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1. 发明申请

US20080091010A1 Intermediates for imidazonaphthyridines 有权
公开(公告)号：US20080091010A1
公开(公告)日：2008-04-17
申请号：US11999602
申请日：2007-12-06
申请人： John Gerster , Kyle Lindstrom , Stephen Crooks , Philip Heppner , Gregory Marszalek , Peter Maye , Bryon Merrill , John Mickelson , Michael Rice
发明人： John Gerster , Kyle Lindstrom , Stephen Crooks , Philip Heppner , Gregory Marszalek , Peter Maye , Bryon Merrill , John Mickelson , Michael Rice
IPC分类号： C07D413/14 , C07D239/38 , C07D259/00 , C07D473/04 , C07D471/14 , C07D401/14
CPC分类号： C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.

2. 发明申请

US20060128674A1 INTERMEDIATES FOR IMIDAZONAPHTHYRIDINES 有权
标题翻译：咪达噻嗪的中间体
公开(公告)号：US20060128674A1
公开(公告)日：2006-06-15
申请号：US11276074
申请日：2006-02-13
申请人： John Gerster , Kyle Lindstrom , Stephen Crooks , Philip Heppner , Gregory Marszalek , Peter Maye , Bryon Merrill , John Mickelson , Michael Rice
发明人： John Gerster , Kyle Lindstrom , Stephen Crooks , Philip Heppner , Gregory Marszalek , Peter Maye , Bryon Merrill , John Mickelson , Michael Rice
IPC分类号： A61K31/4745 , A61K31/4439 , C07D403/02 , C07D471/02 , A61K31/655
CPC分类号： C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
摘要翻译：咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。该化合物显示抗病毒和抗肿瘤性质。公开了制备可用于制备化合物的化合物和中间体的方法。

3. 发明申请

US20050288320A1 IMIDAZONAPHTHYRIDINES 有权
标题翻译：咪唑嗪
公开(公告)号：US20050288320A1
公开(公告)日：2005-12-29
申请号：US11188418
申请日：2005-07-25
申请人： John Gerster , Kyle Lindstrom , Stephen Crooks , Philip Heppner , Gregory Marszalek , Peter Maye , Bryon Merrill , John Mickelson , Michael Rice
发明人： John Gerster , Kyle Lindstrom , Stephen Crooks , Philip Heppner , Gregory Marszalek , Peter Maye , Bryon Merrill , John Mickelson , Michael Rice
IPC分类号： A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/522 , A61P7/00 , A61P17/00 , A61P29/00 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D213/00 , C07D233/00 , C07D257/00 , C07D401/04 , C07D471/04 , C07D471/14 , C07D471/22 , C07D519/00
CPC分类号： C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
摘要翻译：咪唑并吡啶和四氢咪唑并萘啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。该化合物显示抗病毒和抗肿瘤性质。还公开了制备可用于制备化合物的化合物和中间体的方法。

4. 发明申请

US20050107421A1 Imidazonaphthyridines 有权
公开(公告)号：US20050107421A1
公开(公告)日：2005-05-19
申请号：US11004674
申请日：2004-12-03
申请人： John Gerster , Kyle Lindstrom , Stephen Crooks , Philip Heppner , Gregory Marszalck , Peter Maye , Bryon Merrill , John Mickelson , Michael Rice
发明人： John Gerster , Kyle Lindstrom , Stephen Crooks , Philip Heppner , Gregory Marszalck , Peter Maye , Bryon Merrill , John Mickelson , Michael Rice
IPC分类号： A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/522 , A61P7/00 , A61P17/00 , A61P29/00 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D213/00 , C07D233/00 , C07D257/00 , C07D401/04 , C07D471/04 , C07D471/14 , C07D471/22 , C07D519/00
CPC分类号： C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

5. 发明申请

US20060111387A1 ARYL SUBSTITUTED IMIDAZOQUINOLINES 失效
标题翻译： ARYL取代的咪唑啉酮
公开(公告)号：US20060111387A1
公开(公告)日：2006-05-25
申请号：US11275553
申请日：2006-01-13
申请人： David Hays , Tushar Kshirsagar , Philip Heppner , Bryon Merrill , Michael Danielson , John Gerster , Chad Haraldson , Sarah Johannessen , Maureen Kavanagh , Kyle Lindstrom , Michael Rice , David Squire , Sarah Strong , Joshua Wurst
发明人： David Hays , Tushar Kshirsagar , Philip Heppner , Bryon Merrill , Michael Danielson , John Gerster , Chad Haraldson , Sarah Johannessen , Maureen Kavanagh , Kyle Lindstrom , Michael Rice , David Squire , Sarah Strong , Joshua Wurst
IPC分类号： A61K31/4745 , C07D487/02
CPC分类号： C07D471/04
摘要： Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
摘要翻译：公开了芳基取代的咪唑并喹啉化合物，含有化合物的化合物的药物组合物，中间体和这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成和治疗包括病毒和肿瘤的疾病。

6. 发明申请

US20070060754A1 Alkoxy substituted imidazoquinolines 有权
标题翻译：烷氧基取代的咪唑并喹啉
公开(公告)号：US20070060754A1
公开(公告)日：2007-03-15
申请号：US10595230
申请日：2004-10-01
申请人： Kyle Lindstrom , Bryon Merrill , Chad Haraldson , Michael Rice , Tushar Kshirsagar , Philip Heppner , Joshua Wurst , Shri Niwas , Sarah Johannessen
发明人： Kyle Lindstrom , Bryon Merrill , Chad Haraldson , Michael Rice , Tushar Kshirsagar , Philip Heppner , Joshua Wurst , Shri Niwas , Sarah Johannessen
IPC分类号： C07D471/00
CPC分类号： C07D471/04 , A61K31/4745 , C07D413/14 , C07D519/00 , Y02A50/409 , Y02A50/411 , Y02A50/463
摘要： Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
摘要翻译：含有6,7,8或9位烷氧基取代基的咪唑并喹啉化合物含有化合物，中间体，制备方法，以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成，在包括病毒和肿瘤的疾病的治疗中。

