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1. 发明申请

US20110168172A1 PRESERVATIVE-FREE SINGLE DOSE INHALER SYSTEMS 有权
标题翻译：无保护的单剂量吸入系统
公开(公告)号：US20110168172A1
公开(公告)日：2011-07-14
申请号：US13004662
申请日：2011-01-11
申请人： John S. Patton , Ryan S. Patton , Mei-Chang Kuo , Yehuda Ivri
发明人： John S. Patton , Ryan S. Patton , Mei-Chang Kuo , Yehuda Ivri
IPC分类号： A61M11/00
CPC分类号： A61M15/0028 , A61K9/0073 , A61K9/122 , A61K33/30 , A61K38/28 , A61M11/00 , A61M11/001 , A61M11/005 , A61M15/0021 , A61M15/0065 , A61M15/0085 , A61M15/009 , A61M15/0091 , A61M2016/0021 , A61M2016/0039 , A61M2202/0468 , A61M2205/3334 , A61M2205/583 , A61M2205/587
摘要： An aerosolization system includes a squeezable container having a resilient container body. The container is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator comprises a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
摘要翻译：雾化系统包括具有弹性容器主体的可挤压容器。容器被配置为在挤压一次时输送单位剂量的液体。该系统还包括由限定了接口管的壳体和设置在壳体中的气溶胶发生器构成的雾化器。气溶胶发生器包括具有前表面和后表面的可振动膜和用于振动膜的可振动元件。此外，壳体包括适于从容器接收单位剂量的液体的开口。开口提供到可振动膜的后表面的液体路径。

2. 发明授权

US09180261B2 Preservative free insulin formulations and systems and methods for aerosolizing 有权
标题翻译：防腐剂游离胰岛素配方和雾化系统和方法
公开(公告)号：US09180261B2
公开(公告)日：2015-11-10
申请号：US13004645
申请日：2011-01-11
申请人： John S. Patton , Ryan S. Patton , Mei-chang Kuo , Yehuda Ivri
发明人： John S. Patton , Ryan S. Patton , Mei-chang Kuo , Yehuda Ivri
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00 , A61K38/28 , A61K9/00
CPC分类号： A61M15/0028 , A61K9/0073 , A61K9/122 , A61K33/30 , A61K38/28 , A61M11/00 , A61M11/001 , A61M11/005 , A61M15/0021 , A61M15/0065 , A61M15/0085 , A61M15/009 , A61M15/0091 , A61M2016/0021 , A61M2016/0039 , A61M2202/0468 , A61M2205/3334 , A61M2205/583 , A61M2205/587
摘要： One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation includes a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.
摘要翻译：一个实施方案描述了专门用于雾化的胰岛素制剂。该制剂包括大量的水和少量的胰岛素。此外，该制剂是无防腐剂的，不含间甲酚，甲酚或苯酚，以允许使用振动孔板将制剂雾化，而没有胰岛素制剂的实质发泡。

3. 发明授权

US08950394B2 Preservative-free single dose inhaler systems 有权
标题翻译：无防腐剂的单剂量吸入器系统
公开(公告)号：US08950394B2
公开(公告)日：2015-02-10
申请号：US13004662
申请日：2011-01-11
申请人： John S. Patton , Ryan S. Patton , Mei-Chang Kuo , Yehuda Ivri
发明人： John S. Patton , Ryan S. Patton , Mei-Chang Kuo , Yehuda Ivri
IPC分类号： B05B17/06 , A61M11/00 , A61M15/00 , A61K38/28 , A61K9/00 , A61M11/02 , A61M16/00
CPC分类号： A61M15/0028 , A61K9/0073 , A61K9/122 , A61K33/30 , A61K38/28 , A61M11/00 , A61M11/001 , A61M11/005 , A61M15/0021 , A61M15/0065 , A61M15/0085 , A61M15/009 , A61M15/0091 , A61M2016/0021 , A61M2016/0039 , A61M2202/0468 , A61M2205/3334 , A61M2205/583 , A61M2205/587
摘要： An aerosolization system includes a squeezable container having a resilient container body. The container is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
摘要翻译：雾化系统包括具有弹性容器主体的可挤压容器。容器被配置为在挤压一次时输送单位剂量的液体。该系统还包括由限定了接口管的壳体和设置在壳体中的气溶胶发生器构成的雾化器。气溶胶发生器包括具有前表面和后表面的可振动膜，以及用于振动膜的可振动元件。此外，壳体包括适于从容器接收单位剂量的液体的开口。开口提供到可振动膜的后表面的液体路径。

