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1. 发明申请

US20060028727A1 Method and apparatus for drug product tracking using encoded optical identification elements 有权
标题翻译：使用编码的光学识别元件的药物产品跟踪的方法和装置
公开(公告)号：US20060028727A1
公开(公告)日：2006-02-09
申请号：US11187262
申请日：2005-07-21
申请人： John Moon , Martin Putnam , Alan Kersey , David Fournier , Joseph Pinto
发明人： John Moon , Martin Putnam , Alan Kersey , David Fournier , Joseph Pinto
IPC分类号： G02B5/18
CPC分类号： G06K19/06009 , G03H1/0011 , G03H2001/0016 , G06K19/16 , G06K2019/0629 , G07D7/0032 , G07D7/128
摘要： A method and apparatus for drug product tracking (or other pharmaceutical, health care or cosmetics products, and/or the packages or containers they are supplied with) using diffraction grating-based encoded optical identification elements 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has one or more colocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely from the side of the substrate 10 (or from an end) with a narrow band (single wavelength) or multiple wavelength source, and the code is represented by a spatial distribution of light or a wavelength spectrum, respectively, or a combination thereof. The encoded element 8 may be used to label any desired item, such as drugs or medicines, or other pharmaceutical or health care products or cosmetics. The label may be used for many different purposes, such as for sorting, tracking, identification, verification, authentication, anti-theft/anti-counterfeit, security/anti-terrorism, or for other purposes. In a manufacturing environment, the elements 8 may be used to track inventory for production information or sales of goods/products. Such labeling provides product identification at the pill or liquid medicine level, which provides traceability of these products to their manufacturer, thereby reducing counterfeit products in the marketplace. Also, the elements 8 may be incorporated into a film, liquid, coating or adhesive tape at attached to the product package.
摘要翻译：使用基于衍射光栅的编码光学识别元件8的药物追踪（或其他药物，保健或化妆品产品和/或其提供的包装或容器）的方法和装置包括具有至少一个设置在其中的衍射光栅12。光栅12具有一个或多个共同定位的间距Lambda，其表示当被入射光24照射时检测到的唯一识别数字码。入射光24可以从具有窄带（单波长）或多个波长源的基板10的一侧（或从一端）横向引导，并且代码由光或波长光谱的空间分布表示，或其组合。编码元件8可以用于标记任何期望的物品，例如药物或药物，或其它药物或保健产品或化妆品。该标签可用于许多不同的目的，例如用于分类，跟踪，识别，验证，认证，防盗/防伪，安全/反恐，或用于其他目的。在制造环境中，元件8可用于跟踪生产信息的库存或货物/产品的销售。这种标签在药丸或液体药物级别提供产品鉴定，这些产品可以向制造商提供可追溯性，从而减少市场上的假冒产品。此外，元件8可以结合到附接到产品包装上的膜，液体，涂层或胶带中。

2. 发明申请

US20060071075A1 Optical reader for diffraction grating-based encoded optical identification elements 有权
$Optical reader for diffraction grating-based encoded optical identification elements$
标题翻译：用于衍射光栅编码光学识别元件的光学读取器
公开(公告)号：US20060071075A1
公开(公告)日：2006-04-06
申请号：US10956791
申请日：2004-10-01
申请人： John Moon , David Fournier , Martin Putnam , Alan Kersey , Tuo Li
发明人： John Moon , David Fournier , Martin Putnam , Alan Kersey , Tuo Li
IPC分类号： G06K7/10
CPC分类号： G06K7/12 , B01J2219/005 , B01J2219/0056 , G06K7/1094 , G06K19/06009 , G06K2019/06225 , G06K2019/06234 , G06K2019/0629 , G07D7/0032 , G07D7/004
摘要： An optical reader system 7 for diffraction grating-based encoded microbeads (or bead reader system), comprises a reader box 100, which accepts a bead cell (or cuvette) 102 that holds the microbeads 8, having an embedded code therein. The reader box 100 interfaces along lines 103 with a known computer system 104. The reader box 100 interfaces with a stage position controller 112 and the controller 112 interfaces along a line 115 with the computer system 104 and a manual control device (or joy stick) 116 along a line 117. The reader interrogates the microbeads to determine the embedded code and/or the fluorescence level on the beads. The reader provides information similar to a bead flow cytometer but in a planar format, i.e., a virtual cytometer.
摘要翻译：用于基于衍射光栅的编码微珠（或珠读取器系统）的光学读取器系统7包括读取器盒100，其接收保持微珠8的珠细胞（或比色杯）102，其中具有嵌入代码。读取器箱100沿着线103与已知的计算机系统104相接口。读取箱100与平台位置控制器112连接，并且控制器112沿着线115与计算机系统104和手动控制装置（或操纵杆） 116.读取器询问微珠以确定珠上的嵌入代码和/或荧光水平。读者提供类似于珠流式细胞仪的信息，但是以平面格式，即虚拟血细胞计数器。

