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1. 发明授权

US5103014A Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propano ic acid derivatives 失效
标题翻译：某些3,3' - [[[（2-苯基-4-噻唑基）甲氧基]苯基]亚甲基]二硫代双 - 丙酸衍生物
公开(公告)号：US5103014A
公开(公告)日：1992-04-07
申请号：US525418
申请日：1990-05-18
申请人： John H. Musser , Reinhold H. W. Bender , Anthony F. Kreft, III , James A. Nelson
发明人： John H. Musser , Reinhold H. W. Bender , Anthony F. Kreft, III , James A. Nelson
IPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D413/12 , C07D417/12
CPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D413/12 , C07D417/12
摘要： There are disclosed compounds of the formula ##STR1## wherein X is ##STR2## Y is ##STR3## Z is --(CH.sub.2).sub.n O--, --(CH.sub.2).sub.n S--, ##STR4## R.sup.1 is ##STR5## n is 0-5; R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;R.sup.3 is ##STR6## W represents a bond or --O--, --S-- or ##STR7## m is 1-15; R.sup.4 is hydrogen or loweralkyl;R.sup.5 is lower alkyl, monofluoroloweralkyl, difluroloweralkyl, polyfluroloweralkyl, perfluoroloweralkyl or ##STR8## R.sup.6 is hydrogen lower alkyl, --COOR.sup.4 or ##STR9## R.sup.7 is OR.sup.4 or N(R.sup.4).sub.2 ; R.sup.8 is OR.sup.4 or N(R.sup.4).sub.2 ;and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstruction airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, as antiinflammatory agents.
摘要翻译：公开了下式的化合物，其中X是Y，Z是 - （CH 2）n O-， - （CH 2）n -S-， R 1是 n为0-5; R2是氢，低级烷基，低级烷氧基，低级烷氧基羰基，三氟甲基，硝基，氰基或卤素; R3表示W表示键或-O - ， - S-或m表示1-15; R4是氢或低级烷基; R 5是低级烷基，一氟代低级烷基，二氟氟烷基，聚芴基烷基，全氟低级烷基或R 6是氢低级烷基，-COOR 4或者R 7是OR 4或N（R 4）2; R8为OR4或N（R4）2; 及其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管阻塞空气通道条件（例如过敏性鼻炎，过敏性支气管哮喘等）中作为抗炎剂的用途。

2. 发明授权

US5071988A Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives 失效
标题翻译：取代的苯甲酰基苯，联苯基和2-恶唑烷酸衍生物
公开(公告)号：US5071988A
公开(公告)日：1991-12-10
申请号：US661734
申请日：1991-02-27
申请人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah
发明人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah
IPC分类号： C07C45/00 , C07C45/63 , C07C45/72 , C07C59/90 , C07C69/738 , C07C205/45 , C07C255/40 , C07D215/14 , C07D263/32 , C07D413/12
CPC分类号： C07D413/10 , C07C205/45 , C07C255/40 , C07C45/004 , C07C45/63 , C07C45/72 , C07C59/90 , C07C69/738 , C07D215/14 , C07D263/32
摘要： There are disclosed compounds of the formulaA(CH.sub.2).sub.n O--BwhereinA is ##STR1## n is 1-2; B is ##STR2## wherein R.sup.4 and R.sup.5 are each, independently, hydrogen or lower alkyl;R.sup.6 is hydrogen, halo or nitro; ##STR3## R.sup.8 is lower alkyl; m is 0-3;and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated nasobronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
摘要翻译：公开了式A（CH 2）n O-B的化合物，其中A是n是1-2; B是，其中R 4和R 5各自独立地是氢或低级烷基; R6是氢，卤素或硝基; R8是低级烷基; m为0-3; 及其药理学上可接受的盐及其在治疗炎性病症如类风湿性关节炎，溃疡性结肠炎，牛皮癣和其他立即超敏反应中的用途; 治疗白三烯介导的鼻支气管阻塞性通气条件如过敏性鼻炎，过敏性支气管哮喘等; 和作为胃细胞保护剂。

