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1. 发明授权

US5207219A Atrial defibrillator and method for providing interval timing prior to cardioversion 失效
标题翻译：心房除颤器和在心脏复律前提供间隔时间的方法
公开(公告)号：US5207219A
公开(公告)日：1993-05-04
申请号：US965195
申请日：1992-10-23
申请人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger , Joseph M. Bocek
发明人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger , Joseph M. Bocek
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/395 , A61N1/3987
摘要： An implantable atrial defibrillator provides cardioverting electrical energy to the atria of a human heart in need of cardioversion. The atrial defibrillator includes a first detector for detecting ventricular activations of the heart, a second detector for detecting atrial activity of the heart, and an atrial fibrillation detector responsive to the second detector for determining when the atria of the heart are in need of cardioversion. The atrial defibrillator also includes a cardioverting stage for applying the cardioverting electrical energy to the atria of the heart when the atria of the heart are in need of cardioversion and when the time between immediately successive ventricular activations is greater than a preselected minimum time interval.

2. 发明授权

US5269298A Atrial defibrillator and method for providing synchronized delayed cardioversion 失效
标题翻译：心房除颤器和提供同步延迟心脏复律的方法
公开(公告)号：US5269298A
公开(公告)日：1993-12-14
申请号：US965168
申请日：1992-10-23
申请人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger , Yixuan Jin
发明人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger , Yixuan Jin
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/395 , A61N1/3987
摘要： An implantable atrial defibrillator provides cardioverting electrical energy to the atria of a human heart in need of cardioversion. The atrial defibrillator includes a first detector for detecting ventricular activations of the heart, a second detector for detecting atrial activity of the heart, and an atrial fibrillation detector responsive to the second detector for determining when the atria of the heart are in need of cardioversion. The atrial defibrillator further includes a cardioverter for applying the cardioverting electrical energy to the atria of the heart when the atria of the heart are in need of cardioversion, and a timer delay stage responsive to the first detector for causing the cardioverter to apply the cardioverting electrical energy to the atria of the heart a predetermined delay time after the first detector detects one of the ventricular activations and before the T wave of the heart immediately following the one of the ventricular activations.

3. 发明授权

US5348021A Apparatus and method for reliably detecting a depolarization activation wave of the heart and atrial defibrillator utilizing same 失效
标题翻译：利用其可靠地检测心脏和心房除颤器的去极化激活波的装置和方法
公开(公告)号：US5348021A
公开(公告)日：1994-09-20
申请号：US861184
申请日：1992-03-31
申请人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger
发明人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger
IPC分类号： A61N1/39 , A61B5/046
CPC分类号： A61N1/3956 , A61N1/395 , A61N1/3987
摘要： An atrial defibrillator reliably detects a depolarization activation wave of the heart and delivers cardioverting electrical energy to the atria of the heart in synchronism with a detected depolarization activation wave. The atrial defibrillator includes a first sensor for producing a first electrical output having a duration substantially equal to the duration of the depolarization activation wave sensed between a first pair of spaced apart locations of the heart. The atrial defibrillator further includes a second sensor for producing a second electrical output having a duration substantially equal to the duration of the depolarization activation wave sensed between a second pair of spaced apart locations of the heart. The spacing between the second pair of locations is greater than the spacing between the first pair of locations. A microprocessor is responsive to the first and second electrical outputs for providing an indication signal indicating the occurrence of the depolarization activation wave when the second electrical output is longer in duration than the first electrical output. A pulse generator coupled to the microprocessor applies electrical cardioverting energy to the atria of the heart in response to the indication signal.
摘要翻译：心房除颤器可靠地检测心脏的去极化激活波，并且与检测到的去极化激活波同步地将心电转移到心脏的心房。心房除颤器包括用于产生第一电输出的第一传感器，其具有基本上等于在心脏的第一对间隔位置之间感测到的去极化激活波的持续时间的持续时间。心房除颤器还包括第二传感器，用于产生第二电输出，该第二电输出的持续时间基本上等于在心脏的第二对间隔位置之间感测的去极化激活波的持续时间。第二对位置之间的间隔大于第一对位置之间的间隔。当第二电输出的持续时间比第一电输出更长时，微处理器响应于第一和第二电输出，用于提供指示去极化激活波的发生的指示信号。耦合到微处理器的脉冲发生器响应于指示信号将心脏转换能量施加到心脏的心房。

