matthew R. Pincus
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C12N15/12 , C12N15/11 , C12N15/63 , C12N5/10
CPC分类号： A61K47/48238 , C07K14/705 , A61K38/00
摘要： The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide more reactive with yon Willebrand factor. Preferably, the mutation is in the hinge region of GP Ib.alpha., such as the substitution of valine for glycine at residue 233. These mutations alter the three-dimensional structure of the mutant polypeptide from a beta bend conformation to an alpha helix formation, and also create an amphipathic region within the mutant polypeptide. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
摘要翻译：本发明提供由天然存在的野生型血小板糖蛋白Ibα编码的纯化多肽，其具有使得多肽与阴离子血友病因子更具反应性的突变。优选地，突变位于GPIbα的铰链区，例如在残基233处取代缬氨酸甘氨酸。这些突变将突变多肽的三维结构从β弯曲构象改变为α螺旋形成，并且还在突变体多肽内产生两亲性区域。还提供了编码突变体多肽的DNA，以及用于产生突变体多肽的表达系统。还提供了使用与突变体多肽互补的突变多肽和DNA寡聚体的方法和组合物。

2. 发明授权

US5593959A Mutations in the gene encoding the alpha chain of platelet glycoprotein Ib 失效
标题翻译：编码血小板糖蛋白Ⅰα链的基因突变
公开(公告)号：US5593959A
公开(公告)日：1997-01-14
申请号：US135929
申请日：1993-10-14
申请人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch , Matthew R. Pincus
发明人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch , Matthew R. Pincus
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C12N15/12 , C07K14/745 , A61K38/17 , A61K38/36
CPC分类号： A61K47/48238 , C07K14/705 , A61K38/00
摘要： The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide more reactive with von Willebrand factor. Preferably, the mutation is in the hinge region of GP Ib.alpha., such as the substitution of valine for glycine at residue 233. These mutations alter the three-dimensional structure of the mutant polypeptide from a beta bend conformation to an alpha helix formation, and also create an amphipathic region within the mutant polypeptide. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
摘要翻译：本发明提供由天然存在的野生型血小板糖蛋白Ibα编码的纯化多肽，其具有使得多肽与血管性血友病因子更具反应性的突变。优选地，突变位于GPIbα的铰链区，例如在残基233处取代缬氨酸甘氨酸。这些突变将突变多肽的三维结构从β弯曲构象改变为α螺旋形成，并且还在突变体多肽内产生两亲性区域。还提供了编码突变体多肽的DNA，以及用于产生突变体多肽的表达系统。还提供了使用与突变体多肽互补的突变多肽和DNA寡聚体的方法和组合物。

3. 发明授权

US5317097A Mutations in the gene encoding the .alpha. chain on platelet glycoprotein IB 失效
标题翻译：编码血小板糖蛋白IB上α链的基因突变
公开(公告)号：US5317097A
公开(公告)日：1994-05-31
申请号：US770968
申请日：1991-10-07
申请人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
发明人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C12N15/12 , C12N15/11 , C12Q1/68 , G01N33/50
CPC分类号： A61K47/48238 , C07K14/705 , A61K38/00
摘要： The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide more reactive with von Willebrand factor. Preferably, the mutation is in the hinge region of GP Ib.alpha., such as the substitution of valine for glycine at residue 233. These mutations alter the three-dimensional structure of the mutant polypeptide from a beta bend conformation to an alpha helix formation, and also create an amphipathic region within the mutant polypeptide. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
摘要翻译：本发明提供由天然存在的野生型血小板糖蛋白Ibα编码的纯化多肽，其具有使得多肽与血管性血友病因子更具反应性的突变。优选地，突变位于GPIbα的铰链区，例如在残基233处取代缬氨酸甘氨酸。这些突变将突变多肽的三维结构从β弯曲构象改变为α螺旋形成，并且还在突变体多肽内产生两亲性区域。还提供了编码突变体多肽的DNA，以及用于产生突变体多肽的表达系统。还提供了使用与突变体多肽互补的突变多肽和DNA寡聚体的方法和组合物。

4. 发明授权

US5492809A Mutations rendering platelet glycoprotein Ib-.alpha. less reactive 失效
标题翻译：引起血小板糖蛋白Ib-α反应性的突变
公开(公告)号：US5492809A
公开(公告)日：1996-02-20
申请号：US119262
申请日：1993-09-09
申请人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
发明人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C12N15/12 , C12N15/00 , C12N15/63 , C12Q1/68
CPC分类号： C07K14/705 , A61K47/48238 , A61K38/00
摘要： The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide less reactive with von Willebrand factor. Preferably, the mutation is in the leucine rich region of GPIb.alpha., such as the substitution of phenylalanine for leucine at residue 57. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
摘要翻译：本发明提供由天然存在的野生型血小板糖蛋白Ibα编码的纯化多肽，其具有使得多肽与血管性血友病因子反应性较低的突变。优选地，突变位于GPIbα的富含亮氨酸的区域中，例如在残基57处用苯丙氨酸取代亮氨酸。还提供了编码突变多肽的DNA，以及用于产生突变多肽的表达系统。还提供了使用与突变体多肽互补的突变多肽和DNA寡聚体的方法和组合物。

