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1. 发明授权

US07229603B2 Stablilized and lyophilized radiopharmaceutical agents 失效
标题翻译：稳定和冻干放射性药剂
公开(公告)号：US07229603B2
公开(公告)日：2007-06-12
申请号：US10904099
申请日：2004-10-22
申请人： John H. Kuperus , Robert G. McKenzie, Jr. , Brooke Schumm, III
发明人： John H. Kuperus , Robert G. McKenzie, Jr. , Brooke Schumm, III
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/10 , A61K51/1241 , A61K51/1282
摘要： A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.
摘要翻译：通过设计用于快速冷冻和脱水放射性药物组合物以最小化自动放射分解的装置，以稳定的，可运输的冻干形式制备放射性诊断性放射性药物的新方法。该方法提出了快速冷却和去除环境蒸汽，然后在消除爆炸性液氧的潜力时进行超冷去除。在稳定化之后，放射性诊断放射性药物不需要进一步冷藏或冷藏储存，包括关于运输。优选的组合物可以通过加入合适的稀释剂“现场”重构，以使放射性药物复合物以所需浓度进入溶液。

2. 发明授权

US4638809A Method of preparing radionuclide doses 失效
标题翻译：制备放射性核素剂量的方法
公开(公告)号：US4638809A
公开(公告)日：1987-01-27
申请号：US592091
申请日：1984-03-22
申请人： John H. Kuperus
发明人： John H. Kuperus
IPC分类号： A61M5/28 , A61M5/31 , A61M5/34 , A61B5/14
CPC分类号： A61M5/34 , A61M5/284 , A61M5/3145
摘要： Dosages of a radionuclide carrier for use in diagnostic nuclear medicine are prepared in separate, aliquot quantities by storing a discrete amount of a lyophilized radionuclide carrier material in tubular containers. The containers are closed to exclude moisture and air. The radionuclide carrier is reconstituted as an aliquot dosage by interposing the container between the needle and barrel of a hypodermic syringe, and drawing a predetermined amount of a reconstituting liquid into the syringe barrel through the needle and through the container. The liquid dissolves the lyophilized carrier to form an aliquot dosage for each patient, only as needed.
摘要翻译：用于诊断性核医学的放射性核素载体的剂量通过将分离量的冻干放射性核素载体材料储存在管状容器中而以分开的等分量制备。容器关闭以排除湿气和空气。放射性核素载体通过将容器插入皮下注射器的针头和针筒之间，作为等分量剂量重新构成，并通过针头并通过容器将预定量的重构液体抽吸到注射器筒中。液体溶解冻干载体，以便根据需要为每个患者形成等分试剂。

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