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1. 发明授权

US6113557A Variable stiffness angioplasty guide wire 失效
标题翻译：可变刚度血管成形术导丝
公开(公告)号：US6113557A
公开(公告)日：2000-09-05
申请号：US879569
申请日：1997-06-20
申请人： John R. Fagan , Richard Choh , Richard Morrill
发明人： John R. Fagan , Richard Choh , Richard Morrill
IPC分类号： A61B5/00 , A61B8/14 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/0915 , A61M2025/09175
摘要： An angioplasty guidewire includes a proximal shaft and an intermediate section extending from the shaft to a distal joint and having a stiffener and a flexible member. The stiffener and the flexible member are disposed in coaxial slidable relationship and operable, as the stiffener and flexible member undergo relative axial shifting, to cooperatively impart a variable stiffening force on the intermediate section. A flexible distal tip mounts to the end of the intermediate section and projects axially therefrom.
摘要翻译：血管成形术导丝包括近轴和从轴延伸到远侧关节并具有加强件和柔性构件的中间部分。加强件和柔性构件以同轴可滑动的关系设置，并且当加强件和柔性构件进行相对轴向移动时可操作，以协同地在中间部分上赋予可变的加强力。柔性远端尖端安装到中间部分的端部并从其轴向突出。

2. 发明授权

US07083633B2 Arterial embolic filter deployed from catheter 失效
标题翻译：从导管部署动脉栓塞过滤器
公开(公告)号：US07083633B2
公开(公告)日：2006-08-01
申请号：US10653812
申请日：2003-09-03
申请人： Richard J Morrill , John R. Fagan , David O. Williams
发明人： Richard J Morrill , John R. Fagan , David O. Williams
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0021 , A61F2230/008
摘要： An improved arterial catheter device for capturing emboli within the aorta and other arteries is described. The system typically includes an elongated catheter member bearing a filtration apparatus disposed at its the distal region, comprising a filter membrane and a mechanism for deploying and collapsing the filter. For reliable deployment, the deployment mechanism comprises at least one pair of struts, one being a compression strut and the other a tension strut. In use, the catheter is positioned so that the filter membrane is down stream from the possible embolic source and upstream from any vital organs of concern. When deployed the filter membrane will capture emboli from the blood stream, and upon filter removal will extract the emboli from the patient.
摘要翻译：描述了用于捕获主动脉和其他动脉内的栓塞的改进的动脉导管装置。该系统通常包括细长的导管构件，其具有设置在其远端区域处的过滤装置，包括过滤膜和用于展开和塌缩过滤器的机构。为了可靠地部署，部署机构包括至少一对支柱，一个是压缩支柱，另一个是张力支柱。在使用中，定位导管，使得过滤膜从可能的栓塞源向下流，并且从所关心的任何重要器官的上游排出。当部署时，过滤膜将从血液中捕获栓子，并且在过滤器移除后将从患者中提取栓子。

3. 发明授权

US5545132A Helically grooved balloon for dilatation catheter and method of using 失效
标题翻译：用于扩张导管的螺旋槽球囊和使用方法
公开(公告)号：US5545132A
公开(公告)日：1996-08-13
申请号：US171061
申请日：1993-12-21
申请人： John R. Fagan , Jeffrey Kling
发明人： John R. Fagan , Jeffrey Kling
IPC分类号： A61M25/00 , A61F2/958 , A61M29/00
CPC分类号： A61M25/1002 , A61M2025/1086
摘要： A dilatation balloon having at least one helical groove disposed in at least a portion of the dilating surface of the dilatation balloon is mounted on the distal end of a catheter shaft. Multiple helical grooves may be provided in the dilatation balloon extending parallel to each other or opposite to each other in the dilating surface. Each helical groove has a pitch, width and depth. According to one aspect of the invention, the pitch, width and depth of the helical groove, as well as the number of grooves, are selected to allow perfusion of blood past the dilatation catheter when the dilatation balloon is inflated in a blood vessel. According to another aspect of the invention, the pitch, width, and depth of the helical groove, as well as the number of grooves, are selected so that the dilatation balloon conforms to a tortuous blood vessel and does not straighten the blood vessel during dilation. According to another aspect of the invention, the pitch, width, and depth of the helical groove, as well as the number of grooves, are selected to control the diametrical compliance of the dilatation balloon. The pitch, width, and depth of the helical groove may be selected to provide both conformance to the shape of tortuous blood vessels and diametrical compliance. The helical groove also permits the dilatation balloon to deflate without "winging", i.e., forming undesirable flat folds that extend outward from the rest of the catheter.
摘要翻译：具有设置在扩张球囊的扩张表面的至少一部分中的至少一个螺旋槽的扩张球囊安装在导管轴的远端。可以在膨胀气囊中设置多个螺旋槽，该膨胀气囊在扩张表面中彼此平行延伸或彼此相对延伸。每个螺旋槽具有间距，宽度和深度。根据本发明的一个方面，选择螺旋槽的间距，宽度和深度以及凹槽的数量，以便当膨胀球囊在血管中膨胀时允许血液经过扩张导管灌注。根据本发明的另一方面，选择螺旋槽的间距，宽度和深度以及凹槽的数量，使得膨胀球囊符合曲折的血管并且在扩张期间不使血管伸直。根据本发明的另一方面，选择螺旋槽的间距，宽度和深度以及凹槽的数量以控制膨胀气囊的直径依从性。可以选择螺旋槽的螺距，宽度和深度以提供符合曲折血管形状和直径依从性。螺旋槽还允许扩张气囊在没有“翼”的情况下放气，即形成从导管的其余部分向外延伸的不期望的平折。

