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1. 发明授权

US08372092B2 Applicator instruments having protective carriers for hemostats and methods therefor 有权
标题翻译：具有止血垫保护载体的敷贴仪器及其方法
公开(公告)号：US08372092B2
公开(公告)日：2013-02-12
申请号：US12049869
申请日：2008-03-17
申请人： Jonathan Gabel , Jason C. Livingston , Dwayne Looney , Michael E. Guglielmo , Greg R. Furnish , John Miser
发明人： Jonathan Gabel , Jason C. Livingston , Dwayne Looney , Michael E. Guglielmo , Greg R. Furnish , John Miser
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/00491 , A61B17/3468 , A61B50/30 , A61B2017/0053 , A61B2017/00544 , A61B2017/00557 , A61B2017/00575 , A61B2017/00623 , A61B2017/00659 , A61B2017/00884 , A61F2002/0072 , A61M37/0069
摘要： An instrument for controlling bleeding includes an outer shaft, an intermediate shaft telescopically received within a central lumen of the outer shaft, and an inner shaft telescopically received within a central lumen of the intermediate shaft, the inner shaft having a proximal end and a distal end that extends distally from the intermediate shaft. The instrument includes a hemostat disposed at the distal end of the inner shaft, and a fluid-resistant element connected to the distal end of the outer shaft and surrounding the hemostat. The fluid-resistant element has a breakable, fluid-resistant seal at a distal end thereof that protects the hemostat from fluids until the hemostat is delivered and deployed onto tissue. In one embodiment, the instrument includes an inflatable balloon to deploy and tamponade the hemostat.
摘要翻译：用于控制出血的仪器包括外轴，可伸缩地容纳在外轴的中心腔内的中间轴以及可伸缩地容纳在中间轴的中心腔内的内轴，内轴具有近端和远端其从中间轴向远侧延伸。仪器包括设置在内轴的远端的止血器，以及连接到外轴的远端并围绕止血钳的流体阻力元件。耐流体元件在其远端处具有可破坏的耐流体密封，其保护止血剂免受流体的影响，直到止血剂被输送并展开到组织上。在一个实施例中，该仪器包括用于部署和填充止血剂的可充气气囊。

2. 发明申请

US20090234380A1 APPLICATOR INSTRUMENTS HAVING PROTECTIVE CARRIERS FOR HEMOSTATS AND METHODS THEREFOR 有权
标题翻译：具有HEMOSTATS的保护载体的应用仪器及其方法
公开(公告)号：US20090234380A1
公开(公告)日：2009-09-17
申请号：US12049869
申请日：2008-03-17
申请人： Jonathan Gabel , Jason C. Livingston , Dwayne Looney , Michael E. Guglielmo , Greg R. Furnish , John Miser
发明人： Jonathan Gabel , Jason C. Livingston , Dwayne Looney , Michael E. Guglielmo , Greg R. Furnish , John Miser
IPC分类号： A61M29/02 , A61M31/00
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/00491 , A61B17/3468 , A61B50/30 , A61B2017/0053 , A61B2017/00544 , A61B2017/00557 , A61B2017/00575 , A61B2017/00623 , A61B2017/00659 , A61B2017/00884 , A61F2002/0072 , A61M37/0069
摘要： An instrument for controlling bleeding includes an outer shaft having a proximal end, a distal end, and a central lumen extending to the distal end thereof, an intermediate shaft telescopically received within the central lumen of the outer shaft, the intermediate shaft having a proximal end, a distal end, and a central lumen extending to the distal end thereof, and an inner shaft telescopically received within the central lumen of the intermediate shaft, the inner shaft having a proximal end and a distal end that extends distally from the intermediate shaft. The instrument includes a hemostat disposed at the distal end of the inner shaft, and a fluid-resistant element connected to the distal end of the outer shaft and surrounding the hemostat. The fluid-resistant element has a breakable, fluid-resistant seal at a distal end thereof that protects the hemostat from fluids until the hemostat is delivered and deployed onto tissue. In one embodiment, the instrument includes an inflatable balloon to deploy and tamponade a hemostat.
摘要翻译：用于控制出血的仪器包括具有近端，远端和延伸到其远端的中心腔的外轴，可伸缩地容纳在所述外轴的中心腔内的中间轴，所述中轴具有近端，远端和延伸到其远端的中心腔，以及可伸缩地容纳在中间轴的中心腔内的内轴，内轴具有从中间轴向远侧延伸的近端和远端。仪器包括设置在内轴的远端的止血器，以及连接到外轴的远端并围绕止血钳的流体阻力元件。耐流体元件在其远端处具有可破坏的耐流体密封，其保护止血剂免受流体的影响，直到止血剂被输送并展开到组织上。在一个实施例中，该仪器包括用于展开和填充止血剂的可膨胀气囊。