4. 发明授权

US5403353A Post-heart surgery cardioverting system and method 失效
标题翻译：心脏手术心脏转复系统及方法
公开(公告)号：US5403353A
公开(公告)日：1995-04-04
申请号：US100492
申请日：1993-07-30
申请人： Clifton A. Alferness , Gregory M. Ayers , Jerry C. Griffin , Kenneth R. Infinger
发明人： Clifton A. Alferness , Gregory M. Ayers , Jerry C. Griffin , Kenneth R. Infinger
IPC分类号： A61N1/05 , A61N1/362 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3918 , A61N1/05 , A61N1/0587 , A61N1/362 , A61N1/39 , A61N1/395
摘要： A post-surgical cardioverting system and method applies cardioverting electrical energy to the atria of the heart of a post-surgical heart patient. The system includes a first lead including a first elongated electrode having a proximal end and a distal end, a second lead including a second elongated electrode having a proximal end and a distal end, and sutures for releasably anchoring the distal ends of the first and second electrodes to the pericardium and disposing the first and second electrodes along the pericardium overlying the right and left atria respectively. A non-implantable cardiovertor is coupled to the first and second leads for applying the cardioverting electrical energy to the first and second electrodes. When cardioversion is no longer required, the first and second leads may be pulled out of the patient's chest.
摘要翻译：手术后心脏转复系统和方法将心脏转移电能应用于手术后心脏病人心脏的心房。该系统包括第一引线，其包括具有近端和远端的第一细长电极，第二引线包括具有近端和远端的第二细长电极，以及用于可释放地锚固第一和第二末端的缝合线的缝合线电极到心包，并且分别沿着包围右心房和左心房的心包布置第一和第二电极。非植入式心律转换器耦合到第一和第二引线，用于将心电转换电能施加到第一和第二电极。当不再需要心脏复律时，可以将第一和第二引线从病人的胸部拉出。

5. 再颁专利

USRE35779E Post-heart surgery cardioverting system and method 失效
公开(公告)号：USRE35779E
公开(公告)日：1998-04-28
申请号：US608410
申请日：1996-02-28
申请人： Clifton A. Alferness , Gregory M. Ayers , Jerry C. Griffin , Kenneth R. Infinger
发明人： Clifton A. Alferness , Gregory M. Ayers , Jerry C. Griffin , Kenneth R. Infinger
IPC分类号： A61N1/05 , A61N1/362 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3918 , A61N1/05 , A61N1/0587 , A61N1/362 , A61N1/39 , A61N1/395
摘要： A post-surgical cardioverting system and method applies cardioverting electrical energy to the atria of the heart of a post-surgical heart patient. The system includes a first lead including a first elongated electrode having a proximal end and a distal end, a second lead including a second elongated electrode having a proximal end and a distal end, and sutures for releasably anchoring the distal ends of the first and second electrodes to the pericardium and disposing the first and second electrodes along the pericardium overlying the right and left atria respectively. A non-implantable cardiovertor is coupled to the first and second leads for applying the cardioverting electrical energy to the first and second electrodes. When cardioversion is no longer required, the first and second leads may be pulled out of the patient's chest.

6. 发明授权

US10064615B2 Tissue fixation devices and a transoral endoscopic gastroesophageal flap valve restoration device and assembly using same 有权
公开(公告)号：US10064615B2
公开(公告)日：2018-09-04
申请号：US13604276
申请日：2012-09-05
申请人： Steve G. Baker , Brett J. Carter , Stefan J. M. Kraemer , Clifton A. Alferness , John M. Adams
发明人： Steve G. Baker , Brett J. Carter , Stefan J. M. Kraemer , Clifton A. Alferness , John M. Adams
IPC分类号： A61B17/04 , A61B17/064 , A61B17/068 , A61B17/00
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/068 , A61B2017/00827 , A61B2017/0409 , A61B2017/0414 , A61B2017/0419
摘要： Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together. The fasteners include a first member, a second member, and a connecting member extending between the first and second members. The first and second members are substantially parallel to each other. The fasteners may be deployed in limited spaces and in various applications including the restoration of a gastroesophageal flap valve.

7. 发明授权

US08956374B2 Shockwave balloon catheter system 有权
公开(公告)号：US08956374B2
公开(公告)日：2015-02-17
申请号：US13049199
申请日：2011-03-16
申请人： Daniel Hawkins , Clifton A. Alferness , John M. Adams
发明人： Daniel Hawkins , Clifton A. Alferness , John M. Adams
IPC分类号： A61B17/22 , A61B17/225 , A61B17/3207
CPC分类号： A61B17/22022 , A61B17/2202 , A61B17/22029 , A61B17/2251 , A61B17/320725 , A61B2017/22001 , A61B2017/22021 , A61B2017/22024 , A61B2017/22025 , A61B2017/22038 , A61B2017/22058 , A61B2017/22061 , A61B2017/22062
摘要： A system for breaking obstructions in body lumens includes a catheter including an elongated carrier, a balloon about the carrier in sealed relation thereto, the balloon being arranged to receive a fluid therein that inflates the balloon, and an arc generator including at least one electrode within the balloon that forms a mechanical shock wave within the balloon. The system further includes a power source that provides electrical energy to the arc generator.