3. 发明申请

US20060118630A1 Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same 有权
公开(公告)号：US20060118630A1
公开(公告)日：2006-06-08
申请号：US11281910
申请日：2005-11-16
申请人： Alan Kersey , John Moon , Martin Putnam
发明人： Alan Kersey , John Moon , Martin Putnam
IPC分类号： G06K7/10
CPC分类号： G06K7/10663
摘要： A method and apparatus is provided for writing a code on an optical element, wherein the code is written on the optical element in the form of a holographic image of an n-dimensional code generated by an interference pattern between a reference beam and a signal beam reflected off a spatial light modulation device having the n-dimensional code configured thereon. The method includes steps of generating the interference pattern between the reference beam and the signal beam reflected off the spatial light modulation device having the n-dimensional code thereon; as well as writing the interference pattern on the optical element as a holographic image of the n-dimensional code.

4. 发明申请

US20060023310A1 Optical identification element using separate or partially overlapped diffraction gratings 审中-公开
$Optical identification element using separate or partially overlapped diffraction gratings$
标题翻译：使用单独或部分重叠的衍射光栅的光学识别元件
公开(公告)号：US20060023310A1
公开(公告)日：2006-02-02
申请号：US11063666
申请日：2005-02-22
申请人： Martin Putnam , John Moon , Alan Kersey
发明人： Martin Putnam , John Moon , Alan Kersey
IPC分类号： G02B5/18
CPC分类号： G02B5/1842 , G02B3/06
摘要： An optical identification element 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has a one or more of collocated pitches Λ which represent a unique identification N bit digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely onto the side or onto an end of the substrate 10 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The element 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The element 8 can be used in any application that requires sorting, tagging, tracking or identification, and can be made on a micron scale “microbeads” if desired, or larger “macro-elements” for larger applications. The code may be digital binary or may be other numerical bases.
摘要翻译：光学识别元件8包括其中设置有至少一个衍射光栅12的光学基板10。光栅12具有一个或多个并置的间距λ，它们表示当被入射光24照射时检测到的唯一识别N位数字码。入射光24可以以窄带（单波长）或多个波长源横向地引导到基板10的一侧或一端上，在这种情况下，代码由光或波长光谱的空间分布表示，分别。元件8可以提供大量独特的代码，例如大于6700万个代码，并且可以承受恶劣的环境。元件8可用于任何需要排序，标记，跟踪或识别的应用中，如果需要，可以在微米尺度“微珠”上制造，或者对于更大的应用可以使用更大的“宏观元件”。代码可以是数字二进制的，也可以是其他的数字基础。