3. 发明授权

US5364944A Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid compounds 失效
标题翻译：取代苯甲酰基苯，联苯基和2-恶唑烷酸化合物
公开(公告)号：US5364944A
公开(公告)日：1994-11-15
申请号：US001141
申请日：1993-01-06
申请人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah , Dennis M. Kubrak
发明人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah , Dennis M. Kubrak
IPC分类号： C07C45/00 , C07C45/63 , C07C45/72 , C07C59/90 , C07C69/738 , C07C205/45 , C07C255/40 , C07D215/14 , C07D263/32 , C07D277/24 , C07D413/12 , C07D233/54
CPC分类号： C07C45/004 , C07C205/45 , C07C255/40 , C07C45/63 , C07C45/72 , C07C59/90 , C07C69/738 , C07D215/14 , C07D263/32 , C07D413/10
摘要： There are disclosed substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid derivatives and the pharmacologically acceptable salts thereof as inhibitors of PLA.sub.2 and lipoxygenase, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
摘要翻译：公开了取代的苯甲酰基苯，联苯基和2-恶唑烷酸衍生物及其药理学上可接受的盐作为PLA2和脂氧合酶的抑制剂，以及它们在治疗炎性病症如类风湿性关节炎，溃疡性结肠炎，牛皮癣和其他立即超敏反应; 治疗白三烯介导的鼻支气管阻塞性通气条件，如过敏性鼻炎，过敏性支气管哮喘等; 和作为胃细胞保护剂。

4. 发明授权

US5229516A Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase 失效
标题翻译：取代的吲哚，茚，吡喃吲哚和四氢咔唑 - 链烷酸衍生物作为PLA2和脂氧合酶的抑制剂
公开(公告)号：US5229516A
公开(公告)日：1993-07-20
申请号：US911434
申请日：1992-07-10
申请人： John H. Musser , Anthony F. Kreft, III , Amedeo A. Failli , Christopher A. Demerson , Uresh S. Shah , James A. Nelson
发明人： John H. Musser , Anthony F. Kreft, III , Amedeo A. Failli , Christopher A. Demerson , Uresh S. Shah , James A. Nelson
IPC分类号： C07C323/62 , C07D209/22 , C07D215/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D491/04
CPC分类号： C07D401/12 , C07C323/62 , C07D209/22 , C07D215/14 , C07D401/14 , C07D417/12 , C07D491/04
摘要： There are disclosed compounds of the formulaA(CH.sub.2).sub.n O-BwhereinA is C.sub.4 -C.sub.8 alkyl, phenoxyethyl, phenoxyphenyl or a group having the formula ##STR1## wherein ##STR2## R.sup.1 is hydrogen, lower alkyl, phenyl or phenyl substituted with trifluoromethyl;R.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 taken together form a benzene ring;R.sup.3 is hydrogen or lower alkyl;n is 1-2;B is ##STR3## wherein ##STR4## m is 0-3; R.sup.5 is ##STR5## or phenyl or phenyl substituted by halo, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl;R.sup.6 is A(CH.sub.2).sub.n O-- or halo; with the proviso that when R.sup.6 is halo, R.sup.5 is ##STR6## R.sup.7 is lower alkyl; Y is --CH.sub.2 -- or --O--;R.sup.8 is lower alkyl or --(CH.sub.2).sub.m CO.sub.2 R.sup.3 ;R.sup.9 is ##STR7## or --CH.sub.2 R.sup.10 ; R.sup.10 is lower alkyl, phenyl, phenyl substituted with carboxy, halo, loweralkylthio or loweralkylsulfinyl, pyridyl, furanyl or quinolinyl;R.sup.11 is lower alkyl or phenyl;Z is hydrogen, lower alkyl or --N(CH.sub.3)OH;and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
摘要翻译：公开了式A（CH 2）n O-B的化合物，其中A是C 4 -C 8烷基，苯氧基乙基，苯氧基苯基或具有下式的基团：其中R 1是氢，低级烷基，苯基或被三氟甲基取代的苯基; R2是氢或低级烷基; 或R 1和R 2一起形成苯环; R3是氢或低级烷基; n为1-2; B是其中 m是0-3; R 5为苯基或被卤素，低级烷硫基，低级烷基亚磺酰基或低级烷基磺酰基取代的苯基; R6是A（CH2）nO-或卤素; 条件是当R 6为卤素时，R 5为低级烷基; Y是-CH 2 - 或-O-; R8是低级烷基或 - （CH2）mCO2R3; R9是或-CH2R10; R 10为低级烷基，苯基，被羧基，卤素，低级烷硫基或低级烷基亚磺酰基取代的苯基，吡啶基，呋喃基或喹啉基; R11为低级烷基或苯基; Z是氢，低级烷基或-N（CH 3）OH; 及其药理学上可接受的盐及其在治疗炎性病症如类风湿性关节炎，溃疡性结肠炎，牛皮癣和其他立即超敏反应中的用途; 治疗白三烯介导的鼻支气管阻塞性通气条件，如过敏性鼻炎，过敏性支气管哮喘等; 和作为胃细胞保护剂。