8. 发明授权

US08956371B2 Shockwave balloon catheter system 有权
标题翻译：冲击波球导管系统
公开(公告)号：US08956371B2
公开(公告)日：2015-02-17
申请号：US12482995
申请日：2009-06-11
申请人： Daniel Hawkins , Clifton A. Alferness , John M. Adams
发明人： Daniel Hawkins , Clifton A. Alferness , John M. Adams
IPC分类号： A61B17/22 , A61B17/225 , A61B17/3207
CPC分类号： A61B17/22022 , A61B17/2202 , A61B17/22029 , A61B17/2251 , A61B17/320725 , A61B2017/22001 , A61B2017/22021 , A61B2017/22024 , A61B2017/22025 , A61B2017/22038 , A61B2017/22058 , A61B2017/22061 , A61B2017/22062
摘要： A system for breaking obstructions in body lumens includes a catheter including an elongated carrier, a balloon about the carrier in sealed relation thereto, the balloon being arranged to receive a fluid therein that inflates the balloon, and an arc generator including at least one electrode within the balloon that forms a mechanical shock wave within the balloon. The system further includes a power source that provides electrical energy to the arc generator.
摘要翻译：用于破坏体腔内的障碍物的系统包括导管，其包括细长的载体，围绕载体与其密封的关系的气囊，所述气囊被布置成在其中容纳使气囊膨胀的流体，以及包括至少一个电极的电弧发生器气球在气球内形成机械冲击波。该系统还包括向电弧发生器提供电能的电源。

9. 发明授权

US08162923B2 Disposable infusion device with automatic unlocking mechanism 有权
标题翻译：具有自动解锁机构的一次性输液装置
公开(公告)号：US08162923B2
公开(公告)日：2012-04-24
申请号：US11516812
申请日：2006-09-06
申请人： John M. Adams , Clifton A. Alferness , Daniel Hawkins
发明人： John M. Adams , Clifton A. Alferness , Daniel Hawkins
IPC分类号： A61K9/22
CPC分类号： A61M5/152 , A61M5/14248
摘要： A wearable infusion device delivers a liquid medicant to a patient. The infusion device comprises a base that contacts a patient's skin and a reservoir arranged to be filled with a liquid medicant to be delivered beneath a patient's skin. The reservoir has an outlet through which the medicant flows. The infusion device further comprises a flexible conduit communicating with the outlet of the reservoir, a pump that causes the medicant to flow down the conduit, an actuator that performs a function related to the operation of the device, and an enable mechanism that enables the actuator in response to the filling of the reservoir with the liquid medicant.
摘要翻译：可戴式输液装置将液体药剂递送给患者。输液装置包括接触患者皮肤的基部和布置成填充有待在患者皮肤下方递送的液体药物的储存器。储存器具有药物流过的出口。输液装置还包括与储存器的出口连通的柔性导管，使得药剂沿着管道流下的泵，执行与装置的操作有关的功能的致动器，以及启动机构，其使致动器响应于用液体药物填充储存器。

10. 发明申请

US20110166570A1 SHOCKWAVE BALLOON CATHETER SYSTEM 有权
标题翻译：冲击气球导管系统
公开(公告)号：US20110166570A1
公开(公告)日：2011-07-07
申请号：US13049199
申请日：2011-03-16
申请人： Daniel Hawkins , Clifton A. Alferness , John M. Adams
发明人： Daniel Hawkins , Clifton A. Alferness , John M. Adams
IPC分类号： A61B18/18 , A61B17/22
CPC分类号： A61B17/22022 , A61B17/2202 , A61B17/22029 , A61B17/2251 , A61B17/320725 , A61B2017/22001 , A61B2017/22021 , A61B2017/22024 , A61B2017/22025 , A61B2017/22038 , A61B2017/22058 , A61B2017/22061 , A61B2017/22062
摘要： A system for breaking obstructions in body lumens includes a catheter including an elongated carrier, a balloon about the carrier in sealed relation thereto, the balloon being arranged to receive a fluid therein that inflates the balloon, and an arc generator including at least one electrode within the balloon that forms a mechanical shock wave within the balloon. The system further includes a power source that provides electrical energy to the arc generator.
摘要翻译：用于破坏体腔内的障碍物的系统包括导管，其包括细长的载体，围绕载体与其密封的关系的气囊，所述气囊被布置成在其中容纳使气囊膨胀的流体，以及包括至少一个电极的电弧发生器气球在气球内形成机械冲击波。该系统还包括向电弧发生器提供电能的电源。

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