5. 发明申请

US20070121181A1 Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction 有权
$Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction$
标题翻译：使用以X射线衍射为特征的光学识别元件进行标记的方法和装置
公开(公告)号：US20070121181A1
公开(公告)日：2007-05-31
申请号：US11601584
申请日：2006-11-16
申请人： John Moon , Martin Putnam , Alan Kersey , Paul Szczepanek
发明人： John Moon , Martin Putnam , Alan Kersey , Paul Szczepanek
IPC分类号： G03H1/00
CPC分类号： G03H5/00 , G01N23/2005 , G03H2001/0016 , G07D7/003
摘要： An optical identification element for identifying an item comprises a binder material and one or more materials embedded in the binder material. The one or more materials provide an encoded composite X-ray diffraction pattern when illuminated by an X-ray beam. The encoded composite X-ray diffraction pattern is indicative of the item. The one or more materials are preferably powdered crystal materials. The optical identification element may be shaped as a microbead or a macrobead. Alternatively, the binder material may be in the form of a thread or fiber. The labeled item may be selected from the group, comprising: large or small objects, products, solids, powders, liquids, gases, plants, pharmaceuticals, currency, ID cards, minerals, cells and/or animals. The item may be a chemical or a DNA sequence. The optical identification element may be used for many different purposes, such as for sorting, tracking, identification, verification, authentication, anti-theft/anti-counterfeit, security/anti-terrorism, or for other purposes. In a manufacturing environment, the elements 8 may be used to track inventory for production information or sales of goods/products.
摘要翻译：用于识别物品的光学识别元件包括粘合剂材料和嵌入粘合剂材料中的一种或多种材料。一种或多种材料在由X射线束照射时提供编码的复合X射线衍射图案。编码的复合X射线衍射图表示该项目。一种或多种材料优选为粉末状晶体材料。光学识别元件可以成形为微珠或大珠粒。或者，粘合剂材料可以是线或纤维的形式。标签物品可以从组中选择，包括：大或小物体，产品，固体，粉末，液体，气体，植物，药物，货币，身份证，矿物质，细胞和/或动物。该物品可以是化学物质或DNA序列。光学识别元件可以用于许多不同的目的，例如用于分类，跟踪，识别，验证，认证，防盗/防伪，安全/反恐，或用于其他目的。在制造环境中，元件8可用于跟踪生产信息的库存或货物/产品的销售。

6. 发明申请

US20050270603A1 Optical identification element using separate or partially overlapped diffraction gratings 审中-公开
$Optical identification element using separate or partially overlapped diffraction gratings$
标题翻译：使用单独或部分重叠的衍射光栅的光学识别元件
公开(公告)号：US20050270603A1
公开(公告)日：2005-12-08
申请号：US11158782
申请日：2005-06-21
申请人： Martin Putnam , John Moon , Alan Kersey
发明人： Martin Putnam , John Moon , Alan Kersey
IPC分类号： G03H1/00 , G03H1/26
CPC分类号： G03H1/26 , G03H2001/0016 , G03H2230/10
摘要： An optical identification element 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has a one or more of collocated pitches A which represent a unique identification N bit digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely onto the side or onto an end of the substrate 10 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The element 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The element 8 can be used in any application that requires sorting, tagging, tracking or identification, and can be made on a micron scale “microbeads” if desired, or larger “macro-elements” for larger applications. The code may be digital binary or may be other numerical bases.
摘要翻译：光学识别元件8包括其中设置有至少一个衍射光栅12的光学基板10。光栅12具有一个或多个并置间距A，其表示当被入射光24照射时检测到的唯一识别N位数字码。入射光24可以以窄带（单波长）或多个波长源横向地引导到基板10的一侧或一端上，在这种情况下，代码由光或波长光谱的空间分布表示，分别。元件8可以提供大量独特的代码，例如大于6700万个代码，并且可以承受恶劣的环境。元件8可用于任何需要排序，标记，跟踪或识别的应用中，如果需要，可以在微米尺度“微珠”上制造，或者对于更大的应用可以使用更大的“宏观元件”。代码可以是数字二进制的，也可以是其他的数字基础。

