专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120184455A1 Method and Nucleic Acids for the Improved Treatment of Breast Cell Proliferative Disorders 审中-公开
标题翻译：改善乳腺增生性疾病治疗的方法和核酸
公开(公告)号：US20120184455A1
公开(公告)日：2012-07-19
申请号：US13352238
申请日：2012-01-17
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime P. Look , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime P. Look , Almuth Marx , Heinz Hoefler
IPC分类号： C40B30/00 , C40B40/06 , C40B30/04 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译：本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与乳腺组织的细胞增殖性病症的反应的方法，进行内分泌治疗。

2. 发明申请

US20060121467A1 Method and nucleic acids for the improved treatment of breast cell proliferative disorders 有权
标题翻译：用于改善乳腺增生性疾病治疗的方法和核酸
公开(公告)号：US20060121467A1
公开(公告)日：2006-06-08
申请号：US10517741
申请日：2003-10-01
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime Look , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime Look , Almuth Marx , Heinz Hoefler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译：本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与乳腺组织的细胞增殖性病症的反应的方法，进行内分泌治疗。

3. 发明申请

US20080254447A1 Method and Nucleic Acids for the Improved Treatment of Breast Cell Proliferative Disorders 有权
标题翻译：改善乳腺增生性疾病治疗的方法和核酸
公开(公告)号：US20080254447A1
公开(公告)日：2008-10-16
申请号：US10582705
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译：本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与细胞的无病存活和/或应答的方法乳腺组织增生性疾病，进行内分泌治疗。

4. 发明申请

US20060024684A1 Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients 审中-公开
公开(公告)号：US20060024684A1
公开(公告)日：2006-02-02
申请号：US11011332
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.

5. 发明申请

US20090111707A1 MARKERS FOR THE PREDICTION OF OUTCOME OF ANTHRACYCLINE TREATMENT 有权
标题翻译：预防治疗精神分裂症患者的标志物
公开(公告)号：US20090111707A1
公开(公告)日：2009-04-30
申请号：US12067633
申请日：2006-09-21
申请人： John Foekens , John Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
发明人： John Foekens , John Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.
摘要翻译：本发明涉及预测细胞增殖性疾病患者蒽环类治疗结果的方法。这通过确定选自PITX2的至少一种基因的表达水平来实现; TFF1和PLAU。本发明还涉及可以在所述方法中使用的序列，寡核苷酸和抗体。

6. 发明申请

US20070031873A1 Predicting bone relapse of breast cancer 审中-公开
标题翻译：预测乳腺癌的骨复发
公开(公告)号：US20070031873A1
公开(公告)日：2007-02-08
申请号：US11497180
申请日：2006-08-01
申请人： Yixin Wang , Yi Zhang , David Atkins , Anieta Sieuwerts , Marcel Smid , Jan Klijn , John Martens , John Foekens
发明人： Yixin Wang , Yi Zhang , David Atkins , Anieta Sieuwerts , Marcel Smid , Jan Klijn , John Martens , John Foekens
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , G16B25/00 , G16B40/00
摘要： A method of providing predicting relapse of breast cancer in bone is conducted by analyzing the expression of a group of genes. Gene expression profiles in a variety of medium such as microarrays are included as are kits that contain them.
摘要翻译：通过分析一组基因的表达来进行骨骼中预测乳腺癌复发的方法。包括微阵列在内的各种培养基中的基因表达谱也包含在其中。

7. 发明申请

US20060070791A1 Method and system for anti-static steering for vehicle steering systems 有权
标题翻译：车辆转向系统防静电转向方法及系统
公开(公告)号：US20060070791A1
公开(公告)日：2006-04-06
申请号：US10953000
申请日：2004-09-29
申请人： John Martens , Chester Gryczan
发明人： John Martens , Chester Gryczan
IPC分类号： B62D7/09
CPC分类号： B62D7/159
摘要： A method for implementing anti-static steering for vehicle steering systems includes receiving a desired rear wheel angle input and receiving a vehicle speed input. An approved rear wheel angle output is generated using the desired rear wheel angle input and the vehicle speed input, wherein the approved rear wheel angle is based upon one of a plurality of defined operating states, the plurality of operating states including operation at a speed in a first range, operation at a speed in a second range, and transitions therebetween.
摘要翻译：用于实现车辆转向系统的防静电转向的方法包括：接收期望的后轮角输入并接收车速输入。使用期望的后轮角度输入和车辆速度输入产生认可的后轮角度输出，其中所述经批准的后轮角度基于多个限定的操作状态之一，所述多个操作状态包括以第一范围，以第二范围内的速度操作，以及在它们之间的转变。