5. 发明授权

US5298239A Mutations rendering platelet glycoprotein IB .alpha. less reactive 失效
标题翻译：突变引起血小板糖蛋白IBα较少反应
公开(公告)号：US5298239A
公开(公告)日：1994-03-29
申请号：US821717
申请日：1992-01-15
申请人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
发明人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C12N15/12 , A61K37/02 , A61K37/547
CPC分类号： C07K14/705 , A61K47/48238 , A61K38/00
摘要： The subject invention provides purified polypeptide encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide less reactive with von Willebrand factor. Preferably, the mutation is in the leucine rich region of GPIb.alpha., such as the substitution of phenylalanine for leucine at residue 57. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
摘要翻译：本发明提供由天然存在的野生型血小板糖蛋白Ibα编码的纯化多肽，其具有使得多肽与血管性血友病因子反应性较低的突变。优选地，突变位于GPIb（α）的富含亮氨酸的区域中，例如在残基57处取代苯丙氨酸用于亮氨酸。还提供了编码突变体多肽的DNA，以及用于产生突变多肽的表达系统。还提供了使用与突变体多肽互补的突变多肽和DNA寡聚体的方法和组合物。

6. 发明授权

US09440482B2 Adjustable grid drawing frame 有权
标题翻译：可调网格画框
公开(公告)号：US09440482B2
公开(公告)日：2016-09-13
申请号：US14329370
申请日：2014-07-11
申请人： David Cunningham
发明人： David Cunningham
IPC分类号： B43L13/00 , B43L13/14
CPC分类号： B43L13/149 , B43L13/148
摘要： A drawing tool is provided for assisting artists in transcribing images onto a blank medium. The device is a drawing frame of geometrical shape and has a plurality of notches disposed along the outer perimeter length. These notches are channels cut out of the edge, forming protruding segments between any two notches. Protruding segments are used as anchor sites for a series of elastic threads. A portion of the threads is wound around protruding segments disposed on opposing dies of the frame body, thereby stretching the elastic thread across the front surface of the frame body. A first grouping of the threads is secured in parallel lateral alignment, while a second group is secured in a parallel longitudinal alignment. This configuration presents a grid pattern that can be laid over an image or blank piece of paper to serve as a guide for transcription.
摘要翻译：提供绘图工具来帮助艺术家将图像转录到空白介质上。该装置是几何形状的绘图框架，并且具有沿着外周长设置的多个凹口。这些凹口是从边缘切出的通道，在任何两个凹口之间形成突出的段。突出部分用作一系列弹性线的锚点。螺纹的一部分缠绕在设置在框体的相对的模具上的突出部分上，从而将弹性线拉伸穿过框体的前表面。螺纹的第一组分以平行的横向对准固定，而第二组以平行的纵向对准固定。该配置呈现可以放置在图像或空白纸上以用作转录指南的网格图案。

7. 发明申请

US20070099526A1 Densely woven quasi-unidirectional fabric for ballistic applications 有权
标题翻译：用于弹道应用的强制编织准单向织物
公开(公告)号：US20070099526A1
公开(公告)日：2007-05-03
申请号：US11545115
申请日：2006-10-05
申请人： Jason Heerden , Shekoufeh Shahkarami , David Cunningham , Laura Pritchard
发明人： Jason Heerden , Shekoufeh Shahkarami , David Cunningham , Laura Pritchard
IPC分类号： B32B27/12 , B32B27/04 , B32B5/12
CPC分类号： D03D15/02 , D03D1/0052 , D03D15/0016 , D03D25/005 , D04B21/16 , D10B2331/021 , D10B2401/063 , F41H5/0485 , Y10S428/911 , Y10T428/24058 , Y10T428/24132 , Y10T428/24174 , Y10T442/2615 , Y10T442/2623 , Y10T442/2762 , Y10T442/2861 , Y10T442/2992
摘要： A fabric including a first layer of high-performance unidirectional yarns and a second layer of high-performance unidirectional yarns disposed transversely to the first layer. The fabric also includes warp and fill encapsulating yarns woven around the unidirectional yarns to substantially stabilize the unidirectional yarns. The encapsulating yarns have tenacities and tensile moduli substantially less than the tenacities and tensile moduli of the unidirectional yarns. The fabric has a cover factor between approximately 0.75 and approximately 1.50.
摘要翻译：包括第一层高性能单向纱线和横向于第一层布置的第二层高性能单向纱线的织物。织物还包括围绕单向纱线编织的经纱和填充包封纱，以基本上稳定单向纱线。封装纱线具有显着小于单向纱线的强度和拉伸模量的强度和拉伸模量。织物的覆盖系数在约0.75至约1.50之间。

