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1. 发明授权

US06183735B2 Immortalized retinal pigmentary epithelial cell lines and their applications 失效
标题翻译：永生化视网膜色素上皮细胞系及其应用
公开(公告)号：US06183735B2
公开(公告)日：2001-02-06
申请号：US08973553
申请日：1998-01-22
申请人： John Greenwood , Peter Adamson , Raymond Lund
发明人： John Greenwood , Peter Adamson , Raymond Lund
IPC分类号： A61K3500
CPC分类号： C12N5/0621 , C12N2503/00 , C12N2510/04
摘要： The invention features immortalized retina-derived (retinal endothelial or retinal epithelial pigmentary) cell lines capable of being implanted in the retina and of carrying a therapeutic substance to the eye and to the central nervous system. Such lines can also be used as a model for studying blood central nervous system interfaces. These lines are derived from primary retinal cultures selected from the group consisting of primary retinal endothelial cells and primary retinal epithelial cells, comprise a nucleic acid fragment containing at least one immortalizing fragment of a heat-sensitive viral oncogene, which nucleic fragment is optionally associated with at least one selection gene, and have the morphological characteristics and at least the expression characteristics of the surface antigens of corresponding primary cultures.
摘要翻译：本发明具有能够植入视网膜并将治疗物质携带到眼睛和中枢神经系统的永生视网膜衍生（视网膜内皮或视网膜上皮色素）细胞系。这样的线也可以用作研究血液中枢神经系统界面的模型。这些品系衍生自选自原代视网膜内皮细胞和原代视网膜上皮细胞的原代视网膜培养物，包含含有至少一种热敏病毒致癌基因的永生化片段的核酸片段，该核酸片段任选地与至少一种选择基因，并且具有相应原代培养物的表面抗原的形态特征和至少表达特征。

2. 发明授权

US6090624A Immortalized retinal cell lines and their applications 失效
标题翻译：永生化视网膜细胞系及其应用
公开(公告)号：US6090624A
公开(公告)日：2000-07-18
申请号：US182516
申请日：1998-10-30
申请人： John Greenwood , Peter Adamson , Raymond Lund
发明人： John Greenwood , Peter Adamson , Raymond Lund
IPC分类号： A61K35/12 , C12N5/071 , C12N5/08
CPC分类号： C12N5/0621 , A61K35/12 , C12N2510/04
摘要： Immortalized cell lines of retinal origin (retinal endothelial and retinal pigmentary epithelial origin) which are capable of being implanted in the retina and of conveying a substance of therapeutic interest into the eye and the central nervous system. Such lines can also serve as a model for studying the blood/central nervous system interfaces.These lines are derived from primary cultures of retinal cells selected from the group comprising the primary retinal endothelial cells and the primary retinal epithelial cells, comprise a nucleic acid fragment containing at least one immortalizing fragment of a heat-sensitive viral oncogene, which nucleic acid fragment may be associated with at least one selection gene, and exhibit the morphological characteristics and at least the surface antigen expression characteristics of the corresponding primary culture cells.
摘要翻译：能够植入视网膜并将治疗感兴趣的物质输送到眼睛和中枢神经系统中的视网膜源（视网膜内皮和视网膜色素上皮起源）的永生化细胞系。这样的线也可以作为研究血液/中枢神经系统界面的模型。这些品系衍生自视网膜细胞的原代培养物，所述视网膜细胞选自包含主要视网膜内皮细胞和原代视网膜上皮细胞的组，包含含有热敏病毒致癌基因的至少一个永生化片段的核酸片段，该核酸片段可能与至少一种选择基因相关，并且表现出相应原代培养细胞的形态特征和至少表面抗原表达特征。

3. 发明授权

US06878544B2 Retinal cell lines with extended life-span and their applications 失效
标题翻译：具有延长使用寿命的视网膜细胞系及其应用
公开(公告)号：US06878544B2
公开(公告)日：2005-04-12
申请号：US09559707
申请日：2000-04-27
申请人： John Greenwood , Peter Adamson , Raymond Lund , Weng Tao
发明人： John Greenwood , Peter Adamson , Raymond Lund , Weng Tao
IPC分类号： C12N15/09 , A61K35/12 , A61K35/44 , A61P27/02 , A61P29/00 , A61P35/00 , C12N5/071 , C12N5/10 , C12P21/02 , C12N5/06
CPC分类号： C12N5/0621 , A61K35/12 , C12N2503/00 , C12N2510/02 , C12N2510/04
摘要： The invention features retina-derived (retinal endothelial or retinal epithelial pigment) cell lines with extended life-span and capable of being implanted in the retina and of carrying a therapeutic substance to the eye and to the central nervous system. Such lines can also be used as a model for studying blood central nervous system interfaces. These lines are derived from primary retinal cultures selected from the group consisting of primary retinal endothelial cells and primary retinal epithelial cells, comprise a polynucleotide containing an oncogene, which polynucleotide is optionally associated with at least one selection gene, and have the morphological characteristics and at least the expression characteristics of the surface antigens of corresponding primary cultures.
摘要翻译：本发明特征在于视网膜衍生（视网膜内皮或视网膜上皮细胞色素）细胞系具有延长的寿命并且能够植入视网膜并且将治疗物质携带到眼睛和中枢神经系统。这样的线也可以用作研究血液中枢神经系统界面的模型。这些系衍生自选自原发性视网膜内皮细胞和原代视网膜上皮细胞的原代视网膜培养物，包含含有癌基因的多核苷酸，所述多核苷酸任选地与至少一个选择基因相关，并具有形态特征最小表达相关原代培养物的表面抗原特征。

