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1. 发明授权

US08747846B2 Compositions and methods for immunization against drug resistant Acinetobacter baumannii 失效
标题翻译：免疫耐药鲍曼不动杆菌的组合物和方法
公开(公告)号：US08747846B2
公开(公告)日：2014-06-10
申请号：US13470177
申请日：2012-05-11
申请人： Brad J. Spellberg , Lin Lin , Ashraf Ibrahim , Guanpingsheng Luo
发明人： Brad J. Spellberg , Lin Lin , Ashraf Ibrahim , Guanpingsheng Luo
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K14/22 , A61K39/02 , A61K39/104 , A61K2039/55505 , C07K14/212 , C07K16/1203 , C07K16/1217 , C07K2317/34
摘要： The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization against A. baumannii infection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization against A. baumannii infection. The compositions and methods of the invention are useful for preventing or treating A. baumannii infections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR) A. baumannii infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR) A. baumannii infections.
摘要翻译：本发明提供包含OmpA或其抗原性片段的疫苗组合物，以及针对鲍曼不动杆菌感染的主动免疫的相关方法。本发明还提供了特异性结合OmpA的抗体及其抗原结合部分，以及针对鲍氏不动杆菌感染的相关的被动免疫方法。本发明的组合物和方法可用于预防或治疗鲍曼不动杆菌感染，包括由对碳青霉烯类耐受的菌株和除粘菌素或替加环素之外的所有其它抗生素引起的鲍曼不动杆菌感染，也被称为极耐药（XDR）A.鲍曼不动杆菌感染，而那些对每一个FDA批准的抗生素都有抗药性，也被称为泛耐药（PDR）A.鲍曼不动杆菌感染。

2. 发明申请

US20070078112A1 Phosphate prodrugs of a farnesyl dibenzodiazepinone, processes for their production and their use as pharmaceuticals 失效
标题翻译：法呢基二苯并二氮杂酮的磷酸酯前药，其制备方法及其作为药物的用途
公开(公告)号：US20070078112A1
公开(公告)日：2007-04-05
申请号：US11527581
申请日：2006-09-27
申请人： Mustapha Aouidate , James McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun Banskota , Maxime Ranger , Gregory White
发明人： Mustapha Aouidate , James McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun Banskota , Maxime Ranger , Gregory White
IPC分类号： A61K31/551 , C07D243/10
CPC分类号： C07D243/10 , C07F9/5535
摘要： This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.
摘要翻译：本发明涉及法呢基化二苯并二氮杂酮的磷酸酯前药，其制备方法，包含前药的药物组合物及其在治疗赘生物中的用途。

3. 发明申请

US20070077256A1 Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents 审中-公开
标题翻译：用于接种弥撒念珠菌病和其他感染因子的药物组合物和方法
公开(公告)号：US20070077256A1
公开(公告)日：2007-04-05
申请号：US11327197
申请日：2006-01-06
申请人： John Edwards , Ashraf Ibrahim , Brad Spellberg , Yue Fu , Scott Filler , Michael Yeaman
发明人： John Edwards , Ashraf Ibrahim , Brad Spellberg , Yue Fu , Scott Filler , Michael Yeaman
IPC分类号： A61K39/02
CPC分类号： A61K39/0002 , A61K39/085 , A61K2039/5156 , A61K2039/58 , C07K16/14 , C07K2317/76
摘要： The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated Als protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The Als protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the Als protein family member includes Als1p, Als3p, Als5p, Als6p, Als7p or Als9p. Also provided is a method of treating or preventing Staphylococcus aureus infections. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译：本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。本发明还提供了治疗或预防血液弥漫性或粘膜皮肤念珠菌病的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的Als蛋白家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 Als蛋白家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，Als蛋白家族成员包括Als1p，Als3p，Als5p，Als6p，Als7p或Als9p 。还提供了治疗或预防金黄色葡萄球菌感染的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。

