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1. 发明申请

US20050164403A1 Liquid dispensing device 失效
标题翻译：液体分配装置
公开(公告)号：US20050164403A1
公开(公告)日：2005-07-28
申请号：US10764710
申请日：2004-01-24
申请人： John Hoffman , John Adams , Brian Ganz , David Jewell , John Moulds , Janet Newman
发明人： John Hoffman , John Adams , Brian Ganz , David Jewell , John Moulds , Janet Newman
IPC分类号： B01L3/02 , B01L99/00 , G01N35/00 , G01N35/10
CPC分类号： G01N35/1002 , B01L3/0293 , B01L2200/16 , B01L2400/0457 , G01N35/0099 , G01N35/109 , Y10T436/2575
摘要： A liquid dispensing device. The liquid dispensing device has a tray for holding a liquid at a relatively constant level. A syringe is used for drawing fluid from the tray. A liquid container containing a liquid is positioned upside-down in the tray such that the opening of the liquid container defines a vertical position that is slightly below the liquid level in the tray. Atmospheric pressure on the liquid in the tray and a vacuum inside the liquid container prevents liquid from draining from the container until the fluid level in the tray drops to a level approximately equal to the vertical position of the opening. The positioning of the syringe for drawing fluid is simplified by reason of the fact that the level of fluid in the tray is maintained at an approximately constant level despite withdrawal of quantities of fluid from the tray.
摘要翻译：液体分配装置。液体分配装置具有用于将液体保持在相对恒定水平的托盘。注射器用于从托盘吸取流体。容纳液体的液体容器被倒置在托盘中，使得液体容器的开口限定了稍低于托盘中液面的垂直位置。托盘中的液体上的大气压力和液体容器内的真空物防止液体从容器中排出，直到托盘中的液面下降到大致等于开口垂直位置的水平。由于以下事实简化了用于抽取流体的注射器的定位：尽管从托盘中取出了大量的流体，但托盘中的流体水平保持在大致恒定的水平。

2. 发明申请

US20060118573A1 Automated small item dispense module 审中-公开
标题翻译：自动小项目分配模块
公开(公告)号：US20060118573A1
公开(公告)日：2006-06-08
申请号：US10980008
申请日：2004-11-03
申请人： Brian Ganz , John Adams , John Hoffman , John Moulds , Thomas Vorndran
发明人： Brian Ganz , John Adams , John Hoffman , John Moulds , Thomas Vorndran
IPC分类号： A24F15/04 , G07F11/16
CPC分类号： G07F13/025 , G07F11/44
摘要： A small item dispense module. Small items are stored inside a first chamber. The small items are then transferred to a second chamber having a first singulator. The first singulator transfers the small items to a third chamber having a second singulator. The second singulator transfers the small items from the third chamber to a discharge tube having a discharge gate. The discharge gate allows for the dispensing of the small items so that they easily accessible. Preferably, the dispense module further includes: a microcontroller with real-time clock, a unique electronic identification number, an external barcode identification label, and an automatic locking mechanism that can be released electronically and controlled by the microcontroller. The microcontroller also preferably keeps track of dispense and fill requests and inventory. In a preferred embodiment, the small items being dispensed are pills.
摘要翻译：小项目分配模块。小物品储存在第一个室内。然后将小物品转移到具有第一分离器的第二室中。第一个单片机将小件物品转移到具有第二个单片机的第三个房间。第二单片机将小件物品从第三室转移到具有排放门的排放管。排放门允许分配小物品，使得它们容易接近。优选地，分配模块还包括：具有实时时钟的微控制器，独特的电子识别号码，外部条形码识别标签以及可由电子控制的微控制器释放的自动锁定机构。微控制器还优选地跟踪分配和填充请求和库存。在优选实施例中，被分配的小物品是丸剂。

