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1. 发明授权

US4826990A 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents 失效
标题翻译： 2-芳基取代的杂环化合物作为抗变应性和抗炎药
公开(公告)号：US4826990A
公开(公告)日：1989-05-02
申请号：US103224
申请日：1987-09-30
申请人： John H. Musser , Reinhold H. W. Bender , Anthony F. Kreft, III
发明人： John H. Musser , Reinhold H. W. Bender , Anthony F. Kreft, III
IPC分类号： C07C309/80 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61P29/00 , A61P37/08 , A61P43/00 , C07C51/00 , C07C57/30 , C07C59/64 , C07C63/331 , C07C65/21 , C07C67/00 , C07C69/618 , C07C69/76 , C07C213/00 , C07C215/30 , C07C217/18 , C07C229/38 , C07C229/42 , C07C229/54 , C07C239/20 , C07C241/00 , C07C243/32 , C07C243/34 , C07C243/38 , C07C253/00 , C07C255/50 , C07C255/54 , C07C259/06 , C07C313/00 , C07C317/32 , C07C317/36 , C07C317/44 , C07C323/32 , C07C323/43 , C07C323/44 , C07C323/49 , C07C323/62 , C07C323/65 , C07D213/30 , C07D239/26 , C07D241/12 , C07D263/32 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/32 , C07D307/40 , C07D413/12 , C07D417/12 , C12N9/99
CPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D413/12 , C07D417/12
摘要： There are disclosed compounds of the formula ##STR1## wherein X is ##STR2## Y is ##STR3## Z is ##STR4## R.sup.1 is ##STR5## n is 0-5; R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;R.sup.3 is ##STR6## W represents a bond or ##STR7## m is 1-15; R.sup.4 is hydrogen or loweralkyl;R.sup.5 is lower alkyl, monofluoroloweralkyl, difluoroloweralkyl, polyfluoroloweralkyl, perfluoroloweralkyl or ##STR8## R.sup.6 is hydrogen, lower alkyl, ##STR9## and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, and as antiinflammatory agents.

2. 发明授权

US4895953A 2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents 失效
标题翻译： 2-芳基取代的杂环化合物作为抗过敏和抗炎药
公开(公告)号：US4895953A
公开(公告)日：1990-01-23
申请号：US311011
申请日：1989-02-15
申请人： John H. Musser , Reinhold H. W. Bender , Anthony F. Kreft, III
发明人： John H. Musser , Reinhold H. W. Bender , Anthony F. Kreft, III
IPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D277/30 , C07D413/12 , C07D417/12
CPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D413/12 , C07D417/12
摘要： There are disclosed compounds of the formula ##STR1## wherein ##STR2## n is 0-5; R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;R.sup.3 ##STR3## W represents a bond or --O--, --S-- or ##STR4## m is 1-15; R.sup.4 is hydrogen or loweralkyl;R.sup.5 is lower alkyl, monofluoroloweralkyl, difluoroloweralkyl, polyfluoroloweralkyl, perfluoroloweralkyl or ##STR5## R.sup.6 is hydrogen, lower alkyl, --COOR.sup.4 or ##STR6## and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, and as antiinflammatory agents.
摘要翻译：公开了下式的化合物，其中 n是0-5; R2是氢，低级烷基，低级烷氧基，低级烷氧基羰基，三氟甲基，硝基，氰基或卤素; R3表示键或-O - ， - S-或m表示1-15; R4是氢或低级烷基; R5是低级烷基，一氟低烷基，二氟低级烷基，聚氟低烷基，全氟低级烷基或R6是氢，低级烷基，-COOR4或其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管梗阻空气通道条件，如过敏性鼻炎，过敏性支气管哮喘等，以及抗炎药。

