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1. 发明授权

US08071699B2 Methods of controlling properties in multimodal systems 有权
标题翻译：控制多模态系统性质的方法
公开(公告)号：US08071699B2
公开(公告)日：2011-12-06
申请号：US12442157
申请日：2006-09-21
申请人： John R. Parrish , Mark L. Nelson
发明人： John R. Parrish , Mark L. Nelson
IPC分类号： C08F2/00 , C08F2/34
CPC分类号： G05B13/042
摘要： The invention is directed to a polymerization system and method of controlling resin properties during the production of bimodal and multimodal polymer compositions using at least one manipulated variable to minimize dynamic deviations from polymer characteristics. In particular embodiments, the method of control includes determining a property of the resin based on a current and/or previous values or estimates or process variables or polymer characteristics. In this manner the control actions serve to reduce process upsets or facilitate in transitioning to a new product or grade to reduce the amount of off-grade resin material produced during transition or during steady state manufacture.
摘要翻译：本发明涉及使用至少一个操作变量来制备双峰和多峰聚合物组合物期间控制树脂性能的聚合体系和方法，以使与聚合物特性的动态偏差最小化。在具体实施方案中，控制方法包括基于当前和/或先前的值或估计或过程变量或聚合物特性确定树脂的性质。以这种方式，控制动作用于减少过程紊乱或促进转换到新产品或等级，以减少过渡期间或在稳态制造期间产生的脱级树脂材料的量。

2. 发明申请

US20100144967A1 METHODS OF CONTROLLING PROPERTIES IN MULTIMODAL SYSTEMS 有权
标题翻译：多模式系统中控制属性的方法
公开(公告)号：US20100144967A1
公开(公告)日：2010-06-10
申请号：US12442157
申请日：2006-09-21
申请人： John R. Parrish , Mark L. Nelson
发明人： John R. Parrish , Mark L. Nelson
IPC分类号： C08F2/00 , C08F2/01
CPC分类号： G05B13/042
摘要： The invention is directed to a polymerization system and method of controlling resin properties during the production of bimodal and multimodal polymer compositions using at least one manipulated variable to minimize dynamic deviations from polymer characteristics. In particular embodiments, the method of control includes determining a property of the resin based on a current and/or previous values or estimates or process variables or polymer characteristics. In this manner the control actions serve to reduce process upsets or facilitate in transitioning to a new product or grade to reduce the amount of off-grade resin material produced during transition or during steady state manufacture.
摘要翻译：本发明涉及使用至少一个操作变量来制备双峰和多峰聚合物组合物期间控制树脂性能的聚合体系和方法，以使与聚合物特性的动态偏差最小化。在具体实施方案中，控制方法包括基于当前和/或先前的值或估计或过程变量或聚合物特性确定树脂的性质。以这种方式，控制动作用于减少过程紊乱或促进转换到新产品或等级，以减少过渡期间或在稳态制造期间产生的脱级树脂材料的量。

3. 发明授权

US08862438B2 Method for improving the prediction of polymer properties 有权
标题翻译：改进聚合物性能预测的方法
公开(公告)号：US08862438B2
公开(公告)日：2014-10-14
申请号：US12670885
申请日：2008-07-24
申请人： Jeffrey B. Drabish , John R. Parrish , Marcel Schaefer , Ivan J. Hartley , Paul K. Samples , Mark L. Nelson
发明人： Jeffrey B. Drabish , John R. Parrish , Marcel Schaefer , Ivan J. Hartley , Paul K. Samples , Mark L. Nelson
IPC分类号： G06F7/60 , G06G7/48 , B01J19/00 , G01N35/08 , G06F19/00
CPC分类号： G06F19/704 , Y10T436/12
摘要： A method for improving the prediction of polymer properties and a system having improved polymer property prediction capabilities is provided. The method for improving the prediction of polymer properties comprises: (1) providing a polymer; (2) providing a prediction model; (3) utilizing said prediction model to define an average polymer property prediction value; (4) determining a feasible range; (5) measuring one or more properties of said polymer; (6) determining whether said one or measured polymer properties are within said feasible range: (7) validating said one or more measured polymer properties if said one or more measured polymer properties fall within the feasible range or invalidating said one or more measured polymer properties if said one or more measured polymer properties fall outside of the feasible range; (8) optionally updating said prediction model; (9) repeating said previous steps at least one or more times; and (10) thereby improving the prediction of polymer properties.
摘要翻译：提供了改进聚合物性能预测的方法和具有改进的聚合物性能预测能力的体系。改进聚合物性能预测的方法包括：（1）提供聚合物; （2）提供预测模型; （3）利用所述预测模型来定义平均聚合物性质预测值; （4）确定可行范围; （5）测量所述聚合物的一种或多种性质; （6）确定所述一种或测量的聚合物性质是否在所述可行范围内：（7）如果所述一种或多种测量的聚合物性能落在可行范围内或者使所述一种或多种测量的聚合物性质无效，则验证所述一种或多种测量的聚合物性质如果所述一种或多种测量的聚合物性质落在可行范围之外; （8）可选地更新所述预测模型; （9）至少一次以上重复上述步骤; 和（10），从而改善聚合物性质的预测。

