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    • 4. 发明授权
    • Therapeutic agents useful for treating inflammatory diseases
    • 用于治疗炎性疾病的治疗剂
    • US5547972A
    • 1996-08-20
    • US244246
    • 1994-06-03
    • Lawrence S. CleggIan M. HunneyballColin G. P. JonesPaul RaffertyLeslie Steele
    • Lawrence S. CleggIan M. HunneyballColin G. P. JonesPaul RaffertyLeslie Steele
    • A61K31/415A61K31/4164A61K31/4166A61P11/06A61P29/00A61P37/08C07D233/61C07D233/64C07D233/68C07D233/70C07D233/72C07D233/74C07D233/76C07D233/78C07D521/00
    • C07D231/12C07D233/56C07D249/08
    • This invention relates to compounds of formula I and pharmaceutically acceptable salts thereof ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 independently represent hydrogen, halo, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, --NR.sub.13 R.sub.14, halogenated alkoxy, halogenated alkyl, benzyloxy, hydroxy, hydroxyalkyl, (C.sub.2-6 alkoxycarbonyl)vinyl, --S(O).sub.n R.sub.7, carbamoylalkyl, alkoxycarbonylalkyl, --CONR.sub.11 R.sub.12, or R.sub.1 and R.sub.2 together with the phenyl ring represent a naphthyl group; R.sub.4 and R.sub.5 independently represent hydrogen, alkyl, phenyl or together with the carbon atom represent C.sub.3-6 cycloalkyl; R.sub.6 represents hydrogen, alkyl or .omega.-hydroxy alkyl; A represents C.sub.2-9 alkylene; R.sub.8 represents hydrogen, alkyl, halo, alkoxy, hydroxyalkyl, benzyl or phenyl; R.sub.9 and R.sub.10 independently represent hydrogen, alkyl, halo, alkoxy, phenyl, hydroxyalkyl, alkoxycarbonyl, nitro, --NR.sub.30 R.sub.31, alkanoyloxyalkyl, or aminomethyl; which are antiinflammatory and antiallergic agents. Compositions containing these compounds and processes to make them are also disclosed.
    • PCT No.PCT / EP92 / 02899 Sec。 371日期:1994年6月3日 102(e)日期1994年6月3日PCT提交1992年12月12日PCT公布。 公开号WO93 / 13075 PCT 日本本发明涉及式I化合物及其药学上可接受的盐代表氢,卤素,烷基,烷氧基,苯氧基,苯基,烷氧基羰基,-NR13R14,卤代烷氧基,卤代烷基,苄氧基,羟基,羟烷基,(C2 -6烷氧基羰基)乙烯基,-S(O)n R 7,氨基甲酰基烷基,烷氧基羰基烷基,-CONR 11 R 12或R 1和R 2与苯环一起代表萘基; R4和R5独立地表示氢,烷基,苯基或与碳原子一起代表C3-6环烷基; R6表示氢,烷基或ω-羟基烷基; A表示C2-9亚烷基; R8代表氢,烷基,卤素,烷氧基,羟基烷基,苄基或苯基; R 9和R 10独立地表示氢,烷基,卤素,烷氧基,苯基,羟基烷基,烷氧基羰基,硝基,-NR 30 R 31,烷酰氧基烷基或氨基甲基。 它们是抗炎和抗过敏剂。 还公开了含有这些化合物的组合物和制备它们的方法。