3. 发明申请

US20050179562A1 Environmental data recorder for micro-well plate 失效
标题翻译：微孔板环境数据记录仪
公开(公告)号：US20050179562A1
公开(公告)日：2005-08-18
申请号：US10769537
申请日：2004-01-30
申请人： Brian Ganz , John Adams , Joseph Gottlieb , John Moulds , Jason Kovach
发明人： Brian Ganz , John Adams , Joseph Gottlieb , John Moulds , Jason Kovach
IPC分类号： G01D9/00 , G08C19/22
CPC分类号： G01D9/005
摘要： An environmental data recorder for recording environmental factors acting on micro-well plates. The environmental data recorder has sensors for sensing environmental factors and it has a microcontroller programmed to receive and process inputs from the sensors. The sensors and microcontroller are housed in a recorder housing unit. The recording housing unit has exterior dimensions that are approximately equal to the exterior dimensions of the micro-well plates enabling the recorder housing unit to be handled by the same robotic device handling the micro-well plates. In a preferred embodiment, the environmental data recorder's sensors are a temperature sensor, a humidity sensor and an accelerometer.
摘要翻译：用于记录作用于微孔板的环境因素的环境数据记录仪。环境数据记录器具有用于感测环境因素的传感器，并且具有被编程为接收和处理来自传感器的输入的微控制器。传感器和微控制器安装在记录器外壳单元中。记录壳体单元的外部尺寸大致等于微孔板的外部尺寸，使得记录器壳体单元能够由处理微孔板的相同的机器人装置来处理。在优选实施例中，环境数据记录器的传感器是温度传感器，湿度传感器和加速度计。

4. 发明授权

US09642673B2 Shock wave balloon catheter with multiple shock wave sources 有权
公开(公告)号：US09642673B2
公开(公告)日：2017-05-09
申请号：US13534658
申请日：2012-06-27
申请人： John Adams , Thomas G. Goff , Doug Hakala
发明人： John Adams , Thomas G. Goff , Doug Hakala
IPC分类号： A61B17/22 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1492 , A61B17/2202 , A61B17/22022 , A61B17/22029 , A61B17/2251 , A61B17/320725 , A61B18/00 , A61B2017/22024 , A61B2017/22025 , A61B2017/22051 , A61B2017/22058 , A61B2017/22061 , A61B2017/22062 , A61B2017/22098
摘要： An apparatus includes a balloon adapted to be placed adjacent a calcified region of a body. The balloon is inflatable with a liquid. The apparatus further includes a shock wave generator within the balloon that produces shock waves that propagate through the liquid for impinging upon the calcified region adjacent the balloon. The shock wave generator includes a plurality of shock wave sources distributed within the balloon.

5. 发明申请

US20070289901A1 ENERGY EFFICIENT METHOD FOR EXOTHERMIC REACTIONS 有权
标题翻译：能量反应的能量有效方法
公开(公告)号：US20070289901A1
公开(公告)日：2007-12-20
申请号：US11845642
申请日：2007-08-27
申请人： Arvids Judzis , Abraham Gelbein , John Adams , Christopher Boyer
发明人： Arvids Judzis , Abraham Gelbein , John Adams , Christopher Boyer
IPC分类号： B01D3/00
CPC分类号： B01D3/009 , B01J19/0033 , B01J2219/00006 , Y10S203/08 , Y10S585/914
摘要： An energy efficient process scheme for a highly exothermic reaction-distillation system in which the reactor is external to the distillation column and the feed to the reactor is a mixture of at least one liquid product stream from the distillation column with or without other liquid/vapor reactants. The reactor is operated under adiabatic and boiling point conditions and at a pressure that results in vaporizing a portion of the liquid flow through the reactor due to the heat of reaction. Under these conditions, reaction temperature is controlled by reactor pressure. The pressure (and hence the temperature) is maintained at a sufficiently high level such that the reactor effluent can be efficiently used to provide reboil heat for the distillation column.
摘要翻译：用于高放热反应 - 蒸馏系统的能量效率方法，其中反应器在蒸馏塔外部和反应器的进料是来自蒸馏塔的至少一种液体产物流与有或没有其它液体/蒸气的混合物反应物。反应器在绝热和沸点条件下运行，并且在由于反应热导致部分液体流过反应器的压力下运行。在这些条件下，反应温度由反应器压力控制。压力（因此温度）保持在足够高的水平，使得反应器流出物可以有效地用于为蒸馏塔提供再沸腾热。

