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1. 发明申请

US20060083750A1 Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis 审中-公开
标题翻译：用于接种传播性念珠菌病的药物组合物和方法
公开(公告)号：US20060083750A1
公开(公告)日：2006-04-20
申请号：US11123873
申请日：2005-05-05
申请人： John Edwards , Scott Filler , Donald Sheppard , Ashraf Ibrahim , Yue Fu , Brad Spellberg , Michael Yeaman
发明人： John Edwards , Scott Filler , Donald Sheppard , Ashraf Ibrahim , Yue Fu , Brad Spellberg , Michael Yeaman
IPC分类号： A61K39/00 , C12N1/18
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/40 , C07K16/14
摘要： The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing disseminated candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated Als protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The Als protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the Als protein family member includes Als1p, Als3p, Als5p, Als6p, Als7p or Als9p.
摘要翻译：本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。本发明还提供了治疗或预防弥漫性念珠菌病的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的Als蛋白家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 Als蛋白家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，Als蛋白家族成员包括Als1p，Als3p，Als5p，Als6p，Als7p或Als9p 。

2. 发明申请

US20070077256A1 Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents 审中-公开
标题翻译：用于接种弥撒念珠菌病和其他感染因子的药物组合物和方法
公开(公告)号：US20070077256A1
公开(公告)日：2007-04-05
申请号：US11327197
申请日：2006-01-06
申请人： John Edwards , Ashraf Ibrahim , Brad Spellberg , Yue Fu , Scott Filler , Michael Yeaman
发明人： John Edwards , Ashraf Ibrahim , Brad Spellberg , Yue Fu , Scott Filler , Michael Yeaman
IPC分类号： A61K39/02
CPC分类号： A61K39/0002 , A61K39/085 , A61K2039/5156 , A61K2039/58 , C07K16/14 , C07K2317/76
摘要： The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated Als protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The Als protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the Als protein family member includes Als1p, Als3p, Als5p, Als6p, Als7p or Als9p. Also provided is a method of treating or preventing Staphylococcus aureus infections. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译：本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。本发明还提供了治疗或预防血液弥漫性或粘膜皮肤念珠菌病的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的Als蛋白家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 Als蛋白家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，Als蛋白家族成员包括Als1p，Als3p，Als5p，Als6p，Als7p或Als9p 。还提供了治疗或预防金黄色葡萄球菌感染的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。

3. 发明申请

US20090297562A1 PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS 审中-公开
标题翻译：药物组合物和抗肿瘤药物和其他感染性药物的方法
公开(公告)号：US20090297562A1
公开(公告)日：2009-12-03
申请号：US12160073
申请日：2007-01-05
申请人： John Edwards , Scott Filler , Ashraf Ibrahim , Yue Fu , Brad Spellberg , Michael Yeaman
发明人： John Edwards , Scott Filler , Ashraf Ibrahim , Yue Fu , Brad Spellberg , Michael Yeaman
IPC分类号： A61K39/00 , C12N5/02
CPC分类号： A61K39/0002 , A61K39/085 , A61K2039/5156 , A61K2039/58 , C07K16/14 , C07K2317/76
摘要： The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译：本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。本发明还提供了治疗或预防血液弥漫性或粘膜皮肤念珠菌病的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。

4. 发明申请

US20120014995A1 PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS 审中-公开
标题翻译：药物组合物和抗肿瘤药物和其他感染性药物的方法
公开(公告)号：US20120014995A1
公开(公告)日：2012-01-19
申请号：US12987949
申请日：2011-01-10
申请人： John E. Edwards, JR. , Ashraf Ibrahim , Brad J. Spellberg , Yue Fu , Scott G. Filler , Michael Yeaman
发明人： John E. Edwards, JR. , Ashraf Ibrahim , Brad J. Spellberg , Yue Fu , Scott G. Filler , Michael Yeaman
IPC分类号： A61K39/00 , A61P37/06 , A61P31/10
CPC分类号： A61K39/0002 , A61K39/085 , A61K2039/5156 , A61K2039/58 , C07K16/14 , C07K2317/76
摘要： The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated Als protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The Als protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the Als protein family member includes Als1p, Als3p, Als5p, Als6p, Als7p or Als9p. Also provided is a method of treating or preventing Staphylococcus aureus infections. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译：本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。本发明还提供了治疗或预防血液弥漫性或粘膜皮肤念珠菌病的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的Als蛋白家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 Als蛋白家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，Als蛋白家族成员包括Als1p，Als3p，Als5p，Als6p，Als7p或Als9p 。还提供了治疗或预防金黄色葡萄球菌感染的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。