4. 发明授权

US5858007A Hemostatic catheter introducer 失效
标题翻译：止血导管导引器
公开(公告)号：US5858007A
公开(公告)日：1999-01-12
申请号：US675220
申请日：1996-07-03
申请人： John R. Fagan , John Zhang
发明人： John R. Fagan , John Zhang
IPC分类号： A61B17/34 , A61M25/00 , A61M25/08 , A61M39/06 , A61M5/00
CPC分类号： A61B17/3462 , A61M39/0606 , A61B17/3498 , A61M2039/062 , A61M2039/0633 , A61M2039/0653 , A61M2039/0666 , A61M2039/0686
摘要： A self-sealing hemostatic valve for use in a catheter apparatus is disclosed, comprising a proximal valve element having a sealing hole, a distal valve element having a flap and biasing means to enhance the force with which the flap bears against the distal side of the proximal valve element to normally seal the hole. The sealing hole seals about an instrument passed through the valve and the flap seals the valve when no instrument is present. The proximal face of the proximal valve element is provided with discontinuities that increase the flexibility of the proximal valve element in a distal direction.
摘要翻译：公开了一种用于导管装置的自密封止血阀，其包括具有密封孔的近侧阀元件，具有瓣的远端阀元件和偏压装置，以增强所述瓣片抵靠所述导管的远端侧的力近端阀元件正常密封孔。密封孔围绕穿过阀门的仪器进行密封，当没有仪器存在时，挡板密封阀门。近端阀元件的近端面设置有不连续性，其增加近端阀元件在远端方向上的柔性。

5. 发明授权

US5715817A Bidirectional steering catheter 失效
标题翻译：双向转向导管
公开(公告)号：US5715817A
公开(公告)日：1998-02-10
申请号：US478206
申请日：1995-06-07
申请人： Debbie E. Stevens-Wright , John R. Fagan , Dino F. Cuscuna , Sarkis Karakozian
发明人： Debbie E. Stevens-Wright , John R. Fagan , Dino F. Cuscuna , Sarkis Karakozian
IPC分类号： A61B18/14 , A61M25/00 , A61M25/01 , A61B5/042 , A61N1/05
CPC分类号： A61M25/0141 , A61B18/1492 , A61M25/0136 , A61M25/0144 , A61M25/0147 , A61B2017/003 , A61B2018/00839 , A61B2018/00946 , A61B2018/00952 , A61M2025/015 , A61M2025/0161 , A61M25/0054
摘要： A bidirectional steering catheter comprising a distal electrode assembly, a flexible tip assembly, an elongated shaft having a central lumen running the length of the shaft, and a handle/actuator. A plurality of ring electrodes are attached to the surface of the flexible tip assembly. Signal wires running the length of the catheter are electrically connected to each ring electrode. At least two pull cables having first and second ends extend distally through the central lumen. The first end of each pull cable is attached to the handle/actuator. The second end of each pull cable is attached to the distal electrode assembly, such that the distal electrode assembly may be moved between a first and a second position within a single plane by manipulating the handle/actuator. At least two reinforcement members are located inside the flexible tip assembly. Each reinforcement member has a proximal section, a middle section and a distal section. Each proximal section has a larger diameter than each middle section, thus being stiffer than the middle section. This variable stiffness along the length of the each reinforcement member distributes stresses evenly along the length of the tip assembly.
摘要翻译：一种双向转向导管，包括远端电极组件，柔性尖端组件，具有延伸轴的长度的中心腔的细长轴和手柄/致动器。多个环形电极附接到柔性末端组件的表面。运行导管长度的信号线与每个环形电极电连接。至少两个具有第一和第二端的牵拉电缆向远侧延伸穿过中心腔。每个拉线的第一端连接到手柄/执行器。每个拉电缆的第二端连接到远端电极组件，使得远端电极组件可以通过操纵手柄/致动器在单个平面内在第一和第二位置之间移动。至少两个加强构件位于柔性末端组件的内部。每个加强构件具有近端部分，中部部分和远侧部分。每个近端部分具有比每个中间部分更大的直径，因此比中间部分更硬。沿着每个加强构件的长度的这种可变刚度沿尖端组件的长度均匀地分布应力。

