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1. 发明授权

US5624817A Mutations in the gene encoding the alpha chain of platelet glycoprotein Ib 失效
标题翻译：编码血小板糖蛋白Ⅰα链的基因突变
公开(公告)号：US5624817A
公开(公告)日：1997-04-29
申请号：US234265
申请日：1994-04-28
申请人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch , Matthew R. Pincus
发明人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch , Matthew R. Pincus
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C12N15/12 , C12N15/11 , C12N15/63 , C12N5/10
CPC分类号： A61K47/48238 , C07K14/705 , A61K38/00
摘要： The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide more reactive with yon Willebrand factor. Preferably, the mutation is in the hinge region of GP Ib.alpha., such as the substitution of valine for glycine at residue 233. These mutations alter the three-dimensional structure of the mutant polypeptide from a beta bend conformation to an alpha helix formation, and also create an amphipathic region within the mutant polypeptide. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
摘要翻译：本发明提供由天然存在的野生型血小板糖蛋白Ibα编码的纯化多肽，其具有使得多肽与阴离子血友病因子更具反应性的突变。优选地，突变位于GPIbα的铰链区，例如在残基233处取代缬氨酸甘氨酸。这些突变将突变多肽的三维结构从β弯曲构象改变为α螺旋形成，并且还在突变体多肽内产生两亲性区域。还提供了编码突变体多肽的DNA，以及用于产生突变体多肽的表达系统。还提供了使用与突变体多肽互补的突变多肽和DNA寡聚体的方法和组合物。

2. 发明授权

US5317097A Mutations in the gene encoding the .alpha. chain on platelet glycoprotein IB 失效
标题翻译：编码血小板糖蛋白IB上α链的基因突变
公开(公告)号：US5317097A
公开(公告)日：1994-05-31
申请号：US770968
申请日：1991-10-07
申请人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
发明人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C12N15/12 , C12N15/11 , C12Q1/68 , G01N33/50
CPC分类号： A61K47/48238 , C07K14/705 , A61K38/00
摘要： The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide more reactive with von Willebrand factor. Preferably, the mutation is in the hinge region of GP Ib.alpha., such as the substitution of valine for glycine at residue 233. These mutations alter the three-dimensional structure of the mutant polypeptide from a beta bend conformation to an alpha helix formation, and also create an amphipathic region within the mutant polypeptide. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
摘要翻译：本发明提供由天然存在的野生型血小板糖蛋白Ibα编码的纯化多肽，其具有使得多肽与血管性血友病因子更具反应性的突变。优选地，突变位于GPIbα的铰链区，例如在残基233处取代缬氨酸甘氨酸。这些突变将突变多肽的三维结构从β弯曲构象改变为α螺旋形成，并且还在突变体多肽内产生两亲性区域。还提供了编码突变体多肽的DNA，以及用于产生突变体多肽的表达系统。还提供了使用与突变体多肽互补的突变多肽和DNA寡聚体的方法和组合物。

3. 发明授权

US5492809A Mutations rendering platelet glycoprotein Ib-.alpha. less reactive 失效
标题翻译：引起血小板糖蛋白Ib-α反应性的突变
公开(公告)号：US5492809A
公开(公告)日：1996-02-20
申请号：US119262
申请日：1993-09-09
申请人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
发明人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C12N15/12 , C12N15/00 , C12N15/63 , C12Q1/68
CPC分类号： C07K14/705 , A61K47/48238 , A61K38/00
摘要： The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide less reactive with von Willebrand factor. Preferably, the mutation is in the leucine rich region of GPIb.alpha., such as the substitution of phenylalanine for leucine at residue 57. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
摘要翻译：本发明提供由天然存在的野生型血小板糖蛋白Ibα编码的纯化多肽，其具有使得多肽与血管性血友病因子反应性较低的突变。优选地，突变位于GPIbα的富含亮氨酸的区域中，例如在残基57处用苯丙氨酸取代亮氨酸。还提供了编码突变多肽的DNA，以及用于产生突变多肽的表达系统。还提供了使用与突变体多肽互补的突变多肽和DNA寡聚体的方法和组合物。

