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1. 发明申请

US20100016209A1 Methods of Reducing Side Effects in Cancer Therapy 审中-公开
标题翻译：减少癌症治疗副作用的方法
公开(公告)号：US20100016209A1
公开(公告)日：2010-01-21
申请号：US12096152
申请日：2006-12-07
申请人： John Huang , Ding Chang , Fengping Shan , Shi-Lung Lo
发明人： John Huang , Ding Chang , Fengping Shan , Shi-Lung Lo
IPC分类号： A61K38/03 , A61P35/00
CPC分类号： A61K38/33
摘要： The present invention provides a method of decreasing side effects in a human or animal cancer patient due to radiation therapy or chemotherapy. With this method, methionine enkephalin is administered to the patient at least one time per week for a first time period, where the first time period is at least three weeks. In one embodiment, the first time period is one or two months. Methionine enkephalin is then administered to the patient one time per month for a second time period, where the second time period is at least one month, and where the second time period is consecutive to the first time period. In one embodiment, the total term of methionine enkephalin treatment is at least six months. Methionine enkephalin may be administered to the patient at the same time as, before, or after administration of radiation or chemotherapy.
摘要翻译：本发明提供了减少由于放射治疗或化疗引起的人或动物癌症患者的副作用的方法。使用这种方法，蛋氨酸脑啡肽每周至少一次给予患者第一个时间段，其中第一时间段至少为三周。在一个实施例中，第一时间段是一个或两个月。然后将甲硫氨酸脑啡肽每月一次施用给患者第二时间段，其中第二时间段至少为一个月，第二时间段连续到第一时间段。在一个实施方案中，甲硫氨酸脑啡肽治疗的总期限为至少6个月。甲硫氨酸脑啡肽可以在给予放射或化疗的同时，之前或之后施用于患者。

2. 发明申请

US20080286315A1 Methionine Enkephalin as an Adjuvant for Vaccine Immunizations 审中-公开
标题翻译：甲硫氨酸脑啡肽作为疫苗免疫的佐剂
公开(公告)号：US20080286315A1
公开(公告)日：2008-11-20
申请号：US12022854
申请日：2008-01-30
申请人： John Huang , Ding Chang , Shi-lung Lo , Feng Ping Shan
发明人： John Huang , Ding Chang , Shi-lung Lo , Feng Ping Shan
IPC分类号： A61K39/00 , A61K35/12 , A61P37/00 , C12N5/06
CPC分类号： C12N5/0639 , A61K38/33 , A61K39/0011 , A61K2039/5154 , A61K2039/55516 , C12N2501/22 , C12N2501/23 , C12N2501/85 , A61K2300/00
摘要： The present invention provides a method of stimulating dendritic cells, comprising contacting the dendritic cells with methionine enkephalin. The present invention also provides methods of enhancing an immune response to an antigen in a mammal. In a first method, dendritic cells are isolated from the mammal. The dendritic cells are then contacted with methionine enkephalin for a time sufficient to stimulate the cells. Next, the stimulated dendritic cells are contacted with the antigen of interest for a time sufficient for the cells to process the antigen. The dendritic cells are then injected into the mammal. The dendritic cells may be injected into the animal either on their own, or along with methionine enkephalin and/or the antigen. In a second method, the antigen of interest and methionine enkephalin are administered to the mammal. The present invention also provides compositions for administration to a mammalian subject having a tumor.
摘要翻译：本发明提供了一种刺激树突状细胞的方法，包括使树状细胞与甲硫氨酸脑啡肽接触。本发明还提供增强对哺乳动物中的抗原的免疫应答的方法。在第一种方法中，从哺乳动物中分离树突状细胞。然后将树突状细胞与甲硫氨酸脑啡肽接触足以刺激细胞的时间。接下来，刺激的树突状细胞与感兴趣的抗原接触足以使细胞处理抗原的时间。然后将树突状细胞注射到哺乳动物中。树突细胞可以自己注射入动物，或与甲硫氨酸脑啡肽和/或抗原一起注射到动物体内。在第二种方法中，向哺乳动物施用目的抗原和甲硫氨酸脑啡肽。本发明还提供了用于给予具有肿瘤的哺乳动物受试者的组合物。

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