6. 发明授权

US06196995B1 Reinforced edge exchange catheter 失效
标题翻译：加强边缘交换导管
公开(公告)号：US06196995B1
公开(公告)日：2001-03-06
申请号：US09164009
申请日：1998-09-30
申请人： John R. Fagan
发明人： John R. Fagan
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M2025/0183 , A61M2025/107
摘要： The invention relates to a catheter and guidewire exchange system in which the guidewire is contained within an indwelling portion of the catheter and with the guidewire and the catheter being separated externally of the patient. The catheter includes a guidewire lumen and a longitudinal slit which penetrates through the catheter wall and into the guidewire lumen. The catheter walls adjacent the slit are provided with reinforced edges which function to maintain the slit in a normally closed position during the catheterization procedure, when desired.
摘要翻译：本发明涉及导管和导丝交换系统，其中导丝包含在导管的留置部分内，并且导丝和导管在患者外部分离。导管包括穿过导管壁并进入导丝管腔的导丝管腔和纵向狭缝。邻近狭缝的导管壁设置有加强边缘，其有助于在需要时在导管插入过程期间将狭缝保持在常闭位置。

7. 发明授权

US5720300A High performance wires for use in medical devices and alloys therefor 失效
标题翻译：用于医疗器械及其合金的高性能电线
公开(公告)号：US5720300A
公开(公告)日：1998-02-24
申请号：US391010
申请日：1995-02-21
申请人： John R. Fagan , Lex P. Jansen , L. Ven Raman , John A. Wright, Jr.
发明人： John R. Fagan , Lex P. Jansen , L. Ven Raman , John A. Wright, Jr.
IPC分类号： A61M25/01 , A61B5/00 , A61M25/09 , C21D1/30 , C21D9/52 , C22C38/00 , C22C38/52
CPC分类号： A61M25/09 , A61M2025/09175
摘要： An elongate flexible wire-like medical device, such as a guidewire for use with a catheter, is formed with a shaft in which the difference between the magnitude of the tensile yield stress and compressive yield stress of the shaft is substantially reduced. The guidewire exhibits superior kink resistance without compromising other desirable characteristics and enables a guidewire to be made in a smaller diameter without loss of performance. The guidewire shaft may be formed from a precipitation hardenable alloy such as an alloy of nickel, cobalt, molybdenum and chromium (MP35N and Elgiloy), 455PH stainless steel or stainless steel alloy 1RK91. Also disclosed is a process for increasing the modulus of elasticity of an alloy of nickel, cobalt molybdenum and chromium. Further, the disclosure relates to an improved management and manufacturing process for constructing the tip of a medical guidewire.
摘要翻译：细长的柔性线状医疗装置，例如与导管一起使用的导丝，形成有轴，其中拉伸屈服应力的大小与轴的压缩屈服应力之间的差异大大降低。导丝在不影响其他期望特性的情况下表现出优异的扭结阻力，并且使导丝可以制造成较小的直径而不损失性能。导丝轴可以由诸如镍，钴，钼和铬的合金（MP35N和Elgiloy），455PH不锈钢或不锈钢合金1RK91的析出可硬化合金形成。还公开了提高镍，钴钼和铬的合金的弹性模量的方法。此外，本公开涉及用于构造医疗导丝的尖端的改进的管理和制造过程。

8. 发明授权

US06206915B1 Drug storing and metering stent 失效
标题翻译：药物储存和计量支架
公开(公告)号：US06206915B1
公开(公告)日：2001-03-27
申请号：US09162540
申请日：1998-09-29
申请人： John R. Fagan , Chirag B. Shah
发明人： John R. Fagan , Chirag B. Shah
IPC分类号： A61F204
CPC分类号： A61F2/07 , A61F2220/0033 , A61F2220/005 , A61F2220/0058 , A61F2250/0067
摘要： A drug storing and metering stent for placement within a vessel comprising an outer member having a lumen, an inner member positioned within the lumen of the outer member. A space separates the inner member from the outer member and within which space a therapeutic drug is disposed. The stent includes at least one protrusion provided on at least one of the inner and outer members and extending across the space so as to cause a friction fit between the inner and outer members. The stent also includes a pattern of perforation across both the inner and outer members to permit the stent to expand radially. The invention also relates to a method of making such a stent, and a method of releasing a therapeutic drug within a vessel.
摘要翻译：一种用于放置在容器内的药物储存和计量支架，包括具有内腔的外部构件，位于外部构件的内腔内的内部构件。空间将内部构件与外部构件隔开，并且在该空间内设置治疗药物。所述支架包括设置在所述内部构件和所述外部构件中的至少一个上的至少一个突起，并延伸穿过所述空间，以便在所述内部构件和所述外部构件之间形成摩擦配合。支架还包括穿过内部构件和外部构件的穿孔图案，以允许支架径向扩张。本发明还涉及制造这种支架的方法以及在血管内释放治疗药物的方法。

