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1. 发明申请

US20100015220A1 NIACIN AND NSAID COMBINATION THERAPY 审中-公开
标题翻译： NIACIN和NSAID组合治疗
公开(公告)号：US20100015220A1
公开(公告)日：2010-01-21
申请号：US12469653
申请日：2009-05-20
申请人： John R. WETTERAU , Lingyu Zhu , Robert A. Scott , Constance H. Keyserling , Jean-Louis H. Dasseux , Daniela Carmen Oniciu , Pierre Autant , Roger Kravtzoff , Catherine Castan , Hervé Guillard
发明人： John R. WETTERAU , Lingyu Zhu , Robert A. Scott , Constance H. Keyserling , Jean-Louis H. Dasseux , Daniela Carmen Oniciu , Pierre Autant , Roger Kravtzoff , Catherine Castan , Hervé Guillard
IPC分类号： A61K9/48 , A61K9/20 , A61K31/455 , A61K9/50 , A61K31/60 , A61P25/34
CPC分类号： A61K31/455 , A61K31/616 , A61K2300/00
摘要： Provided are pharmaceutical compositions and methods for preventing or reducing niacin-induced flushing comprising an aspirin component and a niacin component having different release profiles. Also provided are methods and compositions for preventing or reducing niacin-induced flushing comprising niacin, aspirin and a lipid-lowering drug other than niacin.
摘要翻译：提供了用于预防或减少烟酸诱发的潮红的药物组合物和方法，其包含具有不同释放特征的阿司匹林组分和烟酸组分。还提供了用于预防或减少烟酸诱发的潮红的方法和组合物，其包含烟酸，阿司匹林和除了烟酸以外的降脂药物。

2. 发明申请

US20050266078A1 Compressed tablets comprising microcapsules with modified release 有权
标题翻译：包含经释放的微胶囊的压片
公开(公告)号：US20050266078A1
公开(公告)日：2005-12-01
申请号：US10507886
申请日：2003-03-14
申请人： Rafael Jorda , Pierre Autant
发明人： Rafael Jorda , Pierre Autant
IPC分类号： A61K9/52 , A61K9/20 , A61K9/26 , A61K9/50 , A61K9/56 , A61K31/155 , A61K31/522 , A61K47/04 , A61K47/12 , A61K47/14 , A61K47/32 , A61K47/38 , A61K47/44 , A61K9/24
CPC分类号： A61K9/2081 , A61K9/5073
摘要： A multi(micro)particulate tablet is provided comprising microparticles which comprise a mechanically non-deformable core of active principle (AP). The tablet is formed from reservoir microcapsules with prolonged release of the AP, which are each made up of a non-deformable core comprising AP and covered with at least one film coating controlling release of the AP in vivo. The microcapsules have a particle size of between 50 and 1000 microns and are coated with at least one outer overcoating envelope comprising at least one deformable organic constituent having a melting point of between 40° C. and 120° C. The envelope allows the prolonged release of the AP in vivo without modification of the release profile when the microcapsules are compressed to form a tablet, even for microparticles not specifically formulated for compression.
摘要翻译：提供了包含微粒的多（微）颗粒片剂，其包含有机原理（AP）的机械不可变形核心。片剂由具有延长AP释放的储存器微胶囊形成，其各自由包含AP的不可变形的芯构成并且覆盖有控制AP释放的至少一个膜涂层。微胶囊具有50至1000微米的粒度，并且涂覆有至少一个外涂层外壳，其包含至少一种熔点在40℃和120℃之间的可变形有机成分。所述外壳允许延长释放的AP，而在微胶囊被压缩形成片剂时即使对于未特别配制用于压缩的微粒也不改变释放曲线。