7. 发明申请

US20050131009A1 Urea substituted imidazoquinolines 有权
标题翻译：脲取代的咪唑并喹啉
公开(公告)号：US20050131009A1
公开(公告)日：2005-06-16
申请号：US11038434
申请日：2005-01-20
申请人： Stephen Crooks , George Griesgraber , Kyle Lindstrom , Bryon Merrill , Michael Rice
发明人： Stephen Crooks , George Griesgraber , Kyle Lindstrom , Bryon Merrill , Michael Rice
IPC分类号： A61K31/437 , A61K31/4745 , A61K31/5377 , A61P1/02 , A61P11/06 , A61P27/16 , A61P31/00 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D471/04 , C07D471/02
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译：在1位含有尿素，硫脲，酰基脲或磺酰脲官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

8. 发明申请

US20050026943A1 Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof 失效
标题翻译：噻唑并噻唑并[3,4-c] - 喹啉-4-胺及其类似物
公开(公告)号：US20050026943A1
公开(公告)日：2005-02-03
申请号：US10926385
申请日：2004-08-25
申请人： John Gerster , Kyle Lindstrom , Gregory Marszalek , Michael Rice
发明人： John Gerster , Kyle Lindstrom , Gregory Marszalek , Michael Rice
IPC分类号： A61K31/424 , A61K31/429 , A61K31/4375 , A61K31/4738 , A61K31/5377 , A61P31/12 , A61P35/00 , A61P37/02 , C07D221/00 , C07D263/00 , C07D277/00 , C07D498/04 , C07D498/14 , C07D513/04 , C07D513/14 , C07D517/04 , C07D498/02 , A61K31/4745 , C07D491/02
CPC分类号： C07D513/04 , C07D513/14 , C07D517/04
摘要： Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.
摘要翻译：描述了噻唑并恶唑并[s]噻唑并[4,5-c]喹啉-4-胺及其类似物，包括制造和使用新型中间体的方法。这些化合物是免疫调节剂并诱导细胞因子生物合成，包括干扰素和/或肿瘤生物合成，坏死因子，并抑制T辅助2型免疫应答。该化合物还可用于治疗病毒和肿瘤疾病。

9. 发明申请

US20070208052A1 Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines 有权
标题翻译：芳氧基和芳基亚烷氧基取代的噻唑并喹啉和噻唑烷萘啶
公开(公告)号：US20070208052A1
公开(公告)日：2007-09-06
申请号：US11570704
申请日：2005-06-17
申请人： Ryan Prince , Michael Rice , Joshua Wurst , Bryon Merrill , Tushar Kshirsagar , Philip Heppner
发明人： Ryan Prince , Michael Rice , Joshua Wurst , Bryon Merrill , Tushar Kshirsagar , Philip Heppner
IPC分类号： A61K31/54
CPC分类号： C07D513/04 , C07D513/14
摘要： Thiazoloquinoline and thiazolonaphthyridine compounds having an aryloxy or arylalkyleneoxy substituent at the 6-, 7-, 8-, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：在6-，7-，8-或9-位具有芳氧基或芳基亚烷氧基取代基的噻唑并喹啉和噻唑并萘啶化合物，其含有化合物，中间体和制备方法以及这些化合物作为免疫调节剂的使用方法，用于调节公开了动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

10. 发明授权

US07927062B2 Methods and apparatus for transferring substrates during electronic device manufacturing 有权
标题翻译：在电子设备制造过程中传送基板的方法和装置
公开(公告)号：US07927062B2
公开(公告)日：2011-04-19
申请号：US11554530
申请日：2006-10-30
申请人： Michael Rice , Nicholas Cravalho , Jeffrey A. Brodine
发明人： Michael Rice , Nicholas Cravalho , Jeffrey A. Brodine
IPC分类号： G06F15/00
CPC分类号： H01L21/67748 , H01L21/67742 , H01L21/67745 , H01L21/68707
摘要： In one aspect, a first apparatus is provided that is adapted to transfer a substrate between a transfer chamber and a processing chamber. The first apparatus includes a robot having a first blade, a second blade spaced from the first blade, and a central hub coupled to the first blade by at least a first arm and coupled to the second blade by at least a second arm. The first blade and the second blade are spaced so as to allow (a) both blades to simultaneously extend through a slit valve that separates a transfer chamber from a processing chamber coupled to the transfer chamber when the robot is positioned within the transfer chamber; and (b) the first and second blades to transfer substrates to and remove substrates from the processing chamber without raising or lowering the first and second blades or the robot. Numerous other aspects are provided.
摘要翻译：在一个方面，提供了适于在传送室和处理室之间传送衬底的第一设备。第一装置包括具有第一叶片的机器人，与第一叶片间隔开的第二叶片，以及通过至少第一臂联接到第一叶片并通过至少第二臂联接到第二叶片的中心轮毂。第一叶片和第二叶片间隔开以便（a）当机器人位于传送室内时，两个叶片同时延伸通过狭缝阀，该狭缝阀将传送室与耦合到传送室的处理室分离; 以及（b）第一和第二刀片，用于将基板转移到处理室中并从基板移除基板，而不会升高或降低第一和第二刀片或机器人。提供了许多其他方面。

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