5. 发明授权

US5420289A Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA.sub.2 and lipoxygenase 失效
标题翻译：取代的吲哚，茚，吡喃吲哚和四氢咔唑 - 链烷酸衍生物作为PLA2和脂氧合酶的抑制剂
公开(公告)号：US5420289A
公开(公告)日：1995-05-30
申请号：US29199
申请日：1993-03-10
申请人： John H. Musser , Anthony F. Kreft, III , Amedeo A. Failli , Christopher A. Demerson , Uresh S. Shah , James A. Nelson
发明人： John H. Musser , Anthony F. Kreft, III , Amedeo A. Failli , Christopher A. Demerson , Uresh S. Shah , James A. Nelson
IPC分类号： C07C323/62 , C07D209/22 , C07D215/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D491/04 , C07D417/00
CPC分类号： C07D401/12 , C07C323/62 , C07D209/22 , C07D215/14 , C07D401/14 , C07D417/12 , C07D491/04
摘要： This invention relates to substituted indole derivatives possessing lipoxygenase inhibitory, phospholipase A.sub.2 inhibitory and leukotriene antagonist activity, which are useful as anti-inflammatory, antiallergic and cytoprotective agents.
摘要翻译：本发明涉及具有脂氧合酶抑制剂，磷脂酶A2抑制剂和白三烯拮抗剂活性的取代吲哚衍生物，其可用作抗炎，抗过敏和细胞保护剂。

6. 发明授权

US5218124A Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives as inhibitors of pla2 and lipoxygenase 失效
标题翻译：取代的苯甲酰基苯，联苯基和2-恶唑烷酸衍生物作为pla2和脂氧合酶的抑制剂
公开(公告)号：US5218124A
公开(公告)日：1993-06-08
申请号：US891537
申请日：1992-06-01
申请人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah , Dennis M. Kubrak
发明人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah , Dennis M. Kubrak
IPC分类号： C07C45/00 , C07C45/63 , C07C45/72 , C07C59/90 , C07C69/738 , C07C205/45 , C07C255/40 , C07D215/14 , C07D263/32 , C07D277/24 , C07D413/12
CPC分类号： C07D413/10 , C07C205/45 , C07C255/40 , C07C45/004 , C07C45/63 , C07C45/72 , C07C59/90 , C07C69/738 , C07D215/14 , C07D263/32
摘要： There are disclosed compounds of the formulaA(CH.sub.2).sub.n O--BwhereinA is a group having the formula ##STR1## wherein X is --N-- or ##STR2## Z is ##STR3## R.sup.1 is hydrogen, lower alkyl or phenyl; R.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 taken together form a benzene ring, with the proviso that when X is --N--, Z is other than ##STR4## R.sup.3 is hydrogen or lower alkyl; n is 1-2;B is ##STR5## wherein Y is OR.sup.5 or N(OH)R.sup.8 ;R.sup.4 and R.sup.5 are each, independently, hydrogen or lower alkyl;R.sup.6 is hydrogen, halo or nitro;R.sup.7 is ##STR6## R.sup.8 is lower alkyl; m is 0-3;and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
摘要翻译：公开了式A（CH 2）n O-B的化合物，其中A是具有下式的基团：其中X是-N-或者Z是R 1是氢，低级烷基或苯基; R2是氢或低级烷基; 或者R 1和R 2一起形成苯环，条件是当X是-N-时，Z不是R 3是氢或低级烷基; n为1-2; B是其中Y是OR 5或N（OH）R 8; R 4和R 5各自独立地为氢或低级烷基; R6是氢，卤素或硝基; R7是 R8是低级烷基; m为0-3; 及其药理学上可接受的盐及其在治疗炎性病症如类风湿性关节炎，溃疡性结肠炎，牛皮癣和其他立即超敏反应中的用途; 治疗白三烯介导的鼻支气管阻塞性通气条件，如过敏性鼻炎，过敏性支气管哮喘等; 和作为胃细胞保护剂。