3. 发明授权

US06306427B1 Pellets containing active ingredients protected against degradation in the rumen of ruminants 失效
标题翻译：含有活性成分的颗粒可防止反刍动物瘤胃降解
公开(公告)号：US06306427B1
公开(公告)日：2001-10-23
申请号：US08011864
申请日：1993-02-01
申请人： Claude Annonier , Pierre Autant , Jacques Ruel , Hugues Porte , Jean-Claude Laffay , Alain Sabatier
发明人： Claude Annonier , Pierre Autant , Jacques Ruel , Hugues Porte , Jean-Claude Laffay , Alain Sabatier
IPC分类号： A23K118
CPC分类号： A61K9/5084 , A23K20/20 , A23K40/20 , A23K40/25 , A23K40/35 , A61K9/2081 , Y10S514/965
摘要： The invention relates to a composition, in pellet form, useful for the nutritional and/or medicinal supplementation of ruminants and a method for admixing the pellets with foodstuff. The pellet contains granules of one or more active ingredients/principles protected against degradation in toe rumen and one or more binding agents capable of being solubilized, crosslinked or melted. Optionally, the pellet may also contain an unprotected active ingredient for release in the rumen. The pellet may further contain a disintegrating agent and/or filler.
摘要翻译：本发明涉及可用于营养和/或药物补充反刍动物的颗粒形式的组合物以及将颗粒与食品混合的方法。丸剂含有一种或多种活性成分的颗粒/防止胃内肿瘤降解的原理和一种或多种能够溶解，交联或熔化的结合剂。任选地，颗粒还可含有用于在瘤胃中释放的未受保护的活性成分。颗粒还可以含有崩解剂和/或填料。

4. 发明授权

US6022562A Medicinal and/or nutritional microcapsules for oral administration 失效
标题翻译：用于口服给药的药用和/或营养微胶囊
公开(公告)号：US6022562A
公开(公告)日：2000-02-08
申请号：US544208
申请日：1995-10-17
申请人： Pierre Autant , Jean-Philippe Selles , Gerard Soula
发明人： Pierre Autant , Jean-Philippe Selles , Gerard Soula
IPC分类号： A61K9/50 , A61K47/30 , A61K9/14
CPC分类号： A61K9/5015 , A61K9/5026 , A61K9/5047
摘要： The present invention relates to microcapsules for the oral administration of medicinal and/or nutritional active principles (AP), which are smaller than or equal to 1000 .mu.m in size. These microcapsules consist of particles which are coated with a coating material consisting of a mixture of a film-forming polymer derivative, a hydrophobic plasticizer, a functional agent and a nitrogen-containing polymer. These microcapsules are also characterized by their ability to remain in the small intestine for a long time (at least 5 hours) and to allow, during the residence, release and absorption of the AP. The invention also relates to a process for the production of the said microcapsules.
摘要翻译：本发明涉及用于口服施用小于或等于1000μm的药用和/或营养活性成分（AP）的微胶囊。这些微胶囊由涂覆有由成膜聚合物衍生物，疏水增塑剂，官能剂和含氮聚合物的混合物组成的涂层材料的颗粒组成。这些微胶囊的特征还在于它们能够长时间（至少5小时）保留在小肠中，并允许在AP的释放和吸收期间。本发明还涉及生产所述微胶囊的方法。

5. 发明授权

US08507003B2 Compressed tablets comprising microcapsules with modified release 有权
标题翻译：包含经释放的微胶囊的压片
公开(公告)号：US08507003B2
公开(公告)日：2013-08-13
申请号：US10507886
申请日：2003-03-14
申请人： Rafaël Jorda , Pierre Autant
发明人： Rafaël Jorda , Pierre Autant
IPC分类号： A61K9/14 , A61K9/22 , A61K9/16
CPC分类号： A61K9/2081 , A61K9/5073
摘要： A multi(micro)particulate tablet is provided comprising microparticles which comprise a mechanically non-deformable core of active principle (AP). The tablet is formed from reservoir microcapsules with prolonged release of the AP, which are each made up of a non-deformable core comprising AP and covered with at least one film coating controlling release of the AP in vivo. The microcapsules have a particle size of between 50 and 1000 microns and are coated with at least one outer overcoating envelope comprising at least one deformable organic constituent having a melting point of between 40° C. and 120° C. The envelope allows the prolonged release of the AP in vivo without modification of the release profile when the microcapsules are compressed to form a tablet, even for microparticles not specifically formulated for compression.
摘要翻译：提供了包含微粒的多（微）颗粒片剂，其包含有机原理（AP）的机械不可变形核心。片剂由具有延长AP释放的储存器微胶囊形成，其各自由包含AP的不可变形的芯构成并且覆盖有控制AP释放的至少一个膜涂层。微胶囊具有50至1000微米的粒度，并且涂覆有至少一个外涂层外壳，其包含至少一种熔点在40℃和120℃之间的可变形有机成分。所述外壳允许延长释放的AP，而在微胶囊被压缩形成片剂时即使对于未特别配制用于压缩的微粒也不改变释放曲线。