3. 发明授权

US5103014A Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propano ic acid derivatives 失效
标题翻译：某些3,3' - [[[（2-苯基-4-噻唑基）甲氧基]苯基]亚甲基]二硫代双 - 丙酸衍生物
公开(公告)号：US5103014A
公开(公告)日：1992-04-07
申请号：US525418
申请日：1990-05-18
申请人： John H. Musser , Reinhold H. W. Bender , Anthony F. Kreft, III , James A. Nelson
发明人： John H. Musser , Reinhold H. W. Bender , Anthony F. Kreft, III , James A. Nelson
IPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D413/12 , C07D417/12
CPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D413/12 , C07D417/12
摘要： There are disclosed compounds of the formula ##STR1## wherein X is ##STR2## Y is ##STR3## Z is --(CH.sub.2).sub.n O--, --(CH.sub.2).sub.n S--, ##STR4## R.sup.1 is ##STR5## n is 0-5; R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;R.sup.3 is ##STR6## W represents a bond or --O--, --S-- or ##STR7## m is 1-15; R.sup.4 is hydrogen or loweralkyl;R.sup.5 is lower alkyl, monofluoroloweralkyl, difluroloweralkyl, polyfluroloweralkyl, perfluoroloweralkyl or ##STR8## R.sup.6 is hydrogen lower alkyl, --COOR.sup.4 or ##STR9## R.sup.7 is OR.sup.4 or N(R.sup.4).sub.2 ; R.sup.8 is OR.sup.4 or N(R.sup.4).sub.2 ;and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstruction airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, as antiinflammatory agents.
摘要翻译：公开了下式的化合物，其中X是Y，Z是 - （CH 2）n O-， - （CH 2）n -S-， R 1是 n为0-5; R2是氢，低级烷基，低级烷氧基，低级烷氧基羰基，三氟甲基，硝基，氰基或卤素; R3表示W表示键或-O - ， - S-或m表示1-15; R4是氢或低级烷基; R 5是低级烷基，一氟代低级烷基，二氟氟烷基，聚芴基烷基，全氟低级烷基或R 6是氢低级烷基，-COOR 4或者R 7是OR 4或N（R 4）2; R8为OR4或N（R4）2; 及其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管阻塞空气通道条件（例如过敏性鼻炎，过敏性支气管哮喘等）中作为抗炎剂的用途。

4. 发明授权

US4942236A 2-aryl substituted pyridyl-containing phenyl sulfonamido compounds as antiallergic and antiinflammatory agents 失效
标题翻译： 2-芳基取代的含吡啶基的苯基亚磺酰氨基化合物作为抗过敏和抗炎剂
公开(公告)号：US4942236A
公开(公告)日：1990-07-17
申请号：US311558
申请日：1989-02-15
申请人： John H. Musser , Reinhold H. W. Bender , Anthony F. Kreft, III
发明人： John H. Musser , Reinhold H. W. Bender , Anthony F. Kreft, III
IPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D413/12 , C07D417/12
CPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D413/12 , C07D417/12
摘要： There are disclosed compounds of the formula ##STR1## n is 0-5; R.sup.2 is, independently, hydrogen, loweralkyl, loweralkoxy, trifluoromethyl or halo; ##STR2## W represents a bond or ##STR3## m is 1-15; R.sup.4 is hydrogen or loweralkyl;R.sup.5 is lower alkyl, monofluoroloweralkyl, difluoroloweralkyl, polyfluoroloweralkyl, perfluoroloweralkyl or ##STR4## or a pharmaceutically acceptable salt thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, and as antiinflammatory agents.
摘要翻译：公开了下式的化合物：其中 n是0-5; R2独立地是氢，低级烷基，低级烷氧基，三氟甲基或卤素; W表示键或 m为1-15; R4是氢或低级烷基; R5是低级烷基，一氟低烷基，二氟低级烷基，聚氟低烷基，全氟低级烷基或其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管阻塞性空气通道条件中的用途，如过敏性鼻炎，过敏性支气管哮喘和像抗炎药。