7. 发明授权

US07463828B2 Optical channel monitor 有权
标题翻译：光通道监视器
公开(公告)号：US07463828B2
公开(公告)日：2008-12-09
申请号：US10159370
申请日：2002-05-31
申请人： John Moon , Ralph Jones , Charles Winston , James Sirkis , David Fournier , Joseph Pinto , Robert Brucato , James Dunphy , Christopher Chestnut
发明人： John Moon , Ralph Jones , Charles Winston , James Sirkis , David Fournier , Joseph Pinto , Robert Brucato , James Dunphy , Christopher Chestnut
IPC分类号： G02B6/26 , H01S3/08 , G01J3/18
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0202 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/0256 , G01J3/0291 , G01J3/06 , G01J3/32 , G01J3/36 , G01J2003/064 , G01J2003/1819 , G02B6/2706 , G02B6/2793 , G02B6/2931 , G02B6/29313 , G02B6/29314 , G02B6/29385 , G02B6/29398 , G02B6/3512 , G02B6/359 , G02B6/4215 , G02B6/4246 , H04B10/077 , H04B10/07955 , H04Q2011/0026 , H04Q2011/0049 , H04Q2011/0083
摘要： An optical channel monitor is provided that sequentially or selectively filters an optical channel(s) 11 of light from a (WDM) optical input signal 12 and senses predetermined parameters of the each filtered optical signal (e.g., channel power, channel presence, signal-noise-ratio). The OCM 10 is a free-space optical device that includes a collimator assembly 15, a diffraction grating 20 and a mirror 22. A launch pigtail emits into free space the input signal through the collimator assembly 15 and onto the diffraction grating 20, which separates spatially each of the optical channels 11 of the collimated light, and reflects the separated channels of light onto the mirror 22. A λ/4 plate 26 is disposed between the mirror 22 and the diffraction grating 20. The mirror reflects the separated light back through the λ/4 plate 26 to the diffraction grating 20, which reflects the channels of light back through the collimating lens 18. The lens 18 focuses each separated channel of light (λ1-λN) at a different focal point in space. One of the optical channels 11 is focused onto a receive pigtail 28, which then propagates to a photodetector 30. A pivoting mechanism 34 pivots the diffraction grating 20 or mirror 22 about a pivot point 36 to sequentially or selectively focus each optical channel 11 to the receive pigtail 28. A position sensor 42 detects the displacement of the diffraction grating 24 or mirror.
摘要翻译：提供了一种光通道监视器，其顺序地或选择性地对来自（WDM）光输入信号12的光的通道11进行滤波，并且感测每个滤波的光信号的预定参数（例如，信道功率，信道存在，噪声比）。 OCM 10是包括准直器组件15，衍射光栅20和反射镜22的自由空间光学装置。发射尾纤通过准直器组件15和衍射光栅20将衍射光栅20发射到自由空间中，输入信号分离准直光的每个光通道11，并将分离的光反射到反射镜22上.λ/ 4板26设置在反射镜22和衍射光栅20之间。反射镜将分离的光反射回 λ/ 4板26到衍射光栅20，其反射通过准直透镜18的光通道。透镜18将每个分离的光（λ1-λN）通道在空间中的不同焦点处聚焦。光通道11中的一个被聚焦到接收引线28上，接收引线28然后传播到光电检测器30.枢转机构34围绕枢转点36枢转衍射光栅20或反射镜22，以顺序地或选择性地将每个光通道11聚焦到接收尾纤28.位置传感器42检测衍射光栅24或反射镜的位移。

8. 发明申请

US20060139635A1 Scanner having spatial light modulator 有权
公开(公告)号：US20060139635A1
公开(公告)日：2006-06-29
申请号：US11281937
申请日：2005-11-16
申请人： Alan Kersey , John Moon
发明人： Alan Kersey , John Moon
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01J3/02 , G01J3/021 , G01J3/4406 , G01N2021/6471 , G02B21/0076
摘要： The present invention features incorporating an adaptive spectral filter into a confocal scanner optical arrangement or other suitable optical device to permit real time control of the fluorescence signal spectrum being monitored. This new arrangement would allow for better balancing of the fluorescence signals in the analysis of the array.