4. 发明申请

US20100209307A1 METHOD FOR IMPROVING THE PREDICTION OF POLYMER PROPERTIES AND A SYSTEM HAVING IMPROVED POLYMER PROPERTY PREDICTION CAPABILITIES 有权
标题翻译：改进聚合物性能预测的方法和具有改进的聚合物性能预测能力的系统
公开(公告)号：US20100209307A1
公开(公告)日：2010-08-19
申请号：US12670885
申请日：2008-07-24
申请人： Jeffrey B. Drabish , John R. Parrish , Marcel Schaefer , Ivan J. Hartley , Pjaul K. Samples , Mark L. Nelson
发明人： Jeffrey B. Drabish , John R. Parrish , Marcel Schaefer , Ivan J. Hartley , Pjaul K. Samples , Mark L. Nelson
IPC分类号： B01J19/00 , G06F17/10 , G06G7/58
CPC分类号： G06F19/704 , Y10T436/12
摘要： The instant invention is a method for improving the prediction of polymer properties and a system having improved polymer property prediction capabilities. The method for improving the prediction of polymer properties according to instant invention comprises the following steps of: (1) providing a polymer; (2) providing a prediction model; (3) utilizing said prediction model to define an average polymer property prediction value; (4) determining a feasible range; (5) measuring one or more properties of said polymer; (6) determining whether said one or measured polymer properties are within said feasible range: (7) validating said one or more measured polymer properties if said one or more measured polymer properties fall within the feasible range or invalidating said one or more measured polymer properties if said one or more measured polymer properties fall outside of the feasible range; (8) optionally updating said prediction model; (9) repeating said previous steps at least one or more times; and (10) thereby improving the prediction of polymer properties. The polymerization system having improved polymer property prediction capabilities according to instant invention comprises at least one polymerization reactor; an automated prediction model; means for measuring one or more polymer properties; means for detecting one or more erroneous measured polymer properties; and means for updating said automated predication model.
摘要翻译：本发明是改进聚合物性能预测的方法和具有改进的聚合物性能预测能力的体系。根据本发明的改进聚合物性能预测的方法包括以下步骤：（1）提供聚合物; （2）提供预测模型; （3）利用所述预测模型来定义平均聚合物性质预测值; （4）确定可行范围; （5）测量所述聚合物的一种或多种性质; （6）确定所述一种或测量的聚合物性质是否在所述可行范围内：（7）如果所述一种或多种测量的聚合物性能落在可行范围内或者使所述一种或多种测量的聚合物性质无效，则验证所述一种或多种测量的聚合物性质如果所述一种或多种测量的聚合物性质落在可行范围之外; （8）可选地更新所述预测模型; （9）至少一次以上重复上述步骤; 和（10），从而改善聚合物性质的预测。根据本发明的具有改进的聚合物性能预测能力的聚合体系包括至少一个聚合反应器; 自动预测模型; 用于测量一种或多种聚合物性质的方法; 用于检测一个或多个错误测量的聚合物性质的手段; 以及用于更新所述自动预测模型的装置。

5. 发明授权

US07875649B2 7, 8 and 9-substituted tetracycline compounds 有权
标题翻译： 7,8和9-取代四环素化合物
公开(公告)号：US07875649B2
公开(公告)日：2011-01-25
申请号：US12720258
申请日：2010-03-09
申请人： Mark L. Nelson , Darrell J. Koza , Glen Rennie
发明人： Mark L. Nelson , Darrell J. Koza , Glen Rennie
IPC分类号： C07D319/10 , A61K31/357
CPC分类号： C07C237/26
摘要： 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
摘要翻译： 7,8和9-取代的四环素化合物，治疗四环素应答状态的方法，以及含有7,8和9-取代的四环素化合物的药物组合物。