6. 发明授权

US5441742A Cellular cellulosic material containing a biocide agent and process for preparing same 失效
标题翻译：含有杀生物剂的蜂窝状纤维素材料及其制备方法
公开(公告)号：US5441742A
公开(公告)日：1995-08-15
申请号：US210455
申请日：1994-03-21
申请人： Pierre Autant , Christophe Chalvin , Claudine Colin , Rafael Jorda , Jean-Luc Wertz
发明人： Pierre Autant , Christophe Chalvin , Claudine Colin , Rafael Jorda , Jean-Luc Wertz
IPC分类号： A47K7/03 , A47L13/17 , C08J9/00 , A61K9/14 , A01N25/00 , A01N25/34 , A61K9/50
CPC分类号： C08J9/0061 , A47K7/03 , A47L13/17 , C08J2301/24 , Y10S514/951 , Y10S514/964 , Y10S514/965
摘要： The present invention relates to a cellular cellulosic material containing a biocide agent and to a process for preparing same. Characteristically, matrix type microparticles, containing at least one biocide agent, are distributed in the network of cellulose of said material, ensuring therein, in the presence of moisture or water, a controlled release of the biocide agent or agents.
摘要翻译：本发明涉及含有杀生物剂的细胞纤维素材料及其制备方法。特别地，含有至少一种杀生物剂的基质型微粒分布在所述材料的纤维素网络中，在水分或水的存在下确保杀菌剂或试剂的受控释放。

7. 发明授权

US4877621A Compositions for coating feedstuff additives for ruminants and feedstuff additives thus coated 失效
标题翻译：用于涂覆反刍动物和饲料添加剂的饲料添加剂的组合物
公开(公告)号：US4877621A
公开(公告)日：1989-10-31
申请号：US92139
申请日：1987-09-02
申请人： Pierre Ardaillon , Pierre Autant , Paul Bourrain , Andre Cartillier
发明人： Pierre Ardaillon , Pierre Autant , Paul Bourrain , Andre Cartillier
IPC分类号： A23K1/16 , A23K1/00 , A23K1/18 , A61K9/42 , A61K9/50
CPC分类号： A61K9/5026 , A23K40/35 , A23K50/10 , A61K9/5015
摘要： A composition for coating a biologically active substance, which is stable in a medium with a pH greater than or equal to 5 and which enables the active substance to be released in a medium with a pH less than or equal to 3.5, consisting of a basic amino copolymer (preferably vinyl-pyridine/styrene copolymer) and a hydrophobic substance with a melting point greater than 60.degree. C. (preferably stearic acid), the hydrophobic substance content being between 50 and 90% of the total mass of the coating, and granules comprising a nucleous containing the biologically active substance, coated with this composition.
摘要翻译：一种用于涂覆生物活性物质的组合物，其在pH大于或等于5的介质中是稳定的，并且其能够使活性物质在pH小于或等于3.5的介质中释放，所述介质由碱性氨基共聚物（优选乙烯基 - 吡啶/苯乙烯共聚物）和熔点大于60℃的疏水物质（优选硬脂酸），疏水物质含量在涂层总质量的50-90％之间，和包含含有该组合物的生物活性物质的核的颗粒。