8. 发明授权

US09397392B2 Geodesic radome 有权
标题翻译：测地雷达罩
公开(公告)号：US09397392B2
公开(公告)日：2016-07-19
申请号：US14001554
申请日：2012-03-05
申请人： Eelco van Oosterbosch , Reimo Nickel , Chae Thompson , David Cunningham
发明人： Eelco van Oosterbosch , Reimo Nickel , Chae Thompson , David Cunningham
IPC分类号： H01Q1/42 , B29C70/04 , B29C70/34
CPC分类号： H01Q1/42 , B29C70/04 , B29C70/34
摘要： The invention relates to a geodesic radome comprising shaped panels containing a consolidated plurality of plies, the plies comprising polyolefin tapes, wherein the shaped panels have a compressive strength of between 10 MPa and 100 MPa, an interlaminar shear strength of between 3 MPa and 75 MPa and a thermal expansion of between 1e−6 1/K and 50e−6 1/K.
摘要翻译：本发明涉及一种测地雷达罩，其包括含有固结的多个层的成形板，该层包含聚烯烃带，其中成形板的抗压强度为10MPa至100MPa，层间剪切强度为3MPa至75MPa 和1e-6l / K和50e-6l / K之间的热膨胀。

9. 发明申请

US20140059552A1 TRANSPARENT EFFICIENCY FOR IN-MEMORY EXECUTION OF MAP REDUCE JOB SEQUENCES 审中-公开
标题翻译：地图减少作业序列的内存执行的透明效率
公开(公告)号：US20140059552A1
公开(公告)日：2014-02-27
申请号：US13593718
申请日：2012-08-24
申请人： David Cunningham , Benjamin W. Herta , Vijay A. Saraswat , Avraham E. Shinnar
发明人： David Cunningham , Benjamin W. Herta , Vijay A. Saraswat , Avraham E. Shinnar
IPC分类号： G06F9/46
CPC分类号： G09G5/00 , G06F16/00 , G06F16/2471
摘要： Executing a map reduce sequence may comprise executing all jobs in the sequence by a collection of a plurality of processes with each process running zero or more mappers, combiners, partitioners and reducers for each job, and transparently sharing heap state between the jobs to improve metrics associated with the job. Processes may communicate among themselves to coordinate completion of map, shuffle and reduce phases, and completion of said all jobs in the sequence.
摘要翻译：执行地图缩减序列可以包括通过多个进程的集合执行序列中的所有作业，每个进程为每个作业运行零个或多个映射器，组合器，分区器和缩减器，并且在作业之间透明地共享堆状态以改善度量与工作有关。过程可以在它们之间进行通信，以协调地图的完成，洗牌和减少阶段，以及完成所述序列中的所有作业。

10. 发明申请

US20050033610A1 Method and system for dispensing, tracking and managing pharmaceutical products 有权
标题翻译：配药，跟踪和管理药品的方法和系统.uss
公开(公告)号：US20050033610A1
公开(公告)日：2005-02-10
申请号：US10922302
申请日：2004-08-19
申请人： David Cunningham
发明人： David Cunningham
IPC分类号： G06K17/00 , G06F17/60
CPC分类号： G06K17/00 , G06F19/00 , G06Q50/22 , G06Q50/24
摘要： A new and improved method of dispensing, tracking and managing pharmaceutical product samples by communicatively linking prescribers and pharmacies to a central computing station. The present invention entails utilizing product trial media that is exchanged for actual pharmaceutical product. The media is encoded with information that identifies a particular pharmaceutical trial product, such as by magnetic encoding similar to that used with credit cards. The media is distributed to participating medical doctors or prescribers who then activate the media via the central computing station. The prescriber then transfers the activated media to patients who then present the media to participating pharmacies. Before filling the pharmaceutical trial product identified by the media, the pharmacy validates the media via a link with the central computing station. Then, the pharmacy dispenses the prescribed pharmaceutical trial product. The central computing station also includes a database that records data related to the use of the media so that all pharmaceutical trial products can be accounted for.
摘要翻译：一种新的和改进的方法，通过将处方药和药房通信地连接到中央计算站来分配，跟踪和管理药品样品。本发明需要使用与实际药品交换的产品试验介质。媒体用识别特定药物试验产品的信息进行编码，例如通过与用于信用卡的磁编码类似的磁编码。媒体分发给参与的医生或处方者，然后通过中央计算站激活媒体。然后，处方者将活化的媒介转移给随后向参与药房提供媒体的患者。在填写由媒体确定的药学试用产品之前，药房通过与中央计算站的链接来验证媒体。然后，药店分配处方药试剂。中央计算站还包括一个数据库，记录与媒体的使用相关的数据，以便所有的药物试验产品都可以被考虑。

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