4. 发明申请

US20120301474A1 COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST DRUG RESISTANT ACINETOBACTER BAUMANNII 失效
标题翻译：用于免疫抗药性乙酰胆碱酯酶的组合物和方法
公开(公告)号：US20120301474A1
公开(公告)日：2012-11-29
申请号：US13470177
申请日：2012-05-11
申请人： Brad J. Spellberg , Lin Lin , Ashraf Ibrahim , Guanpingsheng Luo
发明人： Brad J. Spellberg , Lin Lin , Ashraf Ibrahim , Guanpingsheng Luo
IPC分类号： A61K39/02 , C07K7/08 , C07K7/06 , C07K5/08 , A61P37/04 , C12N15/63 , C07K16/12 , A61K39/395 , A61P31/04 , C07K14/21 , C12N15/31
CPC分类号： C07K14/22 , A61K39/02 , A61K39/104 , A61K2039/55505 , C07K14/212 , C07K16/1203 , C07K16/1217 , C07K2317/34
摘要： The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization against A. baumannii infection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization against A. baumannii infection. The compositions and methods of the invention are useful for preventing or treating A. baumannii infections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR) A. baumannii infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR) A. baumannii infections.
摘要翻译：本发明提供包含OmpA或其抗原性片段的疫苗组合物，以及针对鲍曼不动杆菌感染的主动免疫的相关方法。本发明还提供了特异性结合OmpA的抗体及其抗原结合部分，以及针对鲍氏不动杆菌感染的相关的被动免疫方法。本发明的组合物和方法可用于预防或治疗鲍曼不动杆菌感染，包括由对碳青霉烯类耐受的菌株和除粘菌素或替加环素之外的所有其它抗生素引起的鲍曼不动杆菌感染，也被称为极耐药（XDR）A.鲍曼不动杆菌感染，而那些对每一个FDA批准的抗生素都有抗药性，也被称为泛耐药（PDR）A.鲍曼不动杆菌感染。

5. 发明申请

US20090297562A1 PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS 审中-公开
标题翻译：药物组合物和抗肿瘤药物和其他感染性药物的方法
公开(公告)号：US20090297562A1
公开(公告)日：2009-12-03
申请号：US12160073
申请日：2007-01-05
申请人： John Edwards , Scott Filler , Ashraf Ibrahim , Yue Fu , Brad Spellberg , Michael Yeaman
发明人： John Edwards , Scott Filler , Ashraf Ibrahim , Yue Fu , Brad Spellberg , Michael Yeaman
IPC分类号： A61K39/00 , C12N5/02
CPC分类号： A61K39/0002 , A61K39/085 , A61K2039/5156 , A61K2039/58 , C07K16/14 , C07K2317/76
摘要： The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译：本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。本发明还提供了治疗或预防血液弥漫性或粘膜皮肤念珠菌病的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。

6. 发明申请

US20090062255A1 TUMOR-TARGETING EVALUATION METHODOLOGY AND COMPOUNDS RELATED THERETO 审中-公开
标题翻译：肿瘤靶向评估方法及其相关化合物
公开(公告)号：US20090062255A1
公开(公告)日：2009-03-05
申请号：US12192595
申请日：2008-08-15
申请人： Henriette GOURDEAU , Pierre FALARDEAU , My-Anh WIOLAND , Nadia BOUFAIED , James B. MCALPINE , Mustapha AOUIDATE , Thierry BERTOMEU , Ashraf IBRAHIM
发明人： Henriette GOURDEAU , Pierre FALARDEAU , My-Anh WIOLAND , Nadia BOUFAIED , James B. MCALPINE , Mustapha AOUIDATE , Thierry BERTOMEU , Ashraf IBRAHIM
IPC分类号： A61K31/551 , C07D487/00 , A61P31/00 , G01N33/574
CPC分类号： A61K31/551 , C07D243/38 , C07D405/04 , C07D405/14 , G01N33/5011
摘要： The invention relates to a method for evaluating a chemotherapeutic potential of a candidate molecule. In evaluating the candidate molecule, the candidate molecule is tested for its ability to inhibit the in vitro growth of a cancer cell; to bind a cellular receptor produced by a cancer cell, wherein said receptor, such as a peripheral benzodiazepine receptor, is produced in a greater amount by said cancer cell than by a normal cell; and to inhibit the activity of at least one protein member of the MAPK pathway. The invention further relates to dibenzodiazepinone analogues and derivatives thereof.
摘要翻译：本发明涉及一种用于评估候选分子的化疗潜力的方法。在评估候选分子时，检测候选分子的抑制癌细胞体外生长的能力; 结合由癌细胞产生的细胞受体，其中所述受体（例如外周苯并二氮杂受体）由所述癌细胞以比正常细胞更大的量产生; 并抑制MAPK通路中至少一个蛋白质成员的活性。本发明还涉及二苯并二氮杂酮类似物及其衍生物。