4. 发明授权

US08790647B2 Treatment of vasculoproliferative conditions with Lrg1 anatgonists 有权
标题翻译：用Lrg1阴茎病人治疗血管增生症状
公开(公告)号：US08790647B2
公开(公告)日：2014-07-29
申请号：US13393531
申请日：2010-09-06
申请人： John Greenwood , Stephen Moss , Xiaomeng Wang
发明人： John Greenwood , Stephen Moss , Xiaomeng Wang
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K14/47 , C07K14/495 , C07K16/18 , C07K2317/76 , C12N15/113 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2320/30
摘要： This invention relates to the field of molecular physiology. Specifically, this invention relates to treatment of vasculoproliferative conditions, especially those of the eye and in the treatment of tumours that exhibit vascular proliferation. Levels of leucine-rich alpha-2-glycoprotein (Lrg1) have been demonstrated to be increased in patients suffering from such conditions and animal models of such conditions. Antagonists of Lrg1 can be used to treat vasculoproliferative conditions.
摘要翻译：本发明涉及分子生理学领域。具体而言，本发明涉及血管增生性疾病的治疗，特别是眼睛的治疗和治疗显示血管增生的肿瘤。已经证明在患有这些病症的患者和这些病症的动物模型中，富含亮氨酸的α-2-糖蛋白（Lrg1）的水平增加。 Lrg1的拮抗剂可用于治疗血管增生性疾病。

5. 发明申请

US20120231002A1 TREATMENT OF VASCULOPROLIFERATIVE CONDITIONS 有权
标题翻译：治疗血液生化条件
公开(公告)号：US20120231002A1
公开(公告)日：2012-09-13
申请号：US13393531
申请日：2010-09-06
申请人： John Greenwood , Stephen Moss , Xiaomeng Wang
发明人： John Greenwood , Stephen Moss , Xiaomeng Wang
IPC分类号： A61K39/395 , A61K38/02 , A61K31/713 , A61K38/17 , G01N33/566 , A61P9/10 , A61P27/02 , A61P35/00 , C07K16/18 , A61K31/7088 , A61P9/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K14/47 , C07K14/495 , C07K16/18 , C07K2317/76 , C12N15/113 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2320/30
摘要： This invention relates to the field of molecular physiology. Specifically, this invention relates to the prevention and/or treatment of vasculoproliferative conditions, especially those of the eye and in the treatment of tumours that exhibit vascular proliferation. Levels of leucine-rich alpha-2-glycoprotein (Lrg1) have been demonstrated to be increased in patients suffering from such conditions and animal models of such conditions. Antagonists of Lrg1 can be used to prevent and/or treat vasculoproliferative conditions.
摘要翻译：本发明涉及分子生理学领域。具体地，本发明涉及预防和/或治疗血管增生性病症，特别是眼睛和治疗显示血管增生的肿瘤的病症。已经证明在患有这些病症的患者和这些病症的动物模型中，富含亮氨酸的α-2-糖蛋白（Lrg1）的水平增加。 Lrg1的拮抗剂可用于预防和/或治疗血管增生性疾病。

6. 发明申请

US20070065904A1 Recombinant expression vectors for functional nav1.9 sodium channels 审中-公开
标题翻译：功能性nav1.9钠通道的重组表达载体
公开(公告)号：US20070065904A1
公开(公告)日：2007-03-22
申请号：US10508965
申请日：2003-03-20
申请人： Matthew Gonda , John Greenwood
发明人： Matthew Gonda , John Greenwood
IPC分类号： C07H21/04 , C12N15/09 , C07K14/705
CPC分类号： C07K14/705
摘要： The present invention is drawn to the stable cloning and expression of Nav1.9 sodium channel at the mRNA and protein levels, production of sodium channel currents characteristic of native currents in dorsal root ganglion neurons and to cell lines transiently or stably expressing recombinant Nav1.9 sodium channel.
摘要翻译：本发明涉及在mRNA和蛋白质水平上稳定克隆和表达钠钠1.9通道，产生在背根神经节神经元中的天然电流和瞬时的细胞系特征的钠通道电流或稳定表达重组Na + 1.9钠通道。

7. 发明申请

US20060145781A1 Dual band full duplex mobile radio 有权
标题翻译：双频全双工移动无线电
公开(公告)号：US20060145781A1
公开(公告)日：2006-07-06
申请号：US11026832
申请日：2004-12-30
申请人： Dennis Layne , John Greenwood , Brian Justin
发明人： Dennis Layne , John Greenwood , Brian Justin
IPC分类号： H03H7/46
CPC分类号： H04B1/48 , H04B1/0057 , H04B1/52
摘要： A dual band full duplex mobile radio is provided that includes a transmit portion including a dual band filter and a receive portion including a dual band filter. The dual band full duplex mobile radio further includes a circulator connecting the transmit portion and the receive portion and configured to provide transmit and receive switching.
摘要翻译：提供了一种双频全双工移动无线电，其包括包括双频带滤波器的发射部分和包括双频带滤波器的接收部分。双频全双工移动无线电还包括连接发射部分和接收部分并被配置为提供发射和接收切换的循环器。