8. 发明授权

US5585050A Microcapsules containing at least one active ingredient, application of such capsules and one of their preparation methods 失效
标题翻译：含有至少一种活性成分的微胶囊，这种胶囊的应用及其制备方法之一
公开(公告)号：US5585050A
公开(公告)日：1996-12-17
申请号：US80767
申请日：1993-06-24
申请人： Rafael Jorda , Pierre Autant , Rossin Rene
发明人： Rafael Jorda , Pierre Autant , Rossin Rene
IPC分类号： A01N25/28 , A61K8/11 , A61K9/50 , A61L15/44 , A61L31/16 , A61Q3/00 , A61Q17/00 , B01J13/12 , B01J13/02 , B01J13/04
CPC分类号： B01J13/12 , A01N25/28 , A61K8/11 , A61K8/8152 , A61K9/5026 , A61K9/5031 , A61L15/44 , A61L31/16 , A61Q3/00 , A61K2800/412 , A61L2300/208 , A61L2300/404 , A61L2300/622 , A61Q17/005
摘要： The invention relates to microcapsules containing at least one active ingredient, characterized in that they are constituted by:an hydrophilic and essentially non-aqueous liquid inner core, formed of a solution of at least one active ingredient which is water-soluble and amphiphilic in at least one non-aqueous hydrophilic solvent, andby a wall, enclosing said inner core and based on at least one polymer or copolymer, and to one of their preparation methods.The invention finds an application in systems of instant release of active ingredient, such as articles of hygiene, surgical gloves and materials.
摘要翻译：本发明涉及含有至少一种活性成分的微胶囊，其特征在于它们由以下组成：亲水性和基本上非水性的液体内芯，由至少一种水溶性和两亲性的活性成分的溶液形成至少一种非水亲水性溶剂，以及封闭所述内核并基于至少一种聚合物或共聚物的壁，以及其制备方法之一。本发明在诸如卫生用品，手术手套和材料的活性成分即时释放的系统中发现。

9. 发明授权

US5290560A Extrusion of an admixture of a meltable binder and a food or drug 失效
标题翻译：挤出可熔融粘合剂和食品或药物的混合物
公开(公告)号：US5290560A
公开(公告)日：1994-03-01
申请号：US719039
申请日：1991-06-21
申请人： Pierre Autant , Jacques Ruel , Stephen Weinhold , Charles A. McCombs , Ernest P. Smith , Stephen H. Wu , Louis P. Hoskins
发明人： Pierre Autant , Jacques Ruel , Stephen Weinhold , Charles A. McCombs , Ernest P. Smith , Stephen H. Wu , Louis P. Hoskins
IPC分类号： A23K1/18 , A23K1/00 , A61K9/16 , A61K31/195 , A61K47/44 , A61P3/00
CPC分类号： A61K9/1617 , A23K40/35 , Y10S426/807
摘要： The present invention relates to new granules, as well as the process for their preparation, obtained by extrusion of a mixture containing a meltable binder in an amount such that it permits the passage of the mixture through a die. The granules obtained are then coated with a polymer permitting their trans-rumen passage without degradation. After coating, these granules are used for animal feeding of ruminants.
摘要翻译：本发明涉及新的颗粒，以及它们的制备方法，其通过挤出包含可熔粘合剂的混合物获得，其量使其允许混合物通过模头。然后将所获得的颗粒用聚合物包被，其允许其经转运通道而不降解。涂布后，将这些颗粒用于反刍动物饲养。

10. 发明授权

US5186937A Composition for feeding ruminants 失效
标题翻译：喂食反刍动物的组成
公开(公告)号：US5186937A
公开(公告)日：1993-02-16
申请号：US541195
申请日：1990-06-22
申请人： Robert E. Sparks , Norbert S. Mason , Pierre Autant , Andre Cartillier , Raymond Pigeon
发明人： Robert E. Sparks , Norbert S. Mason , Pierre Autant , Andre Cartillier , Raymond Pigeon
IPC分类号： A23K1/00 , A23K1/18 , A61K9/50
CPC分类号： A61K9/5073 , A23K40/35 , A23K50/10 , A61K9/5026
摘要： A composition which is stable in a medium in which the pH is greater than or equal to 5.5 and which permits the release of an active substance in a medium in which the pH is less than or equal to 3.5, comprising the active substance, which contains inclusions of, or which is completely or partially covered by, a pH sensitive material whose extent and/or rate of swelling is greater in an acidic medium than in a neutral medium, and a coating of a hydrophobic layer.
摘要翻译：在pH大于或等于5.5的培养基中稳定的组合物，其允许活性物质在pH小于或等于3.5的培养基中释放，所述培养基包含活性物质，其含有在酸性介质中的溶胀程度和/或膨胀速率比在中性介质中更大的pH敏感材料或疏水层的涂层完全或部分地被其包覆，或完全或部分地被其覆盖。

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