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1. 发明授权

US07357835B2 Production of crystalline materials by using high intensity ultrasound 有权
标题翻译：通过使用高强度超声波生产结晶材料
公开(公告)号：US07357835B2
公开(公告)日：2008-04-15
申请号：US10514883
申请日：2003-05-13
申请人： Linda Jane McCausland , John Patrick Perkins
发明人： Linda Jane McCausland , John Patrick Perkins
IPC分类号： B01D9/00 , C30B1/00
CPC分类号： B01D9/0013 , B01D9/0036 , B01D9/0063 , B01D9/0081 , C07K5/0613 , Y10T117/1024 , Y10T117/1028
摘要： A crystalline material sufficiently pure for use in pharmaceuticals may be made by forming a saturated solution of the material, changing the temperature of the solution so it becomes supersaturated, and subjecting the solution to irradiation by high intensity ultrasound, the frequency of the ultrasound being scanned over a range of frequencies. For example the ultrasound may be varied between 19.5 and 20.5 kHz, and this variation may be sinusoidal. Preferably the ultrasound is provided only briefly, say for less than 5 s, before allowing the solution to cool gradually without further irradiation. The ultrasound may be applied using a vessel with an array of ultrasonic transducers attached to a wall, so each transducer radiates no more than 3 W/cm2 yet the power dissipation within the vessel is between 25 and 150 W/litre. This method can reduce the metastable zone width to less than 10 K. It is applicable in particular to aspartame.
摘要翻译：可以通过形成饱和的材料溶液，改变溶液的温度，使其变得过饱和，并通过高强度超声波对该溶液进行照射，使超声频率被扫描，可以制备足够纯的用于药物的结晶物质在一个频率范围内。例如，超声可以在19.5和20.5kHz之间变化，并且该变化可以是正弦的。优选地，在允许溶液逐渐冷却而不进一步照射之前，仅提供超声波，例如少于5秒。可以使用具有附接到壁的超声波换能器阵列的血管来应用超声波，因此每个换能器辐射不超过3W / cm 2，而容器内的功率耗散在25和150之间 W /升。该方法可将亚稳区宽度减小到10K以下。特别适用于阿斯巴甜。

2. 发明授权

US07354556B2 Process and apparatus for irradiating fluids 有权
标题翻译：用于照射流体的方法和装置
公开(公告)号：US07354556B2
公开(公告)日：2008-04-08
申请号：US10722494
申请日：2003-11-28
申请人： John Patrick Perkins
发明人： John Patrick Perkins
IPC分类号： B06B1/00
CPC分类号： B01J19/10 , B01J2219/0877
摘要： Fluids in a vessel are subjected to a high ultrasonic intensity, by means of several ultrasonic transducers attached to a wall of the vessel, each transducer (14) radiating no more than 3 W/cm2, the transducers being sufficiently close to each other, and the number of transducers being sufficiently high, that the power dissipation within the vessel is at least 25 W/liter. The number of transducers, the power of the transducers, and the volume of the vessel may be such that the power density is between 40 and 80 W/liter. The vessel may be double walled, and the space between the two walls be filled by a low attenuation buffer liquid (36) whose cavitation threshold is above that of the liquid being treated.
摘要翻译：容器中的流体通过附着在容器壁上的几个超声波换能器受到高超声波强度，每个换能器（14）辐射不超过3W / cm 2，换能器彼此足够接近，并且换能器的数量足够高，容器内的功率消耗至少为25W /升。换能器的数量，换能器的功率和容器的体积可以是功率密度在40和80W /升之间。容器可以是双壁的，并且两个壁之间的空间由其空化阈值高于被处理液体的低衰减缓冲液（36）填充。

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