9. 发明申请

US20060072177A1 Diffraction grating-based encoded microparticle assay stick 有权
$Diffraction grating-based encoded microparticle assay stick$
标题翻译：基于衍射光栅的编码微粒测定棒
公开(公告)号：US20060072177A1
公开(公告)日：2006-04-06
申请号：US11226914
申请日：2005-09-13
申请人： Martin Putnam , John Moon , Tuo Li
发明人： Martin Putnam , John Moon , Tuo Li
IPC分类号： G03H1/00
CPC分类号： G01N21/4788 , G01N21/6428 , G03H1/26 , G03H2001/0033
摘要： An assay stick 7 includes a transparent reaction vessel or tube 14 having one or more microbeads 8 disposed therein. The microbeads 8 have a plurality of unique identification digital codes based on a diffraction grating 12 disposed therein that are detected when illuminated by incident light 24. The incident light 24 may be directed transversely onto the side or onto an end of the tube 14 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The assay stick 7 may be reused or disposed upon completion of the assay. Alternatively, the beads may be attached to a strip or planar surface. The encoded beads can also provide traceability, quality-control, and authenticity of each bead 8 to its source and/or to the chemistry on each bead 8. Also, the low sample volume of the assay stick allows for faster reactions and better sensitivity.
摘要翻译：测定棒7包括其中设置有一个或多个微珠8的透明反应容器或管14。微珠8具有基于设置在其中的衍射光栅12的多个唯一的识别数字代码，其被入射光24照射时检测。入射光24可以以窄带（单波长）或多个波长源横向地引导到管14的一侧或一端上，在这种情况下，代码由光或波长光谱的空间分布表示，分别。测定棒7可以在测定完成后重复使用或放置。或者，珠可以附接到条或平面表面。编码的珠粒还可以提供每个珠粒8到其源和/或每个珠粒8上的化学物质的可追溯性，质量控制和真实性。此外，测定棒的低样品体积允许更快的反应和更好的灵敏度。

10. 发明申请

US20060057729A1 Diffraction grating-based encoded element having a substance disposed thereon 审中-公开
$Diffraction grating-based encoded element having a substance disposed thereon$
标题翻译：衍射光栅编码元件，其上设置有物质
公开(公告)号：US20060057729A1
公开(公告)日：2006-03-16
申请号：US11206987
申请日：2005-08-18
申请人： John Moon , Martin Putnam , Michel Perbost
发明人： John Moon , Martin Putnam , Michel Perbost
IPC分类号： G03H1/00 , G01N21/64
CPC分类号： G01N21/6428 , G01N21/4788 , G03H1/26 , G03H2001/0033
摘要： The present invention generally provides multicomponent articles of manufacture and methods of making them. In its broadest aspect, the invention provides a multicomponent article that includes a diffraction grating-based encoded element, wherein the encoded element includes an optical substrate having at least one surface, and an optical coding element; and a substance disposed on at least a portion of the surface of the substrate. The optical substrate may be made from a wide variety of materials. Importantly the multicomponent article may be a reagent particle wherein the substance includes a reagent. The reagent may be chosen from a wide range of biological macromolecules and oligomeric molecules, from any organic chemical or inorganic chemical compound including pharmaceutical agents and candidate pharmaceutical agents, modifications of any of them, and from any microbiological entity, a cell, and similar entities. In another aspect the invention provides a coded reagent library including a plurality of reagent particles described herein the preceding paragraphs. In another aspect the invention provides a method of preparing a multicomponent article including the steps of providing a diffraction grating-based encoded element, and binding a substance to a surface of said optical substrate. The invention also provides a method of preparing a coded reagent library. Additionally the invention provides a method of synthesizing a polynucleotide reagent on a multicomponent article.
摘要翻译：本发明通常提供多组分制品及其制备方法。在其最广泛的方面，本发明提供了一种包括基于衍射光栅的编码元件的多组分制品，其中编码元件包括具有至少一个表面的光学基底和光学编码元件; 以及设置在所述基板的表面的至少一部分上的物质。光学基底可以由各种各样的材料制成。重要的是，多组分制品可以是试剂颗粒，其中物质包括试剂。试剂可以选自广泛范围的生物大分子和低聚分子，包括任何有机化学或无机化合物，包括药剂和候选药剂，其任何一种的修饰，以及任何微生物实体，细胞和类似实体。在另一方面，本发明提供了一种编码的试剂库，其包括前述各段所述的多种试剂颗粒。在另一方面，本发明提供了一种制备多组分制品的方法，包括以下步骤：提供基于衍射光栅的编码元件，并将物质结合到所述光学基底的表面。本发明还提供了编码试剂库的方法。另外，本发明提供了在多组分制品上合成多核苷酸试剂的方法。

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