8. 发明申请

US20070074578A1 System and method for sensing differential pressure 有权
标题翻译：用于感应差压的系统和方法
公开(公告)号：US20070074578A1
公开(公告)日：2007-04-05
申请号：US11241049
申请日：2005-09-30
申请人： Kanakasabapathi Subramanian , Kuna Kishore , Parag Thakre , Russell Craddock , Peter Kinnell , John Greenwood
发明人： Kanakasabapathi Subramanian , Kuna Kishore , Parag Thakre , Russell Craddock , Peter Kinnell , John Greenwood
IPC分类号： G01L13/02
CPC分类号： G01L9/0019
摘要： A differential pressure sensing system is provided. The sensing system includes a membrane layer having a channel extending diametrically therein, and including one or more cavities provided radially outbound of the channel and at least one resonant beam disposed in the channel and configured to oscillate at a desired frequency. The system further includes sensing circuitry configured to detect oscillation of the at least one resonant beam indicative of deformation in the membrane layer.
摘要翻译：提供差压感测系统。感测系统包括膜层，其具有在其中径向延伸的通道，并且包括设置在通道中径向出入的一个或多个空腔，以及设置在通道中并被配置为以期望频率振荡的至少一个谐振束。该系统还包括感测电路，其被配置为检测指示膜层变形的至少一个谐振光束的振荡。

9. 发明申请

US20060292320A1 Machine and methods for the manufacture of air-filled cushions 有权
公开(公告)号：US20060292320A1
公开(公告)日：2006-12-28
申请号：US11185927
申请日：2005-07-19
申请人： John Greenwood , Neil Price
发明人： John Greenwood , Neil Price
IPC分类号： B31B45/00 , A63B39/00 , B32B37/00 , B32B38/04
CPC分类号： B65B1/04 , B29C65/18 , B29C65/787 , B29C66/1122 , B29C66/439 , B29C66/81465 , B29C66/8161 , B29C66/8221 , B29C66/83423 , B29C66/872 , B29C66/87443 , B29C66/91431 , B29C66/91641 , B29C66/934 , B31D5/0073 , B31D2205/0023 , B31D2205/0047 , B31D2205/0052 , B31D2205/0082 , B32B2553/023 , B65B1/02 , B65B41/12 , B65B51/30 , B65B61/02 , Y10T156/12 , Y10T156/17 , Y10T156/1702 , Y10T156/1712 , Y10T156/1715 , Y10T428/13
摘要： A device and method are disclosed for forming air filled cushions. The device includes a drive mechanism to move inflatable tubing through the apparatus, and an injector, optionally including an outlet, located continuously within, or within a portion of, the tubing. This arrangement can permit the formation of air filled cushions in a continuous stream. Also disclosed is a roll of plastic tubing that is sealed transversely at a succession of intervals, with each pair of seals stopping just short of a longitudinal center line of the tubing. Such tubing might be used in conjunction with the apparatus, the central gap between the seals allowing passage of the injector.

10. 发明申请

US20050204700A1 Method and machine for the manufacture of air pillows 有权
标题翻译：制造空气枕头的方法和机器
公开(公告)号：US20050204700A1
公开(公告)日：2005-09-22
申请号：US10940590
申请日：2004-09-13
申请人： John Greenwood , Neil Price
发明人： John Greenwood , Neil Price
IPC分类号： B31D5/00 , B65B31/00 , B65B57/00
CPC分类号： B31D5/0073 , B29L2031/7138 , B31D2205/0023
摘要： Devices and methods for forming air pillows are described. In accordance with embodiments of the invention, an apparatus for manufacturing air-filled pillows from a tube material includes a plurality of support rollers, a drive means, an injector means, and a sealing means. The plurality of support rollers support a roll of a tube material along an outer circumferential extent of the roll, in which the tube material includes two opposing sheets joined along at least one longitudinal edge thereof. The drive means draws the tube material from the roll along the support rollers, the injector means injects air into an interior space between the two opposing sheets of the tube material drawn from the roll, and the sealing means seals the two opposing sheets together with the injected air entrapped in the interior space therebetween.
摘要翻译：描述了用于形成气枕的装置和方法。根据本发明的实施例，用于从管材制造充气枕头的装置包括多个支撑辊，驱动装置，注射器装置和密封装置。多个支撑辊沿着辊的外圆周范围支撑一卷管材料，其中管材料包括沿其至少一个纵向边缘连接的两个相对的片材。驱动装置沿着支撑辊从辊中抽出管材，喷射器装置将空气注入到从卷筒抽出的管材的两个相对的片材之间的内部空间中，并且密封装置将两个相对的片材与注入的空气被夹在其间的内部空间中。

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