5. 发明授权

US4904786A Quinoline compounds as antiallergic and antiinflammatory agents 失效
标题翻译：喹啉化合物作为抗过敏和抗炎药
公开(公告)号：US4904786A
公开(公告)日：1990-02-27
申请号：US231130
申请日：1988-08-11
申请人： John H. Musser , Dennis M. Kubrak , Anthony F. Kreft, III , Reinhold H. W. Bender
发明人： John H. Musser , Dennis M. Kubrak , Anthony F. Kreft, III , Reinhold H. W. Bender
IPC分类号： C07D215/14 , C07D333/56
CPC分类号： C07D215/14 , C07D333/56
摘要： There are disclosed compounds of the formula ##STR1## wherein R.sup.1 is ##STR2## n is 0-5; R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;R.sup.3 is hydrogen or loweralkyl;R.sup.4 hydrogen, lower alkyl, --COOR.sup.3 or ##STR3## R.sup.5 is lower alkyl, monofluoroloweralkyl, difluoroloweralkyl, polyfluoroloweralkyl, perfluoroloweralkyl or ##STR4## and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, and as antiinflammatory agents.
摘要翻译：公开了下式的化合物：其中R 1是0-5;其中R 1是0-5; R2是氢，低级烷基，低级烷氧基，低级烷氧基羰基，三氟甲基，硝基，氰基或卤素; R3是氢或低级烷基; R4氢，低级烷基，-COOR3或R5是低级烷基，一氟氟烷基，二氟低级烷基，聚氟低烷基，全氟低级烷基或其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管阻塞性空气通道中的用途过敏性鼻炎，过敏性支气管哮喘等，作为抗炎药。

6. 发明授权

US4876346A Quinoline compounds 失效
标题翻译：喹啉化合物
公开(公告)号：US4876346A
公开(公告)日：1989-10-24
申请号：US863666
申请日：1986-05-15
申请人： John H. Musser , Anthony F. Kreft, III , Reinhold H. W. Bender
发明人： John H. Musser , Anthony F. Kreft, III , Reinhold H. W. Bender
IPC分类号： C07D215/14 , C07D235/12 , C07D277/64 , C07D401/12 , C07D409/12
CPC分类号： C07D401/12 , C07D215/14 , C07D235/12 , C07D277/64 , C07D409/12
摘要： There are disclosed compounds of the formula ##STR1## wherein X is N or CR.sup.1Y is O, S, NR.sup.1, CHR.sup.1 or C(R.sup.1).sub.2 when n=O, or N or CR.sup.1 when n=1;p is 0-3;R.sup.1 is hydrogen or lower alkyl;R.sup.2 is H, ##STR2## --SO.sub.2 R.sup.3 or --SO.sub.2 N(R.sup.3).sub.2, lower alkyl, lower alkenyl, lower alkynyl or lower alkyl carbonyl prolinate;R.sup.3 is H, lower alkyl or perfluoro lower alkyl;R.sup.4 is lower alkyl, phenyl, pyridyl or thienyl;R.sup.5 is hydrogen, lower alkyl, phenyl or pyridyl;A is O or NR.sup.1 ;B is OR.sup.1 or N(R.sup.5).sub.2 ;m is 0-2;and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like.
摘要翻译：当n = 0时，公开了下式的化合物，其中X为N或CR1Y为O，S，NR1，CHR1或C（R1）2，当n = 1时，为N或CR1; p为0-3; R1是氢或低级烷基; R2是H，-SO2R3或-SO2N（R3）2，低级烷基，低级烯基，低级炔基或低级烷基羰基脯氨酸; R3是H，低级烷基或全氟低级烷基; R4是低级烷基，苯基，吡啶基或噻吩基; R5是氢，低级烷基，苯基或吡啶基; A是O或NR1; B为OR1或N（R5）2; m为0-2; 及其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管阻塞性空气通道病症如过敏性鼻炎，过敏性支气管哮喘等中的用途。