7. 发明授权

US10472886B2 Micro gap roller shade system and method of installation 有权
公开(公告)号：US10472886B2
公开(公告)日：2019-11-12
申请号：US15721515
申请日：2017-09-29
申请人： James A. Nelson
发明人： James A. Nelson
IPC分类号： E06B9/42 , E06B9/44 , E06B9/72
摘要： The invention is a roller shade tube assembly with a main housing having a lumen divided into two sections by an internal spring stop. The distal end of the main housing has a recessed mounting cavity coupleable to a motor. The proximal end of the main housing has one or more interlocking fingers. A spring inside the proximal lumen abuts the spring stop. An inner guide cylinder is coupled to slide inside the main housing against the spring and coupled to a lumen of an auxiliary housing that is movably coupled to the main housing. The distal end of the auxiliary housing includes one or more complementary interlocking fingers and a second recessed mounting cavity at its proximal end. Wall mounting brackets on each side of the tube assembly are configured to fit into the recessed mounting cavities. A shade fabric is coupled to the roller shade tube assembly.

8. 再颁专利

USRE33334E Vehicle wash and dryer 失效
标题翻译：洗车和烘干机
公开(公告)号：USRE33334E
公开(公告)日：1990-09-18
申请号：US259339
申请日：1988-10-18
申请人： James A. Nelson
发明人： James A. Nelson
IPC分类号： B60S3/00 , B60S3/06
CPC分类号： B60S3/002 , B60S3/06
摘要： An apparatus for both washing and drying an automotive vehicle. The apparatus includes a track gantry that moves along the track and over the vehicle. Water outlets and brushes are on the gantry to wash the car. The apparatus further includes a blower, nozzle, and oscillator. The blower, also mounted on the gantry, expels air onto the vehicle. The nozzle, positioned on the blower, defines an orientation and directs the air from the blower substantially parallel to the orientation. The oscillator periodically changes the orientation of the nozzle and the direction of the air from the blower.

9. 发明授权

US4685169A Vehicle wash and dryer 失效
标题翻译：洗车和烘干机
公开(公告)号：US4685169A
公开(公告)日：1987-08-11
申请号：US769666
申请日：1985-08-26
申请人： James A. Nelson
发明人： James A. Nelson
IPC分类号： B60S3/00 , B60S3/06
CPC分类号： B60S3/002 , B60S3/06 , Y10S15/02
摘要： An apparatus for both washing and drying an automotive vehicle. The apparatus includes a track gantry that moves along the track and over the vehicle. Water outlets and brushes are on the gantry to wash the car. The apparatus further includes a blower, nozzle, and oscillator. The blower, also mounted on the gantry, expels air onto the vehicle. The nozzle, positioned on the blower, defines an orientation and directs the air from the blower substantially parallel to the orientation. The oscillator periodically changes the orientation of the nozzle and the direction of the air from the blower.
摘要翻译：一种用于洗涤和干燥机动车辆的装置。该装置包括沿轨道和车辆上方移动的轨道台架。龙门架上的出水口和刷子都要洗车。该装置还包括鼓风机，喷嘴和振荡器。也安装在龙门架上的鼓风机将空气排出到车辆上。定位在鼓风机上的喷嘴限定了取向，并将来自鼓风机的空气基本上平行于取向引导。振荡器周期性地改变喷嘴的方向和来自鼓风机的空气的方向。

10. 发明授权

US4553960A Peritoneal fluid treatment apparatus, package and method 失效
公开(公告)号：US4553960A
公开(公告)日：1985-11-19
申请号：US632956
申请日：1984-07-20
申请人： Harrison Lazarus , James A. Nelson
发明人： Harrison Lazarus , James A. Nelson
IPC分类号： A61B17/34 , A61B19/02 , A61M25/01 , A61M5/00
CPC分类号： A61B17/3415 , A61B50/33 , A61M25/0111
摘要： The cannula of a conventional intravascular catheter is placed into the peritoneal cavity through a small shallow incision in antiseptically prepared skin. The stylet or trocar of the conventional catheter is removed; and a stainless steel elongated flexible guide is inserted through the catheter's cannula into the peritoneal cavity. The catheter's cannula is removed and a flexible elongated cannula inserted into the cavity over the guide and secured in place with a suture. Fluid operation means is connected to the elongated cannula by connector means to permit fluid treatment after removal of the guide. Apparatus to effect peritoneal fluid treatment are placed in sterile openable sealed packages for storage and transport.

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