4. 发明申请

US20110168170A1 PRESERVATIVE FREE INSULIN FORMULATIONS AND SYSTEMS AND METHODS FOR AEROSOLIZING 有权
标题翻译：无保护的胰岛素制剂和系统以及用于气溶胶的方法
公开(公告)号：US20110168170A1
公开(公告)日：2011-07-14
申请号：US13004645
申请日：2011-01-11
申请人： John S. Patton , Ryan S. Patton , Mei-chang Kuo , Yehuda Ivri
发明人： John S. Patton , Ryan S. Patton , Mei-chang Kuo , Yehuda Ivri
IPC分类号： A61M11/00 , A61K38/28
CPC分类号： A61M15/0028 , A61K9/0073 , A61K9/122 , A61K33/30 , A61K38/28 , A61M11/00 , A61M11/001 , A61M11/005 , A61M15/0021 , A61M15/0065 , A61M15/0085 , A61M15/009 , A61M15/0091 , A61M2016/0021 , A61M2016/0039 , A61M2202/0468 , A61M2205/3334 , A61M2205/583 , A61M2205/587
摘要： One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation comprises a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.
摘要翻译：一个实施方案描述了专门用于雾化的胰岛素制剂。该制剂包含主要量的水和少量的胰岛素。此外，该制剂是无防腐剂的，不含间甲酚，甲酚或苯酚，以允许使用振动孔板将制剂雾化，而没有胰岛素制剂的实质发泡。

5. 发明申请

US20140252128A1 PRESSURE MULTIPLYING AEROSOL PUMP 有权
标题翻译：压力传感器
公开(公告)号：US20140252128A1
公开(公告)日：2014-09-11
申请号：US14197487
申请日：2014-03-05
申请人： Yehuda Ivri
发明人： Yehuda Ivri
IPC分类号： B05B7/04
CPC分类号： B05B11/3001 , A45D34/00 , A45D2200/056 , A45D2200/057 , A61L9/14 , A61L2209/134 , B05B1/341 , B05B11/061 , B05B11/3005 , B05B11/3052 , B05B11/3066
摘要： A hand-held dispensing device operable to dispense a fluid as an atomized spray by hydraulic pressure. The device includes a cartridge containing a fluid to be dispensed and a pressure-multiplying piston pump operable by liquefied gas pressure and manually controlled by a valve. The pump is configured to receive pressure from a compartment containing liquefied gas and transmit higher pressure to the fluid to be dispensed. The pressure multiplying pump produces high pressure, typically between 6-30 bar, which is suitable for generation of fine spray by hydraulic atomization. The device uses about 1/10th the amount of liquefied gas compared to a propellant-based aerosol therefore it has a significant ecological and health benefits.
摘要翻译：一种手持式分配装置，其可操作以通过液压作为雾化喷雾分配流体。该装置包括容纳要分配的流体的筒，以及可由液化气压力操作的手动控制的增压活塞泵。该泵构造成从包含液化气体的隔室接受压力，并将更高的压力传递给待分配的流体。压力倍增泵产生高压，通常在6-30巴之间，适用于通过液压雾化产生细微喷雾。与基于推进剂的气溶胶相比，该装置使用大约1/10的液化气体，因此具有显着的生态和健康益处。

6. 发明申请

US20120012665A1 AEROSOL GENERATORS WITH ENHANCED CORROSION RESISTANCE 审中-公开
标题翻译：具有增强耐腐蚀性的气溶胶发生器
公开(公告)号：US20120012665A1
公开(公告)日：2012-01-19
申请号：US13008897
申请日：2011-01-18
申请人： Yehuda Ivri
发明人： Yehuda Ivri
IPC分类号： B05B17/04
CPC分类号： A61M11/005 , B05B17/0646
摘要： An apparatus for generating an aerosol that includes a support member having a first face and a second face and defining an opening therethrough, where the support member includes a first material having a first galvanic potential, and an aerosolization element mounted on the support member and disposed substantially over the opening and defining at least one aperture therethrough. The aerosolization element may include a second material having a second galvanic potential that is substantially equal to the first galvanic potential of the first material. Also, a method of aerosolizing a liquid medicament by providing an aperture plate made of a first material and having a top surface and a bottom surface. The aperture plate is mounted on a support member that includes a second material that has an opening such that the aperture plate covers the opening, and where the first and second materials have similar galvanic potentials.
摘要翻译：一种用于产生气溶胶的装置，包括具有第一面和第二面并且限定穿过其中的开口的支撑构件，其中支撑构件包括具有第一电位的第一材料和安装在支撑构件上的雾化元件，基本上在开口上方并且限定穿过其中的至少一个孔。雾化元件可以包括具有基本上等于第一材料的第一电偶电位的第二电位的第二材料。另外，通过提供由第一材料制成并具有顶表面和底表面的孔板来雾化液体药物的方法。孔板安装在支撑构件上，该支撑构件包括具有开口的第二材料，使得孔板覆盖开口，并且其中第一和第二材料具有相似的电偶电位。