5. 发明申请

US20060135416A1 Multifunctional context-activated protides and methods of use 有权
公开(公告)号：US20060135416A1
公开(公告)日：2006-06-22
申请号：US10524952
申请日：2003-01-29
申请人： Michael Yeaman , Nanette Yount , John Edwards Jr. , Eric Brass
发明人： Michael Yeaman , Nanette Yount , John Edwards Jr. , Eric Brass
IPC分类号： A61K38/17 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , C07K14/001 , C07K2319/00
摘要： This invention is directed to multifunctional, context-activated protides that have two or more effectors with individually distinct biological functions and one or more corresponding activator sites that can each initiate or amplify the biological function of one or more effectors upon context-activation. The context-activated protides of the invention are useful in the diagnosis, prophylaxis, and therapy of a broad range of pathological conditions.

6. 发明申请

US20060074016A1 Multifunctional context-activated protides and methods of use 失效
公开(公告)号：US20060074016A1
公开(公告)日：2006-04-06
申请号：US10225562
申请日：2002-08-20
申请人： Michael Yeaman , Nannette Yount , John Edwards , Eric Brass
发明人： Michael Yeaman , Nannette Yount , John Edwards , Eric Brass
IPC分类号： A61K38/16 , C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/001 , C07K2319/00
摘要： This invention is directed to multifunctional, context-activated protides that have two or more effectors with individually distinct biological functions and one or more corresponding activator sites that can each initiate or amplify the biological function of one or more effectors upon context-activation. The context-activated protides of the invention are useful in the diagnosis, prophylaxis, and therapy of a broad range of pathological conditions.

7. 发明申请

US20110143996A1 ANTIMICROBIAL KINOCIDIN COMPOSITIONS AND METHODS OF USE 有权
标题翻译：抗微生物杀鼠剂组合物及其使用方法
公开(公告)号：US20110143996A1
公开(公告)日：2011-06-16
申请号：US12947793
申请日：2010-11-16
申请人： Nannette I. Yount , Michael Yeaman
发明人： Nannette I. Yount , Michael Yeaman
IPC分类号： A61K38/10 , A61K38/19 , A61P31/00
CPC分类号： C07K14/521 , A61K38/00 , C07K14/4723 , Y02A50/409 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention provides novel kinocidin peptides comprising a C-terminal portion of a kinocidin, wherein the C-terminal portion encompasses an α-helical secondary structure and further displays antimicrobial activity. The kinocidin peptides of the invention are derived from and correspond to a C-terminal portion of a kinocidin that includes a γκo core and that can be a CXC, CC, or C class chemokine Structural, physicochemical and functional properties of this novel class of antimicrobial peptides and amino acid sequences of particular kinocidin peptides are also disclosed. The invention also provides related antimicrobial methods.
摘要翻译：本发明提供了包含激肽基的C-末端部分的新的激肽基肽，其中C末端部分包含α-螺旋二级结构并进一步显示抗微生物活性。本发明的激肽肽衍生自并对应于包含γ和核心的激肽释放酶的C-末端部分，并且可以是CXC，CC或C类趋化因子该新型类的结构，物理化学和功能性质的抗菌肽和特定的激肽原肽的氨基酸序列也被公开。本发明还提供了相关的抗微生物方法。

8. 发明授权

US09428566B2 Antimicrobial kinocidin compositions and methods of use 有权
标题翻译：抗微生物激肽素组合物及其使用方法
公开(公告)号：US09428566B2
公开(公告)日：2016-08-30
申请号：US12947793
申请日：2010-11-16
申请人： Nannette Y. Yount , Michael Yeaman
发明人： Nannette Y. Yount , Michael Yeaman
IPC分类号： C07K14/00 , C07K14/52 , C07K14/47 , A61K38/00
CPC分类号： C07K14/521 , A61K38/00 , C07K14/4723 , Y02A50/409 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention provides novel kinocidin peptides comprising a C-terminal portion of a kinocidin, wherein the C-terminal portion encompasses an α-helical secondary structure and further displays antimicrobial activity. The kinocidin peptides of the invention are derived from and correspond to a C-terminal portion of a kinocidin that includes a γκo core and that can be a CXC, CC, or C class chemokine. Structural, physicochemical and functional properties of this novel class of antimicrobial peptides and amino acid sequences of particular kinocidin peptides are also disclosed. The invention also provides related antimicrobial methods.
摘要翻译：本发明提供了包含激肽基的C-末端部分的新的激肽基肽，其中C末端部分包含α-螺旋二级结构并进一步显示抗微生物活性。本发明的激肽肽衍生自并对应于包含γκα核心并且可以是CXC，CC或C类趋化因子的激肽释放酶的C-末端部分。还公开了这种新型抗菌肽和特定的激肽肽的氨基酸序列的结构，物理化学和功能性质。本发明还提供了相关的抗微生物方法。