3. 发明授权

US08361100B2 Applicator instruments for the delivery, deployment, and tamponade of hemostats and methods therefor 有权
标题翻译：用于输送，部署和填充止血剂的敷料器及其方法
公开(公告)号：US08361100B2
公开(公告)日：2013-01-29
申请号：US12049849
申请日：2008-03-17
申请人： Jonathan Gabel , Jason C. Livingston , Dwayne Looney , Michael E. Guglielmo , Greg R. Furnish , John Miser , John Edrington
发明人： Jonathan Gabel , Jason C. Livingston , Dwayne Looney , Michael E. Guglielmo , Greg R. Furnish , John Miser , John Edrington
IPC分类号： A61M29/00
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/00491 , A61B17/3468 , A61B50/30 , A61B2017/0053 , A61B2017/00544 , A61B2017/00557 , A61B2017/00575 , A61B2017/00623 , A61B2017/00659 , A61B2017/00884 , A61F2002/0072 , A61M37/0069
摘要： An instrument for deploying hemostats has an intermediate shaft having a proximal end, a distal end, and a central lumen, and an inner shaft telescopically received within the central lumen of the intermediate shaft. The instrument includes an inflatable balloon, a first actuator for inflating the balloon, and a second actuator for moving the distal ends of the intermediate and inner shafts relative to one another for changing the shape of the inflated balloon. A proximal end of the balloon is secured to the distal end of the intermediate shaft and the distal end of the balloon is secured to the distal end of the inner shaft. The intermediate and inner shafts are moveable so that the inflated balloon has a toroidal shape and a flattened distal face. The inflated balloon has a major axis that is perpendicular to the longitudinal axis of the intermediate shaft.
摘要翻译：用于部署止血器的仪器具有中间轴，其具有近端，远端和中心腔，以及内轴，其可伸缩地容纳在中间轴的中心腔内。该仪器包括一个可充气气囊，一个用于使球囊充气的第一致动器，以及用于相对于彼此移动中间轴和内轴的远端的第二致动器，用于改变膨胀球囊的形状。球囊的近端固定到中间轴的远端，并且球囊的远端固定到内轴的远端。中间轴和内轴是可移动的，使得充气球囊具有环形形状和平坦的远侧面。充气气球具有垂直于中间轴的纵向轴线的长轴。

4. 发明申请

US20090234374A1 APPLICATOR INSTRUMENTS FOR THE DELIVERY, DEPLOYMENT, AND TAMPONADE OF HEMOSTATS AND METHODS THEREFOR 有权
标题翻译： HEMOSTATS的交付，部署和延期的申请人仪器及其方法
公开(公告)号：US20090234374A1
公开(公告)日：2009-09-17
申请号：US12049849
申请日：2008-03-17
申请人： Jonathan Gabel , Jason C. Livingston , Dwayne Looney , Michael E. Guglielmo , Greg R. Furnish , John Miser , John Edrington
发明人： Jonathan Gabel , Jason C. Livingston , Dwayne Looney , Michael E. Guglielmo , Greg R. Furnish , John Miser , John Edrington
IPC分类号： A61B17/10
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/00491 , A61B17/3468 , A61B50/30 , A61B2017/0053 , A61B2017/00544 , A61B2017/00557 , A61B2017/00575 , A61B2017/00623 , A61B2017/00659 , A61B2017/00884 , A61F2002/0072 , A61M37/0069
摘要： An instrument used for the delivery, deployment, and tamponade of a hemostat such as a topically applied hemostat includes an intermediate shaft having a proximal end, a distal end, and a central lumen extending to the distal end, and an inner shaft telescopically received within the central lumen of the intermediate shaft, the inner shaft having a proximal end and a distal end that extends distally from the intermediate shaft. The instrument includes an inflatable balloon having a proximal end secured to the intermediate shaft and a distal end secured to the inner shaft, a first actuator for inflating the balloon, and a second actuator for moving the distal ends of the intermediate and inner shafts relative to one another between a first position and a second position for changing the shape of the balloon when the balloon is inflated. The proximal end of the balloon is secured to the distal end of the intermediate shaft and the distal end of the balloon is secured to the distal end of the inner shaft. The balloon has a spherical shape when the intermediate and inner shafts are in the first position and a toroidal shape when the intermediate and inner shafts are in the second position.
摘要翻译：用于诸如局部应用的止血剂之类的止血钳的传送，展开和填塞的仪器包括具有延伸到远端的近端，远端和中心腔的中间轴，以及可伸缩地接纳在内侧的内轴中间轴的中央腔，内轴具有从中间轴向远侧延伸的近端和远端。仪器包括一个可膨胀气囊，其具有固定到中间轴的近端和固定到内轴的远端，用于使球囊膨胀的第一致动器和用于使中轴和内轴的远端相对移动的第二致动器，彼此之间在第一位置和第二位置之间，用于当气囊膨胀时改变气囊的形状。球囊的近端固定到中间轴的远端，并且球囊的远端固定到内轴的远端。当中间轴和内轴处于第一位置时，气球具有球形，当中间轴和内轴处于第二位置时，气球呈圆环形。

