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    • 1. 发明申请
    • Breath-based sensors for non-invasive molecular detection
    • 基于呼吸的传感器用于非侵入性分子检测
    • US20060130557A1
    • 2006-06-22
    • US11305799
    • 2005-12-16
    • Johna LeddyLuke Haverhals
    • Johna LeddyLuke Haverhals
    • G01N1/22
    • G01N33/497G01N33/4972H01M8/04753H01M8/1023H01M8/1039H01M2250/00Y10S436/90
    • A method of diagnosing the health of an individual by collecting a breath sample from the individual and measuring the amount of each of a plurality of analytes in the sample. The amount of each analytes is measured by fitting a time response curve of a sample-evaluation fuel cell in which the fuel cell sample electrode is contacted with the sample with the analysis based on a function of standard time response curves for an equivalent fuel cell configuration obtained separately for each of the analytes on a fuel cell with equivalent construction as sample-evaluation fuel cell. Each of the plurality of analytes is generally indicative of an aspect of the individual's health. Suitable analytes include, for example, inorganic compounds as well as compositions that exhibit negative reduction reactions at least for a portion of the time response curve. In particular, acetone exhibits a negative potential/current peak when it is an analyte in a fuel cell in an sample electrode with a counter electrode exposed to oxygen, which may or may not be introduced in the form of air. Various forms of analysis to estimate acetone concentrations in the breath can be used.
    • 一种通过从个体收集呼吸样本并测量样品中多个分析物中的每一个的量来诊断个体健康的方法。 通过根据等效燃料电池配置的标准时间响应曲线的函数,通过拟合燃料电池样品电极与样品接触的样品评估燃料电池的时间响应曲线来测量每种分析物的量 在具有等效结构的燃料电池上的每个分析物分别获得作为样品评价燃料电池。 多个分析物中的每一个通常表示个体健康的一个方面。 合适的分析物包括例如无机化合物以及至少对于时间响应曲线的一部分呈现负还原反应的组合物。 特别是丙酮在样品电极中的分析物处于负电势/电流峰值时,其对置电极暴露于氧气,这可能是或可能不以空气的形式引入。 可以使用各种形式的分析来估计呼吸中的丙酮浓度。
    • 2. 发明申请
    • Multicomponent analysis of volatile organic compositions in vapor samples
    • 蒸汽样品中挥发性有机成分的多组分分析
    • US20050214169A1
    • 2005-09-29
    • US11090318
    • 2005-03-25
    • Johna LeddyLuke Haverhals
    • Johna LeddyLuke Haverhals
    • G01N27/407G01N31/00G01N33/00G01N33/497H01M8/04
    • G01N27/407G01N33/0047G01N33/497H01M8/04089
    • Amounts of volatile organic compositions can be evaluated from vapor samples based on the time dependent response of a fuel cell contacted with the vapor sample at its anode. The time response of the fuel cell signal, e.g., voltage or current, is de-convoluted using a set of standard curves for an equivalent fuel cell configuration obtained separately for each of the volatile organic compositions of a fuel cell with an equivalent construction as the sample-evaluation fuel cell. The methodology can be implemented on a system with an appropriate vapor collection device suitable for the particular application. The method and system can be used to analyze breath samples to evaluate ethanol levels or other volatile organic composition. The system can be a breathalyzer, a vehicle interlock, a medical analysis device or a sensor of environmental or industrial interest.
    • 挥发性有机组合物的量可以基于在其阳极处与蒸气样品接触的燃料电池的时间依赖性响应从蒸气样品评估。 燃料电池信号(例如电压或电流)的时间响应使用用于燃料电池的每种挥发性有机组合物分别获得的等效燃料电池配置的一组标准曲线进行去卷积,其具有与 样品评估燃料电池。 该方法可以在适合于特定应用的适当的蒸气收集装置的系统上实现。 该方法和系统可用于分析呼吸样本以评估乙醇水平或其他挥发性有机成分。 该系统可以是呼吸机,车辆联锁装置,医疗分析装置或环境或工业感兴趣的传感器。