4. 发明授权

US5298239A Mutations rendering platelet glycoprotein IB .alpha. less reactive 失效
标题翻译：突变引起血小板糖蛋白IBα较少反应
公开(公告)号：US5298239A
公开(公告)日：1994-03-29
申请号：US821717
申请日：1992-01-15
申请人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
发明人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C12N15/12 , A61K37/02 , A61K37/547
CPC分类号： C07K14/705 , A61K47/48238 , A61K38/00
摘要： The subject invention provides purified polypeptide encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide less reactive with von Willebrand factor. Preferably, the mutation is in the leucine rich region of GPIb.alpha., such as the substitution of phenylalanine for leucine at residue 57. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
摘要翻译：本发明提供由天然存在的野生型血小板糖蛋白Ibα编码的纯化多肽，其具有使得多肽与血管性血友病因子反应性较低的突变。优选地，突变位于GPIb（α）的富含亮氨酸的区域中，例如在残基57处取代苯丙氨酸用于亮氨酸。还提供了编码突变体多肽的DNA，以及用于产生突变多肽的表达系统。还提供了使用与突变体多肽互补的突变多肽和DNA寡聚体的方法和组合物。

5. 发明授权

US5593959A Mutations in the gene encoding the alpha chain of platelet glycoprotein Ib 失效
标题翻译：编码血小板糖蛋白Ⅰα链的基因突变
公开(公告)号：US5593959A
公开(公告)日：1997-01-14
申请号：US135929
申请日：1993-10-14
申请人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch , Matthew R. Pincus
发明人： Jonathan L. Miller , David Cunningham , Vicki A. Lyle , Clara N. Finch , Matthew R. Pincus
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C12N15/12 , C07K14/745 , A61K38/17 , A61K38/36
CPC分类号： A61K47/48238 , C07K14/705 , A61K38/00
摘要： The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide more reactive with von Willebrand factor. Preferably, the mutation is in the hinge region of GP Ib.alpha., such as the substitution of valine for glycine at residue 233. These mutations alter the three-dimensional structure of the mutant polypeptide from a beta bend conformation to an alpha helix formation, and also create an amphipathic region within the mutant polypeptide. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
摘要翻译：本发明提供由天然存在的野生型血小板糖蛋白Ibα编码的纯化多肽，其具有使得多肽与血管性血友病因子更具反应性的突变。优选地，突变位于GPIbα的铰链区，例如在残基233处取代缬氨酸甘氨酸。这些突变将突变多肽的三维结构从β弯曲构象改变为α螺旋形成，并且还在突变体多肽内产生两亲性区域。还提供了编码突变体多肽的DNA，以及用于产生突变体多肽的表达系统。还提供了使用与突变体多肽互补的突变多肽和DNA寡聚体的方法和组合物。

6. 发明授权

US07074888B1 Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX 失效
公开(公告)号：US07074888B1
公开(公告)日：2006-07-11
申请号：US09258947
申请日：1999-03-01
申请人： Jonathan L. Miller , Vicki A. Lyle
发明人： Jonathan L. Miller , Vicki A. Lyle
IPC分类号： A61K38/00
CPC分类号： C07K14/705 , C07K14/001 , C07K14/70596 , C07K16/2896 , C07K2317/34
摘要： The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.

7. 发明授权

US5877155A Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX 失效
公开(公告)号：US5877155A
公开(公告)日：1999-03-02
申请号：US556597
申请日：1995-11-13
申请人： Jonathan L. Miller , Vicki A. Lyle
发明人： Jonathan L. Miller , Vicki A. Lyle
IPC分类号： A61K45/00 , A61K38/00 , A61P7/02 , A61P43/00 , C07K7/06 , C07K14/00 , C07K14/705 , C07K16/28 , A61K38/08 , A61K39/395
CPC分类号： C07K14/001 , C07K14/705 , C07K14/70596 , C07K16/2896 , C07K2317/34
摘要： The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.