5. 发明申请

US20070096354A1 Process of making flowable hemostatic compositions and devices containing such compositions 有权
标题翻译：制备可流动止血组合物和含有这种组合物的装置的方法
公开(公告)号：US20070096354A1
公开(公告)日：2007-05-03
申请号：US11264584
申请日：2005-11-01
申请人： Jonathan Gabel , Dwayne Looney , Michael Guglielmo
发明人： Jonathan Gabel , Dwayne Looney , Michael Guglielmo
IPC分类号： B27N3/00 , A61K9/70
CPC分类号： A61K9/12 , A61K9/0019
摘要： The present invention is directed to processes of making flowable hemostatic compositions and devices that include the flowable hemostatic composition disposed therein, where a volume of a biocompatible liquid, a volume of a biocompatible gas, and an amount of solid particles of a biocompatible polymer are mixed together to form a substantially homogenous composition including a discontinuous gas phase and the solid particles substantially homogenously dispersed throughout a continuous liquid phase to form a flowable hemostatic composition, and the composition then transferred into a device suitable for applying the flowable hemostatic composition to a site of a body requiring hemostasis under conditions effective to maintain the substantially homogeneous dispersion of the gas phase and the solid particles throughout the liquid phase, wherein said transfer of said substantially homogenous hemostatic composition is conducted at an angle.
摘要翻译：本发明涉及制备可流动止血组合物和装置的方法，其包括设置在其中的可流动止血组合物，其中生物相容性液体的体积，生物相容性气体的体积和生物相容性聚合物的固体颗粒的量混合一起形成基本上均匀的组合物，其包括不连续气相，并且固体颗粒基本均匀地分散在整个连续液相中以形成可流动的止血组合物，然后将组合物转移到适于将可流动止血组合物施用于一种在有效维持气相和固体颗粒在整个液相中基本上均匀分散的条件下需要止血的体，其中所述基本均匀的止血组合物的转移是以一定角度进行的。

6. 发明申请

US20100230845A9 Process of making flowable hemostatic compositions and devices containing such compositions 有权
标题翻译：制备可流动止血组合物和含有这种组合物的装置的方法
公开(公告)号：US20100230845A9
公开(公告)日：2010-09-16
申请号：US11264584
申请日：2005-11-01
申请人： Jonathan Gabel , Dwayne Looney , Michael Guglielmo
发明人： Jonathan Gabel , Dwayne Looney , Michael Guglielmo
IPC分类号： B27N3/00 , A61K9/70
CPC分类号： A61K9/12 , A61K9/0019
摘要： The present invention is directed to processes of making flowable hemostatic compositions and devices that include the flowable hemostatic composition disposed therein, where a volume of a biocompatible liquid, a volume of a biocompatible gas, and an amount of solid particles of a biocompatible polymer are mixed together to form a substantially homogenous composition including a discontinuous gas phase and the solid particles substantially homogenously dispersed throughout a continuous liquid phase to form a flowable hemostatic composition, and the composition then transferred into a device suitable for applying the flowable hemostatic composition to a site of a body requiring hemostasis under conditions effective to maintain the substantially homogeneous dispersion of the gas phase and the solid particles throughout the liquid phase, wherein said transfer of said substantially homogenous hemostatic composition is conducted at an angle.
摘要翻译：本发明涉及制备可流动止血组合物和装置的方法，其包括设置在其中的可流动止血组合物，其中生物相容性液体的体积，生物相容性气体的体积和生物相容性聚合物的固体颗粒的量混合一起形成基本上均匀的组合物，其包括不连续气相，并且固体颗粒基本均匀地分散在整个连续液相中以形成可流动的止血组合物，然后将组合物转移到适于将可流动止血组合物施用于一种在有效维持气相和固体颗粒在整个液相中基本上均匀分散的条件下需要止血的体，其中所述基本均匀的止血组合物的转移是以一定角度进行的。