7. 发明授权

US07628339B2 Systems and methods for controlling fluid feed to an aerosol generator 失效
标题翻译：用于控制向气溶胶发生器输送流体的系统和方法
公开(公告)号：US07628339B2
公开(公告)日：2009-12-08
申请号：US11418841
申请日：2006-05-05
申请人： Yehuda Ivri , Markus Flierl
发明人： Yehuda Ivri , Markus Flierl
IPC分类号： B05B1/08
CPC分类号： B05B17/0676 , B05B17/0646
摘要： A method for controlling the supply of liquid to an aerosol generator comprises operating a liquid supply system to supply a liquid to a vibratable aperture plate of an aerosol generator which senses an amount of liquid adhering to the vibratable aperture plate, and controls operation of the liquid supply system to adjust the amount of liquid adhering to the vibratable aperture plate.
摘要翻译：一种用于控制向气溶胶发生器供应液体的方法，包括操作液体供应系统以将液体供应到气溶胶发生器的可振动孔板，其感测附着在可振动孔板上的液体的量，并且控制液体的操作供应系统调节粘附在可振动孔板上的液体量。

8. 发明授权

US07040549B2 Systems and methods for controlling fluid feed to an aerosol generator 失效
公开(公告)号：US07040549B2
公开(公告)日：2006-05-09
申请号：US10394512
申请日：2003-03-21
申请人： Yehuda Ivri , Markus Flierl
发明人： Yehuda Ivri , Markus Flierl
IPC分类号： B05B1/08
CPC分类号： B05B17/0646 , A61M11/005 , A61M11/007 , A61M11/042 , A61M15/0065 , A61M15/0085 , A61M2016/0021 , A61M2016/0039 , A61M2205/3306 , A61M2205/3379 , A61M2205/3382 , A61M2205/3386 , A61M2205/3389 , A61M2205/8206 , B05B12/081 , B05B12/085 , B05B17/0676 , B05B17/0684 , B41J2/025 , B41J2/04 , B41J2202/15
摘要： A method for controlling the supply of liquid to an aerosol generator comprises operating a liquid supply system to supply a liquid to a vibratable aperture plate of an aerosol generator which senses an amount of liquid adhering to the vibratable aperture plate, and controls operation of the liquid supply system to adjust the amount of liquid adhering to the vibratable aperture plate.

9. 发明授权

US06205999B1 Methods and apparatus for storing chemical compounds in a portable inhaler 有权
标题翻译：用于将便携式吸入器中的化合物储存的方法和装置
公开(公告)号：US06205999B1
公开(公告)日：2001-03-27
申请号：US09149426
申请日：1998-09-08
申请人： Yehuda Ivri , Linda R. De Young , Cheng H. Wu , Miro S. Cater , Vijay Kumar , Markus Flierl
发明人： Yehuda Ivri , Linda R. De Young , Cheng H. Wu , Miro S. Cater , Vijay Kumar , Markus Flierl
IPC分类号： A61M1100
CPC分类号： B05B17/0684 , A61M15/0028 , A61M15/0065 , A61M15/0085 , A61M15/025 , A61M2016/0021 , A61M2016/0039 , A61M2205/0233 , A61M2205/3306 , A61M2205/8206 , B05B11/00416 , B05B11/309 , B05B11/3094 , B05B12/08 , B05B17/0646 , B41J2/025 , C25D1/08
摘要： The invention provides exemplary aerosolization apparatus and methods for aerosolizing a substance. According to one exemplary method, a liquid is transferred from a first chamber into a second chamber having a substance that is in a dry state to form a solution. The solution is then transferred from the second chamber and onto an atomization member. The atomization member is operated to aerosolize the solution.
摘要翻译：本发明提供了用于使物质雾化的示例性雾化装置和方法。根据一个示例性方法，液体从第一室转移到具有处于干燥状态的物质形成溶液的第二室中。然后将溶液从第二室转移到雾化构件上。操作雾化构件以使溶液雾化。

10. 发明授权

US5938117A Methods and apparatus for dispensing liquids as an atomized spray 失效
公开(公告)号：US5938117A
公开(公告)日：1999-08-17
申请号：US417311
申请日：1995-04-05
申请人： Yehuda Ivri
发明人： Yehuda Ivri
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00 , B05B11/02 , B05B12/08 , B05B17/00 , B05B17/06 , B41J2/025 , B41J2/04 , G01D15/16 , G01D15/18
CPC分类号： A61M11/005 , A61M11/006 , A61M15/0065 , A61M15/0085 , A61M15/025 , B05B12/08 , B05B17/0646 , B05B17/0676 , B05B17/0684 , B41J2/025 , B41J2/04 , A61M2016/0039 , A61M2205/3306 , A61M2205/3379 , A61M2205/3382 , A61M2205/3386 , A61M2205/3389 , A61M2205/8206 , B41J2202/15
摘要： The invention provides exemplary methods and apparatus for dispensing liquids as an atomized spray. In one particularly preferably method, a liquid is dispensed as an atomized spray from a vibratable member having a front surface and a rear surface, with the member having at least one tapered hole between the surfaces for dispensing the liquid. The tapered hole has a larger cross-sectional area at the rear surface than at the front surface. The liquid is delivered from a supply container to the rear surface of the vibratable member in an amount sufficient to cover the hole with liquid. The vibratable member is then vibrated to dispense at least a portion of the liquid through the hole and from the front surface. Additional liquid is delivered from the supply container and to the rear surface in volumes that are substantially equal to the volumes dispensed.

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