6. 发明申请

US20070262180A1 Vehicle engine-driven pressure-washing system and method 审中-公开
标题翻译：汽车发动机驱动的压力清洗系统及方法
公开(公告)号：US20070262180A1
公开(公告)日：2007-11-15
申请号：US11434424
申请日：2006-05-12
申请人： John Adams
发明人： John Adams
IPC分类号： B08B3/00 , B08B3/12 , B05B3/00
CPC分类号： B08B3/026 , B08B2203/007 , B08B2203/0241 , B08B2203/027
摘要： Mobile pressure-washing systems are disclosed that can be coupled to a carrier vehicle's engine for receiving operational power and heat power from the engine. The system includes a pump that is driven by a driven member of the engine. The system captures heat from the engine, particularly while the engine is running, such as from liquid coolant used for cooling the engine and/or from hot exhaust gases produced by the running engine. The carrier vehicle can include a utility bay including hydraulic fittings connected to the pump and heat exchanger and connectable to a supply of pressure-washing liquid and to a conduit used for discharging the stream of heated and pressurized liquid. The supply can be a tank carried on the vehicle.
摘要翻译：公开了可连接到运载工具发动机的移动式压力清洗系统，用于从发动机接收操作功率和热功率。该系统包括由发动机的从动构件驱动的泵。该系统捕获来自发动机的热量，特别是在发动机运行时，例如用于冷却发动机的液体冷却剂和/或来自运行的发动机产生的热废气。运载工具可以包括一个公用设施，包括连接到泵和热交换器的液压配件，并可连接到供应的压力清洗液体和用于排出加热和加压液体流的导管。供应可以是车上携带的坦克。

7. 发明申请

US20070254903A1 Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof 审中-公开
标题翻译：新型螺二氢吲哚或螺异喹啉化合物，其使用方法和组合
公开(公告)号：US20070254903A1
公开(公告)日：2007-11-01
申请号：US10583839
申请日：2004-12-22
申请人： P. Boatman , John Adams , Jeanne Moody , Eric Babych , Thomas Schrader
发明人： P. Boatman , John Adams , Jeanne Moody , Eric Babych , Thomas Schrader
IPC分类号： A61K31/438 , A61P25/00 , A61P9/00 , C07D401/04 , C12N5/08 , G01N33/566
CPC分类号： G01N33/6893 , C07D471/10 , G01N33/5008 , G01N33/502 , G01N33/68 , G01N33/6872 , G01N2500/00
摘要： The invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates and stereoisomers thereof, wherein A, B, E, G, W, X, Y, Z, o, and R1 are as disclosed herein (“Compound(s) of the Invention”), which are useful as cardio-protective and/or neuro-protective agents. The invention also provides pharmaceutical compositions comprising a Compound of the Invention and methods for treating, preventing and/or managing a vascular, cardiovascular or neurological disease or disorder, comprising administering to a patient in need thereof a Compound of the Invention.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，溶剂合物和立体异构体，其中A，B，E，G，W，X，Y，Z，o和R 1是如本文所公开的（“本发明的化合物”），其可用作心脏保护和/或神经保护剂。本发明还提供了包含本发明化合物和治疗，预防和/或控制血管，心血管或神经疾病或病症的方法的药物组合物，其包括向有需要的患者施用本发明的化合物。

8. 发明申请

US20070231792A1 Human g protein-coupled receptor and modulators thereof for the treatment of cardiovascular disorders 有权
标题翻译：人类g蛋白偶联受体及其调节剂用于治疗心血管疾病
公开(公告)号：US20070231792A1
公开(公告)日：2007-10-04
申请号：US10561132
申请日：2004-06-17
申请人： John Adams , Daniel Connolly
发明人： John Adams , Daniel Connolly
IPC分类号： C12Q1/68 , G01N33/53 , A61K38/55 , A01K67/027
CPC分类号： G01N33/74 , A01K67/027 , A01K67/0275 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/705 , C07K14/723 , C07K2319/00 , C12N2799/022 , G01N33/6893 , G01N33/76 , G01N2333/726 , G01N2800/32 , G01N2800/325
摘要： The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In some embodiments, the GPCR is mammalian, preferably human. In some embodiments, the GPCR is expressed endogenously by cardiomyocytes. In some embodiments, the GPCR is coupled to Gq. In some embodiments, the GPCR increases the intracellular level of inositol 1,4,5-triphosphate (IP3). In some embodiments, a modulator of the GPCR is a modulator of cardiomyocyte hypertrophy. The present invention further relates to methods of using a modulator of the GPCR. Preferred modulators are inverse agonists and antagonists. Inverse agonists and antagonists of the invention are useful as therapeutic agents for the prevention or treatment of heart disease, including hypertrophic cardiomyopathy and congestive heart failure, in particular hypertrophic cardiomyopathy resulting from post-myocardial infarction remodeling, cardiac valve disease, sustained cardiac afterload, myocarditis, and familial hypertrophic cardiomyopathy.
摘要翻译：本发明涉及鉴定候选化合物是G蛋白偶联受体（GPCR）的调节剂的方法。在一些实施方案中，GPCR是哺乳动物，优选人。在一些实施方案中，GPCR由心肌细胞内源性表达。在一些实施例中，GPCR耦合到Gq。在一些实施方案中，GPCR增加1,4,5-三磷酸肌醇（IP3）的细胞内水平。在一些实施方案中，GPCR的调节剂是心肌细胞肥大的调节剂。本发明还涉及使用GPCR调制器的方法。优选的调节剂是反向激动剂和拮抗剂。本发明的反向激动剂和拮抗剂可用作预防或治疗心脏病，包括肥厚性心肌病和充血性心力衰竭的治疗剂，特别是由心肌梗死后重建，心脏瓣膜疾病，持续的心脏后负荷，心肌炎引起的肥大性心肌病，和家族性肥厚型心肌病。