7. 发明申请

US20070021717A1 Intradermal Delivery Device 审中-公开
标题翻译：皮内输送装置
公开(公告)号：US20070021717A1
公开(公告)日：2007-01-25
申请号：US11463472
申请日：2006-08-09
申请人： Jonathan Gabel , Bradley Wilkinson , Charles Hwang
发明人： Jonathan Gabel , Bradley Wilkinson , Charles Hwang
IPC分类号： A61M31/00
CPC分类号： A61M5/14248 , A61M37/0015 , A61M2005/14268 , A61M2005/14506 , A61M2037/0023 , A61M2037/003
摘要： A delivery device for delivering a substance intradermally into the skin of a patient including a housing for contacting the surface of the skin and a disposable cartridge to be received in the housing. The cartridge includes an internal reservoir containing a substance to be delivered to the patient, a plurality of micro skin penetrating members and a fluid channel extending between the micro skin penetrating members and the reservoir. The housing includes a bottom wall with a central opening and a cover member. The cartridge is positioned in the housing with the micro skin penetrating members extending through the central opening of the bottom wall and positioned on the surface of the skin of a patient. The cover is closed onto the cartridge to dispense the substance from the cartridge through the micro skin penetrating members and into or through the skin of the patient.
摘要翻译：一种用于将物质皮内递送到患者皮肤中的输送装置，包括用于接触皮肤表面的壳体和待接收在壳体中的一次性药筒。该药筒包括一个含有待递送给病人的物质的内部储存器，多个微皮肤穿透构件和在微皮肤穿透构件和储存器之间延伸的流体通道。壳体包括具有中心开口和盖构件的底壁。药筒定位在壳体中，微皮肤穿透构件延伸穿过底壁的中心开口并且定位在患者皮肤的表面上。盖子封闭在盒上，以通过微皮肤穿透构件从药筒分配物质并进入或穿过患者皮肤。

8. 发明申请

US20060129309A1 Method and system for performing programmatic actions based upon vehicle approximate locations 有权
标题翻译：基于车辆近似位置执行编程动作的方法和系统
公开(公告)号：US20060129309A1
公开(公告)日：2006-06-15
申请号：US11011635
申请日：2004-12-14
申请人： Neal Alewine , Jonathan Gabel , Joseph Rusnak , Anthony Wrobel
发明人： Neal Alewine , Jonathan Gabel , Joseph Rusnak , Anthony Wrobel
IPC分类号： G01C21/26
CPC分类号： G01C21/26 , G06Q30/0251 , G06Q30/0252 , G06Q30/0261 , G06Q30/0266
摘要： A system for communicating between networked applications and vehicles that includes a vehicle response server and a vehicle response agent. The vehicle response server can manage communications between at least one vehicle and at least one application remotely located from the vehicle, wherein the application can provide activation contexts to the vehicle. The vehicle response agent can be disposed in the vehicle. The vehicle response agent can receive the activation contexts and determine event occurrences based in part upon the activation contexts and in part upon a location of the vehicle relative to previously defined geographical boundaries specified by the vehicle response server.
摘要翻译：一种用于在网络应用和车辆之间通信的系统，其包括车辆响应服务器和车辆响应代理。车辆响应服务器可以管理至少一个车辆与远离车辆的至少一个应用之间的通信，其中应用可以向车辆提供激活上下文。车辆响应剂可以设置在车辆中。车辆响应代理可以部分地基于激活上下文并且部分地基于车辆相对于由车辆响应服务器指定的先前定义的地理边界的位置来接收激活上下文并确定事件发生。