7. 发明授权

US4772703A 2-(phenoxymethyl)-quinazolines as antiallergic and antiinflammatory agents 失效
标题翻译： 2-（苯氧基甲基） - 喹唑啉作为抗过敏和抗炎药
公开(公告)号：US4772703A
公开(公告)日：1988-09-20
申请号：US50595
申请日：1987-05-15
申请人： John H. Musser , Dennis M. Kubrak , Anthony F. Kreft, III , Reinhold H. W. Bender
发明人： John H. Musser , Dennis M. Kubrak , Anthony F. Kreft, III , Reinhold H. W. Bender
IPC分类号： C07D215/14 , C07D333/56 , A61K31/505 , C07D239/74
CPC分类号： C07D333/56 , C07D215/14
摘要： There are disclosed compounds of the formula ##STR1## wherein ##STR2## R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;R.sup.3 is hydrogen or loweralkyl;R.sup.4 is hydrogen, lower alkyl, --COOR.sup.3 or ##STR3## R.sup.5 is lower alkyl, monofluoroloweralkyl, difluoroloweralkyl, polyfluoroloweralkyl, perfluoroloweralkyl or ##STR4## and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, and as antiinflammatory agents.
摘要翻译：公开了下式的化合物：其中，R 1是氢，低级烷基，低级烷氧基，低级烷氧基羰基，三氟甲基，硝基，氰基或卤素; R3是氢或低级烷基; R4是氢，低级烷基，-COOR3或R5是低级烷基，一氟氟烷基，二氟低级烷基，聚氟低烷基，全氟低级烷基或其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管梗阻空气通道条件，如过敏性鼻炎，过敏性支气管哮喘等，以及抗炎药。

8. 发明授权

US5364944A Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid compounds 失效
标题翻译：取代苯甲酰基苯，联苯基和2-恶唑烷酸化合物
公开(公告)号：US5364944A
公开(公告)日：1994-11-15
申请号：US001141
申请日：1993-01-06
申请人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah , Dennis M. Kubrak
发明人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah , Dennis M. Kubrak
IPC分类号： C07C45/00 , C07C45/63 , C07C45/72 , C07C59/90 , C07C69/738 , C07C205/45 , C07C255/40 , C07D215/14 , C07D263/32 , C07D277/24 , C07D413/12 , C07D233/54
CPC分类号： C07C45/004 , C07C205/45 , C07C255/40 , C07C45/63 , C07C45/72 , C07C59/90 , C07C69/738 , C07D215/14 , C07D263/32 , C07D413/10
摘要： There are disclosed substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid derivatives and the pharmacologically acceptable salts thereof as inhibitors of PLA.sub.2 and lipoxygenase, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
摘要翻译：公开了取代的苯甲酰基苯，联苯基和2-恶唑烷酸衍生物及其药理学上可接受的盐作为PLA2和脂氧合酶的抑制剂，以及它们在治疗炎性病症如类风湿性关节炎，溃疡性结肠炎，牛皮癣和其他立即超敏反应; 治疗白三烯介导的鼻支气管阻塞性通气条件，如过敏性鼻炎，过敏性支气管哮喘等; 和作为胃细胞保护剂。