9. 发明申请

US20070158986A1 Adjustable sun lounge 审中-公开
标题翻译：可调太阳椅
公开(公告)号：US20070158986A1
公开(公告)日：2007-07-12
申请号：US11641351
申请日：2006-12-19
申请人： John Adams , Ronald Dunning
发明人： John Adams , Ronald Dunning
IPC分类号： B60N2/02
CPC分类号： B60N2/36
摘要： An adjustable sun lounge for a performance or pleasure boat. The sun lounge converts from a seating configuration into a sunbathing configuration. The sun lounge generally includes a backrest which is movable via a double-pivot hinge and guided by a guide arm from an upright position to a substantially horizontal position. The sun lounge also includes a sunpad and a center cushion movable via a single-pivot hinge from an inclined position to a substantially horizontal position. When the backrest is in the substantially horizontal position and the center cushion is in the substantially horizontal position, the sun lounge is substantially horizontal and flat to accommodate a sunbathing person stretched out thereon. In the upright position, the backrest forms part of a seat structure which may be used when sunbathing is not desired, for example, while the boat is moving.
摘要翻译：一个可调节的阳光休息室，用于表演或游船。阳光休息室从座位配置转换为日光浴配置。阳光休息室通常包括靠背，其可以通过双枢转铰链移动并且由引导臂从直立位置引导到基本水平的位置。阳光休息室还包括一个防晒垫和一个中心垫，可以通过单摆动铰链从倾斜位置到基本水平的位置移动。当靠背处于基本上水平的位置并且中心垫处于基本上水平的位置时，太阳椅基本上是水平和平坦的，以容纳在其上伸展的日光浴人。在直立位置，靠背形成座椅结构的一部分，当不希望日光浴时，例如在船移动时可以使用座椅结构。

10. 发明申请

US20060157337A1 Energy efficient method and apparatus for exothermic reactions 有权
标题翻译：节能方法和放热反应装置
公开(公告)号：US20060157337A1
公开(公告)日：2006-07-20
申请号：US11038755
申请日：2005-01-19
申请人： Arvids Judzis , Abraham Gelbein , John Adams , Christopher Boyer
发明人： Arvids Judzis , Abraham Gelbein , John Adams , Christopher Boyer
IPC分类号： B01D3/00
CPC分类号： B01D3/009 , B01J19/0033 , B01J2219/00006 , Y10S203/08 , Y10S585/914
摘要： An energy efficient process scheme for a highly exothermic reaction-distillation system in which the reactor is external to the distillation column and the feed to the reactor comprises a mixture of at least one liquid product stream from the distillation column with or without other liquid/vapor reactants. The reactor is operated under adiabatic and boiling point conditions and at a pressure that results in vaporizing a portion of the liquid flow through the reactor due to the heat of reaction. Under these conditions, reaction temperature is controlled by reactor pressure. The pressure (and hence the temperature) is maintained at a sufficiently high level such that the reactor effluent can be efficiently used to provide reboil heat for the distillation column.
摘要翻译：用于高放热反应 - 蒸馏系统的能量有效的方法，其中反应器在蒸馏塔外部和反应器的进料包括来自蒸馏塔的至少一种液体产物流与有或没有其它液体/蒸气的混合物反应物。反应器在绝热和沸点条件下运行，并且在由于反应热导致部分液体流过反应器的压力下运行。在这些条件下，反应温度由反应器压力控制。压力（因此温度）保持在足够高的水平，使得反应器流出物可以有效地用于为蒸馏塔提供再沸腾热。

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