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1. 发明申请

US20080286315A1 Methionine Enkephalin as an Adjuvant for Vaccine Immunizations 审中-公开
标题翻译：甲硫氨酸脑啡肽作为疫苗免疫的佐剂
公开(公告)号：US20080286315A1
公开(公告)日：2008-11-20
申请号：US12022854
申请日：2008-01-30
申请人： John Huang , Ding Chang , Shi-lung Lo , Feng Ping Shan
发明人： John Huang , Ding Chang , Shi-lung Lo , Feng Ping Shan
IPC分类号： A61K39/00 , A61K35/12 , A61P37/00 , C12N5/06
CPC分类号： C12N5/0639 , A61K38/33 , A61K39/0011 , A61K2039/5154 , A61K2039/55516 , C12N2501/22 , C12N2501/23 , C12N2501/85 , A61K2300/00
摘要： The present invention provides a method of stimulating dendritic cells, comprising contacting the dendritic cells with methionine enkephalin. The present invention also provides methods of enhancing an immune response to an antigen in a mammal. In a first method, dendritic cells are isolated from the mammal. The dendritic cells are then contacted with methionine enkephalin for a time sufficient to stimulate the cells. Next, the stimulated dendritic cells are contacted with the antigen of interest for a time sufficient for the cells to process the antigen. The dendritic cells are then injected into the mammal. The dendritic cells may be injected into the animal either on their own, or along with methionine enkephalin and/or the antigen. In a second method, the antigen of interest and methionine enkephalin are administered to the mammal. The present invention also provides compositions for administration to a mammalian subject having a tumor.
摘要翻译：本发明提供了一种刺激树突状细胞的方法，包括使树状细胞与甲硫氨酸脑啡肽接触。本发明还提供增强对哺乳动物中的抗原的免疫应答的方法。在第一种方法中，从哺乳动物中分离树突状细胞。然后将树突状细胞与甲硫氨酸脑啡肽接触足以刺激细胞的时间。接下来，刺激的树突状细胞与感兴趣的抗原接触足以使细胞处理抗原的时间。然后将树突状细胞注射到哺乳动物中。树突细胞可以自己注射入动物，或与甲硫氨酸脑啡肽和/或抗原一起注射到动物体内。在第二种方法中，向哺乳动物施用目的抗原和甲硫氨酸脑啡肽。本发明还提供了用于给予具有肿瘤的哺乳动物受试者的组合物。

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