8. 发明授权

US07544774B2 Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX 失效
标题翻译：人类血小板糖蛋白Ib / IX的模拟表位和抗模拟表位
公开(公告)号：US07544774B2
公开(公告)日：2009-06-09
申请号：US11003951
申请日：2004-12-03
申请人： Jonathan L. Miller , Vicki A. Lyle
发明人： Jonathan L. Miller , Vicki A. Lyle
IPC分类号： C07K5/00
CPC分类号： C07K14/705 , C07K14/001 , C07K14/70596 , C07K16/2896 , C07K2317/34
摘要： The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.
摘要翻译：本发明涉及功能上模拟单克隆抗体的结合位点的分离的肽，该单克隆抗体识别人血小板糖蛋白Ib / IX复合物内的表位。该肽被称为模拟表位。本发明还提供能够结合肽或模拟表位的分离的分子，该分子可以是抗体，第二肽，碳水化合物，DNA分子，RNA分子或其它天然或化学合成的分子。这种分离的分子称为抗模拟表位。具体提供了模拟单克隆抗体C-34和SZ-2的结合位点的模拟表位，以及C-34模拟表位的抗模拟表位。

9. 发明授权

US5817748A Mimotopes of human Platelet glycoprotein Ib/IX 失效
标题翻译：人血小板糖蛋白Ib / IX的模拟表位
公开(公告)号：US5817748A
公开(公告)日：1998-10-06
申请号：US406330
申请日：1995-03-17
申请人： Jonathan L. Miller , Vicki A. Lyle
发明人： Jonathan L. Miller , Vicki A. Lyle
IPC分类号： C07K14/00 , C07K14/705 , C07K16/28 , C07K7/00 , A61K38/08 , A61K38/36 , C07K14/745
CPC分类号： C07K16/2896 , C07K14/001 , C07K14/705 , C07K14/70596 , C07K2317/34
摘要： The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 are specifically provided.
摘要翻译：本发明涉及功能上模拟单克隆抗体的结合位点的分离的肽，识别人糖蛋白Ib / IX复合物中的表位的单克隆抗体。该肽被称为模拟表位。本发明还提供能够结合肽或模拟表位的分离的分子，该分子可以是抗体，第二肽，碳水化合物，DNA分子，RNA分子或其它天然或化学合成的分子。这种分离的分子称为抗模拟表位。具体提供了模拟单克隆抗体C-34的结合位点的模拟表位。

10. 发明授权

US09004492B2 Shrouded face seal and components thereof 有权
标题翻译：有罩面罩及其部件
公开(公告)号：US09004492B2
公开(公告)日：2015-04-14
申请号：US12826629
申请日：2010-06-29
申请人： Colin D. Craig , Enzo Dibenedetto , Christopher P. Kmetz , Jonathan L. Miller , Mark R. Sondeen
发明人： Colin D. Craig , Enzo Dibenedetto , Christopher P. Kmetz , Jonathan L. Miller , Mark R. Sondeen
IPC分类号： F16J15/00 , F16J15/34 , F01D11/00
CPC分类号： F16J15/3468 , F01D11/003 , F05D2240/55
摘要： One embodiment of the face seal described herein includes a seal seat and a seal element carried by a seal housing. The seal element cooperates with the seal seat to establish a seal. The housing includes a seal element support and a shroud. The seal housing is made of a parent material and the shroud has a tip impregnated with a second material.
摘要翻译：本文所述的面密封件的一个实施例包括密封座和由密封壳体承载的密封元件。密封元件与密封座配合以建立密封。壳体包括密封元件支撑件和护罩。密封壳体由母体材料制成并且护罩具有浸渍有第二材料的尖端。

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