9. 发明申请

US20100113342A1 ANTIMICROBIAL KINOCIDIN COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：抗微生物杀鼠剂组合物及其使用方法
公开(公告)号：US20100113342A1
公开(公告)日：2010-05-06
申请号：US12438923
申请日：2007-06-20
申请人： Nannette I. Yount , Michael Yeaman
发明人： Nannette I. Yount , Michael Yeaman
IPC分类号： A61K38/03 , C07K2/00 , C07K14/00 , C07K7/08 , C07K7/06 , A61K38/02 , A61P31/04 , A01P1/00
CPC分类号： C07K14/521 , A61K38/00 , C07K14/4723 , Y02A50/409 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention provides novel kinocidin peptides comprising a C-terminal portion of a kinocidin, wherein the C-terminal portion encompasses an α-helical secondary structure and further displays antimicrobial activity. The kinocidin peptides of the invention are derived from and correspond to a C-terminal portion of a kinocidin that includes a γκo core and that can be a CXC, CC, or C class chemokine. Structural, physicochemical and functional properties of this novel class of antimicrobial peptides and amino acid sequences of particular kinocidin peptides are also disclosed. The invention also provides related antimicrobial methods.
摘要翻译：本发明提供了包含激肽基的C-末端部分的新的激肽基肽，其中C末端部分包含α-螺旋二级结构并进一步显示抗微生物活性。本发明的激肽肽衍生自并对应于包含γ和核心的激肽原的C末端部分，并且可以是CXC，CC或C类趋化因子。还公开了这种新型抗菌肽和特定的激肽肽的氨基酸序列的结构，物理化学和功能性质。本发明还提供了相关的抗微生物方法。

10. 发明授权

US08809263B2 Anti-infective hydroxy-phenyl-benzoates and methods of use 有权
标题翻译：抗感染性羟基苯基苯甲酸酯及其使用方法
公开(公告)号：US08809263B2
公开(公告)日：2014-08-19
申请号：US13201447
申请日：2009-10-26
申请人： Michael Yeaman , Arnold Bayer
发明人： Michael Yeaman , Arnold Bayer
IPC分类号： A61K38/00 , C07K7/08
CPC分类号： A61K31/60 , A61K31/5377 , A61K31/603 , A61K38/14 , Y02A50/402 , Y02A50/47 , Y02A50/473 , Y02A50/481 , Y02A50/483
摘要： The invention provides a method for preventing or treating a disease caused by an extracellular microorganism, said method comprising systemically administering to a subject in need thereof a prophylactically or therapeutically effective amount of a salicylic acid (SAL) or a SAL analogue. The extracellular microorganism can be of the bacterial genus Staphylococcus, for example, Staphylococcus aureus. The extracellular microorganism can be a strain that is resistant to at least one antibiotic. The strain can be selected from the group consisting of methycillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate Staphylococcus aureus (VISA) and vancomycin-resistant Staphylococcus aureus (VRSA). The invention also provides a method for preventing or treating an infectious disease caused by of methycillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate Staphylococcus aureus (VISA) or vancomycin-resistant Staphylococcus aureus (VRSA), comprising systemically coadministering in a synergistic combination to a subject in need thereof prophylactically or therapeutically effective amounts, individually or collectively, of a salicylic acid (SAL) or a SAL analogue and at least one additional antimicrobial agent, for example, vancomycin and/or linezolid.
摘要翻译：本发明提供了一种预防或治疗由细胞外微生物引起的疾病的方法，所述方法包括向有需要的受试者全身施用预防或治疗有效量的水杨酸（SAL）或SAL类似物。细胞外微生物可以是细菌属葡萄球菌，例如金黄色葡萄球菌。细胞外微生物可以是对至少一种抗生素具有抗性的菌株。该菌株可以选自耐甲氧西林金黄色葡萄球菌（MRSA），万古霉素 - 中间体金黄色葡萄球菌（VISA）和耐万古霉素金黄色葡萄球菌（VRSA）。本发明还提供了一种预防或治疗由耐甲氧西林金黄色葡萄球菌（MRSA），万古霉素中间体金黄色葡萄球菌（VISA）或万古霉素耐药金黄色葡萄球菌（VRSA）引起的感染性疾病的方法，其包括以协同组合系统地共同施用（SAL）或SAL类似物和至少一种另外的抗微生物剂例如万古霉素和/或利奈唑胺的预防或治疗有效量的预防或治疗有效量。

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