9. 发明授权

US6110144A Method and apparatus for regulating the fluid flow rate to and preventing over-pressurization of a balloon catheter 失效
标题翻译：用于调节流体流速并防止球囊导管过度加压的方法和装置
公开(公告)号：US6110144A
公开(公告)日：2000-08-29
申请号：US359805
申请日：1999-07-26
申请人： Richard T. Choh , John R. Fagan , Stephen J. Forcucci
发明人： Richard T. Choh , John R. Fagan , Stephen J. Forcucci
IPC分类号： A61F2/958 , A61M29/00
CPC分类号： A61M25/10184 , A61M25/1018 , A61M2025/0001 , A61M2025/105
摘要： The invention relates to an apparatus and method for limiting the pressure of inflation fluid injected into a drug delivery catheter balloon, while permitting continuous and uninterrupted flow of such fluid to the balloon. The apparatus includes an elongated hollow housing having a fluid entrance, a fluid exit and a bore extending therebetween which forms an interconnecting chamber and passageway. A piston and piston shaft assembly is disposed inside the housing and is longitudinally movable within the chamber. The piston and piston shaft assembly is biased against the fluid pressure of the fluid entering the housing by a spring. The piston shaft has a distal end which extends toward the passageway inlet. As the incoming fluid pressure increases and approaches the predetermined maximum pressure level of the apparatus, the piston shaft distal end moves within the chamber against the biasing force of the spring toward a position adjacent the passageway inlet. When the incoming fluid pressure reaches and exceeds the predetermined maximum pressure level, the piston shaft distal end enters and extends into the passageway, thereby forming an annulus within the passageway. The annulus functions to restrict the flow rate and limit the pressure of the fluid exiting the housing and entering the catheter balloon.
摘要翻译：本发明涉及一种用于限制注射到药物递送导管球囊中的充气流体的压力的装置和方法，同时允许这种流体连续且不间断地流入气囊。该装置包括细长的中空壳体，其具有流体入口，流体出口和在其间延伸的孔，其形成互连室和通道。活塞和活塞轴组件设置在壳体内部并且可在腔室内纵向移动。活塞和活塞轴组件被抵抗通过弹簧进入壳体的流体的流体压力而偏置。活塞轴具有朝向通道入口延伸的远端。当进入的流体压力增加并且接近装置的预定最大压力水平时，活塞轴远端抵抗弹簧的偏置力抵抗通道入口附近的位置移动。当进入的流体压力达到并超过预定的最大压力水平时，活塞轴远端进入并延伸到通道中，从而在通道内形成环形空间。环的作用是限制流速并限制离开壳体并进入导管气囊的流体的压力。

10. 发明授权

US5993416A Method and apparatus for regulating the fluid flow rate to and preventing over-pressurization of a balloon catheter 失效
公开(公告)号：US5993416A
公开(公告)日：1999-11-30
申请号：US7427
申请日：1998-01-15
申请人： Richard T. Choh , John R. Fagan , Stephen J. Forcucci
发明人： Richard T. Choh , John R. Fagan , Stephen J. Forcucci
IPC分类号： A61F2/958 , A61M29/00
CPC分类号： A61M25/10184 , A61M25/1018 , A61M2025/0001 , A61M2025/105
摘要： The invention relates to an apparatus and method for limiting the pressure of inflation fluid injected into a drug delivery catheter balloon, while permitting continuous and uninterrupted flow of such fluid to the balloon. The apparatus includes an elongated hollow housing having a fluid entrance, a fluid exit and a bore extending therebetween which forms an interconnecting chamber and passageway. A piston and piston shaft assembly is disposed inside the housing and is longitudinally movable within the chamber. The piston and piston shaft assembly is biased against the fluid pressure of the fluid entering the housing by a spring. The piston shaft has a distal end which extends toward the passageway inlet. As the incoming fluid pressure increases and approaches the predetermined maximum pressure level of the apparatus, the piston shaft distal end moves within the chamber against the biasing force of the spring toward a position adjacent the passageway inlet. When the incoming fluid pressure reaches and exceeds the predetermined maximum pressure level, the piston shaft distal end enters and extends into the passageway, thereby forming an annulus within the passageway. The annulus functions to restrict the flow rate and limit the pressure of the fluid exiting the housing and entering the catheter balloon.

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