7. 发明申请

US20060083750A1 Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis 审中-公开
标题翻译：用于接种传播性念珠菌病的药物组合物和方法
公开(公告)号：US20060083750A1
公开(公告)日：2006-04-20
申请号：US11123873
申请日：2005-05-05
申请人： John Edwards , Scott Filler , Donald Sheppard , Ashraf Ibrahim , Yue Fu , Brad Spellberg , Michael Yeaman
发明人： John Edwards , Scott Filler , Donald Sheppard , Ashraf Ibrahim , Yue Fu , Brad Spellberg , Michael Yeaman
IPC分类号： A61K39/00 , C12N1/18
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/40 , C07K16/14
摘要： The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing disseminated candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated Als protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The Als protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the Als protein family member includes Als1p, Als3p, Als5p, Als6p, Als7p or Als9p.
摘要翻译：本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。本发明还提供了治疗或预防弥漫性念珠菌病的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的Als蛋白家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 Als蛋白家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，Als蛋白家族成员包括Als1p，Als3p，Als5p，Als6p，Als7p或Als9p 。

8. 发明授权

US08709446B2 HYR1 as a target for active and passive immunization against Candida 有权
标题翻译： HYR1作为针对念珠菌的主动和被动免疫的靶标
公开(公告)号：US08709446B2
公开(公告)日：2014-04-29
申请号：US13382088
申请日：2010-07-02
申请人： Yue Fu , Guanpingsheng Luo , Ashraf Ibrahim , Brad Spellberg , John Edwards, Jr.
发明人： Yue Fu , Guanpingsheng Luo , Ashraf Ibrahim , Brad Spellberg , John Edwards, Jr.
IPC分类号： A61K39/00 , A61K38/00 , C07K1/00
CPC分类号： C07K14/40 , A61K39/00 , A61K39/0002 , C07K2319/21
摘要： The invention features HYR1 as a vaccine target and as a prophylactic strategy for combating disseminated candidiasis.
摘要翻译：本发明的特征在于HYR1作为疫苗靶点，并且作为防治传播性念珠菌病的预防策略。

9. 发明申请

US20120014995A1 PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS 审中-公开
标题翻译：药物组合物和抗肿瘤药物和其他感染性药物的方法
公开(公告)号：US20120014995A1
公开(公告)日：2012-01-19
申请号：US12987949
申请日：2011-01-10
申请人： John E. Edwards, JR. , Ashraf Ibrahim , Brad J. Spellberg , Yue Fu , Scott G. Filler , Michael Yeaman
发明人： John E. Edwards, JR. , Ashraf Ibrahim , Brad J. Spellberg , Yue Fu , Scott G. Filler , Michael Yeaman
IPC分类号： A61K39/00 , A61P37/06 , A61P31/10
CPC分类号： A61K39/0002 , A61K39/085 , A61K2039/5156 , A61K2039/58 , C07K16/14 , C07K2317/76
摘要： The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated Als protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The Als protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the Als protein family member includes Als1p, Als3p, Als5p, Als6p, Als7p or Als9p. Also provided is a method of treating or preventing Staphylococcus aureus infections. The method includes administering an immunogenic amount of a vaccine an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译：本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。本发明还提供了治疗或预防血液弥漫性或粘膜皮肤念珠菌病的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的Als蛋白家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 Als蛋白家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，Als蛋白家族成员包括Als1p，Als3p，Als5p，Als6p，Als7p或Als9p 。还提供了治疗或预防金黄色葡萄球菌感染的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗。

10. 发明授权

US07384935B2 Phosphate prodrugs of a farnesyl dibenzodiazepinone, processes for their production and their use as pharmaceuticals 失效
标题翻译：法呢基二苯并二氮杂酮的磷酸酯前药，其制备方法及其作为药物的用途
公开(公告)号：US07384935B2
公开(公告)日：2008-06-10
申请号：US11527581
申请日：2006-09-27
申请人： Mustapha Aouidate , James B. McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun H. Banskota , Maxime Ranger , Gregory L. White
发明人： Mustapha Aouidate , James B. McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun H. Banskota , Maxime Ranger , Gregory L. White
IPC分类号： C07D243/10 , A61K31/551 , A61P35/00
CPC分类号： C07D243/10 , C07F9/5535
摘要： This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.
摘要翻译：本发明涉及法呢基化二苯并二氮杂酮的磷酸酯前药，其制备方法，包含前药的药物组合物及其在治疗赘生物中的用途。

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