8. 发明申请

US20050043874A1 Active steering for handling/stability enhancement 审中-公开
标题翻译：主动转向处理/稳定性增强
公开(公告)号：US20050043874A1
公开(公告)日：2005-02-24
申请号：US10951979
申请日：2004-09-28
申请人： Hsien Chen , John Martens , Todd Brown , Ashok Chandy , Chester Gryczan
发明人： Hsien Chen , John Martens , Todd Brown , Ashok Chandy , Chester Gryczan
IPC分类号： B62D6/00 , B62D12/00 , G06F7/00
CPC分类号： B62D6/003
摘要： A control system for a steering system in a vehicle comprising: a reference model responsive to an operator input that computes desired states of the vehicle; a feedforward controller in operable communication with the reference model. The feedforward controller computes a first control value based on input from said reference model and based on at least one of: a lateral velocity, a rate of lateral velocity, a lateral acceleration, and a combination, wherein the combination includes a yaw rate with at least one of a lateral velocity, a rate of lateral velocity, and a lateral acceleration of the motor vehicle. The system also includes an actuator for affecting the steering system based on the first control value, the actuator in operable communication with the feedforward controller.
摘要翻译：一种用于车辆中的转向系统的控制系统，包括：响应于计算车辆的期望状态的操作员输入的参考模型; 与参考模型可操作地通信的前馈控制器。所述前馈控制器基于来自所述参考模型的输入并基于以下至少一个来计算第一控制值：横向速度，横向速度速率，横向加速度和组合，其中所述组合包括横摆率机动车辆的侧向速度，侧向速度速率和横向加速度中的至少一个。该系统还包括用于基于第一控制值影响转向系统的致动器，致动器可与前馈控制器可操作地通信。

9. 发明申请

US20060235590A1 Parking assist utilizing steering system 审中-公开
标题翻译：停车辅助利用转向系统
公开(公告)号：US20060235590A1
公开(公告)日：2006-10-19
申请号：US11351980
申请日：2006-02-10
申请人： Farhad Bolourchi , Todd Brown , John Martens
发明人： Farhad Bolourchi , Todd Brown , John Martens
IPC分类号： B62D6/00
CPC分类号： B62D7/159 , B60T2201/10 , B60W30/06 , B62D15/027 , B62D15/0285
摘要： The invention may comprise devices and methods for headfirst vehicle parallel parking using front and/or rear wheel steering systems.
摘要翻译：本发明可以包括使用前轮和/或后轮转向系统的头部第一车辆并行停车的装置和方法。

10. 发明申请

US20050096799A1 Method for automatically adjusting reference models in vehicle stability enhancement (VSE) systems 审中-公开
公开(公告)号：US20050096799A1
公开(公告)日：2005-05-05
申请号：US10994708
申请日：2004-11-22
申请人： Karen Boswell , John Martens , Edward Bedner , Brian McDonald , Hsien Chen
发明人： Karen Boswell , John Martens , Edward Bedner , Brian McDonald , Hsien Chen
IPC分类号： B60G17/0195 , B60T8/1755 , B62D6/00 , B62D7/15 , G06F7/00
CPC分类号： B60T8/17552 , B60G17/0195 , B60G2600/02 , B60G2600/20 , B60G2800/016 , B60G2800/212 , B60G2800/70 , B60T2260/022 , B60T2270/86 , B62D6/00 , B62D7/159
摘要： A method for automatically adjusting a vehicle stability enhancement (VSE) system is disclosed. The VSE system is used in conjunction with a steering system having a plurality of driver-selectable steering modes associated therewith. In an exemplary embodiment, the method includes configuring a reference model within the VSE system to generate desired vehicle handling aspects, the desired vehicle handling aspects being a function of one or more driver inputs to the steering system. Then, a determination is made as to which of the plurality of driver-selectable steering modes is activated, wherein each of the desired vehicle handling aspects generated is made further dependent upon a specific steering mode selected.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式