9. 发明授权

US5229516A Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase 失效
标题翻译：取代的吲哚，茚，吡喃吲哚和四氢咔唑 - 链烷酸衍生物作为PLA2和脂氧合酶的抑制剂
公开(公告)号：US5229516A
公开(公告)日：1993-07-20
申请号：US911434
申请日：1992-07-10
申请人： John H. Musser , Anthony F. Kreft, III , Amedeo A. Failli , Christopher A. Demerson , Uresh S. Shah , James A. Nelson
发明人： John H. Musser , Anthony F. Kreft, III , Amedeo A. Failli , Christopher A. Demerson , Uresh S. Shah , James A. Nelson
IPC分类号： C07C323/62 , C07D209/22 , C07D215/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D491/04
CPC分类号： C07D401/12 , C07C323/62 , C07D209/22 , C07D215/14 , C07D401/14 , C07D417/12 , C07D491/04
摘要： There are disclosed compounds of the formulaA(CH.sub.2).sub.n O-BwhereinA is C.sub.4 -C.sub.8 alkyl, phenoxyethyl, phenoxyphenyl or a group having the formula ##STR1## wherein ##STR2## R.sup.1 is hydrogen, lower alkyl, phenyl or phenyl substituted with trifluoromethyl;R.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 taken together form a benzene ring;R.sup.3 is hydrogen or lower alkyl;n is 1-2;B is ##STR3## wherein ##STR4## m is 0-3; R.sup.5 is ##STR5## or phenyl or phenyl substituted by halo, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl;R.sup.6 is A(CH.sub.2).sub.n O-- or halo; with the proviso that when R.sup.6 is halo, R.sup.5 is ##STR6## R.sup.7 is lower alkyl; Y is --CH.sub.2 -- or --O--;R.sup.8 is lower alkyl or --(CH.sub.2).sub.m CO.sub.2 R.sup.3 ;R.sup.9 is ##STR7## or --CH.sub.2 R.sup.10 ; R.sup.10 is lower alkyl, phenyl, phenyl substituted with carboxy, halo, loweralkylthio or loweralkylsulfinyl, pyridyl, furanyl or quinolinyl;R.sup.11 is lower alkyl or phenyl;Z is hydrogen, lower alkyl or --N(CH.sub.3)OH;and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
摘要翻译：公开了式A（CH 2）n O-B的化合物，其中A是C 4 -C 8烷基，苯氧基乙基，苯氧基苯基或具有下式的基团：其中R 1是氢，低级烷基，苯基或被三氟甲基取代的苯基; R2是氢或低级烷基; 或R 1和R 2一起形成苯环; R3是氢或低级烷基; n为1-2; B是其中 m是0-3; R 5为苯基或被卤素，低级烷硫基，低级烷基亚磺酰基或低级烷基磺酰基取代的苯基; R6是A（CH2）nO-或卤素; 条件是当R 6为卤素时，R 5为低级烷基; Y是-CH 2 - 或-O-; R8是低级烷基或 - （CH2）mCO2R3; R9是或-CH2R10; R 10为低级烷基，苯基，被羧基，卤素，低级烷硫基或低级烷基亚磺酰基取代的苯基，吡啶基，呋喃基或喹啉基; R11为低级烷基或苯基; Z是氢，低级烷基或-N（CH 3）OH; 及其药理学上可接受的盐及其在治疗炎性病症如类风湿性关节炎，溃疡性结肠炎，牛皮癣和其他立即超敏反应中的用途; 治疗白三烯介导的鼻支气管阻塞性通气条件，如过敏性鼻炎，过敏性支气管哮喘等; 和作为胃细胞保护剂。

10. 发明授权

US4754043A Oxazole and thiazole naphthalenes as antiallergic agents 失效
标题翻译：恶唑和噻唑萘作为抗过敏剂
公开(公告)号：US4754043A
公开(公告)日：1988-06-28
申请号：US915444
申请日：1986-10-06
申请人： Anthony F. Kreft, III , John H. Musser , Thomas W. Pattison , John P. Yardley
发明人： Anthony F. Kreft, III , John H. Musser , Thomas W. Pattison , John P. Yardley
IPC分类号： C07D213/30 , C07D215/14 , C07D277/24 , C07D277/64 , C07D277/62 , C07D263/30 , C07D263/54 , C07D277/20
CPC分类号： C07D213/30 , C07D215/14 , C07D277/64
摘要： There are disclosed compounds of the formula ##STR1## wherein X is --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## Z is CR or N, where n=1; or Z is O,S, or NR, when n=0; R is hydrogen or loweralkyl;n is 0 or 1;R.sup.1 is hydroxy, amino, loweralkyl sulfonamido, perfluoro loweralkyl sulfonamido or OR;R.sup.2 is hydrogen or loweralkyl;R.sup.3 is hydrogen or loweralkyl; orR.sup.2 and R.sup.3 taken together form a benzene ring; andthe dotted line represents an optional double bond;and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like.
摘要翻译：公开了下式的化合物，其中X是-CH 2 CH 2 - ， - CH = CH-，Z是CR或N，其中n = 1; 或当N = 0时，Z为O，S或NR; R是氢或低级烷基; n为0或1; R1是羟基，氨基，低级烷基亚磺酰氨基，全氟低级烷基亚磺酰氨基或OR; R2是氢或低级烷基; R3是氢或低级烷基; 或R 2和R 3一起形成苯环; 虚线表示任选的双键; 及其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管阻塞性空气通道病症如过敏性鼻炎，过敏性支气管哮喘等中的用途。

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