9. 发明申请

US20050101973A1 Surgical instrument and method for the treatment of urinary incontinence 有权
标题翻译：手术器械及尿失禁治疗方法
公开(公告)号：US20050101973A1
公开(公告)日：2005-05-12
申请号：US10706559
申请日：2003-11-12
申请人： Daniel Smith , Jonathan Gabel , Henri Decloux
发明人： Daniel Smith , Jonathan Gabel , Henri Decloux
IPC分类号： A61B17/00 , A61B17/04 , A61F2/00 , A61B17/10
CPC分类号： A61B17/06109 , A61B17/0469 , A61B2017/00805 , A61F2/0045
摘要： A surgical assembly is provided including a surgical passer having a wire portion coupled to a handle, with the wire portion having a free distal end, an outer periphery, and at least one recess therein in a distal end region. The assembly further includes a tube element having a proximal end, a tissue penetrating distal end, and a channel extending therein from an opening at the proximal end and defined by an inner periphery. The channel has at least one projection projecting outwardly into the channel in a distal end region thereof. The outer periphery of the surgical passer is dimensioned relative to the inner periphery of the channel of the tube element so that the surgical passer is positionable within the tube element, and when so positioned, the at least one tube element projection engages the at least one surgical passer recess to removably couple the surgical passer to the tube element.
摘要翻译：提供了一种手术组件，其包括具有联接到手柄的线部分的外科路径，其中线部分具有自由远端，外周边以及远端区域中的至少一个凹部。组件还包括具有近端，组织穿透远端的管元件和从近端的开口延伸并由内周限定的通道。通道具有在其远端区域中向外突出到通道中的至少一个突起。手术路人的外周相对于管元件的通道的内周尺寸设定，使得手术路径器可定位在管元件内，并且当这样定位时，至少一个管元件突出物接合至少一个手术通道凹槽，以可移除地将外科路口耦合到管元件。

10. 发明授权

US06413237B1 Hypodermic syringe with selectively retractable needle 有权
标题翻译：具有选择性伸缩针的皮下注射器
公开(公告)号：US06413237B1
公开(公告)日：2002-07-02
申请号：US09652374
申请日：2000-08-31
申请人： Richard Caizza , Simon Cohn , Jonathan Gabel
发明人： Richard Caizza , Simon Cohn , Jonathan Gabel
IPC分类号： A61M500
CPC分类号： A61M5/3234 , A61M5/508 , A61M2005/31516 , A61M2209/06
摘要： A hypodermic syringe with a selectively retractable needle includes an elongate barrel having an open proximal end, an open distal end and a hollow bore. The syringe includes an elongate plunger including a hollow outer housing having an open proximal end and an open distal end. The plunger has a hollow inner sleeve defining a cavity therein. The plunger has releasable engagement elements preventing relative axial movement between the outer housing and the inner sleeve, the elements allowing the relative axial movement when released and a distal stopper. There is an open cutter mounted at a proximal end of the inner sleeve to cut through the stopper to expose the cavity in the inner sleeve when the engagement elements are released and sufficient distal axial force is applied to the plunger. The syringe has a hub housing with an open proximal end having an inwardly projecting shoulder, a hub with a proximal flange and an axial stem, sized to fit within the hub housing. There is a spring disposed about the stem between the flange and the shoulder. The syringe has a needle with a sharp point extending outwardly. The needle retracts into the cavity in the plunger when sufficient distal force is applied to the plunger to release the engagement elements. The release allows movement of the inner sleeve with respect to the outer housing so that the cutter cuts through the stopper and the flange and the spring urges movement of the needle into the cavity.
摘要翻译：具有可选择性缩回针的皮下注射器包括具有开口近端，开口远端和中空孔的细长筒。注射器包括细长的柱塞，其包括具有敞开的近端和敞开的远端的中空的外壳。柱塞具有在其中限定空腔的中空内套筒。柱塞具有可释放的接合元件，防止外部壳体和内部套筒之间的相对轴向运动，所述元件在释放时允许相对轴向移动，并且远端止动件。当接合元件被释放并且向柱塞施加足够的远端轴向力时，存在安装在内套筒的近端处的开式切割器，以切割止动件以露出内套筒中的空腔。注射器具有轮毂壳体，其具有敞开的近端，其具有向内突出的肩部，具有近侧凸缘和轴向杆的轮毂，其尺寸适于装配在轮毂壳体内。在法兰和肩部之间设置有围绕杆的弹簧。注射器具有尖端向外延伸的针头。当足够的远端力施加到柱塞以释放接合元件时，针缩回到柱塞中的空腔中。释放允许内套筒相对于外壳移动，使得切割器切穿塞子并且凸缘和弹簧推动针头进入腔体的运动。

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