6. 发明授权

US07851460B2 7-phenyl-substituted tetracycline compounds 失效
标题翻译： 7-苯基取代的四环素化合物
公开(公告)号：US07851460B2
公开(公告)日：2010-12-14
申请号：US12425852
申请日：2009-04-17
申请人： Mark L. Nelson , Glen Rennie , Darrell Koza
发明人： Mark L. Nelson , Glen Rennie , Darrell Koza
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： C07C237/26 , A61K31/65 , C07C2603/46 , Y02A50/473
摘要： 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
摘要翻译： 7-苯基取代的四环素化合物，治疗四环素应答状态的方法和含有7-苯基取代的四环素化合物的药物组合物。

7. 发明授权

US07829543B2 Substituted polyamines as inhibitors of bacterial efflux pumps 失效
标题翻译：取代的多胺作为细菌外排泵的抑制剂
公开(公告)号：US07829543B2
公开(公告)日：2010-11-09
申请号：US10754041
申请日：2004-01-07
申请人： Mark L. Nelson , Michael N. Alekshun
发明人： Mark L. Nelson , Michael N. Alekshun
IPC分类号： A61K31/7036 , A61K31/70 , A61K31/715
CPC分类号： A61K31/70 , A61K31/00 , A61K31/132 , A61K31/133 , A61K31/7036 , Y02A50/401 , Y02A50/406 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： Disclosed are methods of treating bacterial infections including those caused by multidrug resistant bacteria using polyamine efflux pump inhibiting compounds, including for example N-benzylated polyazaalkanes, N-benzylated polyaminoalkanes, or mixed N-benzylated poly(aza/amino)alkanes, optionally in combination with other drugs such as antibiotics, as well as pharmaceutical compositions thereof.
摘要翻译：公开的是使用多胺外排泵抑制化合物治疗细菌感染的方法，包括由多重耐药细菌引起的细菌感染的方法，包括例如N-苄基化的多烷基烷烃，N-苄基化聚氨基烷烃或混合的N-苄基化聚（氮杂/氨基）烷烃，任选地组合与其他药物如抗生素，以及其药物组合物。

8. 发明授权

US07786099B2 Aromatic a-ring derivatives of tetracycline compounds 失效
标题翻译：四环素化合物的芳香环烯衍生物
公开(公告)号：US07786099B2
公开(公告)日：2010-08-31
申请号：US11039230
申请日：2005-01-18
申请人： Mark L. Nelson
发明人： Mark L. Nelson
IPC分类号： A61K31/65 , C07C50/22 , C07C50/36
CPC分类号： C07C237/48 , C07C237/26 , C07C2603/46
摘要： Aromatized A-ring derivatives of tetracycline compounds are described.
摘要翻译：描述了四环素化合物的芳香化A环衍生物。

9. 发明申请

US20100160265A1 7, 8 AND 9-SUBSTITUTED TETRACYCLINE COMPOUNDS 有权
标题翻译： 7,8和9-取代的四环素化合物
公开(公告)号：US20100160265A1
公开(公告)日：2010-06-24
申请号：US12720258
申请日：2010-03-09
申请人： Mark L. Nelson , Darrell J. Koza , Glen Rennie
发明人： Mark L. Nelson , Darrell J. Koza , Glen Rennie
IPC分类号： A61K31/65 , A61P31/04 , C07C237/26
CPC分类号： C07C237/26
摘要： 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
摘要翻译： 7,8和9-取代的四环素化合物，治疗四环素应答状态的方法，以及含有7,8和9-取代的四环素化合物的药物组合物。

10. 发明申请

US20100160263A1 7,9-SUBSTITUTED TETRACYCLINE COMPOUNDS 审中-公开
标题翻译： 7,9取代的四环素化合物
公开(公告)号：US20100160263A1
公开(公告)日：2010-06-24
申请号：US12617111
申请日：2009-11-12
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Laura McIntyre , Beena Bhatia , Paul Hawkins , Laxma Reddy Nagavelli , Karen Stepleton , Tad Warchol , Paul Sheahan
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Laura McIntyre , Beena Bhatia , Paul Hawkins , Laxma Reddy Nagavelli , Karen Stepleton , Tad Warchol , Paul Sheahan
IPC分类号： A61K31/65 , C07C237/26 , C07D403/10 , C07D213/30 , C07D215/14 , A61P31/00
CPC分类号： C07C237/26 , B32B37/0007 , B32B37/003 , B32B37/1284 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D209/48 , C07D213/82 , C07D215/14 , C07D307/24 , C07D317/60
摘要： The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明涉及新的7,9-取代的四环素化合物。这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。

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